SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MAY'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 11 LEU A 496
ASN A 498
TYR A 493
GLY A 239
LEU A 372
None
None
None
MAY  A 600 (-3.6A)
MAY  A 600 (-4.6A)
1.40A 1fkpA-1mt5A:
undetectable
1fkpA-1mt5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 6 ASN A 498
ARG A 243
ILE A 491
GLY A 239
None
None
MAY  A 600 (-4.0A)
MAY  A 600 (-3.6A)
0.99A 1oniA-1mt5A:
0.0
1oniB-1mt5A:
0.0
1oniA-1mt5A:
13.04
1oniB-1mt5A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 6 ASN A 498
ARG A 243
ILE A 491
GLY A 239
None
None
MAY  A 600 (-4.0A)
MAY  A 600 (-3.6A)
0.99A 1oniD-1mt5A:
0.0
1oniF-1mt5A:
0.0
1oniD-1mt5A:
13.04
1oniF-1mt5A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 SER A 246
GLY A 281
GLY A 235
ASP A 237
LEU A 297
None
None
None
MAY  A 600 (-4.4A)
None
1.21A 2zw9A-1mt5A:
undetectable
2zw9A-1mt5A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 LEU A 234
GLY A 235
SER A 217
LEU A 280
LEU A 261
None
None
MAY  A 600 (-3.1A)
None
None
1.17A 3cjtG-1mt5A:
undetectable
3cjtG-1mt5A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
6 / 12 LEU A 234
GLY A 235
SER A 217
VAL A 187
LEU A 280
LEU A 261
None
None
MAY  A 600 (-3.1A)
None
None
None
1.26A 3cjtO-1mt5A:
undetectable
3cjtO-1mt5A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 10 LEU A 496
ASN A 498
TYR A 493
GLY A 239
LEU A 372
None
None
None
MAY  A 600 (-3.6A)
MAY  A 600 (-4.6A)
1.22A 3lp1A-1mt5A:
0.0
3lp1A-1mt5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 LEU A 496
ASN A 498
TYR A 493
GLY A 239
LEU A 372
None
None
None
MAY  A 600 (-3.6A)
MAY  A 600 (-4.6A)
1.36A 3medA-1mt5A:
0.0
3medB-1mt5A:
0.0
3medA-1mt5A:
21.78
3medB-1mt5A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 VAL A 495
TYR A 335
LEU A 447
GLY A 378
ALA A 377
MAY  A 600 (-4.8A)
None
None
None
MAY  A 600 (-3.7A)
1.02A 4coxA-1mt5A:
undetectable
4coxA-1mt5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 VAL A 495
TYR A 335
LEU A 447
GLY A 378
ALA A 377
MAY  A 600 (-4.8A)
None
None
None
MAY  A 600 (-3.7A)
1.02A 4coxB-1mt5A:
0.0
4coxB-1mt5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 VAL A 495
TYR A 335
LEU A 447
GLY A 378
ALA A 377
MAY  A 600 (-4.8A)
None
None
None
MAY  A 600 (-3.7A)
1.02A 4coxD-1mt5A:
0.0
4coxD-1mt5A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 5 LEU A 192
LEU A 404
MET A 436
THR A 488
TRP A 531
MAY  A 600 ( 4.2A)
None
None
MAY  A 600 ( 4.2A)
None
0.77A 4do3A-1mt5A:
68.6
4do3A-1mt5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
6 / 6 LEU A 192
LEU A 404
ILE A 407
MET A 436
THR A 488
TRP A 531
MAY  A 600 ( 4.2A)
None
None
None
MAY  A 600 ( 4.2A)
None
0.80A 4do3B-1mt5A:
68.3
4do3B-1mt5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 VAL A 495
TYR A 335
LEU A 447
GLY A 378
ALA A 377
MAY  A 600 (-4.8A)
None
None
None
MAY  A 600 (-3.7A)
1.07A 4otyB-1mt5A:
0.0
4otyB-1mt5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
5 / 12 ILE A 407
GLY A 384
PHE A 432
THR A 488
LEU A 389
None
None
MAY  A 600 ( 4.9A)
MAY  A 600 ( 4.2A)
None
1.00A 5byjA-1mt5A:
undetectable
5byjA-1mt5A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus)
4 / 7 VAL A 495
LEU A 447
GLY A 378
ALA A 377
MAY  A 600 (-4.8A)
None
None
MAY  A 600 (-3.7A)
0.69A 5f1aB-1mt5A:
undetectable
5f1aB-1mt5A:
22.22