SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'M2A'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 182
ARG A 176
ILE A 196
THR A 145
 None
None
None
M2A  A 501 (-3.5A)
 1.34A 3cl9A-5elxA:
1.7		 3cl9A-5elxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 395
GLU A 184
SER A 400
 M2A  A 501 (-2.7A)
M2A  A 501 (-3.6A)
None
 0.84A 3p2kA-5elxA:
3.1		 3p2kA-5elxA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 7 SER A 438
ARG A 429
GLY A 428
THR A 142
 None
BEF  A 503 ( 2.6A)
None
M2A  A 501 (-4.5A)
 0.97A 5btaA-5elxA:
undetectable
5btaC-5elxA:
undetectable
5btaD-5elxA:
2.0		 5btaA-5elxA:
22.65
5btaC-5elxA:
22.65
5btaD-5elxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 6 SER A 438
ARG A 429
GLY A 428
THR A 142
 None
BEF  A 503 ( 2.6A)
None
M2A  A 501 (-4.5A)
 0.97A 5btaA-5elxA:
undetectable
5btaB-5elxA:
2.5
5btaC-5elxA:
undetectable		 5btaA-5elxA:
22.65
5btaB-5elxA:
20.96
5btaC-5elxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 6 SER A 438
ARG A 429
GLY A 428
THR A 142
 None
BEF  A 503 ( 2.6A)
None
M2A  A 501 (-4.5A)
 1.00A 5btcA-5elxA:
undetectable
5btcC-5elxA:
undetectable
5btcD-5elxA:
2.0		 5btcA-5elxA:
22.65
5btcC-5elxA:
22.65
5btcD-5elxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5elx ATP-DEPENDENT RNA
HELICASE DBP5
(Saccharomyces
cerevisiae) 		4 / 6 SER A 438
ARG A 429
GLY A 428
THR A 142
 None
BEF  A 503 ( 2.6A)
None
M2A  A 501 (-4.5A)
 1.01A 5btcA-5elxA:
undetectable
5btcB-5elxA:
2.5
5btcC-5elxA:
undetectable		 5btcA-5elxA:
22.65
5btcB-5elxA:
20.96
5btcC-5elxA:
22.65