SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MAP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 1qpg 3-PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 335
TRP A 333
GLY A 210
VAL A 325
 MAP  A 450 (-3.7A)
None
None
None
 0.89A 1dbbH-1qpgA:
undetectable
1dbbL-1qpgA:
undetectable		 1dbbH-1qpgA:
19.37
1dbbL-1qpgA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1qpg 3-PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		6 / 12 THR A 373
GLY A 211
GLY A 210
VAL A 214
ASP A 256
ILE A 254
 MAP  A 450 (-3.7A)
MAP  A 450 (-3.6A)
None
None
None
None
 1.46A 2b25A-1qpgA:
2.9		 2b25A-1qpgA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1qpg 3-PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 380
GLY A 211
LEU A 209
ASN A 334
VAL A 376
 None
MAP  A 450 (-3.6A)
None
MAP  A 450 (-3.3A)
None
 1.11A 2zulA-1qpgA:
3.4		 2zulA-1qpgA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1qpg 3-PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 320
GLY A 234
ILE A 208
VAL A 278
GLY A 335
 None
None
None
None
MAP  A 450 (-3.7A)
 0.99A 3bwcB-1qpgA:
3.4		 3bwcB-1qpgA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1qpg 3-PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 380
GLY A 211
LEU A 209
ASN A 334
VAL A 376
 None
MAP  A 450 (-3.6A)
None
MAP  A 450 (-3.3A)
None
 1.06A 3dmhA-1qpgA:
3.2		 3dmhA-1qpgA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 1qpg 3-PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 370
ASP A 372
GLY A 210
LEU A 209
VAL A 356
 MAP  A 450 (-3.5A)
MAP  A 450 (-3.9A)
None
None
None
 0.94A 3em4A-1qpgA:
undetectable		 3em4A-1qpgA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1qpg 3-PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 8 GLY A 370
ASP A 372
GLY A 210
LEU A 209
VAL A 356
 MAP  A 450 (-3.5A)
MAP  A 450 (-3.9A)
None
None
None
 1.00A 3em6A-1qpgA:
undetectable		 3em6A-1qpgA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 1qpg 3-PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 208
PRO A 280
ILE A 254
GLY A 235
 None
None
None
MAP  A 450 (-3.5A)
 0.97A 3n3iA-1qpgA:
undetectable		 3n3iA-1qpgA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 1qpg 3-PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 310
GLY A 236
GLY A 235
ASP A 287
ASP A 312
 None
MAP  A 450 (-3.5A)
MAP  A 450 (-3.5A)
None
None
 1.14A 4b17A-1qpgA:
2.2		 4b17A-1qpgA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 1qpg 3-PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 370
ASN A 334
PHE A 194
ILE A 367
 MAP  A 450 (-3.5A)
MAP  A 450 (-3.3A)
None
None
 1.00A 4j4vC-1qpgA:
undetectable		 4j4vC-1qpgA:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1qpg 3-PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		9 / 12 GLY A 211
ALA A 212
GLY A 235
GLY A 236
PHE A 239
PHE A 289
LEU A 311
GLY A 338
VAL A 339
 MAP  A 450 (-3.6A)
MAP  A 450 ( 4.2A)
MAP  A 450 (-3.5A)
MAP  A 450 (-3.5A)
MAP  A 450 (-4.8A)
None
None
MAP  A 450 (-3.2A)
MAP  A 450 (-3.3A)
 0.46A 4o33A-1qpgA:
54.4		 4o33A-1qpgA:
64.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1qpg 3-PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 211
GLY A 235
PHE A 239
PHE A 289
LEU A 311
VAL A 339
 MAP  A 450 (-3.6A)
MAP  A 450 (-3.5A)
MAP  A 450 (-4.8A)
None
None
MAP  A 450 (-3.3A)
 1.31A 4o33A-1qpgA:
54.4		 4o33A-1qpgA:
64.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1qpg 3-PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		9 / 12 GLY A 211
ALA A 212
GLY A 235
GLY A 236
PHE A 239
PHE A 289
LEU A 311
GLY A 338
VAL A 339
 MAP  A 450 (-3.6A)
MAP  A 450 ( 4.2A)
MAP  A 450 (-3.5A)
MAP  A 450 (-3.5A)
MAP  A 450 (-4.8A)
None
None
MAP  A 450 (-3.2A)
MAP  A 450 (-3.3A)
 0.40A 4o3fA-1qpgA:
53.1		 4o3fA-1qpgA:
64.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 1qpg 3-PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 205
THR A 373
LEU A 400
 None
MAP  A 450 (-3.7A)
None
 0.74A 4qztA-1qpgA:
0.0		 4qztA-1qpgA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1qpg 3-PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 235
GLY A 338
GLY A 348
ALA A 212
LYS A 213
 MAP  A 450 (-3.5A)
MAP  A 450 (-3.2A)
None
MAP  A 450 ( 4.2A)
None
 1.00A 5c0oG-1qpgA:
4.2		 5c0oG-1qpgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 1qpg 3-PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 376
GLY A 348
GLY A 338
ILE A 284
ALA A 347
 None
None
MAP  A 450 (-3.2A)
None
None
 0.91A 5x7fA-1qpgA:
3.6		 5x7fA-1qpgA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 1qpg 3-PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 239
GLY A 235
VAL A 339
PHE A 289
GLY A 338
 MAP  A 450 (-4.8A)
MAP  A 450 (-3.5A)
MAP  A 450 (-3.3A)
None
MAP  A 450 (-3.2A)
 1.21A 5yjsA-1qpgA:
0.0		 5yjsA-1qpgA:
11.89