SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LWY'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)
3n2c PROLIDASE
(unidentified)
5 / 12 LEU A 272
TYR A 275
GLY A 302
LEU A 306
HIS A 249
None
LWY  A 427 ( 4.7A)
None
None
ZN  A 426 ( 3.8A)
1.04A 3e23A-3n2cA:
undetectable
3e23A-3n2cA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)
3n2c PROLIDASE
(unidentified)
5 / 12 VAL A 295
ILE A 202
GLY A 194
HIS A 249
HIS A 229
None
None
LWY  A 427 (-3.5A)
ZN  A 426 ( 3.8A)
ZN  A 426 ( 3.2A)
0.95A 3hgiA-3n2cA:
undetectable
3hgiA-3n2cA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)
3n2c PROLIDASE
(unidentified)
5 / 12 GLY A 317
VAL A 295
TYR A 275
ASN A 251
VAL A 298
None
None
LWY  A 427 ( 4.7A)
None
None
1.20A 4ffwA-3n2cA:
undetectable
4ffwA-3n2cA:
21.67