SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LZ6'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
5 / 12 PHE A  10
ARG A  13
PRO A 110
VAL A 111
ALA A 216
None
None
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
0.97A 1gseA-4hj2A:
35.9
1gseA-4hj2A:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
8 / 12 TYR A   9
ARG A  13
GLY A  14
LEU A 107
LEU A 108
PRO A 110
VAL A 111
ALA A 216
LZ6  A 301 (-4.6A)
None
LZ6  A 301 ( 3.9A)
LZ6  A 301 (-4.4A)
None
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
0.57A 1gseA-4hj2A:
35.9
1gseA-4hj2A:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
5 / 12 TYR A   9
ARG A  13
GLY A  14
MET A 208
ALA A 216
LZ6  A 301 (-4.6A)
None
LZ6  A 301 ( 3.9A)
LZ6  A 301 (-4.0A)
LZ6  A 301 ( 4.6A)
0.83A 1gseA-4hj2A:
35.9
1gseA-4hj2A:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
9 / 12 TYR A   9
ARG A  13
GLY A  14
LEU A 107
LEU A 108
PRO A 110
VAL A 111
LEU A 213
ALA A 216
LZ6  A 301 (-4.6A)
None
LZ6  A 301 ( 3.9A)
LZ6  A 301 (-4.4A)
None
LZ6  A 301 (-3.5A)
None
None
LZ6  A 301 ( 4.6A)
0.56A 1gseB-4hj2A:
36.0
1gseB-4hj2A:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
6 / 12 TYR A   9
ARG A  13
GLY A  14
MET A 208
LEU A 213
ALA A 216
LZ6  A 301 (-4.6A)
None
LZ6  A 301 ( 3.9A)
LZ6  A 301 (-4.0A)
None
LZ6  A 301 ( 4.6A)
1.00A 1gseB-4hj2A:
36.0
1gseB-4hj2A:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
6 / 8 TYR A   9
GLY A  14
ARG A  15
LEU A 107
MET A 208
PHE A 220
LZ6  A 301 (-4.6A)
LZ6  A 301 ( 3.9A)
None
LZ6  A 301 (-4.4A)
LZ6  A 301 (-4.0A)
LZ6  A 301 (-3.7A)
0.44A 1gsfA-4hj2A:
36.3
1gsfA-4hj2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
6 / 8 TYR A   9
GLY A  14
ARG A  15
LEU A 107
VAL A 111
MET A 208
LZ6  A 301 (-4.6A)
LZ6  A 301 ( 3.9A)
None
LZ6  A 301 (-4.4A)
None
LZ6  A 301 (-4.0A)
0.55A 1gsfA-4hj2A:
36.3
1gsfA-4hj2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
6 / 8 TYR A   9
GLY A  14
ARG A  15
LEU A 107
MET A 208
PHE A 220
LZ6  A 301 (-4.6A)
LZ6  A 301 ( 3.9A)
None
LZ6  A 301 (-4.4A)
LZ6  A 301 (-4.0A)
LZ6  A 301 (-3.7A)
0.44A 1gsfB-4hj2A:
36.3
1gsfB-4hj2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
6 / 8 TYR A   9
GLY A  14
ARG A  15
LEU A 107
VAL A 111
MET A 208
LZ6  A 301 (-4.6A)
LZ6  A 301 ( 3.9A)
None
LZ6  A 301 (-4.4A)
None
LZ6  A 301 (-4.0A)
0.55A 1gsfB-4hj2A:
36.3
1gsfB-4hj2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
7 / 8 TYR A   9
GLY A  14
ARG A  15
LEU A 107
VAL A 111
MET A 208
PHE A 220
LZ6  A 301 (-4.6A)
LZ6  A 301 ( 3.9A)
None
LZ6  A 301 (-4.4A)
None
LZ6  A 301 (-4.0A)
LZ6  A 301 (-3.7A)
0.65A 1gsfC-4hj2A:
36.3
1gsfC-4hj2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
6 / 8 TYR A   9
GLY A  14
ARG A  15
LEU A 107
MET A 208
PHE A 220
LZ6  A 301 (-4.6A)
LZ6  A 301 ( 3.9A)
None
LZ6  A 301 (-4.4A)
LZ6  A 301 (-4.0A)
LZ6  A 301 (-3.7A)
0.45A 1gsfD-4hj2A:
36.3
1gsfD-4hj2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
6 / 8 TYR A   9
GLY A  14
ARG A  15
LEU A 107
VAL A 111
MET A 208
LZ6  A 301 (-4.6A)
LZ6  A 301 ( 3.9A)
None
LZ6  A 301 (-4.4A)
None
LZ6  A 301 (-4.0A)
0.55A 1gsfD-4hj2A:
36.3
1gsfD-4hj2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
5 / 12 THR A  68
TYR A   9
LEU A 108
VAL A 111
ALA A  12
LZ6  A 301 (-3.5A)
LZ6  A 301 (-4.6A)
None
None
None
1.19A 1q23A-4hj2A:
undetectable
1q23B-4hj2A:
undetectable
1q23A-4hj2A:
17.96
1q23B-4hj2A:
17.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
5 / 8 TYR A   9
GLY A  14
ARG A  15
LEU A 107
LEU A 108
LZ6  A 301 (-4.6A)
LZ6  A 301 ( 3.9A)
None
LZ6  A 301 (-4.4A)
None
0.43A 2vctA-4hj2A:
36.0
2vctA-4hj2A:
94.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
5 / 8 TYR A   9
GLY A  14
ARG A  15
LEU A 107
LEU A 108
LZ6  A 301 (-4.6A)
LZ6  A 301 ( 3.9A)
None
LZ6  A 301 (-4.4A)
None
0.44A 2vctB-4hj2A:
35.8
2vctB-4hj2A:
94.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
5 / 8 TYR A   9
GLY A  14
ARG A  15
LEU A 107
LEU A 108
LZ6  A 301 (-4.6A)
LZ6  A 301 ( 3.9A)
None
LZ6  A 301 (-4.4A)
None
0.40A 2vctC-4hj2A:
36.0
2vctC-4hj2A:
94.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
4 / 7 TYR A   9
GLY A  14
ARG A  15
LEU A 108
LZ6  A 301 (-4.6A)
LZ6  A 301 ( 3.9A)
None
None
0.42A 2vctD-4hj2A:
35.7
2vctD-4hj2A:
94.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
4 / 7 TYR A   9
PHE A  10
PRO A 110
ALA A 216
LZ6  A 301 (-4.6A)
None
LZ6  A 301 (-3.5A)
LZ6  A 301 ( 4.6A)
0.67A 2vcvA-4hj2A:
36.4
2vcvA-4hj2A:
90.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
4 / 7 TYR A   9
PRO A 110
LEU A 213
ALA A 216
LZ6  A 301 (-4.6A)
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
0.70A 2vcvA-4hj2A:
36.4
2vcvA-4hj2A:
90.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
5 / 6 PHE A  10
LEU A 107
PRO A 110
LEU A 213
ALA A 216
None
LZ6  A 301 (-4.4A)
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
0.80A 2vcvB-4hj2A:
36.4
2vcvB-4hj2A:
90.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
6 / 9 TYR A   9
PHE A  10
LEU A 107
PRO A 110
LEU A 213
ALA A 216
LZ6  A 301 (-4.6A)
None
LZ6  A 301 (-4.4A)
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
0.79A 2vcvD-4hj2A:
36.5
2vcvD-4hj2A:
90.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
6 / 9 TYR A   9
PHE A  10
LEU A 107
PRO A 110
LEU A 213
ALA A 216
LZ6  A 301 (-4.6A)
None
LZ6  A 301 (-4.4A)
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
0.84A 2vcvE-4hj2A:
36.4
2vcvE-4hj2A:
90.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
4 / 7 LEU A 108
PRO A 110
LEU A 213
ALA A 216
None
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
0.84A 2vcvG-4hj2A:
36.5
2vcvG-4hj2A:
90.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
5 / 7 PHE A  10
LEU A 107
PRO A 110
LEU A 213
ALA A 216
None
LZ6  A 301 (-4.4A)
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
0.74A 2vcvG-4hj2A:
36.5
2vcvG-4hj2A:
90.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
6 / 9 TYR A   9
PHE A  10
LEU A 107
PRO A 110
LEU A 213
ALA A 216
LZ6  A 301 (-4.6A)
None
LZ6  A 301 (-4.4A)
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
0.83A 2vcvH-4hj2A:
36.4
2vcvH-4hj2A:
90.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
6 / 9 TYR A   9
PHE A  10
LEU A 107
PRO A 110
LEU A 213
ALA A 216
LZ6  A 301 (-4.6A)
None
LZ6  A 301 (-4.4A)
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
0.67A 2vcvI-4hj2A:
36.5
2vcvI-4hj2A:
90.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo
sapiens)
6 / 8 PHE A  10
LEU A 107
LEU A 108
PRO A 110
LEU A 213
ALA A 216
None
LZ6  A 301 (-4.4A)
None
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
0.68A 2vcvP-4hj2A:
36.3
2vcvP-4hj2A:
90.78