SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'M3R'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 5 HIS A  90
HIS A 252
HIS A 272
ASP A 344
 ZN  A   1 ( 3.2A)
ZN  A   2 ( 3.2A)
ZN  A   2 ( 3.3A)
M3R  A 430 ( 2.4A)
 0.78A 1e9yB-3mtwA:
19.3		 1e9yB-3mtwA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 6 HIS A  90
HIS A  92
HIS A 252
HIS A 272
ASP A 344
 ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.2A)
ZN  A   2 ( 3.2A)
ZN  A   2 ( 3.3A)
M3R  A 430 ( 2.4A)
 0.78A 1fweC-3mtwA:
19.8		 1fweC-3mtwA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 6 HIS A  90
HIS A 171
HIS A 252
HIS A 272
ASP A 344
 ZN  A   1 ( 3.2A)
M3R  A 430 (-3.9A)
ZN  A   2 ( 3.2A)
ZN  A   2 ( 3.3A)
M3R  A 430 ( 2.4A)
 1.25A 1fweC-3mtwA:
19.8		 1fweC-3mtwA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 5 SER A 274
TYR A 363
SER A 373
ASP A 294
 None
SO4  A   5 (-4.6A)
None
M3R  A 430 (-3.2A)
 1.39A 1vidA-3mtwA:
undetectable		 1vidA-3mtwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 6 SER A 274
TYR A 363
SER A 373
ASP A 294
 None
SO4  A   5 (-4.6A)
None
M3R  A 430 (-3.2A)
 1.40A 2cl5B-3mtwA:
undetectable		 2cl5B-3mtwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 11 GLY A 226
ASP A 294
THR A 215
GLY A 216
HIS A 252
 None
M3R  A 430 (-3.2A)
None
None
ZN  A   2 ( 3.2A)
 1.28A 2hmaA-3mtwA:
undetectable		 2hmaA-3mtwA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 8 HIS A 171
GLY A 216
ASN A 223
PHE A 176
 M3R  A 430 (-3.9A)
None
None
None
 1.25A 3ccfA-3mtwA:
undetectable		 3ccfA-3mtwA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 8 HIS A 171
GLY A 216
ASN A 223
PHE A 219
 M3R  A 430 (-3.9A)
None
None
M3R  A 430 (-4.3A)
 1.12A 3ccfA-3mtwA:
undetectable		 3ccfA-3mtwA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 7 ASN A 297
TYR A 296
ASN A 308
ALA A 303
 M3R  A 430 (-3.7A)
None
None
None
 1.34A 3frqB-3mtwA:
undetectable		 3frqB-3mtwA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 5 HIS A  90
HIS A 252
HIS A 272
ASP A 344
 ZN  A   1 ( 3.2A)
ZN  A   2 ( 3.2A)
ZN  A   2 ( 3.3A)
M3R  A 430 ( 2.4A)
 0.78A 4h9mA-3mtwA:
21.2		 4h9mA-3mtwA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 12 GLY A 217
LEU A 275
THR A 301
ILE A 347
PHE A 219
 M3R  A 430 (-3.5A)
None
None
M3R  A 430 ( 4.9A)
M3R  A 430 (-4.3A)
 1.40A 4p6xE-3mtwA:
undetectable		 4p6xE-3mtwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 12 GLY A 217
LEU A 275
THR A 301
ILE A 347
PHE A 219
 M3R  A 430 (-3.5A)
None
None
M3R  A 430 ( 4.9A)
M3R  A 430 (-4.3A)
 1.41A 4p6xG-3mtwA:
undetectable		 4p6xG-3mtwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 6 HIS A  90
HIS A  92
HIS A 252
HIS A 272
ASP A 344
 ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.2A)
ZN  A   2 ( 3.2A)
ZN  A   2 ( 3.3A)
M3R  A 430 ( 2.4A)
 0.66A 4ubpC-3mtwA:
19.3		 4ubpC-3mtwA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 5 THR A 301
GLY A 305
GLU A 312
ASP A 318
 None
None
None
M3R  A 430 (-3.8A)
 1.04A 5c0oH-3mtwA:
undetectable		 5c0oH-3mtwA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 5 SER A 274
TYR A 363
SER A 373
ASP A 294
 None
SO4  A   5 (-4.6A)
None
M3R  A 430 (-3.2A)
 1.39A 5fhrA-3mtwA:
undetectable		 5fhrA-3mtwA:
21.59