SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MAN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 5ihr PROBABLE
BETA-GALACTOSIDASE A
(Aspergillus
niger) 		5 / 12 LEU A 979
LEU A 910
ASN A 911
GLN A 942
LEU A 952
 None
None
MAN  A1376 (-3.8A)
None
None
 1.39A 1a28B-5ihrA:
undetectable		 1a28B-5ihrA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1bvw PROTEIN
(CELLOBIOHYDROLASE
II)
(Humicola
insolens) 		5 / 12 PHE A 439
LEU A 443
PHE A 379
ALA A 128
HIS A 110
 None
None
None
None
MAN  A 650 (-4.6A)
 1.32A 1a4lB-1bvwA:
5.1		 1a4lB-1bvwA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		4 / 6 LEU A 103
ILE A 186
TYR A 164
VAL A 135
 None
None
MAN  A 431 ( 4.2A)
None
 1.10A 1db1A-1rmgA:
undetectable		 1db1A-1rmgA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 6 TRP A 307
GLY A 308
ASN A 936
PRO A 310
 None
NAG  A1149 (-3.4A)
None
MAN  A1153 (-3.7A)
 1.20A 1dedA-4iugA:
9.8		 1dedA-4iugA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 5ihr PROBABLE
BETA-GALACTOSIDASE A
(Aspergillus
niger) 		4 / 6 TRP A 307
GLY A 308
ASN A 938
PRO A 310
 None
MAN  A1917 (-3.3A)
None
None
 1.24A 1dedA-5ihrA:
11.0		 1dedA-5ihrA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 1g0v PROTEINASE A
(Saccharomyces
cerevisiae) 		4 / 5 LYS A 187
ALA A 188
ASP A 126
GLY A 124
 None
None
MAN  A 329 ( 4.9A)
None
 1.21A 1e7bA-1g0vA:
undetectable		 1e7bA-1g0vA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 1g0v PROTEINASE A
(Saccharomyces
cerevisiae) 		4 / 5 LYS A 187
ALA A 188
ASP A 126
GLY A 124
 None
None
MAN  A 329 ( 4.9A)
None
 0.91A 1e7cA-1g0vA:
undetectable		 1e7cA-1g0vA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 1bwu PROTEIN (AGGLUTININ)
(Allium
sativum) 		4 / 8 LEU Q  87
SER Q  42
GLN Q  26
THR Q  45
 None
MAN  Q 313 ( 3.9A)
MAN  Q 313 (-3.4A)
None
 1.07A 1ig3A-1bwuQ:
undetectable
1ig3B-1bwuQ:
undetectable		 1ig3A-1bwuQ:
19.08
1ig3B-1bwuQ:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4m18 PULMONARY
SURFACTANT-ASSOCIATE
D PROTEIN D
(Homo
sapiens) 		3 / 3 ASN A 341
PHE A 292
VAL A 343
 MAN  A 406 ( 2.6A)
None
MAN  A 406 ( 4.7A)
 0.60A 1kijA-4m18A:
undetectable		 1kijA-4m18A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4ymd COLLECTIN-11
(Homo
sapiens) 		3 / 3 ASN A 252
PHE A 202
VAL A 254
 MAN  A 302 ( 2.6A)
None
MAN  A 302 ( 4.7A)
 0.74A 1kijA-4ymdA:
undetectable		 1kijA-4ymdA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 5vyb C-TYPE LECTIN DOMAIN
FAMILY 6 MEMBER A
(Homo
sapiens) 		3 / 3 ASN A 190
PHE A 137
VAL A 192
 MAN  A 302 ( 2.9A)
None
MAN  A 302 ( 4.6A)
 0.74A 1kijA-5vybA:
undetectable		 1kijA-5vybA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5b0s LIN0857 PROTEIN
(Listeria
innocua) 		5 / 12 SER A 208
GLY A  99
ASP A  87
PHE A 100
LEU A 215
 None
None
None
None
MAN  A 403 ( 4.8A)
 1.15A 1lhuA-5b0sA:
undetectable		 1lhuA-5b0sA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 8 GLY A 126
SER A 153
THR A  90
ASP A 122
 MAN  A1950 ( 3.7A)
None
None
None
 0.90A 1m4iA-4cvuA:
undetectable		 1m4iA-4cvuA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 PHE A 545
TYR A 454
PRO A 452
 NAG  A 713 (-3.5A)
MAN  A 717 (-3.9A)
NAG  A 713 (-4.6A)
 1.13A 1mcnA-4gwnA:
undetectable
1mcnB-4gwnA:
undetectable
1mcnP-4gwnA:
undetectable		 1mcnA-4gwnA:
17.59
1mcnB-4gwnA:
17.59
1mcnP-4gwnA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 2whl BETA-MANNANASE
(Salipaludibacill
us
agaradhaerens) 		4 / 6 SER A 259
THR A 258
ASN A 256
ASP A 264
 None
None
MAN  A1301 (-3.6A)
None
 1.24A 1mxdA-2whlA:
9.2		 1mxdA-2whlA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4ymd COLLECTIN-11
(Homo
sapiens) 		5 / 11 ARG A 200
GLY A 250
GLU A 232
GLU A 244
SER A 248
 MAN  A 301 (-3.4A)
None
MAN  A 302 ( 2.4A)
MAN  A 301 (-3.2A)
None
 1.25A 1odiA-4ymdA:
undetectable		 1odiA-4ymdA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4ymd COLLECTIN-11
(Homo
sapiens) 		5 / 11 ARG A 200
GLY A 250
GLU A 232
GLU A 244
SER A 248
 MAN  A 301 (-3.4A)
None
MAN  A 302 ( 2.4A)
MAN  A 301 (-3.2A)
None
 1.23A 1odiC-4ymdA:
undetectable		 1odiC-4ymdA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4ymd COLLECTIN-11
(Homo
sapiens) 		5 / 11 ARG A 200
GLY A 250
GLU A 232
GLU A 244
SER A 248
 MAN  A 301 (-3.4A)
None
MAN  A 302 ( 2.4A)
MAN  A 301 (-3.2A)
None
 1.24A 1odiD-4ymdA:
undetectable		 1odiD-4ymdA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 2whl BETA-MANNANASE
(Salipaludibacill
us
agaradhaerens) 		3 / 3 ASP A  89
THR A  91
GLU A 222
 None
MAN  A1301 ( 4.4A)
None
 0.76A 1pj7A-2whlA:
undetectable		 1pj7A-2whlA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5foh POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		5 / 6 LEU A  86
GLU A 110
THR A 211
TYR A 212
TYR A 192
 None
None
MAN  A1224 (-3.3A)
None
None
 1.45A 1qvuA-5fohA:
undetectable		 1qvuA-5fohA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		4 / 6 GLU A 611
THR A 553
TYR A 556
TYR A 420
 MAN  A 709 ( 2.8A)
None
None
None
 1.25A 1qvuA-5kkbA:
undetectable		 1qvuA-5kkbA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 1xc6 BETA-GALACTOSIDASE
(Penicillium
sp.) 		3 / 3 GLU A 323
ASN A 321
TRP A 273
 MAN  A3007 (-3.5A)
None
None
 1.22A 1r15C-1xc6A:
1.8		 1r15C-1xc6A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 3ogr BETA-GALACTOSIDASE
(Trichoderma
reesei) 		3 / 3 GLU A 322
ASN A 320
TRP A 272
 MAN  A1029 (-3.5A)
MAN  A1031 (-3.9A)
None
 1.27A 1r15C-3ogrA:
undetectable		 1r15C-3ogrA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 GLU A 322
ASN A 320
TRP A 272
 CD  A1114 ( 2.5A)
MAN  A1142 (-3.8A)
None
 1.16A 1r15C-4iugA:
undetectable		 1r15C-4iugA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 5ihr PROBABLE
BETA-GALACTOSIDASE A
(Aspergillus
niger) 		3 / 3 GLU A 322
ASN A 320
TRP A 272
 MAN  A1626 (-3.7A)
MAN  A1627 (-3.7A)
None
 1.25A 1r15C-5ihrA:
1.8		 1r15C-5ihrA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 1xc6 BETA-GALACTOSIDASE
(Penicillium
sp.) 		3 / 3 GLU A 323
ASN A 321
TRP A 273
 MAN  A3007 (-3.5A)
None
None
 1.21A 1r15D-1xc6A:
1.7		 1r15D-1xc6A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 3ogr BETA-GALACTOSIDASE
(Trichoderma
reesei) 		3 / 3 GLU A 322
ASN A 320
TRP A 272
 MAN  A1029 (-3.5A)
MAN  A1031 (-3.9A)
None
 1.26A 1r15D-3ogrA:
undetectable		 1r15D-3ogrA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 GLU A 322
ASN A 320
TRP A 272
 CD  A1114 ( 2.5A)
MAN  A1142 (-3.8A)
None
 1.16A 1r15D-4iugA:
undetectable		 1r15D-4iugA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 5ihr PROBABLE
BETA-GALACTOSIDASE A
(Aspergillus
niger) 		3 / 3 GLU A 322
ASN A 320
TRP A 272
 MAN  A1626 (-3.7A)
MAN  A1627 (-3.7A)
None
 1.23A 1r15D-5ihrA:
1.6		 1r15D-5ihrA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 1xc6 BETA-GALACTOSIDASE
(Penicillium
sp.) 		3 / 3 GLU A 323
ASN A 321
TRP A 273
 MAN  A3007 (-3.5A)
None
None
 1.21A 1r15E-1xc6A:
1.8		 1r15E-1xc6A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 3ogr BETA-GALACTOSIDASE
(Trichoderma
reesei) 		3 / 3 GLU A 322
ASN A 320
TRP A 272
 MAN  A1029 (-3.5A)
MAN  A1031 (-3.9A)
None
 1.26A 1r15E-3ogrA:
1.8		 1r15E-3ogrA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 GLU A 322
ASN A 320
TRP A 272
 CD  A1114 ( 2.5A)
MAN  A1142 (-3.8A)
None
 1.15A 1r15E-4iugA:
1.9		 1r15E-4iugA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 5ihr PROBABLE
BETA-GALACTOSIDASE A
(Aspergillus
niger) 		3 / 3 GLU A 322
ASN A 320
TRP A 272
 MAN  A1626 (-3.7A)
MAN  A1627 (-3.7A)
None
 1.24A 1r15E-5ihrA:
undetectable		 1r15E-5ihrA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 1xc6 BETA-GALACTOSIDASE
(Penicillium
sp.) 		3 / 3 GLU A 323
ASN A 321
TRP A 273
 MAN  A3007 (-3.5A)
None
None
 1.17A 1r15F-1xc6A:
1.7		 1r15F-1xc6A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 3ogr BETA-GALACTOSIDASE
(Trichoderma
reesei) 		3 / 3 GLU A 322
ASN A 320
TRP A 272
 MAN  A1029 (-3.5A)
MAN  A1031 (-3.9A)
None
 1.22A 1r15F-3ogrA:
undetectable		 1r15F-3ogrA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 GLU A 322
ASN A 320
TRP A 272
 CD  A1114 ( 2.5A)
MAN  A1142 (-3.8A)
None
 1.12A 1r15F-4iugA:
2.0		 1r15F-4iugA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 5ihr PROBABLE
BETA-GALACTOSIDASE A
(Aspergillus
niger) 		3 / 3 GLU A 322
ASN A 320
TRP A 272
 MAN  A1626 (-3.7A)
MAN  A1627 (-3.7A)
None
 1.21A 1r15F-5ihrA:
undetectable		 1r15F-5ihrA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 4zet C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER C
(Homo
sapiens) 		5 / 12 ILE A 182
GLY A 143
ILE A 205
SER A 145
GLU A 178
 None
None
None
None
MAN  A 303 (-2.4A)
 1.26A 1sg9A-4zetA:
undetectable		 1sg9A-4zetA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3ogr BETA-GALACTOSIDASE
(Trichoderma
reesei) 		5 / 12 ALA A 303
GLY A 302
GLY A 301
ASP A 265
GLY A 357
 None
None
None
MAN  A1039 ( 2.9A)
None
 1.03A 1sqfA-3ogrA:
undetectable		 1sqfA-3ogrA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 7 ASP A 363
GLY A 391
ILE A 386
THR A 426
 CA  A 613 ( 4.5A)
None
None
MAN  A 618 (-2.0A)
 0.79A 1t7iB-5iryA:
undetectable		 1t7iB-5iryA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 7 ASP A 363
GLY A 391
ILE A 386
THR A 426
 CA  A 613 ( 4.5A)
None
None
MAN  A 618 (-2.0A)
 0.80A 1t7jB-5iryA:
undetectable		 1t7jB-5iryA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1jpc AGGLUTININ
(Galanthus
nivalis) 		3 / 3 GLY A  46
ASP A  28
ASN A  44
 MAN  A 115 ( 4.7A)
MAN  A 115 (-3.1A)
MAN  A 117 (-3.1A)
 0.52A 1vq1A-1jpcA:
undetectable		 1vq1A-1jpcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1jpc AGGLUTININ
(Galanthus
nivalis) 		3 / 3 GLY A  78
ASP A  59
ASN A  76
 MAN  A 113 ( 4.8A)
MAN  A 113 (-3.2A)
MAN  A 114 (-3.1A)
 0.53A 1vq1A-1jpcA:
undetectable		 1vq1A-1jpcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3dzw AGGLUTININ
(Narcissus
pseudonarcissus) 		3 / 3 GLY A  46
ASP A  28
ASN A  44
 MAN  A 113 ( 4.7A)
MAN  A 113 (-3.1A)
None
 0.58A 1vq1A-3dzwA:
undetectable		 1vq1A-3dzwA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3dzw AGGLUTININ
(Narcissus
pseudonarcissus) 		3 / 3 GLY A  78
ASP A  59
ASN A  76
 MAN  A 115 ( 4.8A)
MAN  A 115 (-2.9A)
None
 0.55A 1vq1A-3dzwA:
undetectable		 1vq1A-3dzwA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 1qmo MANNOSE BINDING
LECTIN, FRIL
MANNOSE BINDING
LECTIN, FRIL
(Lablab
purpureus;
Lablab
purpureus) 		4 / 6 LEU A 106
GLY A 104
ASN E 144
ILE E 162
 None
MAN  A 302 (-3.7A)
MAN  A 302 ( 3.0A)
None
 0.89A 1xf1B-1qmoA:
undetectable		 1xf1B-1qmoA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3t6q CD180 ANTIGEN
LYMPHOCYTE ANTIGEN
86
(Mus
musculus) 		3 / 3 THR A 306
GLU C 103
HIS A 379
 None
MAN  A 806 (-3.0A)
MAN  A 806 ( 4.0A)
 0.88A 1xwfA-3t6qA:
undetectable		 1xwfA-3t6qA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3t6q CD180 ANTIGEN
LYMPHOCYTE ANTIGEN
86
(Mus
musculus) 		3 / 3 THR A 306
GLU C 103
HIS A 379
 None
MAN  A 806 (-3.0A)
MAN  A 806 ( 4.0A)
 0.85A 1xwfB-3t6qA:
undetectable		 1xwfB-3t6qA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3t6q CD180 ANTIGEN
LYMPHOCYTE ANTIGEN
86
(Mus
musculus) 		3 / 3 THR A 306
GLU C 103
HIS A 379
 None
MAN  A 806 (-3.0A)
MAN  A 806 ( 4.0A)
 0.88A 1xwfC-3t6qA:
undetectable		 1xwfC-3t6qA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3t6q CD180 ANTIGEN
LYMPHOCYTE ANTIGEN
86
(Mus
musculus) 		3 / 3 THR A 306
GLU C 103
HIS A 379
 None
MAN  A 806 (-3.0A)
MAN  A 806 ( 4.0A)
 0.83A 1xwfD-3t6qA:
undetectable		 1xwfD-3t6qA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 3wcs ERYTHROAGGLUTININ
(Phaseolus
vulgaris) 		5 / 12 GLY A 235
GLY A 124
LEU A 126
GLY A 128
ARG A  69
 NAG  A1005 ( 3.8A)
MAN  A1004 (-3.5A)
MAN  A1004 (-4.2A)
None
None
 1.23A 1y4lA-3wcsA:
undetectable		 1y4lA-3wcsA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		5 / 10 MET A 483
THR A 477
GLY A 412
THR A 635
GLU A 549
 None
None
MAN  A 707 ( 3.5A)
MAN  A 709 (-3.1A)
MAN  A 709 ( 3.3A)
 1.40A 1z35A-5kkbA:
undetectable		 1z35A-5kkbA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 5fyj GP120 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1) 		5 / 12 PRO G 437
THR G 320
ASN G 302
ARG G 379
ALA G 440
 None
None
None
MAN  G2626 (-3.0A)
None
 1.31A 2axnA-5fyjG:
undetectable		 2axnA-5fyjG:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ymd COLLECTIN-11
(Homo
sapiens) 		5 / 12 GLU A 211
GLY A 212
ASN A 234
ASP A 207
ALA A 213
 CA  A 303 (-2.2A)
None
MAN  A 302 ( 2.5A)
CA  A 303 ( 2.5A)
None
 1.28A 2br4B-4ymdA:
undetectable		 2br4B-4ymdA:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 2ciy CHLOROPEROXIDASE
(Leptoxyphium
fumago) 		6 / 6 ALA A  71
PHE A 103
ILE A 179
VAL A 182
GLU A 183
PHE A 186
 HEM  A 396 (-3.6A)
DMS  A3036 (-3.8A)
DMS  A3036 (-4.8A)
MAN  A 741 ( 4.3A)
CYN  A1802 ( 3.6A)
HEM  A 396 ( 4.0A)
 0.24A 2cizA-2ciyA:
53.5		 2cizA-2ciyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2ciy CHLOROPEROXIDASE
(Leptoxyphium
fumago) 		5 / 5 LEU A  70
ASN A  74
PHE A 103
VAL A 182
ALA A 267
 DMS  A3036 (-3.9A)
DMS  A3036 (-3.9A)
DMS  A3036 (-3.8A)
MAN  A 741 ( 4.3A)
EDO  A 802 (-4.1A)
 0.31A 2cizA-2ciyA:
53.5		 2cizA-2ciyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 1xc6 BETA-GALACTOSIDASE
(Penicillium
sp.) 		3 / 3 LYS A 330
GLY A 511
PRO A 512
 None
None
MAN  A3008 (-4.3A)
 0.94A 2hreB-1xc6A:
undetectable		 2hreB-1xc6A:
15.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2ciy CHLOROPEROXIDASE
(Leptoxyphium
fumago) 		6 / 6 LEU A  70
ASN A  74
PHE A 103
ILE A 179
VAL A 182
ALA A 267
 DMS  A3036 (-3.9A)
DMS  A3036 (-3.9A)
DMS  A3036 (-3.8A)
DMS  A3036 (-4.8A)
MAN  A 741 ( 4.3A)
EDO  A 802 (-4.1A)
 0.18A 2j5mA-2ciyA:
53.4		 2j5mA-2ciyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 6en3 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE
F2,MULTIFUNCTIONAL-A
UTOPROCESSING
REPEATS-IN-TOXIN
(Streptococcus
pyogenes;
Vibrio
cholerae) 		5 / 12 LEU A 230
ARG A 181
ILE A 180
PHE A 148
GLY A 266
 None
MAN  A1305 ( 4.7A)
None
None
None
 1.21A 2lbdA-6en3A:
undetectable		 2lbdA-6en3A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 5o2x GLYCOSIDE HYDROLASE
FAMILY 61
(Trichoderma
reesei) 		5 / 12 GLN A  50
ASP A 105
PRO A  52
GLY A 195
LEU A 198
 None
None
MAN  A 304 (-4.0A)
None
None
 1.34A 2nv4A-5o2xA:
undetectable		 2nv4A-5o2xA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5szp PROTOCADHERIN GAMMA
B7
(Mus
musculus) 		4 / 6 THR A 193
ASP A 186
ASN A 135
ASP A  95
 MAN  A 510 ( 1.9A)
CA  A 503 (-3.5A)
None
CA  A 502 (-3.3A)
 1.33A 2okcA-5szpA:
undetectable		 2okcA-5szpA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE B 344
ILE B  98
GLU B 227
SER B 200
ASP B 142
 MAN  B1386 ( 4.1A)
MAN  B1386 ( 4.9A)
MAN  B1386 (-3.7A)
MAN  B1386 ( 4.3A)
MAN  B1386 (-3.1A)
 1.42A 2pgfA-5a7vB:
undetectable		 2pgfA-5a7vB:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 5nbs BETA-GLUCOSIDASE
(Neurospora
crassa) 		3 / 3 LEU A 731
PRO A 732
ARG A 325
 MAN  A1126 (-4.4A)
MAN  A1126 (-3.6A)
None
 0.57A 2qd4B-5nbsA:
undetectable		 2qd4B-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 5nbs BETA-GLUCOSIDASE
(Neurospora
crassa) 		3 / 3 LEU A 731
PRO A 732
ARG A 325
 MAN  A1126 (-4.4A)
MAN  A1126 (-3.6A)
None
 0.60A 2qd5A-5nbsA:
3.2		 2qd5A-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4utf GLYCOSYL HYDROLASE
FAMILY 71
(Bacteroides
xylanisolvens) 		3 / 3 ASN A 298
ARG A 295
ASP A 196
 MAN  A 511 (-3.4A)
MAN  A 511 ( 3.1A)
MAN  A 510 (-2.8A)
 0.90A 2qe6A-4utfA:
undetectable		 2qe6A-4utfA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4utf GLYCOSYL HYDROLASE
FAMILY 71
(Bacteroides
xylanisolvens) 		3 / 3 ASN A 298
ARG A 295
ASP A 196
 MAN  A 511 (-3.4A)
MAN  A 511 ( 3.1A)
MAN  A 510 (-2.8A)
 0.91A 2qe6B-4utfA:
undetectable		 2qe6B-4utfA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 2whl BETA-MANNANASE
(Salipaludibacill
us
agaradhaerens) 		3 / 3 GLN A 166
THR A  91
TRP A 251
 None
MAN  A1301 ( 4.4A)
MAN  A1301 (-4.5A)
 1.15A 2rctA-2whlA:
undetectable		 2rctA-2whlA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 2whl BETA-MANNANASE
(Salipaludibacill
us
agaradhaerens) 		6 / 12 ASN A 126
GLU A 127
HIS A 192
TYR A 194
GLU A 222
TRP A 251
 None
None
None
None
None
MAN  A1301 (-4.5A)
 0.73A 2v3dA-2whlA:
15.2		 2v3dA-2whlA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 2whl BETA-MANNANASE
(Salipaludibacill
us
agaradhaerens) 		5 / 11 ASN A 126
GLU A 127
TYR A 194
GLU A 222
TRP A 251
 None
None
None
None
MAN  A1301 (-4.5A)
 0.82A 2v3dB-2whlA:
5.7		 2v3dB-2whlA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_B_PQNB1774_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4iig BETA-GLUCOSIDASE 1
(Aspergillus
aculeatus) 		5 / 10 SER A 260
ARG A 329
ALA A 291
LEU A 292
ALA A 737
 MAN  A 919 ( 4.8A)
None
None
None
None
 1.50A 2wseB-4iigA:
undetectable		 2wseB-4iigA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		5 / 12 VAL A 375
SER A 416
THR A 635
ASN A 634
ALA A 424
 None
MAN  A 708 ( 4.7A)
MAN  A 709 (-3.1A)
None
None
 1.27A 2x2iA-5kkbA:
undetectable		 2x2iA-5kkbA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 1v0z NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 TRP A 466
VAL A 402
TRP A 464
 None
MAN  A 509 (-4.8A)
None
 1.01A 2xdcC-1v0zA:
undetectable
2xdcD-1v0zA:
undetectable		 2xdcC-1v0zA:
4.31
2xdcD-1v0zA:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 1v0z NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 TRP A 466
VAL A 402
TRP A 464
 None
MAN  A 509 (-4.8A)
None
 0.93A 2xdcE-1v0zA:
undetectable
2xdcF-1v0zA:
undetectable		 2xdcE-1v0zA:
4.31
2xdcF-1v0zA:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1v0z NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 TRP A 466
VAL A 402
TRP A 464
 None
MAN  A 509 (-4.8A)
None
 0.98A 2y5mE-1v0zA:
undetectable
2y5mF-1v0zA:
undetectable		 2y5mE-1v0zA:
4.31
2y5mF-1v0zA:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1v0z NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 TRP A 466
VAL A 402
TRP A 464
 None
MAN  A 509 (-4.8A)
None
 0.96A 2y6nC-1v0zA:
undetectable
2y6nD-1v0zA:
undetectable		 2y6nC-1v0zA:
4.31
2y6nD-1v0zA:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1v0z NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 TRP A 466
VAL A 402
TRP A 464
 None
MAN  A 509 (-4.8A)
None
 0.99A 2y6nE-1v0zA:
undetectable
2y6nF-1v0zA:
undetectable		 2y6nE-1v0zA:
4.31
2y6nF-1v0zA:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		6 / 12 THR A 170
ILE A 152
GLY A   4
THR A   3
GLY A 168
THR A  19
 None
None
MAN  A1001 (-4.0A)
MAN  A1001 (-2.4A)
None
None
 1.34A 2y7hB-1izeA:
undetectable		 2y7hB-1izeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1ize ASPARTIC PROTEINASE
(Aspergillus
oryzae) 		6 / 12 THR A 170
ILE A 152
GLY A   4
THR A   3
GLY A 168
THR A  19
 None
None
MAN  A1001 (-4.0A)
MAN  A1001 (-2.4A)
None
None
 1.34A 2y7hC-1izeA:
undetectable		 2y7hC-1izeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED
(Bacteroides
thetaiotaomicron) 		4 / 5 ALA B 184
GLY B 197
CYH B 198
LYS B 199
 None
None
None
MAN  B1485 ( 2.8A)
 1.41A 2ylgA-5a7vB:
undetectable		 2ylgA-5a7vB:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 3q2v CADHERIN-1
(Mus
musculus) 		5 / 11 HIS A 299
ASN A 263
VAL A 261
ASP A 264
PRO A 265
 MAN  A 804 ( 4.3A)
None
None
None
None
 1.15A 2zwfA-3q2vA:
undetectable
2zwfB-3q2vA:
undetectable		 2zwfA-3q2vA:
19.53
2zwfB-3q2vA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 3q2v CADHERIN-1
(Mus
musculus) 		5 / 11 HIS A 299
ASN A 263
VAL A 261
ASP A 264
PRO A 265
 MAN  A 804 ( 4.3A)
None
None
None
None
 1.13A 2zwgA-3q2vA:
undetectable
2zwgB-3q2vA:
undetectable		 2zwgA-3q2vA:
19.53
2zwgB-3q2vA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 2ciy CHLOROPEROXIDASE
(Leptoxyphium
fumago) 		4 / 5 VAL A 141
VAL A 142
THR A 250
THR A 137
 MAN  A 751 ( 4.1A)
None
MAN  A 750 (-2.0A)
None
 0.98A 3bjwG-2ciyA:
undetectable		 3bjwG-2ciyA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 2ciy CHLOROPEROXIDASE
(Leptoxyphium
fumago) 		4 / 5 VAL A 141
VAL A 142
THR A 250
THR A 137
 MAN  A 751 ( 4.1A)
None
MAN  A 750 (-2.0A)
None
 1.00A 3bjwC-2ciyA:
undetectable		 3bjwC-2ciyA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 5erd DESMOGLEIN-2
(Homo
sapiens) 		5 / 12 VAL A 343
SER A 345
THR A 435
ILE A 398
ASN A 439
 MAN  A 615 ( 3.6A)
None
MAN  A 615 (-2.2A)
None
None
 1.17A 3ddyA-5erdA:
undetectable		 3ddyA-5erdA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 5j5j DESMOCOLLIN-2,DESMOG
LEIN-2
(Homo
sapiens) 		5 / 12 VAL A 341
SER A 343
THR A 433
ILE A 396
ASN A 437
 MAN  A 611 ( 4.4A)
None
MAN  A 611 (-2.1A)
None
None
 1.15A 3ddyA-5j5jA:
undetectable		 3ddyA-5j5jA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		6 / 12 ASN A 367
ASP A 293
ASN A 295
LEU A 394
THR A 339
THR A 337
 None
CA  A 502 (-3.3A)
CA  A 502 (-3.0A)
None
None
MAN  A 514 ( 4.9A)
 1.48A 3eeyF-4wk4A:
undetectable		 3eeyF-4wk4A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 3rwk INULINASE
(Aspergillus
ficuum) 		5 / 9 ASP X 296
ASP X 440
ILE X 437
GLY X 445
VAL X 470
 None
MAN  X 517 (-2.4A)
None
None
None
 1.30A 3ekyB-3rwkX:
undetectable		 3ekyB-3rwkX:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5o2x GLYCOSIDE HYDROLASE
FAMILY 61
(Trichoderma
reesei) 		5 / 11 LEU A 133
GLY A 235
ILE A  90
SER A 231
VAL A 141
 None
None
None
MAN  A 311 (-1.4A)
MAN  A 313 ( 4.9A)
 1.18A 3gyqB-5o2xA:
undetectable		 3gyqB-5o2xA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 9 ALA A 146
ILE A 221
THR A 226
SER A 225
PHE A 233
 None
None
MAN  A 241 (-3.3A)
None
None
 1.48A 3hbbB-2ow4A:
undetectable		 3hbbB-2ow4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4m18 PULMONARY
SURFACTANT-ASSOCIATE
D PROTEIN D
(Homo
sapiens) 		4 / 8 LEU A 268
ARG A 349
SER A 298
GLY A 346
 None
MAN  A 407 (-3.9A)
None
None
 1.16A 3hcrA-4m18A:
undetectable		 3hcrA-4m18A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4m18 PULMONARY
SURFACTANT-ASSOCIATE
D PROTEIN D
(Homo
sapiens) 		4 / 7 LEU A 268
ARG A 349
SER A 298
GLY A 346
 None
MAN  A 407 (-3.9A)
None
None
 1.05A 3hcrB-4m18A:
undetectable		 3hcrB-4m18A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		4 / 6 GLU A 330
ASN A 327
TRP A 284
SER A 658
 MAN  A 707 ( 4.2A)
MAN  A 713 (-3.7A)
None
None
 1.45A 3i9jB-5kijA:
undetectable		 3i9jB-5kijA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2ciy CHLOROPEROXIDASE
(Leptoxyphium
fumago) 		4 / 7 LEU A 196
VAL A 141
ILE A 207
ARG A 157
 None
MAN  A 751 ( 4.1A)
None
None
 1.19A 3ik3A-2ciyA:
undetectable		 3ik3A-2ciyA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2ciy CHLOROPEROXIDASE
(Leptoxyphium
fumago) 		4 / 7 LEU A 196
VAL A 141
ILE A 207
ARG A 157
 None
MAN  A 751 ( 4.1A)
None
None
 1.21A 3ik3B-2ciyA:
undetectable		 3ik3B-2ciyA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 5fji BETA-GLUCOSIDASE
(Aspergillus
fumigatus) 		5 / 12 GLY A 485
GLY A 423
ALA A 491
ALA A 494
ASP A 492
 MAN  A1506 (-3.3A)
None
None
None
EDO  A1864 ( 4.8A)
 1.07A 3keeA-5fjiA:
undetectable		 3keeA-5fjiA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 5fji BETA-GLUCOSIDASE
(Aspergillus
fumigatus) 		5 / 12 GLY A 485
GLY A 423
ALA A 491
ALA A 494
ASP A 492
 MAN  A1506 (-3.3A)
None
None
None
EDO  A1864 ( 4.8A)
 1.10A 3keeD-5fjiA:
undetectable		 3keeD-5fjiA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 4utf GLYCOSYL HYDROLASE
FAMILY 71
(Bacteroides
xylanisolvens) 		4 / 7 GLU A 156
TYR A 198
TYR A 250
PHE A  44
 IFM  A 501 (-2.8A)
MAN  A 510 (-4.5A)
None
None
 1.35A 3ku9B-4utfA:
undetectable		 3ku9B-4utfA:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5vgj VRC38.01 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 10 TRP H  47
SER H  50
TYR H  58
GLY H  95
TRP H 103
 None
None
MAN  G1563 (-3.9A)
MAN  G1606 (-4.1A)
None
 0.69A 3ls4H-5vgjH:
26.4		 3ls4H-5vgjH:
60.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5t9t PROTOCADHERIN GAMMA
B2-ALPHA C
(Mus
musculus) 		3 / 3 SER A 403
SER A 404
HIS A 355
 MAN  A 619 (-1.4A)
None
None
 0.82A 3mzeA-5t9tA:
undetectable		 3mzeA-5t9tA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT
(Pseudonaja
textilis) 		5 / 12 LYS V 366
GLY V 589
ALA V 522
ASP V 592
ALA V 286
 None
None
None
MAN  V1501 (-3.8A)
None
 1.23A 3nmuA-4bxsV:
undetectable
3nmuF-4bxsV:
undetectable		 3nmuA-4bxsV:
14.50
3nmuF-4bxsV:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1qmo MANNOSE BINDING
LECTIN, FRIL
MANNOSE BINDING
LECTIN, FRIL
(Lablab
purpureus;
Lablab
purpureus) 		3 / 3 TYR E 147
GLY A 104
ASP A  86
 None
MAN  A 302 (-3.7A)
MAN  A 302 (-3.2A)
 0.52A 3ou6C-1qmoE:
undetectable		 3ou6C-1qmoE:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 2ciy CHLOROPEROXIDASE
(Leptoxyphium
fumago) 		4 / 7 GLN A 180
GLU A 166
ARG A 160
PRO A 253
 None
None
None
MAN  A 751 (-3.4A)
 1.40A 3ql6A-2ciyA:
undetectable		 3ql6A-2ciyA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 6ck9 35O22 SCFV HEAVY
CHAIN PORTION
35O22 SCFV LIGHT
CHAIN PORTION
GP41 ECTODOMAIN OF
ENVELOPE
GLYCOPROTEIN GP160
(Homo
sapiens;
Human
immunodeficiency
virus
1) 		4 / 5 SER B 534
GLY D 100
GLU E  53
GLU E  50
 None
MAN  G 884 (-3.7A)
None
None
 1.16A 3raeB-6ck9B:
undetectable
3raeD-6ck9B:
undetectable		 3raeB-6ck9B:
10.26
3raeD-6ck9B:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2vn7 GLUCOAMYLASE
(Trichoderma
reesei) 		5 / 12 LEU A 533
VAL A 515
THR A 579
LEU A 551
VAL A 549
 None
None
MAN  A 608 ( 2.4A)
None
None
 1.24A 3sp9B-2vn7A:
undetectable		 3sp9B-2vn7A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		4 / 6 ASN A 394
PHE A 417
ALA A 350
THR A 354
 None
None
MAN  A 708 ( 3.3A)
None
 1.19A 3t3sB-5kkbA:
undetectable		 3t3sB-5kkbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4utf GLYCOSYL HYDROLASE
FAMILY 71
(Bacteroides
xylanisolvens) 		5 / 10 THR A 329
PHE A  44
SER A 284
TYR A 250
PHE A 253
 None
None
None
None
MAN  A 510 (-4.6A)
 1.49A 3u9fI-4utfA:
undetectable		 3u9fI-4utfA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4fbv MYXOBACTERIAL
HEMAGGLUTININ
(Myxococcus
xanthus) 		3 / 3 SER A 147
GLY A 146
GLN A 143
 None
MAN  A 303 (-3.4A)
None
 0.48A 3v4tH-4fbvA:
undetectable		 3v4tH-4fbvA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4gk9 AGGLUTININ (BOA)
(Burkholderia
oklahomensis) 		3 / 3 SER A  21
GLY A  20
GLN A  17
 None
MAN  A 319 (-3.5A)
None
 0.64A 3v4tH-4gk9A:
undetectable		 3v4tH-4gk9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4gk9 AGGLUTININ (BOA)
(Burkholderia
oklahomensis) 		3 / 3 SER A  88
GLY A  87
GLN A  84
 None
MAN  A 309 (-3.4A)
None
 0.36A 3v4tH-4gk9A:
undetectable		 3v4tH-4gk9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4gk9 AGGLUTININ (BOA)
(Burkholderia
oklahomensis) 		3 / 3 SER A 155
GLY A 154
GLN A 151
 None
MAN  A 304 (-3.5A)
None
 0.27A 3v4tH-4gk9A:
undetectable		 3v4tH-4gk9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5wdu BNAB NIH45-46 SCFV
LIGHT CHAIN
(Homo
sapiens) 		3 / 3 SER E  28
GLY E  29
GLN E  88
 MAN  G 626 (-4.0A)
NAG  G 633 ( 4.5A)
None
 0.00A 3v4tH-5wduE:
undetectable		 3v4tH-5wduE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 3q2w CADHERIN-2
(Mus
musculus) 		4 / 5 ASP A 420
SER A 427
GLY A 428
ASP A 364
 CA  A 609 (-3.1A)
MAN  A 708 (-1.4A)
MAN  A 709 ( 4.9A)
CA  A 609 (-2.6A)
 1.06A 3w9tB-3q2wA:
undetectable		 3w9tB-3q2wA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1v0z NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 TRP A 466
VAL A 402
TRP A 464
 None
MAN  A 509 (-4.8A)
None
 1.26A 3zq8A-1v0zA:
undetectable
3zq8B-1v0zA:
undetectable		 3zq8A-1v0zA:
4.31
3zq8B-1v0zA:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4utf GLYCOSYL HYDROLASE
FAMILY 71
(Bacteroides
xylanisolvens) 		5 / 12 GLY A 286
GLY A 337
GLY A 288
HIS A 335
GLU A 336
 None
None
None
MAN  A 500 (-4.5A)
IFM  A 501 ( 2.8A)
 0.90A 4ctjC-4utfA:
undetectable		 4ctjC-4utfA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1nmb N9 NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 SER N 367
ASN N 325
ASP N 324
VAL N 321
ARG N 300
 None
None
CA  N 478 (-3.5A)
MAN  N 473 ( 4.5A)
None
 1.15A 4dx5B-1nmbN:
undetectable		 4dx5B-1nmbN:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5ju6 BETA-GLUCOSIDASE
(Rasamsonia
emersonii) 		6 / 12 GLY A 284
SER A 283
ILE A 322
ALA A 316
VAL A 317
ARG A 326
 NAG  A 918 (-3.1A)
MAN  A 922 ( 4.6A)
None
NAG  A 917 ( 3.9A)
None
None
 1.44A 4dx5B-5ju6A:
undetectable		 4dx5B-5ju6A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1qmo MANNOSE BINDING
LECTIN, FRIL
MANNOSE BINDING
LECTIN, FRIL
(Lablab
purpureus;
Lablab
purpureus) 		5 / 12 GLY A 103
GLY A 104
TYR E 147
ASN E 144
VAL A  43
 MAN  A 302 ( 3.8A)
MAN  A 302 (-3.7A)
None
MAN  A 302 ( 3.0A)
None
 1.08A 4fglA-1qmoA:
undetectable
4fglB-1qmoA:
undetectable		 4fglA-1qmoA:
19.63
4fglB-1qmoA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5erp DESMOCOLLIN-2
(Homo
sapiens) 		3 / 3 GLN A 201
THR A 202
THR A 203
 None
None
MAN  A 801 (-2.1A)
 0.56A 4fu9A-5erpA:
undetectable		 4fu9A-5erpA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5erp DESMOCOLLIN-2
(Homo
sapiens) 		3 / 3 GLN A 201
THR A 202
THR A 203
 None
None
MAN  A 801 (-2.1A)
 0.56A 4fufA-5erpA:
undetectable		 4fufA-5erpA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 4r9g MBP1
(Caldanaerobius
polysaccharolyti
cus) 		4 / 7 ARG A 139
GLY A 192
ASN A 391
GLN A 273
 BMA  A 502 (-4.0A)
None
MAN  A 501 ( 4.9A)
None
 1.09A 4g0vA-4r9gA:
undetectable		 4g0vA-4r9gA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 2whl BETA-MANNANASE
(Salipaludibacill
us
agaradhaerens) 		5 / 12 TRP A 251
ASP A  57
GLU A  86
ALA A  30
GLY A  59
 MAN  A1301 (-4.5A)
None
None
None
None
 1.02A 4hfpD-2whlA:
undetectable		 4hfpD-2whlA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		5 / 12 ASP A 245
PHE A 281
LEU A 291
LEU A 310
HIS A 638
 None
MAN  A 708 ( 4.3A)
None
None
None
 1.13A 4j03A-5kkbA:
undetectable		 4j03A-5kkbA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4r9g MBP1
(Caldanaerobius
polysaccharolyti
cus) 		4 / 8 HIS A 195
ASP A  89
ALA A  60
TYR A  85
 ZN  A 505 ( 3.1A)
ZN  A 505 (-3.0A)
MAN  A 501 ( 4.7A)
None
 0.87A 4k0bB-4r9gA:
undetectable		 4k0bB-4r9gA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4r9g MBP1
(Caldanaerobius
polysaccharolyti
cus) 		4 / 8 HIS A 195
ASP A  89
ALA A  60
TYR A  85
 ZN  A 505 ( 3.1A)
ZN  A 505 (-3.0A)
MAN  A 501 ( 4.7A)
None
 0.87A 4l7iB-4r9gA:
undetectable		 4l7iB-4r9gA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		5 / 11 PHE A 281
GLY A 411
GLY A 412
LEU A 476
GLU A 524
 MAN  A 708 ( 4.3A)
None
MAN  A 707 ( 3.5A)
MAN  A 708 ( 4.1A)
MAN  A 707 ( 4.7A)
 1.13A 4l8fB-5kkbA:
undetectable		 4l8fB-5kkbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		5 / 11 PHE A 281
GLY A 411
GLY A 412
LEU A 476
GLU A 524
 MAN  A 708 ( 4.3A)
None
MAN  A 707 ( 3.5A)
MAN  A 708 ( 4.1A)
MAN  A 707 ( 4.7A)
 1.17A 4l8fD-5kkbA:
undetectable		 4l8fD-5kkbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		3 / 3 ASP A 463
TRP A 389
SER A 400
 MAN  A 708 (-2.5A)
NAG  A 706 (-3.7A)
None
 1.06A 4lrhA-5kijA:
undetectable		 4lrhA-5kijA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 4utf GLYCOSYL HYDROLASE
FAMILY 71
(Bacteroides
xylanisolvens) 		4 / 4 HIS A 335
GLU A 156
HIS A 154
LEU A 121
 MAN  A 500 (-4.5A)
IFM  A 501 (-2.8A)
IFM  A 501 (-4.1A)
None
 1.42A 4m2rA-4utfA:
undetectable		 4m2rA-4utfA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 1xc6 BETA-GALACTOSIDASE
(Penicillium
sp.) 		4 / 6 ASP A 777
ASN A 776
ALA A 755
ASP A 806
 None
MAN  A7007 ( 3.1A)
None
None
 1.05A 4mdaA-1xc6A:
1.7		 4mdaA-1xc6A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4m18 PULMONARY
SURFACTANT-ASSOCIATE
D PROTEIN D
(Homo
sapiens) 		4 / 6 ASP A 297
ASN A 323
ALA A 325
ASP A 330
 CA  A 402 (-2.2A)
MAN  A 406 ( 2.6A)
MAN  A 405 ( 3.7A)
CA  A 403 ( 2.2A)
 1.06A 4mdbA-4m18A:
undetectable		 4mdbA-4m18A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ihr PROBABLE
BETA-GALACTOSIDASE A
(Aspergillus
niger) 		4 / 6 ASN A 320
GLU A 377
GLU A 381
GLU A 322
 MAN  A1627 (-3.7A)
MAN  A1625 (-2.8A)
None
MAN  A1626 (-3.7A)
 1.24A 4mi4A-5ihrA:
undetectable		 4mi4A-5ihrA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3ogr BETA-GALACTOSIDASE
(Trichoderma
reesei) 		4 / 7 ASN A 320
GLU A 377
GLU A 381
GLU A 322
 MAN  A1031 (-3.9A)
MAN  A1028 (-2.7A)
None
MAN  A1029 (-3.5A)
 1.26A 4mi4A-3ogrA:
undetectable
4mi4C-3ogrA:
undetectable		 4mi4A-3ogrA:
11.01
4mi4C-3ogrA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ihr PROBABLE
BETA-GALACTOSIDASE A
(Aspergillus
niger) 		4 / 7 ASN A 320
GLU A 377
GLU A 381
GLU A 322
 MAN  A1627 (-3.7A)
MAN  A1625 (-2.8A)
None
MAN  A1626 (-3.7A)
 1.23A 4mi4A-5ihrA:
undetectable
4mi4C-5ihrA:
undetectable		 4mi4A-5ihrA:
9.94
4mi4C-5ihrA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1xc6 BETA-GALACTOSIDASE
(Penicillium
sp.) 		4 / 7 ASN A 321
GLU A 378
GLU A 382
GLU A 323
 None
MAN  A3005 (-2.9A)
None
MAN  A3007 (-3.5A)
 1.35A 4mj8C-1xc6A:
undetectable		 4mj8C-1xc6A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3ogr BETA-GALACTOSIDASE
(Trichoderma
reesei) 		4 / 7 ASN A 320
GLU A 377
GLU A 381
GLU A 322
 MAN  A1031 (-3.9A)
MAN  A1028 (-2.7A)
None
MAN  A1029 (-3.5A)
 1.30A 4mj8C-3ogrA:
undetectable		 4mj8C-3ogrA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ihr PROBABLE
BETA-GALACTOSIDASE A
(Aspergillus
niger) 		4 / 7 ASN A 320
GLU A 377
GLU A 381
GLU A 322
 MAN  A1627 (-3.7A)
MAN  A1625 (-2.8A)
None
MAN  A1626 (-3.7A)
 1.26A 4mj8C-5ihrA:
undetectable		 4mj8C-5ihrA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		3 / 3 ARG A 249
HIS A 242
SER A 246
 None
MAN  A3103 (-3.8A)
None
 0.89A 4mjwA-1jneA:
0.0
4mjwB-1jneA:
0.0		 4mjwA-1jneA:
22.68
4mjwB-1jneA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 1jne IMAGINAL DISC GROWTH
FACTOR-2
(Drosophila
melanogaster) 		3 / 3 SER A 246
ARG A 249
HIS A 242
 None
None
MAN  A3103 (-3.8A)
 0.84A 4mjwA-1jneA:
0.0
4mjwB-1jneA:
0.0		 4mjwA-1jneA:
22.68
4mjwB-1jneA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 5szn PROTOCADHERIN GAMMA
A9
(Mus
musculus) 		5 / 11 TYR A 187
VAL A 183
ALA A 198
SER A 195
SER A 196
 MAN  A 601 (-4.7A)
None
None
MAN  A 601 (-1.4A)
None
 0.97A 4mmaA-5sznA:
undetectable		 4mmaA-5sznA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 5szn PROTOCADHERIN GAMMA
A9
(Mus
musculus) 		5 / 12 TYR A 187
VAL A 183
ALA A 198
SER A 195
SER A 196
 MAN  A 601 (-4.7A)
None
None
MAN  A 601 (-1.4A)
None
 1.02A 4mmdB-5sznA:
undetectable		 4mmdB-5sznA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 5szm PCDHGA8 OR
PROTOCADHERIN GAMMA
A8
(Mus
musculus) 		4 / 4 LEU A 183
SER A 144
LEU A 198
LEU A 125
 None
None
MAN  A 515 (-3.6A)
None
 1.12A 4n09A-5szmA:
undetectable		 4n09A-5szmA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 146
ILE A 142
THR A 240
VAL A 234
THR A  58
 None
NAG  A2002 ( 4.8A)
None
None
MAN  A3008 ( 4.5A)
 0.87A 4q5mA-1zpuA:
undetectable		 4q5mA-1zpuA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 3eqa GLUCOAMYLASE
(Aspergillus
niger) 		5 / 12 ALA A 466
SER A 465
GLY A 462
ALA A 227
GLY A 223
 MAN  A 600 (-4.9A)
None
None
None
None
 1.18A 4r29A-3eqaA:
undetectable		 4r29A-3eqaA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3eqa GLUCOAMYLASE
(Aspergillus
niger) 		5 / 12 ALA A 466
SER A 465
GLY A 462
ALA A 227
GLY A 223
 MAN  A 600 (-4.9A)
None
None
None
None
 1.21A 4r29C-3eqaA:
undetectable		 4r29C-3eqaA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 1qmo MANNOSE BINDING
LECTIN, FRIL
MANNOSE BINDING
LECTIN, FRIL
(Lablab
purpureus;
Lablab
purpureus) 		5 / 12 SER E 164
GLY E 156
ILE A  84
ALA A  85
GLY A  87
 MN  A 301 ( 3.7A)
None
None
MAN  A 302 ( 3.7A)
None
 1.07A 4r29D-1qmoE:
undetectable		 4r29D-1qmoE:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5no7 LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Trametes
cinnabarina) 		5 / 12 ALA A 242
ILE A 241
ILE A 165
GLY A 172
GLN A 174
 BMA  A 321 ( 4.4A)
MAN  A 322 (-4.7A)
None
None
None
 0.99A 4r3aB-5no7A:
undetectable		 4r3aB-5no7A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1xc6 BETA-GALACTOSIDASE
(Penicillium
sp.) 		4 / 7 ASN A 321
GLU A 378
GLU A 382
GLU A 323
 None
MAN  A3005 (-2.9A)
None
MAN  A3007 (-3.5A)
 1.24A 4r87I-1xc6A:
undetectable		 4r87I-1xc6A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3ogr BETA-GALACTOSIDASE
(Trichoderma
reesei) 		4 / 7 ASN A 320
GLU A 377
GLU A 381
GLU A 322
 MAN  A1031 (-3.9A)
MAN  A1028 (-2.7A)
None
MAN  A1029 (-3.5A)
 1.18A 4r87I-3ogrA:
undetectable		 4r87I-3ogrA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ihr PROBABLE
BETA-GALACTOSIDASE A
(Aspergillus
niger) 		4 / 7 ASN A 320
GLU A 377
GLU A 381
GLU A 322
 MAN  A1627 (-3.7A)
MAN  A1625 (-2.8A)
None
MAN  A1626 (-3.7A)
 1.17A 4r87I-5ihrA:
undetectable		 4r87I-5ihrA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1qmo MANNOSE BINDING
LECTIN, FRIL
MANNOSE BINDING
LECTIN, FRIL
(Lablab
purpureus;
Lablab
purpureus) 		5 / 12 GLY A 104
GLY A 103
GLY A  87
ILE E 155
TYR E 152
 MAN  A 302 (-3.7A)
MAN  A 302 ( 3.8A)
None
None
None
 1.04A 4rtmA-1qmoA:
undetectable		 4rtmA-1qmoA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1qmo MANNOSE BINDING
LECTIN, FRIL
MANNOSE BINDING
LECTIN, FRIL
(Lablab
purpureus;
Lablab
purpureus) 		5 / 12 GLY A 104
GLY A 103
GLY A  87
TYR E 152
TYR E 147
 MAN  A 302 (-3.7A)
MAN  A 302 ( 3.8A)
None
None
None
 0.91A 4rtmA-1qmoA:
undetectable		 4rtmA-1qmoA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		3 / 3 GLU A 419
TYR A 615
GLU A 611
 LA  A 711 ( 4.4A)
None
MAN  A 709 ( 2.8A)
 0.79A 4ryaA-5kkbA:
undetectable		 4ryaA-5kkbA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5ju6 BETA-GLUCOSIDASE
(Rasamsonia
emersonii) 		5 / 12 GLY A 284
SER A 283
ILE A 322
ALA A 316
VAL A 317
 NAG  A 918 (-3.1A)
MAN  A 922 ( 4.6A)
None
NAG  A 917 ( 3.9A)
None
 1.12A 4u8yB-5ju6A:
undetectable		 4u8yB-5ju6A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3uuf LIP1, SECRETORY
LIPASE (FAMILY 3)
(Malassezia
globosa) 		3 / 3 ASP A  33
GLY A 262
ASP A 245
 MAN  A 504 (-4.3A)
None
None
 0.69A 4xdtA-3uufA:
undetectable		 4xdtA-3uufA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3vzg ZYMOGEN GRANULE
MEMBRANE PROTEIN 16
(Homo
sapiens) 		4 / 5 GLY A  34
ARG A 145
GLY A  31
GLU A  29
 MAN  A 202 ( 3.7A)
None
None
None
 1.26A 4z2eB-3vzgA:
undetectable
4z2eC-3vzgA:
undetectable		 4z2eB-3vzgA:
14.94
4z2eC-3vzgA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 4nen INTEGRIN ALPHA-X
(Homo
sapiens) 		5 / 12 PHE A 371
LEU A 330
GLY A 359
SER A 357
SER A 327
 NAG  A1105 (-4.7A)
None
None
NAG  A1105 (-3.2A)
MAN  A1110 (-3.5A)
 1.50A 4zbrA-4nenA:
undetectable		 4zbrA-4nenA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 12 GLY A  98
ILE A  52
GLY A  92
LEU A 156
THR A 226
 MMA  A 242 ( 3.1A)
None
None
None
MAN  A 241 (-3.3A)
 0.96A 4zdyA-2ow4A:
undetectable		 4zdyA-2ow4A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1xc6 BETA-GALACTOSIDASE
(Penicillium
sp.) 		3 / 3 ALA A 573
TYR A 574
PRO A 512
 None
None
MAN  A3008 (-4.3A)
 0.66A 4zdyA-1xc6A:
undetectable		 4zdyA-1xc6A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 12 GLY A  98
ILE A  52
GLY A  92
LEU A 156
THR A 226
 MMA  A 242 ( 3.1A)
None
None
None
MAN  A 241 (-3.3A)
 1.02A 4ze2A-2ow4A:
undetectable		 4ze2A-2ow4A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1xc6 BETA-GALACTOSIDASE
(Penicillium
sp.) 		4 / 5 ALA A 573
TYR A 574
HIS A 435
PRO A 512
 None
None
None
MAN  A3008 (-4.3A)
 1.06A 4ze2A-1xc6A:
undetectable		 4ze2A-1xc6A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 6 ILE A 420
PHE A 383
ARG A 298
ILE A 439
 None
None
None
MAN  A1268 (-3.4A)
 1.27A 4zzcA-5fuuA:
undetectable
4zzcB-5fuuA:
undetectable		 4zzcA-5fuuA:
18.92
4zzcB-5fuuA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 6 ILE A 420
PHE A 383
ARG A 298
ILE A 439
 None
None
None
MAN  A1268 (-3.4A)
 1.32A 4zzcB-5fuuA:
undetectable
4zzcC-5fuuA:
undetectable		 4zzcB-5fuuA:
18.92
4zzcC-5fuuA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 6cbp DH270.6 SINGLE CHAIN
VARIABLE FRAGMENT
(Homo
sapiens) 		6 / 7 TYR A 111
SER A 178
TYR A 180
TYR A 193
GLU A 194
PRO A 199
 MAN  A 304 ( 4.5A)
None
None
MAN  A 305 ( 3.8A)
MAN  A 304 ( 2.7A)
MAN  A 306 ( 4.5A)
 1.10A 5aclA-6cbpA:
14.3		 5aclA-6cbpA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4r9g MBP1
(Caldanaerobius
polysaccharolyti
cus) 		4 / 8 ASN A 391
PRO A 194
PHE A 394
TYR A 399
 MAN  A 501 ( 4.9A)
None
None
None
 1.44A 5amkA-4r9gA:
undetectable		 5amkA-4r9gA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4r9g MBP1
(Caldanaerobius
polysaccharolyti
cus) 		4 / 7 ASN A 391
PRO A 194
PHE A 394
TYR A 399
 MAN  A 501 ( 4.9A)
None
None
None
 1.47A 5amkB-4r9gA:
undetectable		 5amkB-4r9gA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		4 / 7 THR A 367
TYR A 369
THR A 370
SER A 352
 MAN  A 447 (-2.4A)
None
BMA  A 427 (-2.2A)
BMA  A 427 ( 4.3A)
 1.14A 5b6iA-1rmgA:
undetectable		 5b6iA-1rmgA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		4 / 6 THR A 367
TYR A 369
THR A 370
SER A 352
 MAN  A 447 (-2.4A)
None
BMA  A 427 (-2.2A)
BMA  A 427 ( 4.3A)
 1.15A 5b6iB-1rmgA:
0.0		 5b6iB-1rmgA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3rwk INULINASE
(Aspergillus
ficuum) 		5 / 12 GLY X 266
GLY X 264
PRO X 261
ALA X 262
ARG X 295
 NA  X 521 ( 4.2A)
MAN  X 519 (-3.3A)
None
None
MAN  X 517 (-3.1A)
 1.27A 5bw4B-3rwkX:
undetectable		 5bw4B-3rwkX:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 4utf GLYCOSYL HYDROLASE
FAMILY 71
(Bacteroides
xylanisolvens) 		5 / 12 GLY A 286
GLY A 337
GLY A 288
HIS A 335
GLU A 336
 None
None
None
MAN  A 500 (-4.5A)
IFM  A 501 ( 2.8A)
 0.91A 5ekxB-4utfA:
undetectable		 5ekxB-4utfA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ia5 POLYGALACTURONASE
(Aspergillus
aculeatus) 		5 / 12 GLY A   8
GLY A  11
LEU A  40
PHE A 107
THR A  75
 MAN  A 407 ( 4.8A)
MAN  A 414 ( 4.7A)
None
None
None
 1.08A 5eqbA-1ia5A:
0.0		 5eqbA-1ia5A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 12 GLY A  98
ILE A  52
GLY A  92
LEU A 156
THR A 226
 MMA  A 242 ( 3.1A)
None
None
None
MAN  A 241 (-3.3A)
 1.05A 5eqbA-2ow4A:
undetectable		 5eqbA-2ow4A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5szq PROTOCADHERIN
GAMMA-A4
(Mus
musculus) 		4 / 6 GLY A 484
THR A 483
SER A 445
VAL A 485
 None
None
MAN  A 706 ( 2.7A)
None
 1.06A 5ewuA-5szqA:
undetectable		 5ewuA-5szqA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		5 / 12 ILE A 372
GLU A 330
ALA A 462
VAL A 439
THR A 688
 None
MAN  A 707 ( 4.2A)
None
None
MAN  A 707 ( 3.2A)
 1.35A 5igpA-5kijA:
undetectable		 5igpA-5kijA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED
(Bacteroides
thetaiotaomicron) 		4 / 5 ALA B 184
GLY B 197
CYH B 198
LYS B 199
 None
None
None
MAN  B1485 ( 2.8A)
 1.43A 5jliA-5a7vB:
undetectable		 5jliA-5a7vB:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED
(Bacteroides
thetaiotaomicron) 		4 / 5 ALA B 184
GLY B 197
CYH B 198
LYS B 199
 None
None
None
MAN  B1485 ( 2.8A)
 1.49A 5jt4A-5a7vB:
undetectable		 5jt4A-5a7vB:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 LYS A  13
LEU A  27
ILE A  67
 MAN  A 653 ( 4.3A)
None
None
 0.66A 5kc0A-1moxA:
undetectable		 5kc0A-1moxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_A_STIA302_1
(DEOXYCYTIDINE KINASE)		 1v0z NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 VAL A 404
GLU A 284
PHE A 430
SER A 286
GLU A 382
 None
None
None
None
MAN  A 509 (-3.7A)
 1.42A 5mqtA-1v0zA:
0.0		 5mqtA-1v0zA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED
(Bacteroides
thetaiotaomicron) 		3 / 3 SER B 200
SER B 202
PHE B 344
 MAN  B1386 ( 4.3A)
None
MAN  B1386 ( 4.1A)
 0.90A 5mugA-5a7vB:
undetectable		 5mugA-5a7vB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 1ofm CHONDROITINASE B
(Pedobacter
heparinus) 		3 / 3 HIS A 164
ASP A 201
HIS A 202
 None
None
MAN  A 601 ( 3.9A)
 0.92A 5n1tW-1ofmA:
undetectable		 5n1tW-1ofmA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 5o2x GLYCOSIDE HYDROLASE
FAMILY 61
(Trichoderma
reesei) 		4 / 7 ILE A 159
TRP A 140
ASP A  92
SER A 231
 None
None
None
MAN  A 311 (-1.4A)
 1.34A 5nr3A-5o2xA:
undetectable		 5nr3A-5o2xA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3aih PROTEIN OS-9
(Homo
sapiens) 		4 / 8 TRP A 118
THR A 114
TYR A 120
GLN A 129
 MAN  A 301 (-3.8A)
None
None
None
 1.31A 5tzoB-3aihA:
undetectable		 5tzoB-3aihA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3aih PROTEIN OS-9
(Homo
sapiens) 		4 / 8 TRP A 118
THR A 114
TYR A 120
GLN A 129
 MAN  A 301 (-3.8A)
None
None
None
 1.35A 5tzoC-3aihA:
undetectable		 5tzoC-3aihA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 4 GLY A 508
PRO A 509
VAL A 548
ARG A 567
 None
None
None
MAN  A1141 ( 4.0A)
 1.36A 5uunA-4iugA:
0.2
5uunB-4iugA:
undetectable		 5uunA-4iugA:
15.24
5uunB-4iugA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4oit LYSM DOMAIN PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 4 VAL A  53
LEU A  11
ASN A  49
ASP A  31
 None
None
MAN  A 201 (-4.1A)
MAN  A 201 (-3.2A)
 1.32A 5vcyA-4oitA:
undetectable		 5vcyA-4oitA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5fjj BETA-GLUCOSIDASE
(Aspergillus
oryzae) 		5 / 9 GLY A 290
LEU A 293
ILE A 326
LEU A 317
ILE A 338
 MAN  A1310 ( 3.7A)
None
None
None
None
 0.96A 5vkqC-5fjjA:
undetectable
5vkqD-5fjjA:
undetectable		 5vkqC-5fjjA:
19.09
5vkqD-5fjjA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5ju6 BETA-GLUCOSIDASE
(Rasamsonia
emersonii) 		5 / 9 GLY A 286
LEU A 289
ILE A 322
LEU A 313
ILE A 334
 MAN  A 924 ( 3.7A)
None
None
None
None
 0.93A 5vkqC-5ju6A:
undetectable
5vkqD-5ju6A:
undetectable		 5vkqC-5ju6A:
19.49
5vkqD-5ju6A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 4utf GLYCOSYL HYDROLASE
FAMILY 71
(Bacteroides
xylanisolvens) 		5 / 12 GLY A 286
GLY A 337
GLY A 288
HIS A 335
GLU A 336
 None
None
None
MAN  A 500 (-4.5A)
IFM  A 501 ( 2.8A)
 0.85A 5wz1B-4utfA:
undetectable		 5wz1B-4utfA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A 485
VAL A 491
PRO A 442
GLU A 155
THR A 462
 None
None
None
None
MAN  A 602 ( 3.3A)
 1.36A 5xipD-4pfwA:
undetectable		 5xipD-4pfwA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2fmd LECTIN
(Leucomphalos
mildbraedii) 		4 / 7 ALA A  85
GLY A 217
GLY A  45
THR A 130
 MAN  A 241 (-3.2A)
MAN  A 241 (-3.1A)
None
None
 0.69A 5ybbB-2fmdA:
undetectable		 5ybbB-2fmdA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 3q2v CADHERIN-1
(Mus
musculus) 		5 / 11 HIS A 299
ASN A 263
VAL A 261
ASP A 264
PRO A 265
 MAN  A 804 ( 4.3A)
None
None
None
None
 1.12A 5z0hA-3q2vA:
undetectable
5z0hB-3q2vA:
undetectable		 5z0hA-3q2vA:
9.70
5z0hB-3q2vA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 3q2v CADHERIN-1
(Mus
musculus) 		5 / 11 HIS A 299
ASN A 263
VAL A 261
ASP A 264
PRO A 265
 MAN  A 804 ( 4.3A)
None
None
None
None
 1.15A 5z0lA-3q2vA:
undetectable
5z0lB-3q2vA:
undetectable		 5z0lA-3q2vA:
9.70
5z0lB-3q2vA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 3q2v CADHERIN-1
(Mus
musculus) 		5 / 11 HIS A 299
ASN A 263
VAL A 261
ASP A 264
PRO A 265
 MAN  A 804 ( 4.3A)
None
None
None
None
 1.11A 5z0mA-3q2vA:
undetectable
5z0mB-3q2vA:
undetectable		 5z0mA-3q2vA:
9.70
5z0mB-3q2vA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		4 / 7 LEU A 413
ALA A 350
THR A 354
THR A 635
 None
MAN  A 708 ( 3.3A)
None
MAN  A 709 (-3.1A)
 0.85A 6a7jA-5kkbA:
undetectable		 6a7jA-5kkbA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 7 SER X 321
HIS X 447
GLY X 294
ARG X 431
 MAN  X 519 (-4.9A)
None
None
None
 0.90A 6btxA-3rwkX:
undetectable		 6btxA-3rwkX:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 12 GLY A  98
ILE A  52
GLY A  92
LEU A 156
THR A 226
 MMA  A 242 ( 3.1A)
None
None
None
MAN  A 241 (-3.3A)
 0.99A 6e8qA-2ow4A:
undetectable		 6e8qA-2ow4A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU B 266
GLN B 265
LYS B 199
 None
None
MAN  B1485 ( 2.8A)
 0.86A 6exiB-5a7vB:
undetectable		 6exiB-5a7vB:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU B 266
GLN B 265
LYS B 199
 None
None
MAN  B1485 ( 2.8A)
 0.81A 6exiA-5a7vB:
undetectable		 6exiA-5a7vB:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		3 / 3 LEU A 213
ASN A 155
LEU A 258
 None
None
MAN  A1272 (-4.7A)
 0.56A 6exiD-4cr6A:
8.6		 6exiD-4cr6A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED
(Bacteroides
thetaiotaomicron) 		4 / 4 LEU B 105
ASP B 142
PRO B 143
ARG B  89
 None
MAN  B1386 (-3.1A)
None
MAN  B1485 ( 2.7A)
 1.10A 6fgdA-5a7vB:
undetectable		 6fgdA-5a7vB:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 4oit LYSM DOMAIN PROTEIN
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  35
ALA A  42
GLN A  29
 MAN  A 201 ( 4.7A)
MAN  A 201 ( 3.7A)
MAN  A 201 (-3.2A)
 0.70A 6gb9A-4oitA:
undetectable		 6gb9A-4oitA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		4 / 5 LEU A 148
GLN A 150
PHE A 169
PHE A 140
 None
None
MAN  A 324 ( 4.4A)
None
 1.39A 6nmpP-2wedA:
undetectable
6nmpW-2wedA:
undetectable		 6nmpP-2wedA:
23.98
6nmpW-2wedA:
10.46