SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LVS'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DXY_A_SAMA1_0 (TRNA (GUANINE-N(7)-)-METH YLTRANSFERASE)	1ofi	ATP-DEPENDENT PROTEASE HSLV (Haemophilus influenzae)	5 / 11	GLY G 124 GLY G 48 ALA G 122 PHE G 162 ASP G 17	LVS G 0 (-3.5A) LVS G 0 (-3.4A) None None None	0.85A	3dxyA-1ofiG: undetectable	3dxyA-1ofiG: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H0A_A_9RAA500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	1ofi	ATP-DEPENDENT PROTEASE HSLV (Haemophilus influenzae)	5 / 12	ALA G 93 ALA G 47 LEU G 56 ALA G 53 VAL G 113	None LVS G 0 (-4.9A) None LVS G 0 ( 4.2A) None	0.98A	3h0aA-1ofiG: undetectable	3h0aA-1ofiG: 20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MG0_K_BO2K1402_1 (PROTEASOME COMPONENT PRE2 PROTEASOME COMPONENT C5)	1ofi	ATP-DEPENDENT PROTEASE HSLV (Haemophilus influenzae)	5 / 11	THR G 1 LYS G 33 ALA G 47 GLY G 48 SER G 125	LVS G 0 (-2.3A) LVS G 0 (-3.6A) LVS G 0 (-4.9A) LVS G 0 (-3.4A) LVS G 0 (-3.7A)	0.35A	3mg0K-1ofiG: 9.8 3mg0L-1ofiG: 17.2	3mg0K-1ofiG: 25.23 3mg0L-1ofiG: 24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MG0_Y_BO2Y1403_1 (PROTEASOME COMPONENT PRE2 PROTEASOME COMPONENT C5)	1ofi	ATP-DEPENDENT PROTEASE HSLV (Haemophilus influenzae)	5 / 12	THR G 1 LYS G 33 ALA G 47 GLY G 48 SER G 125	LVS G 0 (-2.3A) LVS G 0 (-3.6A) LVS G 0 (-4.9A) LVS G 0 (-3.4A) LVS G 0 (-3.7A)	0.43A	3mg0Y-1ofiG: 20.3 3mg0Z-1ofiG: 18.5	3mg0Y-1ofiG: 25.23 3mg0Z-1ofiG: 24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVV_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	1ofi	ATP-DEPENDENT PROTEASE HSLV (Haemophilus influenzae)	4 / 8	THR G 1 LYS G 33 GLY G 48 GLY G 49	LVS G 0 (-2.3A) LVS G 0 (-3.6A) LVS G 0 (-3.4A) LVS G 0 ( 4.0A)	0.46A	4qvvK-1ofiG: 20.1 4qvvL-1ofiG: 17.1	4qvvK-1ofiG: 25.23 4qvvL-1ofiG: 24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVV_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	1ofi	ATP-DEPENDENT PROTEASE HSLV (Haemophilus influenzae)	4 / 8	THR G 1 LYS G 33 GLY G 48 GLY G 49	LVS G 0 (-2.3A) LVS G 0 (-3.6A) LVS G 0 (-3.4A) LVS G 0 ( 4.0A)	0.45A	4qvvY-1ofiG: 14.2 4qvvZ-1ofiG: 18.4	4qvvY-1ofiG: 25.23 4qvvZ-1ofiG: 24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_B_SAMB301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	1ofi	ATP-DEPENDENT PROTEASE HSLV (Haemophilus influenzae)	5 / 12	ALA G 134 GLY G 127 SER G 125 THR G 1 SER G 132	None None LVS G 0 (-3.7A) LVS G 0 (-2.3A) None	1.27A	5hfjB-1ofiG: undetectable	5hfjB-1ofiG: 21.25

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3DXY_A_SAMA1_0","TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE","1ofi","ATP-DEPENDENT PROTEASE HSLV","Haemophilus influenzae",5,"GLY G 124;GLY G  48;ALA G 122;PHE G 162;ASP G  17","LVS G   0 (-3.5A);LVS G   0 (-3.4A);None;None;None","0.85A","3dxyA-1ofiG:undetectable",null],["3H0A_A_9RAA500_1","RETINOIC ACID RECEPTOR RXR-ALPHA","1ofi","ATP-DEPENDENT PROTEASE HSLV","Haemophilus influenzae",5,"ALA G  93;ALA G  47;LEU G  56;ALA G  53;VAL G 113","None;LVS G   0 (-4.9A);None;LVS G   0 ( 4.2A);None","0.98A","3h0aA-1ofiG:undetectable","3dxyA-1ofiG:19.44"],["3MG0_K_BO2K1402_1","PROTEASOME COMPONENT PRE2;PROTEASOME COMPONENT C5","1ofi","ATP-DEPENDENT PROTEASE HSLV","Haemophilus influenzae",5,"THR G   1;LYS G  33;ALA G  47;GLY G  48;SER G 125","LVS G   0 (-2.3A);LVS G   0 (-3.6A);LVS G   0 (-4.9A);LVS G   0 (-3.4A);LVS G   0 (-3.7A)","0.35A","3mg0K-1ofiG:9.8;3mg0L-1ofiG:17.2","3h0aA-1ofiG:20.85"],["3MG0_Y_BO2Y1403_1","PROTEASOME COMPONENT PRE2;PROTEASOME COMPONENT C5","1ofi","ATP-DEPENDENT PROTEASE HSLV","Haemophilus influenzae",5,"THR G   1;LYS G  33;ALA G  47;GLY G  48;SER G 125","LVS G   0 (-2.3A);LVS G   0 (-3.6A);LVS G   0 (-4.9A);LVS G   0 (-3.4A);LVS G   0 (-3.7A)","0.43A","3mg0Y-1ofiG:20.3;3mg0Z-1ofiG:18.5","3mg0K-1ofiG:25.23;3mg0L-1ofiG:24.23"],["4QVV_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","1ofi","ATP-DEPENDENT PROTEASE HSLV","Haemophilus influenzae",4,"THR G   1;LYS G  33;GLY G  48;GLY G  49","LVS G   0 (-2.3A);LVS G   0 (-3.6A);LVS G   0 (-3.4A);LVS G   0 ( 4.0A)","0.46A","4qvvK-1ofiG:20.1;4qvvL-1ofiG:17.1","3mg0Y-1ofiG:25.23;3mg0Z-1ofiG:24.23"],["4QVV_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","1ofi","ATP-DEPENDENT PROTEASE HSLV","Haemophilus influenzae",4,"THR G   1;LYS G  33;GLY G  48;GLY G  49","LVS G   0 (-2.3A);LVS G   0 (-3.6A);LVS G   0 (-3.4A);LVS G   0 ( 4.0A)","0.45A","4qvvY-1ofiG:14.2;4qvvZ-1ofiG:18.4","4qvvK-1ofiG:25.23;4qvvL-1ofiG:24.23"],["5HFJ_B_SAMB301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","1ofi","ATP-DEPENDENT PROTEASE HSLV","Haemophilus influenzae",5,"ALA G 134;GLY G 127;SER G 125;THR G   1;SER G 132","None;None;LVS G   0 (-3.7A);LVS G   0 (-2.3A);None","1.27A","5hfjB-1ofiG:undetectable","4qvvY-1ofiG:25.23;4qvvZ-1ofiG:24.23"]]