SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'M72'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4KIC_A_SAMA401_0 (METHYLTRANSFERASE MPPJ)	4m73	METHYLTRANSFERASE MPPJ (Streptomyces hygroscopicus)	6 / 12	CYH A 136 GLY A 166 ALA A 194 PHE A 239 MET A 240 MET A 241	M72 A 402 (-2.8A) SAH A 401 (-3.4A) SAH A 401 ( 3.8A) None SAH A 401 ( 4.3A) SAH A 401 ( 3.9A)	1.41A	4kicA-4m73A: 46.3	4kicA-4m73A: 93.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4KIC_A_SAMA401_0 (METHYLTRANSFERASE MPPJ)	4m73	METHYLTRANSFERASE MPPJ (Streptomyces hygroscopicus)	11 / 12	CYH A 136 GLY A 166 GLY A 168 ARG A 172 ILE A 190 ALA A 191 ALA A 218 ARG A 219 PHE A 239 MET A 240 MET A 241	M72 A 402 (-2.8A) SAH A 401 (-3.4A) SAH A 401 (-3.5A) SAH A 401 (-3.8A) SAH A 401 (-3.8A) SAH A 401 (-3.5A) SAH A 401 (-3.5A) SAH A 401 (-4.5A) None SAH A 401 ( 4.3A) SAH A 401 ( 3.9A)	0.64A	4kicA-4m73A: 46.3	4kicA-4m73A: 93.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4KIC_B_SAMB401_0 (METHYLTRANSFERASE MPPJ)	4m73	METHYLTRANSFERASE MPPJ (Streptomyces hygroscopicus)	6 / 12	CYH A 136 GLY A 166 ALA A 194 PHE A 239 MET A 240 MET A 241	M72 A 402 (-2.8A) SAH A 401 (-3.4A) SAH A 401 ( 3.8A) None SAH A 401 ( 4.3A) SAH A 401 ( 3.9A)	1.37A	4kicB-4m73A: 46.1	4kicB-4m73A: 93.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4KIC_B_SAMB401_0 (METHYLTRANSFERASE MPPJ)	4m73	METHYLTRANSFERASE MPPJ (Streptomyces hygroscopicus)	10 / 12	CYH A 136 GLY A 166 GLY A 168 ILE A 190 ALA A 191 ALA A 218 ARG A 219 PHE A 239 MET A 240 MET A 241	M72 A 402 (-2.8A) SAH A 401 (-3.4A) SAH A 401 (-3.5A) SAH A 401 (-3.8A) SAH A 401 (-3.5A) SAH A 401 (-3.5A) SAH A 401 (-4.5A) None SAH A 401 ( 4.3A) SAH A 401 ( 3.9A)	0.65A	4kicB-4m73A: 46.1	4kicB-4m73A: 93.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4KIC_B_SAMB401_0 (METHYLTRANSFERASE MPPJ)	4m73	METHYLTRANSFERASE MPPJ (Streptomyces hygroscopicus)	5 / 12	ILE A 132 CYH A 136 ARG A 219 PHE A 239 MET A 240	M72 A 402 (-4.7A) M72 A 402 (-2.8A) SAH A 401 (-4.5A) None SAH A 401 ( 4.3A)	0.84A	4kicB-4m73A: 46.1	4kicB-4m73A: 93.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZJI_A_PQNA844_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 PHOTOSYSTEM I REACTION CENTER SUBUNIT IX)	4m73	METHYLTRANSFERASE MPPJ (Streptomyces hygroscopicus)	5 / 10	SER A 104 GLY A 103 TRP A 99 ILE A 139 PHE A 312	None None M72 A 402 (-4.5A) M72 A 402 ( 4.6A) HF2 A 404 (-4.4A)	1.09A	5zjiA-4m73A: undetectable 5zjiJ-4m73A: undetectable	5zjiA-4m73A: 12.73 5zjiJ-4m73A: 8.65

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4KIC_A_SAMA401_0","METHYLTRANSFERASE MPPJ","4m73","METHYLTRANSFERASE MPPJ","Streptomyces hygroscopicus",6,"CYH A 136;GLY A 166;ALA A 194;PHE A 239;MET A 240;MET A 241","M72 A 402 (-2.8A);SAH A 401 (-3.4A);SAH A 401 ( 3.8A);None;SAH A 401 ( 4.3A);SAH A 401 ( 3.9A)","1.41A","4kicA-4m73A:46.3",null],["4KIC_A_SAMA401_0","METHYLTRANSFERASE MPPJ","4m73","METHYLTRANSFERASE MPPJ","Streptomyces hygroscopicus",11,"CYH A 136;GLY A 166;GLY A 168;ARG A 172;ILE A 190;ALA A 191;ALA A 218;ARG A 219;PHE A 239;MET A 240;MET A 241","M72 A 402 (-2.8A);SAH A 401 (-3.4A);SAH A 401 (-3.5A);SAH A 401 (-3.8A);SAH A 401 (-3.8A);SAH A 401 (-3.5A);SAH A 401 (-3.5A);SAH A 401 (-4.5A);None;SAH A 401 ( 4.3A);SAH A 401 ( 3.9A)","0.64A","4kicA-4m73A:46.3","4kicA-4m73A:93.56"],["4KIC_B_SAMB401_0","METHYLTRANSFERASE MPPJ","4m73","METHYLTRANSFERASE MPPJ","Streptomyces hygroscopicus",6,"CYH A 136;GLY A 166;ALA A 194;PHE A 239;MET A 240;MET A 241","M72 A 402 (-2.8A);SAH A 401 (-3.4A);SAH A 401 ( 3.8A);None;SAH A 401 ( 4.3A);SAH A 401 ( 3.9A)","1.37A","4kicB-4m73A:46.1","4kicA-4m73A:93.56"],["4KIC_B_SAMB401_0","METHYLTRANSFERASE MPPJ","4m73","METHYLTRANSFERASE MPPJ","Streptomyces hygroscopicus",10,"CYH A 136;GLY A 166;GLY A 168;ILE A 190;ALA A 191;ALA A 218;ARG A 219;PHE A 239;MET A 240;MET A 241","M72 A 402 (-2.8A);SAH A 401 (-3.4A);SAH A 401 (-3.5A);SAH A 401 (-3.8A);SAH A 401 (-3.5A);SAH A 401 (-3.5A);SAH A 401 (-4.5A);None;SAH A 401 ( 4.3A);SAH A 401 ( 3.9A)","0.65A","4kicB-4m73A:46.1","4kicB-4m73A:93.56"],["4KIC_B_SAMB401_0","METHYLTRANSFERASE MPPJ","4m73","METHYLTRANSFERASE MPPJ","Streptomyces hygroscopicus",5,"ILE A 132;CYH A 136;ARG A 219;PHE A 239;MET A 240","M72 A 402 (-4.7A);M72 A 402 (-2.8A);SAH A 401 (-4.5A);None;SAH A 401 ( 4.3A)","0.84A","4kicB-4m73A:46.1","4kicB-4m73A:93.56"],["5ZJI_A_PQNA844_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1;PHOTOSYSTEM I REACTION CENTER SUBUNIT IX","4m73","METHYLTRANSFERASE MPPJ","Streptomyces hygroscopicus",5,"SER A 104;GLY A 103;TRP A  99;ILE A 139;PHE A 312","None;None;M72 A 402 (-4.5A);M72 A 402 ( 4.6A);HF2 A 404 (-4.4A)","1.09A","5zjiA-4m73A:undetectable;5zjiJ-4m73A:undetectable","4kicB-4m73A:93.56"]]