SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'M2C'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 5 GLU A 202
THR A 166
HIS A 180
HIS A  76
 CO  A1001 ( 2.5A)
None
None
M2C  A3001 ( 4.5A)
 1.50A 1d4fD-1qxyA:
undetectable		 1d4fD-1qxyA:
20.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 7 CYH A  67
HIS A  76
HIS A 175
TRP A 219
 M2C  A3001 ( 4.0A)
M2C  A3001 ( 4.5A)
CO  A1003 ( 3.3A)
None
 0.49A 1yvmA-1qxyA:
35.8		 1yvmA-1qxyA:
34.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		3 / 3 SER A  95
ASP A  93
ASP A  59
 M2C  A3001 ( 3.8A)
CO  A1002 ( 1.8A)
None
 0.86A 3iv6C-1qxyA:
undetectable		 3iv6C-1qxyA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 ILE A 251
ALA A  55
ALA A  96
VAL A  94
LEU A 174
 None
M2C  A3001 ( 4.8A)
None
None
M2C  A3001 (-4.5A)
 1.02A 5igtA-1qxyA:
undetectable		 5igtA-1qxyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 7 GLY A 167
HIS A 168
ASP A 104
HIS A  76
 None
CO  A1001 (-3.3A)
CO  A1002 (-2.4A)
M2C  A3001 ( 4.5A)
 0.86A 5nnwD-1qxyA:
0.0		 5nnwD-1qxyA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 7 GLY A 167
HIS A 168
ASP A 104
HIS A  76
 None
CO  A1001 (-3.3A)
CO  A1002 (-2.4A)
M2C  A3001 ( 4.5A)
 0.86A 5no9D-1qxyA:
0.0		 5no9D-1qxyA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1qxy METHIONYL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 8 SER A  69
PHE A  62
PHE A 204
VAL A 212
 None
None
M2C  A3001 (-4.7A)
None
 1.10A 5vkqB-1qxyA:
undetectable
5vkqC-1qxyA:
undetectable		 5vkqB-1qxyA:
10.05
5vkqC-1qxyA:
10.05