SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LYR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 5jsi BACTERIORHODOPSIN
(Candidatus
Actinomarina
minuta) 		5 / 12 THR A 193
TYR A 192
ILE A 109
TYR A 113
TYR A  64
 None
None
LYR  A 200 ( 4.8A)
OLC  A 322 ( 3.7A)
None
 1.20A 1jtxA-5jsiA:
2.0		 1jtxA-5jsiA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 5jsi BACTERIORHODOPSIN
(Candidatus
Actinomarina
minuta) 		4 / 5 TYR A  70
ILE A 109
ARG A 188
GLY A 175
 None
LYR  A 200 ( 4.8A)
IOD  A 316 (-3.6A)
None
 1.33A 1kifA-5jsiA:
undetectable		 1kifA-5jsiA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 5jsi BACTERIORHODOPSIN
(Candidatus
Actinomarina
minuta) 		4 / 5 TYR A  70
ILE A 109
ARG A 188
GLY A 175
 None
LYR  A 200 ( 4.8A)
IOD  A 316 (-3.6A)
None
 1.33A 1kifB-5jsiA:
undetectable		 1kifB-5jsiA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 5jsi BACTERIORHODOPSIN
(Candidatus
Actinomarina
minuta) 		4 / 5 TYR A  70
ILE A 109
ARG A 188
GLY A 175
 None
LYR  A 200 ( 4.8A)
IOD  A 316 (-3.6A)
None
 1.34A 1kifC-5jsiA:
undetectable		 1kifC-5jsiA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 5jsi BACTERIORHODOPSIN
(Candidatus
Actinomarina
minuta) 		4 / 5 TYR A  70
ILE A 109
ARG A 188
GLY A 175
 None
LYR  A 200 ( 4.8A)
IOD  A 316 (-3.6A)
None
 1.34A 1kifD-5jsiA:
undetectable		 1kifD-5jsiA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 5jsi BACTERIORHODOPSIN
(Candidatus
Actinomarina
minuta) 		4 / 5 TYR A  70
ILE A 109
ARG A 188
GLY A 175
 None
LYR  A 200 ( 4.8A)
IOD  A 316 (-3.6A)
None
 1.34A 1kifE-5jsiA:
undetectable		 1kifE-5jsiA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 5jsi BACTERIORHODOPSIN
(Candidatus
Actinomarina
minuta) 		4 / 5 TYR A  70
ILE A 109
ARG A 188
GLY A 175
 None
LYR  A 200 ( 4.8A)
IOD  A 316 (-3.6A)
None
 1.33A 1kifF-5jsiA:
undetectable		 1kifF-5jsiA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 5jsi BACTERIORHODOPSIN
(Candidatus
Actinomarina
minuta) 		4 / 5 TYR A  70
ILE A 109
ARG A 188
GLY A 175
 None
LYR  A 200 ( 4.8A)
IOD  A 316 (-3.6A)
None
 1.33A 1kifG-5jsiA:
undetectable		 1kifG-5jsiA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 5jsi BACTERIORHODOPSIN
(Candidatus
Actinomarina
minuta) 		4 / 5 TYR A  70
ILE A 109
ARG A 188
GLY A 175
 None
LYR  A 200 ( 4.8A)
IOD  A 316 (-3.6A)
None
 1.33A 1kifH-5jsiA:
undetectable		 1kifH-5jsiA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 5jsi BACTERIORHODOPSIN
(Candidatus
Actinomarina
minuta) 		4 / 5 TYR A  70
ILE A 109
ARG A 188
GLY A 175
 None
LYR  A 200 ( 4.8A)
IOD  A 316 (-3.6A)
None
 1.27A 1ve9A-5jsiA:
undetectable		 1ve9A-5jsiA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4xtl SODIUM PUMPING
RHODOPSIN
(Dokdonia
eikasta) 		4 / 4 LEU A 121
LEU A  63
SER A  64
LEU A 262
 None
None
LYR  A 255 ( 4.9A)
None
 1.08A 1ya3A-4xtlA:
undetectable		 1ya3A-4xtlA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 5jsi BACTERIORHODOPSIN
(Candidatus
Actinomarina
minuta) 		4 / 5 TYR A  70
ILE A 109
ARG A 188
GLY A 175
 None
LYR  A 200 ( 4.8A)
IOD  A 316 (-3.6A)
None
 1.21A 2du8G-5jsiA:
undetectable		 2du8G-5jsiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 5jsi BACTERIORHODOPSIN
(Candidatus
Actinomarina
minuta) 		4 / 5 TYR A 192
ILE A 109
ARG A 188
GLY A 175
 None
LYR  A 200 ( 4.8A)
IOD  A 316 (-3.6A)
None
 1.31A 2du8G-5jsiA:
undetectable		 2du8G-5jsiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 5jsi BACTERIORHODOPSIN
(Candidatus
Actinomarina
minuta) 		4 / 5 TYR A  70
ILE A 109
ARG A 188
GLY A 175
 None
LYR  A 200 ( 4.8A)
IOD  A 316 (-3.6A)
None
 1.22A 2du8J-5jsiA:
undetectable		 2du8J-5jsiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_2
(MINERALOCORTICOID
RECEPTOR)		 5jsi BACTERIORHODOPSIN
(Candidatus
Actinomarina
minuta) 		4 / 4 LEU A  79
TRP A 169
LEU A 203
MET A  16
 LFA  A 306 ( 4.9A)
LYR  A 200 ( 3.6A)
None
LYR  A 200 ( 4.0A)
 0.99A 2oaxE-5jsiA:
1.0		 2oaxE-5jsiA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 5jsi BACTERIORHODOPSIN
(Candidatus
Actinomarina
minuta) 		4 / 6 ASP A  72
TYR A 192
PHE A   9
TYR A  52
 LYR  A 200 ( 4.3A)
None
None
None
 1.21A 2w98A-5jsiA:
undetectable
2w98B-5jsiA:
undetectable		 2w98A-5jsiA:
22.95
2w98B-5jsiA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 6eid ARCHAEAL-TYPE OPSIN
2
(Chlamydomonas
reinhardtii) 		5 / 10 GLY A 185
ILE A 228
PHE A 237
PHE A 178
GLY A 163
 LYR  A 257 ( 4.2A)
None
OLC  A1101 (-3.4A)
OLC  A1101 ( 4.0A)
LYR  A 257 ( 3.7A)
 0.99A 3ko0R-6eidA:
undetectable
3ko0T-6eidA:
0.6		 3ko0R-6eidA:
18.81
3ko0T-6eidA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 6eid ARCHAEAL-TYPE OPSIN
2
(Chlamydomonas
reinhardtii) 		5 / 10 GLY A 185
PHE A 237
PHE A 178
GLY A 163
PHE A 230
 LYR  A 257 ( 4.2A)
OLC  A1101 (-3.4A)
OLC  A1101 ( 4.0A)
LYR  A 257 ( 3.7A)
LYR  A 257 ( 4.7A)
 1.48A 3ko0R-6eidA:
undetectable
3ko0T-6eidA:
0.6		 3ko0R-6eidA:
18.81
3ko0T-6eidA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 4xtl SODIUM PUMPING
RHODOPSIN
(Dokdonia
eikasta) 		4 / 8 GLY A 259
LEU A 261
LEU A 262
ILE A 207
 LYR  A 255 ( 3.6A)
None
None
None
 0.88A 3nbqB-4xtlA:
undetectable		 3nbqB-4xtlA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 4xtl SODIUM PUMPING
RHODOPSIN
(Dokdonia
eikasta) 		4 / 8 GLY A 259
LEU A 261
LEU A 262
ILE A 207
 LYR  A 255 ( 3.6A)
None
None
None
 0.88A 3nbqC-4xtlA:
undetectable		 3nbqC-4xtlA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 6eid ARCHAEAL-TYPE OPSIN
2
(Chlamydomonas
reinhardtii) 		4 / 5 GLY A 163
SER A 166
ALA A 167
GLU A 235
 LYR  A 257 ( 3.7A)
None
None
None
 1.07A 4m93B-6eidA:
undetectable
4m93C-6eidA:
undetectable		 4m93B-6eidA:
undetectable
4m93C-6eidA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 4xtl SODIUM PUMPING
RHODOPSIN
(Dokdonia
eikasta) 		4 / 7 ILE A 150
TRP A 113
ASP A 251
SER A 214
 None
LYR  A 255 ( 4.1A)
LYR  A 255 ( 3.8A)
None
 1.30A 5nr3A-4xtlA:
undetectable		 5nr3A-4xtlA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5azd BACTERIORHODOPSIN
(Thermus
thermophilus) 		4 / 6 PRO A 202
GLY A 199
TYR A 201
LEU A 163
 LYR  A 233 ( 4.1A)
None
LYR  A 233 ( 3.2A)
None
 0.89A 5x80A-5azdA:
1.0
5x80B-5azdA:
0.8		 5x80A-5azdA:
18.96
5x80B-5azdA:
18.96