SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'M33'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.71A 1iepA-3b2tA:
25.6		 1iepA-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
 0.79A 1iepB-3b2tA:
25.3		 1iepB-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
ILE A 541
GLY A 570
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
None
 0.67A 1iepB-3b2tA:
25.3		 1iepB-3b2tA:
39.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 9 LEU A 487
GLY A 488
VAL A 495
ALA A 515
TYR A 566
ALA A 567
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
 0.69A 1muoA-3b2tA:
7.7		 1muoA-3b2tA:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
 0.64A 1opjA-3b2tA:
24.3		 1opjA-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
ILE A 541
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-4.5A)
None
 0.68A 1opjA-3b2tA:
24.3		 1opjA-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 495
ALA A 515
MET A 538
ILE A 541
GLY A 570
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
None
 0.75A 1opjB-3b2tA:
30.3		 1opjB-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		4 / 7 VAL A 562
TYR A 566
CYH A 622
ARG A 625
 None
M33  A1996 ( 4.7A)
None
None
 1.24A 1t46A-3b2tA:
34.3		 1t46A-3b2tA:
48.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 9 LEU A 487
VAL A 495
ALA A 515
ALA A 567
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 (-3.8A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.51A 1xbbA-3b2tA:
34.8		 1xbbA-3b2tA:
37.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 11 GLY A 488
GLY A 490
VAL A 495
ALA A 515
TYR A 566
LEU A 633
 M33  A1996 ( 3.8A)
M33  A1996 (-3.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 (-4.5A)
 0.64A 2evaA-3b2tA:
20.1		 2evaA-3b2tA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 11 GLY A 488
VAL A 495
ALA A 515
TYR A 566
ALA A 567
LEU A 633
 M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
 0.42A 2evaA-3b2tA:
20.1		 2evaA-3b2tA:
27.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
LYS A 517
GLU A 534
MET A 538
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.67A 2gqgA-3b2tA:
34.8		 2gqgA-3b2tA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
ALA A 515
GLU A 534
MET A 538
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.64A 2gqgA-3b2tA:
34.8		 2gqgA-3b2tA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.45A 2gqgB-3b2tA:
34.7		 2gqgB-3b2tA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 495
ALA A 515
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.69A 2hyyA-3b2tA:
25.4		 2hyyA-3b2tA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 495
ALA A 515
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.71A 2hyyB-3b2tA:
25.5		 2hyyB-3b2tA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 495
ALA A 515
MET A 538
ILE A 541
LEU A 633
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-4.5A)
None
 0.72A 2hyyD-3b2tA:
25.5		 2hyyD-3b2tA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
ALA A 515
LYS A 517
GLU A 534
MET A 538
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.97A 2itoA-3b2tA:
33.1		 2itoA-3b2tA:
31.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 GLY A 488
LYS A 517
GLU A 534
VAL A 564
TYR A 566
ALA A 567
LEU A 633
 M33  A1996 ( 3.8A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
 0.72A 2ivuA-3b2tA:
29.3		 2ivuA-3b2tA:
50.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
GLY A 488
VAL A 495
GLU A 534
VAL A 564
TYR A 566
ALA A 567
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
 0.55A 2ivuA-3b2tA:
29.3		 2ivuA-3b2tA:
50.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
GLU A 534
VAL A 564
TYR A 566
ALA A 567
LEU A 633
ASP A 644
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
M33  A1996 (-4.0A)
 0.45A 2ivuA-3b2tA:
29.3		 2ivuA-3b2tA:
50.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 495
ALA A 515
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.71A 2oiqA-3b2tA:
24.6		 2oiqA-3b2tA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 GLY A 488
VAL A 495
ALA A 515
TYR A 566
GLY A 570
ALA A 643
 M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
None
 0.71A 2wgjA-3b2tA:
27.5		 2wgjA-3b2tA:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.75A 2y6oA-3b2tA:
26.5		 2y6oA-3b2tA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LYS A 485
ALA A 515
LYS A 517
GLU A 534
MET A 538
GLY A 570
LEU A 633
 None
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 1.08A 2y6oA-3b2tA:
26.5		 2y6oA-3b2tA:
35.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 495
ALA A 515
ILE A 548
GLY A 570
LEU A 633
ASP A 644
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
M33  A1996 (-4.0A)
 0.40A 2y7jA-3b2tA:
23.0		 2y7jA-3b2tA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 10 VAL A 495
ALA A 515
ILE A 548
GLY A 570
LEU A 633
ASP A 644
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
M33  A1996 (-4.0A)
 0.43A 2y7jB-3b2tA:
22.8		 2y7jB-3b2tA:
22.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
LYS A 517
GLU A 534
MET A 538
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.66A 2zvaA-3b2tA:
26.8		 2zvaA-3b2tA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
ALA A 515
GLU A 534
MET A 538
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.65A 2zvaA-3b2tA:
26.8		 2zvaA-3b2tA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
GLY A 488
ALA A 515
LYS A 517
VAL A 564
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.63A 3c7qA-3b2tA:
27.5		 3c7qA-3b2tA:
53.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
MET A 538
ILE A 541
GLY A 570
HIS A 624
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
None
M33  A1996 (-4.5A)
None
 0.56A 3cs9A-3b2tA:
25.7		 3cs9A-3b2tA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 515
MET A 538
ILE A 541
GLY A 570
HIS A 624
ALA A 643
 M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
None
None
 0.63A 3cs9B-3b2tA:
26.4		 3cs9B-3b2tA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 515
MET A 538
ILE A 541
HIS A 624
ALA A 643
 M33  A1996 (-3.3A)
None
None
None
None
 0.64A 3cs9C-3b2tA:
30.4		 3cs9C-3b2tA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 515
MET A 538
ILE A 541
GLY A 570
HIS A 624
ALA A 643
 M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
None
None
 0.57A 3cs9D-3b2tA:
25.5		 3cs9D-3b2tA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 487
GLY A 488
GLY A 490
GLY A 493
VAL A 495
ALA A 515
LYS A 517
TYR A 566
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 (-3.0A)
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 ( 4.7A)
M33  A1996 (-4.5A)
 0.78A 3fupA-3b2tA:
27.0		 3fupA-3b2tA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 11 LEU A 487
VAL A 495
ALA A 515
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.39A 3g0eA-3b2tA:
31.3		 3g0eA-3b2tA:
47.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 11 LEU A 487
VAL A 495
ALA A 515
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.46A 3g0fA-3b2tA:
33.2		 3g0fA-3b2tA:
47.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 10 LEU A 487
VAL A 495
ALA A 515
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.34A 3g0fB-3b2tA:
33.1		 3g0fB-3b2tA:
47.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.55A 3g5dA-3b2tA:
25.8		 3g5dA-3b2tA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.64A 3g5dB-3b2tA:
25.8		 3g5dB-3b2tA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 VAL A 495
ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.67A 3g5dB-3b2tA:
25.8		 3g5dB-3b2tA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
 0.65A 3gvuA-3b2tA:
25.8		 3gvuA-3b2tA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
ILE A 541
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-4.5A)
None
 0.65A 3gvuA-3b2tA:
25.8		 3gvuA-3b2tA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 515
MET A 538
HIS A 624
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
None
None
M33  A1996 (-4.5A)
None
 0.56A 3ik3A-3b2tA:
31.3		 3ik3A-3b2tA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 515
MET A 538
HIS A 624
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
None
None
M33  A1996 (-4.5A)
None
 0.55A 3ik3B-3b2tA:
25.6		 3ik3B-3b2tA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.77A 3k54A-3b2tA:
31.4		 3k54A-3b2tA:
34.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 495
ALA A 515
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.71A 3k5vA-3b2tA:
30.4		 3k5vA-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 495
ALA A 515
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.71A 3k5vB-3b2tA:
30.1		 3k5vB-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
GLY A 488
GLY A 490
VAL A 495
ALA A 515
TYR A 566
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 (-3.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 (-4.5A)
 0.44A 3lxnA-3b2tA:
32.2		 3lxnA-3b2tA:
34.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
GLY A 490
VAL A 495
ALA A 515
ILE A 548
TYR A 566
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 (-3.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.7A)
M33  A1996 (-4.5A)
 0.59A 3lxnA-3b2tA:
32.2		 3lxnA-3b2tA:
34.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
 0.70A 3ms9A-3b2tA:
25.7		 3ms9A-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
ILE A 541
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-4.5A)
None
 0.73A 3ms9A-3b2tA:
25.7		 3ms9A-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.71A 3ms9B-3b2tA:
25.7		 3ms9B-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
 0.73A 3mssA-3b2tA:
25.7		 3mssA-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
ILE A 541
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-4.5A)
None
 0.74A 3mssA-3b2tA:
25.7		 3mssA-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
 0.71A 3mssB-3b2tA:
30.9		 3mssB-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.73A 3mssB-3b2tA:
30.9		 3mssB-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
 0.75A 3mssC-3b2tA:
25.6		 3mssC-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
ILE A 541
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-4.5A)
None
 0.74A 3mssC-3b2tA:
25.6		 3mssC-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
ALA A 515
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.70A 3mssD-3b2tA:
25.7		 3mssD-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
LYS A 517
MET A 538
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.79A 3octA-3b2tA:
12.9		 3octA-3b2tA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
MET A 538
ILE A 541
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.73A 3oezA-3b2tA:
24.4		 3oezA-3b2tA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 495
ALA A 515
LYS A 517
MET A 538
TYR A 566
LEU A 633
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.7A)
M33  A1996 (-4.5A)
None
 0.68A 3oezB-3b2tA:
24.4		 3oezB-3b2tA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 515
MET A 538
ILE A 541
GLY A 570
HIS A 624
ALA A 643
 M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
None
None
 0.69A 3oxzA-3b2tA:
26.2		 3oxzA-3b2tA:
40.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
ALA A 515
MET A 538
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.78A 3pyyA-3b2tA:
25.8		 3pyyA-3b2tA:
39.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.86A 3pyyA-3b2tA:
25.8		 3pyyA-3b2tA:
39.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
ILE A 541
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-4.5A)
None
 0.75A 3pyyB-3b2tA:
26.3		 3pyyB-3b2tA:
39.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.70A 3qlgA-3b2tA:
24.7		 3qlgA-3b2tA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		10 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
ASP A 644
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
M33  A1996 (-4.0A)
 0.67A 3qlgB-3b2tA:
25.4		 3qlgB-3b2tA:
37.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
ILE A 548
TYR A 566
ALA A 567
LEU A 617
HIS A 624
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
None
None
None
 0.82A 3rgfA-3b2tA:
17.3		 3rgfA-3b2tA:
24.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.30A 3sxrA-3b2tA:
31.9		 3sxrA-3b2tA:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.30A 3sxrB-3b2tA:
31.7		 3sxrB-3b2tA:
36.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 GLY A 490
GLY A 493
VAL A 495
ALA A 515
LEU A 633
ASP A 644
 M33  A1996 (-3.0A)
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 (-4.5A)
M33  A1996 (-4.0A)
 0.86A 3v5wA-3b2tA:
25.9		 3v5wA-3b2tA:
17.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
GLY A 488
VAL A 495
ALA A 515
GLU A 534
VAL A 564
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
 1.05A 3wzdA-3b2tA:
33.3		 3wzdA-3b2tA:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
GLY A 488
VAL A 495
ALA A 515
VAL A 564
PHE A 645
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
 1.10A 3wzdA-3b2tA:
33.3		 3wzdA-3b2tA:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
VAL A 495
ALA A 515
VAL A 564
GLY A 570
PHE A 645
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.8A)
None
 0.80A 3wzdA-3b2tA:
33.3		 3wzdA-3b2tA:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
ILE A 541
VAL A 564
LEU A 617
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
None
 0.57A 3wzeA-3b2tA:
25.5		 3wzeA-3b2tA:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
ILE A 541
VAL A 564
GLY A 570
LEU A 617
HIS A 624
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
None
None
 0.53A 3wzeA-3b2tA:
25.5		 3wzeA-3b2tA:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 9 MET A 538
ILE A 547
ILE A 548
TYR A 566
ILE A 642
 None
None
None
M33  A1996 ( 4.7A)
None
 0.66A 3zosA-3b2tA:
23.4		 3zosA-3b2tA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 9 LEU A 487
MET A 538
ILE A 547
TYR A 566
ILE A 642
 M33  A1996 (-4.0A)
None
None
M33  A1996 ( 4.7A)
None
 0.60A 3zosB-3b2tA:
23.4		 3zosB-3b2tA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
LYS A 517
VAL A 564
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.48A 4ag8A-3b2tA:
27.7		 4ag8A-3b2tA:
54.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
LYS A 517
VAL A 564
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.46A 4agcA-3b2tA:
24.9		 4agcA-3b2tA:
49.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 11 LEU A 487
ALA A 515
LYS A 517
VAL A 564
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.63A 4agdA-3b2tA:
33.6		 4agdA-3b2tA:
49.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 9 LEU A 487
VAL A 495
ALA A 515
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.54A 4anqA-3b2tA:
19.0		 4anqA-3b2tA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 9 LEU A 487
VAL A 495
ALA A 515
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.54A 4ansA-3b2tA:
24.5		 4ansA-3b2tA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
VAL A 564
GLY A 570
LEU A 617
HIS A 624
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.8A)
None
None
 0.53A 4asdA-3b2tA:
34.1		 4asdA-3b2tA:
49.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 515
MET A 538
ILE A 548
TYR A 566
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-4.5A)
None
 0.85A 4bkjA-3b2tA:
25.7		 4bkjA-3b2tA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 548
TYR A 566
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
M33  A1996 ( 4.7A)
 0.87A 4bkjA-3b2tA:
25.7		 4bkjA-3b2tA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 495
ALA A 515
MET A 538
ILE A 548
TYR A 566
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.7A)
None
 0.81A 4bkjA-3b2tA:
25.7		 4bkjA-3b2tA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 495
ALA A 515
MET A 538
ILE A 548
LEU A 633
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-4.5A)
None
 0.93A 4bkjB-3b2tA:
25.6		 4bkjB-3b2tA:
34.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		4 / 5 VAL A 495
ILE A 547
TYR A 566
ILE A 642
 M33  A1996 ( 4.7A)
None
M33  A1996 ( 4.7A)
None
 0.41A 4c8bA-3b2tA:
19.6		 4c8bA-3b2tA:
24.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		10 / 11 LEU A 487
GLY A 488
GLY A 490
VAL A 495
ALA A 515
VAL A 564
TYR A 566
ALA A 567
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 (-3.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.72A 4ckiA-3b2tA:
29.5		 4ckiA-3b2tA:
50.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 10 LEU A 487
GLY A 488
VAL A 495
ALA A 515
VAL A 564
TYR A 566
ALA A 567
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
 0.40A 4ckjA-3b2tA:
31.8		 4ckjA-3b2tA:
50.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 GLY A 488
VAL A 495
ALA A 515
LYS A 517
LEU A 550
GLY A 570
LEU A 633
 M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.85A 4ifgA-3b2tA:
21.2		 4ifgA-3b2tA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 8 GLY A 490
VAL A 495
ALA A 515
LYS A 517
LEU A 633
 M33  A1996 (-3.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 (-4.5A)
 0.83A 4l9iB-3b2tA:
19.5		 4l9iB-3b2tA:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
ASP A 644
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.0A)
 0.85A 4mxoA-3b2tA:
25.7		 4mxoA-3b2tA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
LYS A 517
GLU A 534
TYR A 566
GLY A 570
LEU A 633
ASP A 644
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
M33  A1996 (-4.0A)
 0.83A 4mxoB-3b2tA:
25.7		 4mxoB-3b2tA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.84A 4mxxA-3b2tA:
25.5		 4mxxA-3b2tA:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
ALA A 515
LYS A 517
MET A 538
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.83A 4mxxA-3b2tA:
25.5		 4mxxA-3b2tA:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
LYS A 517
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.68A 4mxxB-3b2tA:
26.2		 4mxxB-3b2tA:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.72A 4mxyB-3b2tA:
28.4		 4mxyB-3b2tA:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
LYS A 517
GLU A 534
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.78A 4mxyB-3b2tA:
28.4		 4mxyB-3b2tA:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.72A 4mxzB-3b2tA:
28.4		 4mxzB-3b2tA:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
LYS A 517
GLU A 534
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.78A 4mxzB-3b2tA:
28.4		 4mxzB-3b2tA:
36.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 11 LEU A 487
GLY A 488
VAL A 495
ALA A 515
ASN A 631
LEU A 633
ASP A 644
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 (-4.5A)
M33  A1996 (-4.0A)
 0.67A 4o0sA-3b2tA:
27.5		 4o0sA-3b2tA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 11 LEU A 487
GLY A 488
VAL A 495
ALA A 515
LYS A 517
ASN A 631
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 (-4.5A)
 0.81A 4o0sA-3b2tA:
27.5		 4o0sA-3b2tA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		4 / 6 VAL A 495
ALA A 515
LYS A 517
LEU A 633
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 (-4.5A)
 0.54A 4o0uA-3b2tA:
19.6		 4o0uA-3b2tA:
26.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
LYS A 517
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 ( 4.5A)
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.65A 4otwA-3b2tA:
26.8		 4otwA-3b2tA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
GLU A 534
MET A 538
VAL A 564
LEU A 617
CYH A 622
ARG A 625
 M33  A1996 (-3.3A)
None
None
None
None
None
None
 0.96A 4qrcA-3b2tA:
27.8		 4qrcA-3b2tA:
74.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
MET A 538
VAL A 564
LEU A 617
CYH A 622
ARG A 625
ALA A 643
 M33  A1996 (-3.3A)
None
None
None
None
None
None
 0.80A 4qrcA-3b2tA:
27.8		 4qrcA-3b2tA:
74.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		4 / 5 LEU A 487
VAL A 562
TYR A 566
ARG A 625
 M33  A1996 (-4.0A)
None
M33  A1996 ( 4.7A)
None
 0.59A 4r7iA-3b2tA:
33.4		 4r7iA-3b2tA:
45.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
LYS A 517
GLY A 570
ASN A 631
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 ( 4.8A)
None
M33  A1996 (-4.5A)
None
 0.58A 4twpA-3b2tA:
28.6		 4twpA-3b2tA:
41.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
LYS A 517
GLY A 570
ASN A 631
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 ( 4.8A)
None
M33  A1996 (-4.5A)
None
 0.54A 4twpB-3b2tA:
34.5		 4twpB-3b2tA:
41.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
GLU A 534
MET A 538
ILE A 541
VAL A 564
CYH A 622
HIS A 624
 M33  A1996 (-3.3A)
None
None
None
None
None
None
 0.94A 4tyjA-3b2tA:
29.6		 4tyjA-3b2tA:
74.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 ALA A 515
MET A 538
ILE A 541
VAL A 564
ALA A 567
CYH A 622
HIS A 624
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
None
None
None
M33  A1996 (-3.8A)
None
None
M33  A1996 (-4.5A)
None
 0.58A 4tyjA-3b2tA:
29.6		 4tyjA-3b2tA:
74.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		4 / 6 LEU A 487
VAL A 495
ILE A 547
ILE A 642
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
None
None
 0.44A 4tyjA-3b2tA:
29.6		 4tyjA-3b2tA:
74.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 10 LEU A 487
VAL A 495
GLU A 534
ILE A 547
VAL A 562
TYR A 566
ILE A 642
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
None
None
None
M33  A1996 ( 4.7A)
None
 0.74A 4u0iA-3b2tA:
33.8		 4u0iA-3b2tA:
48.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 10 VAL A 495
GLU A 534
ILE A 547
VAL A 562
TYR A 566
ARG A 625
ILE A 642
 M33  A1996 ( 4.7A)
None
None
None
M33  A1996 ( 4.7A)
None
None
 0.97A 4u0iA-3b2tA:
33.8		 4u0iA-3b2tA:
48.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 11 LEU A 487
GLY A 490
VAL A 495
ALA A 515
TYR A 566
GLY A 570
ASN A 631
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 (-3.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
None
M33  A1996 (-4.5A)
None
 0.45A 4u5jA-3b2tA:
26.1		 4u5jA-3b2tA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 9 LEU A 487
VAL A 495
ALA A 515
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.50A 4u5jB-3b2tA:
25.9		 4u5jB-3b2tA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
ALA A 515
VAL A 564
LEU A 617
CYH A 622
HIS A 624
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
None
None
None
None
M33  A1996 (-4.5A)
None
 0.45A 4uxqA-3b2tA:
28.4		 4uxqA-3b2tA:
73.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 7 VAL A 495
ILE A 548
ALA A 567
ARG A 625
ILE A 642
 M33  A1996 ( 4.7A)
None
M33  A1996 (-3.8A)
None
None
 1.11A 4uxqA-3b2tA:
28.4		 4uxqA-3b2tA:
73.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 7 VAL A 495
MET A 538
ILE A 548
ALA A 567
ARG A 625
 M33  A1996 ( 4.7A)
None
None
M33  A1996 (-3.8A)
None
 1.30A 4uxqA-3b2tA:
28.4		 4uxqA-3b2tA:
73.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 ALA A 515
GLU A 534
MET A 537
MET A 538
ILE A 541
VAL A 564
ALA A 567
LEU A 617
 M33  A1996 (-3.3A)
None
None
None
None
None
M33  A1996 (-3.8A)
None
 0.89A 4v01A-3b2tA:
26.7		 4v01A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 ALA A 515
MET A 537
MET A 538
ILE A 541
VAL A 564
ALA A 567
LEU A 617
ALA A 643
 M33  A1996 (-3.3A)
None
None
None
None
M33  A1996 (-3.8A)
None
None
 0.72A 4v01A-3b2tA:
26.7		 4v01A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 ALA A 515
MET A 538
ILE A 541
VAL A 564
ALA A 567
LEU A 617
HIS A 624
ALA A 643
 M33  A1996 (-3.3A)
None
None
None
M33  A1996 (-3.8A)
None
None
None
 0.65A 4v01A-3b2tA:
26.7		 4v01A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 9 LEU A 487
VAL A 495
ILE A 548
TYR A 566
CYH A 622
ARG A 625
LEU A 633
ILE A 642
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
None
M33  A1996 ( 4.7A)
None
None
M33  A1996 (-4.5A)
None
 0.97A 4v01A-3b2tA:
26.7		 4v01A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 9 LYS A 517
ILE A 548
CYH A 622
ARG A 625
LEU A 633
ILE A 642
 M33  A1996 ( 4.5A)
None
None
None
M33  A1996 (-4.5A)
None
 1.21A 4v01A-3b2tA:
26.7		 4v01A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
GLU A 534
MET A 538
VAL A 564
LEU A 617
CYH A 622
HIS A 624
 M33  A1996 (-3.3A)
None
None
None
None
None
None
 0.92A 4v01B-3b2tA:
26.7		 4v01B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 ALA A 515
MET A 537
MET A 538
VAL A 564
ALA A 567
LEU A 617
CYH A 622
ALA A 643
 M33  A1996 (-3.3A)
None
None
None
M33  A1996 (-3.8A)
None
None
None
 0.76A 4v01B-3b2tA:
26.7		 4v01B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 ALA A 515
MET A 538
VAL A 564
ALA A 567
LEU A 617
CYH A 622
HIS A 624
ALA A 643
 M33  A1996 (-3.3A)
None
None
M33  A1996 (-3.8A)
None
None
None
None
 0.56A 4v01B-3b2tA:
26.7		 4v01B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 9 LEU A 487
VAL A 495
ILE A 541
ILE A 548
TYR A 566
LEU A 633
ILE A 642
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-4.5A)
None
 0.56A 4v01B-3b2tA:
26.7		 4v01B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 9 LEU A 487
VAL A 495
LYS A 517
ILE A 548
TYR A 566
LEU A 633
ILE A 642
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.7A)
M33  A1996 (-4.5A)
None
 0.70A 4v01B-3b2tA:
26.7		 4v01B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 9 VAL A 495
ILE A 541
ILE A 548
TYR A 566
ARG A 625
LEU A 633
ILE A 642
 M33  A1996 ( 4.7A)
None
None
M33  A1996 ( 4.7A)
None
M33  A1996 (-4.5A)
None
 0.88A 4v01B-3b2tA:
26.7		 4v01B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 9 VAL A 495
LYS A 517
ILE A 548
TYR A 566
ARG A 625
LEU A 633
ILE A 642
 M33  A1996 ( 4.7A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.7A)
None
M33  A1996 (-4.5A)
None
 0.93A 4v01B-3b2tA:
26.7		 4v01B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 537
VAL A 564
ALA A 567
LEU A 617
CYH A 622
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
M33  A1996 (-3.8A)
None
None
 0.91A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 495
ALA A 515
GLU A 534
VAL A 564
ALA A 567
HIS A 624
GLY A 646
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-3.8A)
None
None
 1.43A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
GLU A 534
VAL A 564
ALA A 567
LEU A 617
CYH A 622
HIS A 624
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-3.8A)
None
None
None
 0.78A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
MET A 537
VAL A 564
ALA A 567
LEU A 617
CYH A 622
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-3.8A)
None
None
None
 0.77A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 495
ALA A 515
VAL A 564
ALA A 567
HIS A 624
ALA A 643
GLY A 646
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 (-3.8A)
None
None
None
 1.13A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
VAL A 564
ALA A 567
LEU A 617
CYH A 622
HIS A 624
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 (-3.8A)
None
None
None
None
 0.52A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 8 LYS A 517
MET A 538
ILE A 548
ARG A 625
LEU A 633
ILE A 642
 M33  A1996 ( 4.5A)
None
None
None
M33  A1996 (-4.5A)
None
 1.32A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 8 MET A 538
ILE A 548
TYR A 566
ARG A 625
LEU A 633
ILE A 642
 None
None
M33  A1996 ( 4.7A)
None
M33  A1996 (-4.5A)
None
 1.30A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 10 LEU A 487
VAL A 495
MET A 538
ILE A 548
TYR A 566
ARG A 625
LEU A 633
ILE A 642
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
None
None
M33  A1996 ( 4.7A)
None
M33  A1996 (-4.5A)
None
 1.09A 4v04B-3b2tA:
28.5		 4v04B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 10 VAL A 495
LYS A 517
MET A 538
ILE A 548
ARG A 625
LEU A 633
ILE A 642
 M33  A1996 ( 4.7A)
M33  A1996 ( 4.5A)
None
None
None
M33  A1996 (-4.5A)
None
 1.24A 4v04B-3b2tA:
28.5		 4v04B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
GLU A 534
MET A 537
VAL A 564
ALA A 567
LEU A 617
CYH A 622
 M33  A1996 (-3.3A)
None
None
None
M33  A1996 (-3.8A)
None
None
 1.05A 4v04B-3b2tA:
28.5		 4v04B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
GLU A 534
VAL A 564
ALA A 567
LEU A 617
CYH A 622
HIS A 624
 M33  A1996 (-3.3A)
None
None
M33  A1996 (-3.8A)
None
None
None
 0.93A 4v04B-3b2tA:
28.5		 4v04B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
MET A 537
VAL A 564
ALA A 567
LEU A 617
CYH A 622
ALA A 643
 M33  A1996 (-3.3A)
None
None
M33  A1996 (-3.8A)
None
None
None
 0.86A 4v04B-3b2tA:
28.5		 4v04B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 515
VAL A 564
ALA A 567
HIS A 624
ALA A 643
GLY A 646
 M33  A1996 (-3.3A)
None
M33  A1996 (-3.8A)
None
None
None
 1.20A 4v04B-3b2tA:
28.5		 4v04B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
VAL A 564
ALA A 567
LEU A 617
CYH A 622
HIS A 624
ALA A 643
 M33  A1996 (-3.3A)
None
M33  A1996 (-3.8A)
None
None
None
None
 0.63A 4v04B-3b2tA:
28.5		 4v04B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 11 ALA A 515
LYS A 517
GLY A 570
ASN A 631
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 ( 4.8A)
None
M33  A1996 (-4.5A)
None
 0.98A 4wa9A-3b2tA:
30.4		 4wa9A-3b2tA:
40.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 11 LEU A 487
ALA A 515
LYS A 517
GLY A 570
ASN A 631
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 ( 4.8A)
None
M33  A1996 (-4.5A)
 1.02A 4wa9A-3b2tA:
30.4		 4wa9A-3b2tA:
40.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 495
ALA A 515
LYS A 517
GLY A 570
ASN A 631
LEU A 633
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 ( 4.8A)
None
M33  A1996 (-4.5A)
None
 0.86A 4wa9B-3b2tA:
33.4		 4wa9B-3b2tA:
40.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
ALA A 515
LYS A 517
GLU A 534
MET A 538
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.95A 4wkqA-3b2tA:
33.5		 4wkqA-3b2tA:
31.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
LYS A 517
MET A 538
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.75A 4xeyA-3b2tA:
29.9		 4xeyA-3b2tA:
32.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 487
ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.64A 4xliA-3b2tA:
28.2		 4xliA-3b2tA:
42.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.67A 4xliB-3b2tA:
30.9		 4xliB-3b2tA:
42.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
ALA A 515
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.55A 4xliB-3b2tA:
30.9		 4xliB-3b2tA:
42.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 10 LEU A 487
VAL A 495
ALA A 515
LYS A 517
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.53A 5aacA-3b2tA:
4.9		 5aacA-3b2tA:
36.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
ALA A 515
LYS A 517
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.79A 5ajqA-3b2tA:
18.6		 5ajqA-3b2tA:
29.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
GLY A 488
ALA A 515
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.77A 5ajqA-3b2tA:
18.6		 5ajqA-3b2tA:
29.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 487
VAL A 495
ALA A 515
LYS A 517
GLU A 534
MET A 538
ILE A 548
TYR A 566
GLY A 570
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
 0.87A 5bvwA-3b2tA:
30.6		 5bvwA-3b2tA:
34.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		10 / 12 LEU A 487
VAL A 495
ALA A 515
LYS A 517
MET A 538
ILE A 548
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.71A 5bvwA-3b2tA:
30.6		 5bvwA-3b2tA:
34.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 495
ALA A 515
ILE A 548
ALA A 567
PHE A 645
GLY A 646
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 (-3.8A)
None
None
 1.05A 5hesA-3b2tA:
25.4		 5hesA-3b2tA:
30.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 495
ALA A 515
ILE A 548
TYR A 566
ALA A 567
PHE A 645
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
None
 0.84A 5hesA-3b2tA:
25.4		 5hesA-3b2tA:
30.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
LYS A 517
GLU A 534
ILE A 548
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.75A 5i9xA-3b2tA:
32.2		 5i9xA-3b2tA:
35.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.58A 5i9yA-3b2tA:
27.4		 5i9yA-3b2tA:
35.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 11 LEU A 487
GLY A 488
VAL A 495
ALA A 515
TYR A 566
ALA A 567
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
 0.61A 5lvnA-3b2tA:
22.5		 5lvnA-3b2tA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 GLY A 488
VAL A 495
ALA A 515
LYS A 517
GLU A 534
TYR A 566
GLY A 570
 M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
 0.79A 5mafA-3b2tA:
26.3		 5mafA-3b2tA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 515
MET A 538
HIS A 624
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
None
None
M33  A1996 (-4.5A)
None
 0.59A 5mo4A-3b2tA:
26.0		 5mo4A-3b2tA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 12 MET A 538
ILE A 541
HIS A 624
LEU A 633
ALA A 643
 None
None
None
M33  A1996 (-4.5A)
None
 0.76A 5mo4A-3b2tA:
26.0		 5mo4A-3b2tA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A 487
GLY A 488
VAL A 495
ALA A 515
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
 0.52A 5xv7A-3b2tA:
15.5		 5xv7A-3b2tA:
13.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 487
GLY A 488
VAL A 495
ALA A 515
GLU A 534
MET A 538
VAL A 564
TYR A 566
ALA A 567
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
 1.02A 5zv2A-3b2tA:
28.6		 5zv2A-3b2tA:
75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 487
GLY A 488
VAL A 495
ALA A 515
MET A 538
VAL A 564
TYR A 566
ALA A 567
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
None
 0.93A 5zv2A-3b2tA:
28.6		 5zv2A-3b2tA:
75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
VAL A 564
TYR A 566
ALA A 567
GLY A 570
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 ( 4.8A)
None
 0.46A 5zv2A-3b2tA:
28.6		 5zv2A-3b2tA:
75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
GLY A 488
VAL A 495
ALA A 515
GLU A 534
MET A 538
VAL A 564
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
 1.07A 5zv2B-3b2tA:
29.0		 5zv2B-3b2tA:
75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
GLY A 488
VAL A 495
ALA A 515
MET A 538
VAL A 564
ALA A 567
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-3.8A)
None
 0.94A 5zv2B-3b2tA:
29.0		 5zv2B-3b2tA:
75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
LYS A 517
GLU A 534
MET A 538
VAL A 564
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
None
 0.80A 5zv2B-3b2tA:
29.0		 5zv2B-3b2tA:
75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 487
VAL A 495
ALA A 515
LYS A 517
MET A 538
VAL A 564
ALA A 567
GLY A 570
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 (-3.8A)
M33  A1996 ( 4.8A)
None
 0.67A 5zv2B-3b2tA:
29.0		 5zv2B-3b2tA:
75.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
LYS A 517
MET A 538
ILE A 548
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.80A 6bsdA-3b2tA:
25.1		 6bsdA-3b2tA:
12.86