SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MAW'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 7 TYR A 555
GLU A 254
PHE A 462
TRP A 467
 MAW  A1003 (-4.9A)
LGU  A1002 (-4.5A)
MAW  A1003 (-4.4A)
MAW  A1003 (-3.8A)
 1.10A 1b2iA-3aflA:
undetectable		 1b2iA-3aflA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 5h71 ALGQ2
(Sphingomonas
sp.) 		4 / 6 TRP A 270
TYR A 395
ILE A 385
TYR A 379
 BEM  A 502 ( 3.6A)
MAW  A 501 ( 4.5A)
None
None
 1.11A 1maaB-5h71A:
undetectable
1maaD-5h71A:
undetectable		 1maaB-5h71A:
20.50
1maaD-5h71A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		3 / 3 TRP A 467
ARG A 199
PHE A 462
 MAW  A1003 (-3.8A)
MAW  A1003 (-3.7A)
MAW  A1003 (-4.4A)
 1.25A 1zeaH-3aflA:
4.5
1zeaL-3aflA:
4.3		 1zeaH-3aflA:
13.69
1zeaL-3aflA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		4 / 6 THR A 343
ASN A 316
GLY A 313
ASP A 314
 None
None
MAW  A 401 (-3.4A)
MAV  A 402 ( 4.7A)
 1.24A 3w9tE-1hv6A:
undetectable		 3w9tE-1hv6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 7 TYR A 555
ASP A 416
HIS A 311
HIS A 563
 MAW  A1003 (-4.9A)
None
LGU  A1002 ( 3.9A)
None
 1.27A 3zodA-3aflA:
undetectable		 3zodA-3aflA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5h71 ALGQ2
(Sphingomonas
sp.) 		4 / 5 TYR A 129
GLN A 391
ASP A 206
ASP A 189
 BEM  A 502 ( 4.4A)
MAW  A 501 ( 3.7A)
None
None
 1.47A 4qtuB-5h71A:
undetectable		 4qtuB-5h71A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 5h71 ALGQ2
(Sphingomonas
sp.) 		5 / 12 GLU A 190
ASP A 185
ARG A 193
SER A 273
THR A 267
 None
None
None
MAW  A 501 ( 2.5A)
None
 1.08A 4uroD-5h71A:
undetectable		 4uroD-5h71A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5h71 ALGQ2
(Sphingomonas
sp.) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 BEM  A 502 ( 4.2A)
MAW  A 501 ( 4.8A)
None
None
 1.40A 5a06A-5h71A:
undetectable		 5a06A-5h71A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5h71 ALGQ2
(Sphingomonas
sp.) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 BEM  A 502 ( 4.2A)
MAW  A 501 ( 4.8A)
None
None
 1.40A 5a06C-5h71A:
undetectable		 5a06C-5h71A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5h71 ALGQ2
(Sphingomonas
sp.) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 BEM  A 502 ( 4.2A)
MAW  A 501 ( 4.8A)
None
None
 1.39A 5a06D-5h71A:
undetectable		 5a06D-5h71A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5h71 ALGQ2
(Sphingomonas
sp.) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 BEM  A 502 ( 4.2A)
MAW  A 501 ( 4.8A)
None
None
 1.40A 5a06E-5h71A:
undetectable		 5a06E-5h71A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5h71 ALGQ2
(Sphingomonas
sp.) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 BEM  A 502 ( 4.2A)
MAW  A 501 ( 4.8A)
None
None
 1.36A 5a06F-5h71A:
undetectable		 5a06F-5h71A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5h71 ALGQ2
(Sphingomonas
sp.) 		4 / 5 TYR A 393
GLN A 391
GLY A 138
ILE A 408
 None
MAW  A 501 ( 3.7A)
None
None
 1.41A 6debB-5h71A:
undetectable		 6debB-5h71A:
9.55