SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'MAE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.66A 1j36A-4fgmA:
5.5		 1j36A-4fgmA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.67A 1j36B-4fgmA:
5.5		 1j36B-4fgmA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 11 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.63A 1j37A-4fgmA:
5.5		 1j37A-4fgmA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 11 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.64A 1j37B-4fgmA:
3.8		 1j37B-4fgmA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.65A 1o86A-4fgmA:
2.1		 1o86A-4fgmA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.60A 2c6nA-4fgmA:
6.1		 2c6nA-4fgmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.67A 2c6nB-4fgmA:
4.0		 2c6nB-4fgmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 11 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.60A 2x8zA-4fgmA:
7.1		 2x8zA-4fgmA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.62A 2x91A-4fgmA:
5.4		 2x91A-4fgmA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		3 / 3 HIS A 273
GLU A 274
HIS A 277
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
 0.22A 3kecB-4fgmA:
5.4		 3kecB-4fgmA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 5 HIS A 239
HIS A 273
GLU A 274
HIS A 277
 None
ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
 1.10A 4a7bB-4fgmA:
5.6		 4a7bB-4fgmA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 11 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.66A 4c2pA-4fgmA:
6.7		 4c2pA-4fgmA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 9 GLY A 235
HIS A 273
GLU A 274
GLU A 307
TYR A 377
 None
ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.68A 4dprA-4fgmA:
20.1		 4dprA-4fgmA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 GLU A 274
HIS A 277
GLU A 307
TYR A 363
TYR A 377
 MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
None
MAE  A 601 (-4.7A)
 0.86A 4r7lA-4fgmA:
18.2		 4r7lA-4fgmA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.36A 4r7lA-4fgmA:
18.2		 4r7lA-4fgmA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 7 THR A 194
GLY A 196
ALA A 285
ILE A 200
 None
MAE  A 500 ( 3.9A)
None
FAD  A 492 ( 4.3A)
 0.95A 4txnA-1aogA:
undetectable		 4txnA-1aogA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 7 THR A 194
GLY A 196
ALA A 285
ILE A 200
 None
MAE  A 500 ( 3.9A)
None
FAD  A 492 ( 4.3A)
 0.95A 4txnB-1aogA:
undetectable		 4txnB-1aogA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 7 THR A 194
GLY A 196
ALA A 285
ILE A 200
 None
MAE  A 500 ( 3.9A)
None
FAD  A 492 ( 4.3A)
 0.96A 4txnC-1aogA:
undetectable		 4txnC-1aogA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 7 THR A 194
GLY A 196
ALA A 285
ILE A 200
 None
MAE  A 500 ( 3.9A)
None
FAD  A 492 ( 4.3A)
 0.91A 4txnD-1aogA:
undetectable		 4txnD-1aogA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 7 SER A  93
ASP A  91
PHE A  46
SER A  40
 None
None
None
MAE  A 601 ( 3.7A)
 1.21A 5l1fC-4fgmA:
undetectable		 5l1fC-4fgmA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 1yaa ASPARTATE
AMINOTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 194
TYR A 225
CYH A 357
 MAE  A 901 ( 3.4A)
PLP  A 905 (-4.2A)
None
 1.01A 5lsuB-1yaaA:
undetectable		 5lsuB-1yaaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 4 HIS A 277
HIS A 273
TYR A 377
GLU A 307
 ZN  A 602 ( 3.2A)
ZN  A 602 ( 3.4A)
MAE  A 601 (-4.7A)
ZN  A 602 ( 2.3A)
 1.49A 5pahA-4fgmA:
undetectable		 5pahA-4fgmA:
20.31