SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MAV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 TYR A 257
HIS A 202
MET A 264
PRO A 265
ASN A 441
 BEM  A 804 (-4.8A)
MAV  A 803 (-3.8A)
None
None
BEM  A 804 ( 4.7A)
 1.47A 1mrlB-4ojzA:
undetectable
1mrlC-4ojzA:
undetectable		 1mrlB-4ojzA:
14.40
1mrlC-4ojzA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ND4_B_KANB2300_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		5 / 9 ASP A 269
ARG A 186
GLU A 306
ASP A 187
GLU A 189
 None
MAV  A 495 (-3.1A)
None
MAV  A 495 ( 4.4A)
None
 1.45A 1nd4B-1y3nA:
0.0		 1nd4B-1y3nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 10 LEU A 148
ALA A 151
GLU A 150
LEU A 188
HIS A 200
 MAV  A 803 ( 4.8A)
None
None
None
LGU  A 802 ( 4.2A)
 1.41A 2ocfA-4ojzA:
undetectable		 2ocfA-4ojzA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		3 / 3 ASP A 187
ASN A 185
THR A 258
 MAV  A 495 ( 4.4A)
None
None
 0.68A 2q63B-1y3nA:
undetectable		 2q63B-1y3nA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		3 / 3 LEU A 148
TRP A 145
GLY A  81
 MAV  A 803 ( 4.8A)
None
None
 0.64A 3l35A-4ojzA:
undetectable
3l35H-4ojzA:
undetectable		 3l35A-4ojzA:
5.66
3l35H-4ojzA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		3 / 3 LEU A 148
TRP A 145
GLY A  81
 MAV  A 803 ( 4.8A)
None
None
 0.67A 3l35B-4ojzA:
undetectable
3l35K-4ojzA:
undetectable		 3l35B-4ojzA:
5.66
3l35K-4ojzA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		4 / 6 THR A 343
ASN A 316
GLY A 313
ASP A 314
 None
None
MAW  A 401 (-3.4A)
MAV  A 402 ( 4.7A)
 1.24A 3w9tE-1hv6A:
undetectable		 3w9tE-1hv6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1hv6 ALGINATE LYASE
(Sphingomonas
sp.) 		4 / 5 ASP A 314
ASN A 248
ILE A 318
VAL A 289
 MAV  A 402 ( 4.7A)
None
None
None
 1.42A 4hytA-1hv6A:
undetectable		 4hytA-1hv6A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 MAV  A 495 (-4.1A)
BEM  A 494 ( 4.8A)
None
None
 1.42A 5a06A-1y3nA:
undetectable		 5a06A-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 MAV  A 495 (-4.1A)
BEM  A 494 ( 4.8A)
None
None
 1.41A 5a06C-1y3nA:
undetectable		 5a06C-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 MAV  A 495 (-4.1A)
BEM  A 494 ( 4.8A)
None
None
 1.41A 5a06D-1y3nA:
undetectable		 5a06D-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 MAV  A 495 (-4.1A)
BEM  A 494 ( 4.8A)
None
None
 1.42A 5a06E-1y3nA:
undetectable		 5a06E-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 MAV  A 495 (-4.1A)
BEM  A 494 ( 4.8A)
None
None
 1.39A 5a06F-1y3nA:
undetectable		 5a06F-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 8 ASN A 201
ALA A 258
HIS A 202
HIS A 200
 MAV  A 803 ( 4.1A)
None
MAV  A 803 (-3.8A)
LGU  A 802 ( 4.2A)
 1.08A 5km8A-4ojzA:
undetectable
5km8B-4ojzA:
undetectable		 5km8A-4ojzA:
13.07
5km8B-4ojzA:
13.07