SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MBO'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D0V_A_NIOA991_1 (NICOTINATE MONONUCLEOTIDE:5,6-D IMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSF ERASE)	1dr6	DIHYDROFOLATE REDUCTASE (Gallus gallus)	4 / 8	GLY A 117 GLY A 15 PHE A 148 GLY A 17	NAP A 191 (-3.3A) MBO A 201 ( 4.2A) None NAP A 191 (-3.6A)	0.74A	1d0vA-1dr6A: undetectable	1d0vA-1dr6A: 19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JHA_A_NIOA991_1 (NICOTINATE MONONUCLEOTIDE:5,6-D IMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSF ERASE)	1dr6	DIHYDROFOLATE REDUCTASE (Gallus gallus)	4 / 8	GLY A 117 GLY A 15 PHE A 148 GLY A 17	NAP A 191 (-3.3A) MBO A 201 ( 4.2A) None NAP A 191 (-3.6A)	0.74A	1jhaA-1dr6A: undetectable	1jhaA-1dr6A: 19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PKV_A_RBFA100_1 (RIBOFLAVIN SYNTHASE ALPHA CHAIN)	5ec5	LYSENIN (Eisenia fetida)	5 / 11	SER A 269 CYH A 283 LEU A 284 ILE A 232 VAL A 281	MBO A 301 (-2.8A) MBO A 301 (-2.2A) MBO A 302 (-4.6A) None None	1.25A	1pkvA-5ec5A: undetectable 1pkvB-5ec5A: undetectable	1pkvA-5ec5A: 14.14 1pkvB-5ec5A: 14.14

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1D0V_A_NIOA991_1","NICOTINATE MONONUCLEOTIDE:5,6-DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE","1dr6","DIHYDROFOLATE REDUCTASE","Gallus gallus",4,"GLY A 117;GLY A  15;PHE A 148;GLY A  17","NAP A 191 (-3.3A);MBO A 201 ( 4.2A);None;NAP A 191 (-3.6A)","0.74A","1d0vA-1dr6A:undetectable",null],["1JHA_A_NIOA991_1","NICOTINATE MONONUCLEOTIDE:5,6-DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE","1dr6","DIHYDROFOLATE REDUCTASE","Gallus gallus",4,"GLY A 117;GLY A  15;PHE A 148;GLY A  17","NAP A 191 (-3.3A);MBO A 201 ( 4.2A);None;NAP A 191 (-3.6A)","0.74A","1jhaA-1dr6A:undetectable","1d0vA-1dr6A:19.38"],["1PKV_A_RBFA100_1","RIBOFLAVIN SYNTHASE ALPHA CHAIN;RIBOFLAVIN SYNTHASE ALPHA CHAIN","5ec5","LYSENIN","Eisenia fetida",5,"SER A 269;CYH A 283;LEU A 284;ILE A 232;VAL A 281","MBO A 301 (-2.8A);MBO A 301 (-2.2A);MBO A 302 (-4.6A);None;None","1.25A","1pkvA-5ec5A:undetectable;1pkvB-5ec5A:undetectable","1jhaA-1dr6A:19.38"]]