SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LU2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2O4S_A_AB1A400_2 (PROTEASE)	5ndf	POLYPEPTIDE N-ACETYLGALACTOSAMIN YLTRANSFERASE 2 (Homo sapiens)	5 / 12	GLY A 308 ALA A 307 ILE A 351 VAL A 357 ILE A 253	EDO A 604 (-3.7A) EDO A 605 ( 3.4A) EDO A 603 ( 4.4A) None LU2 A 608 ( 4.0A)	0.88A	2o4sB-5ndfA: undetectable	2o4sB-5ndfA: 10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XFF_A_QPSA600_1 (BETA-AMYLASE)	5ndf	POLYPEPTIDE N-ACETYLGALACTOSAMIN YLTRANSFERASE 2 (Homo sapiens)	5 / 12	ALA A 148 GLU A 147 PHE A 361 SER A 225 THR A 155	None None LU2 A 608 ( 3.4A) UDP A 602 (-2.9A) None	1.28A	2xffA-5ndfA: undetectable	2xffA-5ndfA: 20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CYX_A_ROCA201_1 (HIV-1 PROTEASE)	5ndf	POLYPEPTIDE N-ACETYLGALACTOSAMIN YLTRANSFERASE 2 (Homo sapiens)	5 / 12	GLY A 308 ALA A 307 VAL A 249 VAL A 357 ILE A 253	EDO A 604 (-3.7A) EDO A 605 ( 3.4A) None None LU2 A 608 ( 4.0A)	0.96A	3cyxA-5ndfA: undetectable	3cyxA-5ndfA: 10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NU3_B_478B401_1 (PROTEASE)	5ndf	POLYPEPTIDE N-ACETYLGALACTOSAMIN YLTRANSFERASE 2 (Homo sapiens)	5 / 12	GLY A 308 ALA A 307 ILE A 351 VAL A 357 ILE A 253	EDO A 604 (-3.7A) EDO A 605 ( 3.4A) EDO A 603 ( 4.4A) None LU2 A 608 ( 4.0A)	0.96A	3nu3A-5ndfA: undetectable	3nu3A-5ndfA: 10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXV_B_478B200_1 (HIV-1 PROTEASE)	5ndf	POLYPEPTIDE N-ACETYLGALACTOSAMIN YLTRANSFERASE 2 (Homo sapiens)	5 / 9	GLY A 308 ALA A 307 VAL A 249 VAL A 357 ILE A 253	EDO A 604 (-3.7A) EDO A 605 ( 3.4A) None None LU2 A 608 ( 4.0A)	0.89A	3oxvA-5ndfA: undetectable	3oxvA-5ndfA: 9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXX_C_DR7C100_1 (HIV-1 PROTEASE)	5ndf	POLYPEPTIDE N-ACETYLGALACTOSAMIN YLTRANSFERASE 2 (Homo sapiens)	5 / 12	GLY A 308 ALA A 307 ILE A 351 VAL A 357 ILE A 253	EDO A 604 (-3.7A) EDO A 605 ( 3.4A) EDO A 603 ( 4.4A) None LU2 A 608 ( 4.0A)	1.00A	3oxxC-5ndfA: undetectable	3oxxC-5ndfA: 9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXX_C_DR7C100_1 (HIV-1 PROTEASE)	5ndf	POLYPEPTIDE N-ACETYLGALACTOSAMIN YLTRANSFERASE 2 (Homo sapiens)	5 / 12	GLY A 308 ALA A 307 VAL A 249 VAL A 357 ILE A 253	EDO A 604 (-3.7A) EDO A 605 ( 3.4A) None None LU2 A 608 ( 4.0A)	1.00A	3oxxC-5ndfA: undetectable	3oxxC-5ndfA: 9.84

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2O4S_A_AB1A400_2","PROTEASE;PROTEASE","5ndf","POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2","Homo sapiens",5,"GLY A 308;ALA A 307;ILE A 351;VAL A 357;ILE A 253","EDO A 604 (-3.7A);EDO A 605 ( 3.4A);EDO A 603 ( 4.4A);None;LU2 A 608 ( 4.0A)","0.88A","2o4sB-5ndfA:undetectable",null],["2XFF_A_QPSA600_1","BETA-AMYLASE","5ndf","POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2","Homo sapiens",5,"ALA A 148;GLU A 147;PHE A 361;SER A 225;THR A 155","None;None;LU2 A 608 ( 3.4A);UDP A 602 (-2.9A);None","1.28A","2xffA-5ndfA:undetectable","2o4sB-5ndfA:10.58"],["3CYX_A_ROCA201_1","HIV-1 PROTEASE","5ndf","POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2","Homo sapiens",5,"GLY A 308;ALA A 307;VAL A 249;VAL A 357;ILE A 253","EDO A 604 (-3.7A);EDO A 605 ( 3.4A);None;None;LU2 A 608 ( 4.0A)","0.96A","3cyxA-5ndfA:undetectable","2xffA-5ndfA:20.51"],["3NU3_B_478B401_1","PROTEASE;PROTEASE","5ndf","POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2","Homo sapiens",5,"GLY A 308;ALA A 307;ILE A 351;VAL A 357;ILE A 253","EDO A 604 (-3.7A);EDO A 605 ( 3.4A);EDO A 603 ( 4.4A);None;LU2 A 608 ( 4.0A)","0.96A","3nu3A-5ndfA:undetectable","3cyxA-5ndfA:10.96"],["3OXV_B_478B200_1","HIV-1 PROTEASE;HIV-1 PROTEASE","5ndf","POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2","Homo sapiens",5,"GLY A 308;ALA A 307;VAL A 249;VAL A 357;ILE A 253","EDO A 604 (-3.7A);EDO A 605 ( 3.4A);None;None;LU2 A 608 ( 4.0A)","0.89A","3oxvA-5ndfA:undetectable","3nu3A-5ndfA:10.96"],["3OXX_C_DR7C100_1","HIV-1 PROTEASE","5ndf","POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2","Homo sapiens",5,"GLY A 308;ALA A 307;ILE A 351;VAL A 357;ILE A 253","EDO A 604 (-3.7A);EDO A 605 ( 3.4A);EDO A 603 ( 4.4A);None;LU2 A 608 ( 4.0A)","1.00A","3oxxC-5ndfA:undetectable","3oxvA-5ndfA:9.84"],["3OXX_C_DR7C100_1","HIV-1 PROTEASE","5ndf","POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2","Homo sapiens",5,"GLY A 308;ALA A 307;VAL A 249;VAL A 357;ILE A 253","EDO A 604 (-3.7A);EDO A 605 ( 3.4A);None;None;LU2 A 608 ( 4.0A)","1.00A","3oxxC-5ndfA:undetectable","3oxxC-5ndfA:9.84"]]