SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LYN'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTI_D_CCSD47_0 (GLUTATHIONE S-TRANSFERASE)	4v36	LYSYL-TRNA-DEPENDENT L-YSYL-PHOSPHATIDYLG YCEROL SYNTHASE (Bacillus licheniformis)	4 / 7	THR A 842 LEU A 844 GLY A 846 LEU A 698	None None None LYN A1851 ( 4.3A)	1.04A	1gtiD-4v36A: undetectable	1gtiD-4v36A: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P6K_A_MTLA870_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	4v36	LYSYL-TRNA-DEPENDENT L-YSYL-PHOSPHATIDYLG YCEROL SYNTHASE (Bacillus licheniformis)	4 / 8	ARG A 742 GLN A 702 PHE A 701 ASN A 726	LYN A1851 (-4.3A) None None None	1.35A	1p6kA-4v36A: undetectable	1p6kA-4v36A: 23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V95_A_HCYA1375_1 (CORTICOSTEROID-BINDI NG GLOBULIN)	4v36	LYSYL-TRNA-DEPENDENT L-YSYL-PHOSPHATIDYLG YCEROL SYNTHASE (Bacillus licheniformis)	5 / 12	PRO A 729 PHE A 756 ILE A 738 ASP A 739 PHE A 771	None None None LYN A1851 (-4.0A) None	1.18A	2v95A-4v36A: undetectable	2v95A-4v36A: 23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZJO_A_ERYA1101_0 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	3a74	LYSYL-TRNA SYNTHETASE (Geobacillus stearothermophil us)	5 / 12	ASN A 414 ALA A 209 GLU A 418 GLU A 231 LEU A 232	B4P A 494 (-3.8A) None LYN A 495 (-2.9A) LYN A 495 (-3.0A) None	1.35A	4zjoA-3a74A: 1.7	4zjoA-3a74A: 18.35

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GTI_D_CCSD47_0","GLUTATHIONE S-TRANSFERASE","4v36","LYSYL-TRNA-DEPENDENT L-YSYL-PHOSPHATIDYLGYCEROL SYNTHASE","Bacillus licheniformis",4,"THR A 842;LEU A 844;GLY A 846;LEU A 698","None;None;None;LYN A1851 ( 4.3A)","1.04A","1gtiD-4v36A:undetectable",null],["1P6K_A_MTLA870_0","NITRIC-OXIDE SYNTHASE, BRAIN","4v36","LYSYL-TRNA-DEPENDENT L-YSYL-PHOSPHATIDYLGYCEROL SYNTHASE","Bacillus licheniformis",4,"ARG A 742;GLN A 702;PHE A 701;ASN A 726","LYN A1851 (-4.3A);None;None;None","1.35A","1p6kA-4v36A:undetectable","1gtiD-4v36A:20.90"],["2V95_A_HCYA1375_1","CORTICOSTEROID-BINDING GLOBULIN","4v36","LYSYL-TRNA-DEPENDENT L-YSYL-PHOSPHATIDYLGYCEROL SYNTHASE","Bacillus licheniformis",5,"PRO A 729;PHE A 756;ILE A 738;ASP A 739;PHE A 771","None;None;None;LYN A1851 (-4.0A);None","1.18A","2v95A-4v36A:undetectable","1p6kA-4v36A:23.84"],["4ZJO_A_ERYA1101_0","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","3a74","LYSYL-TRNA SYNTHETASE","Geobacillus stearothermophilus",5,"ASN A 414;ALA A 209;GLU A 418;GLU A 231;LEU A 232","B4P A 494 (-3.8A);None;LYN A 495 (-2.9A);LYN A 495 (-3.0A);None","1.35A","4zjoA-3a74A:1.7","2v95A-4v36A:23.75"]]