SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LTI'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		4 / 8 LEU A 645
VAL A 700
CYH A 698
GLY A 639
 None
None
None
LTI  A1839 (-3.4A)
 0.97A 1jlfA-4at3A:
undetectable
1jlfB-4at3A:
undetectable		 1jlfA-4at3A:
20.21
1jlfB-4at3A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 560
GLY A 561
VAL A 568
ALA A 586
TYR A 635
LEU A 699
 LTI  A1839 ( 4.2A)
LTI  A1839 ( 4.3A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-4.7A)
LTI  A1839 (-4.2A)
 0.88A 1muoA-4at3A:
8.8		 1muoA-4at3A:
27.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		5 / 9 LEU A 560
VAL A 568
ALA A 586
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.49A 1xbbA-4at3A:
30.3		 1xbbA-4at3A:
34.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 560
VAL A 568
ALA A 586
LYS A 588
VAL A 617
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.54A 2gqgB-4at3A:
31.1		 2gqgB-4at3A:
37.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		4 / 4 LEU A 560
LYS A 588
VAL A 617
MET A 636
 LTI  A1839 ( 4.2A)
None
None
None
 0.78A 2hyyD-4at3A:
28.0		 2hyyD-4at3A:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 568
ALA A 586
TYR A 635
MET A 636
GLY A 639
ASP A 710
 None
LTI  A1839 (-3.3A)
LTI  A1839 (-4.7A)
None
LTI  A1839 (-3.4A)
None
 0.67A 2wgjA-4at3A:
32.4		 2wgjA-4at3A:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 9 LEU A 560
VAL A 568
ALA A 586
MET A 636
GLY A 639
LEU A 699
GLY A 709
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
LTI  A1839 (-3.4A)
None
 0.66A 2xp2A-4at3A:
30.9		 2xp2A-4at3A:
38.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 568
ALA A 586
PHE A 633
MET A 636
GLY A 639
LEU A 699
 None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.5A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.45A 2y7jA-4at3A:
23.2		 2y7jA-4at3A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 10 VAL A 568
ALA A 586
PHE A 633
MET A 636
GLY A 639
LEU A 699
 None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.5A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.43A 2y7jB-4at3A:
18.0		 2y7jB-4at3A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 10 VAL A 568
ALA A 586
PHE A 633
MET A 636
GLY A 639
LEU A 699
 None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.5A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.46A 2y7jC-4at3A:
17.9		 2y7jC-4at3A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 10 VAL A 568
ALA A 586
PHE A 633
MET A 636
GLY A 639
LEU A 699
 None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.5A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.44A 2y7jD-4at3A:
23.7		 2y7jD-4at3A:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 10 ARG A 558
LEU A 560
ALA A 586
VAL A 617
MET A 636
GLY A 639
LEU A 699
 None
LTI  A1839 ( 4.2A)
LTI  A1839 (-3.3A)
None
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.64A 3aoxA-4at3A:
30.7		 3aoxA-4at3A:
36.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		5 / 10 LEU A 560
VAL A 568
LYS A 588
VAL A 617
ASP A 710
 LTI  A1839 ( 4.2A)
None
None
None
None
 0.79A 3cs9A-4at3A:
34.2		 3cs9A-4at3A:
37.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 586
GLY A 639
PHE A 688
HIS A 690
LEU A 699
 LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
None
None
LTI  A1839 (-4.2A)
 0.37A 3cs9A-4at3A:
34.2		 3cs9A-4at3A:
37.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		5 / 9 LEU A 560
VAL A 568
LYS A 588
VAL A 617
LEU A 699
 LTI  A1839 ( 4.2A)
None
None
None
LTI  A1839 (-4.2A)
 0.81A 3cs9B-4at3A:
32.4		 3cs9B-4at3A:
37.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		5 / 9 LEU A 560
VAL A 568
LYS A 588
VAL A 617
MET A 636
 LTI  A1839 ( 4.2A)
None
None
None
None
 0.78A 3cs9C-4at3A:
31.0		 3cs9C-4at3A:
37.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A 560
VAL A 568
LYS A 588
LEU A 699
 LTI  A1839 ( 4.2A)
None
None
LTI  A1839 (-4.2A)
 0.74A 3cs9D-4at3A:
33.5		 3cs9D-4at3A:
37.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 11 LEU A 560
VAL A 568
ALA A 586
VAL A 617
TYR A 635
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.76A 3g0eA-4at3A:
31.4		 3g0eA-4at3A:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 11 LEU A 560
VAL A 568
ALA A 586
TYR A 635
GLY A 639
ASP A 640
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
 0.70A 3g0fA-4at3A:
30.7		 3g0fA-4at3A:
32.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 10 LEU A 560
VAL A 568
ALA A 586
TYR A 635
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.64A 3g0fB-4at3A:
31.5		 3g0fB-4at3A:
32.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 560
VAL A 568
ALA A 586
VAL A 617
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.2A)
None
 0.68A 3gvuA-4at3A:
32.8		 3gvuA-4at3A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 11 ALA A 586
VAL A 617
PHE A 633
MET A 636
GLY A 639
LEU A 699
 LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.5A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.61A 3miyA-4at3A:
31.6		 3miyA-4at3A:
38.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		5 / 9 ALA A 586
PHE A 633
MET A 636
GLY A 639
LEU A 699
 LTI  A1839 (-3.3A)
LTI  A1839 (-3.5A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.53A 3miyB-4at3A:
31.7		 3miyB-4at3A:
38.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 560
VAL A 568
ALA A 586
VAL A 617
TYR A 635
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.43A 3sxrA-4at3A:
30.2		 3sxrA-4at3A:
36.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 560
VAL A 568
ALA A 586
VAL A 617
TYR A 635
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.44A 3sxrB-4at3A:
30.3		 3sxrB-4at3A:
36.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		5 / 9 ALA A 586
VAL A 617
PHE A 633
ASP A 640
LEU A 699
 LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.5A)
None
LTI  A1839 (-4.2A)
 0.58A 3ti1A-4at3A:
23.3		 3ti1A-4at3A:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		5 / 9 VAL A 617
PHE A 633
ASP A 640
LEU A 699
ASP A 710
 None
LTI  A1839 (-3.5A)
None
LTI  A1839 (-4.2A)
None
 0.86A 3ti1A-4at3A:
23.3		 3ti1A-4at3A:
27.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 560
VAL A 568
ALA A 586
LYS A 588
MET A 636
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.66A 3ug2A-4at3A:
30.7		 3ug2A-4at3A:
31.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 560
GLY A 561
VAL A 568
ALA A 586
GLY A 639
PHE A 711
 LTI  A1839 ( 4.2A)
LTI  A1839 ( 4.3A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
None
 0.66A 3wzdA-4at3A:
31.1		 3wzdA-4at3A:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A 586
MET A 636
GLY A 639
ASP A 640
LEU A 699
ASP A 710
 LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
None
 0.40A 3zbfA-4at3A:
31.6		 3zbfA-4at3A:
38.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 560
ALA A 586
GLY A 639
ASP A 640
GLY A 709
ASP A 710
 LTI  A1839 ( 4.2A)
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
None
LTI  A1839 (-3.4A)
None
 0.66A 3zbfA-4at3A:
31.6		 3zbfA-4at3A:
38.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 560
ALA A 586
GLY A 639
ASP A 640
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
None
 0.66A 3zbfA-4at3A:
31.6		 3zbfA-4at3A:
38.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		5 / 9 ILE A 616
MET A 631
TYR A 635
MET A 636
ILE A 708
 None
None
LTI  A1839 (-4.7A)
None
None
 0.65A 3zosA-4at3A:
31.8		 3zosA-4at3A:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 560
ILE A 616
MET A 631
TYR A 635
MET A 636
ILE A 708
 LTI  A1839 ( 4.2A)
None
None
LTI  A1839 (-4.7A)
None
None
 0.72A 3zosB-4at3A:
32.1		 3zosB-4at3A:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 9 LEU A 560
VAL A 568
ALA A 586
MET A 636
GLY A 639
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
None
 0.44A 4anqA-4at3A:
31.0		 4anqA-4at3A:
36.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 9 LEU A 560
VAL A 568
ALA A 586
MET A 636
GLY A 639
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
None
 0.47A 4ansA-4at3A:
31.0		 4ansA-4at3A:
36.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 568
ALA A 586
MET A 631
TYR A 635
LEU A 699
ASP A 710
 None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
LTI  A1839 (-4.2A)
None
 0.83A 4bkjA-4at3A:
31.0		 4bkjA-4at3A:
47.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		5 / 5 VAL A 568
ILE A 616
TYR A 635
MET A 636
ILE A 708
 None
None
LTI  A1839 (-4.7A)
None
None
 0.58A 4c8bA-4at3A:
26.6		 4c8bA-4at3A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		3 / 3 TYR A 635
MET A 636
ILE A 616
 LTI  A1839 (-4.7A)
None
None
 0.77A 4c8bB-4at3A:
27.2		 4c8bB-4at3A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		3 / 3 TYR A 635
MET A 636
ILE A 708
 LTI  A1839 (-4.7A)
None
None
 0.48A 4c8bB-4at3A:
27.2		 4c8bB-4at3A:
28.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 560
VAL A 568
ALA A 586
MET A 636
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.53A 4hjoA-4at3A:
10.1		 4hjoA-4at3A:
30.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 560
GLY A 563
VAL A 568
ALA A 586
GLY A 639
ASP A 640
LEU A 699
 LTI  A1839 ( 4.2A)
None
None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
 1.45A 4mkcA-4at3A:
30.9		 4mkcA-4at3A:
37.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 560
VAL A 568
ALA A 586
GLY A 639
ASP A 640
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
None
 0.57A 4mkcA-4at3A:
30.9		 4mkcA-4at3A:
37.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 560
VAL A 568
ALA A 586
LYS A 588
VAL A 617
GLY A 639
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
None
 0.76A 4mxoB-4at3A:
29.2		 4mxoB-4at3A:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 560
VAL A 568
ALA A 586
VAL A 617
TYR A 635
MET A 636
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.69A 4mxxB-4at3A:
23.8		 4mxxB-4at3A:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 560
VAL A 568
ALA A 586
LYS A 588
VAL A 617
TYR A 635
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
None
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.79A 4mxyA-4at3A:
29.6		 4mxyA-4at3A:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 560
VAL A 568
ALA A 586
VAL A 617
TYR A 635
GLY A 639
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
None
 0.75A 4mxyA-4at3A:
29.6		 4mxyA-4at3A:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 560
VAL A 568
ALA A 586
LYS A 588
VAL A 617
TYR A 635
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
None
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.68A 4mxyB-4at3A:
29.5		 4mxyB-4at3A:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 560
VAL A 568
ALA A 586
VAL A 617
TYR A 635
GLY A 639
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
None
 0.68A 4mxyB-4at3A:
29.5		 4mxyB-4at3A:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 560
VAL A 568
ALA A 586
LYS A 588
VAL A 617
TYR A 635
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
None
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.79A 4mxzA-4at3A:
29.6		 4mxzA-4at3A:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 560
VAL A 568
ALA A 586
VAL A 617
TYR A 635
GLY A 639
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
None
 0.75A 4mxzA-4at3A:
29.6		 4mxzA-4at3A:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 560
VAL A 568
ALA A 586
LYS A 588
VAL A 617
TYR A 635
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
None
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.68A 4mxzB-4at3A:
29.5		 4mxzB-4at3A:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 560
VAL A 568
ALA A 586
VAL A 617
TYR A 635
GLY A 639
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
None
 0.68A 4mxzB-4at3A:
29.5		 4mxzB-4at3A:
34.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		5 / 7 ALA A 586
ASP A 640
ASN A 697
LEU A 699
ASP A 710
 LTI  A1839 (-3.3A)
None
None
LTI  A1839 (-4.2A)
None
 0.90A 4ogrE-4at3A:
22.5		 4ogrE-4at3A:
25.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		4 / 5 LEU A 560
VAL A 617
TYR A 635
ARG A 691
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-4.7A)
None
 1.08A 4r7iA-4at3A:
33.0		 4r7iA-4at3A:
37.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		4 / 8 LEU A 705
GLY A 701
GLU A 702
ALA A 586
 None
None
None
LTI  A1839 (-3.3A)
 0.89A 4rjdA-4at3A:
undetectable
4rjdB-4at3A:
undetectable		 4rjdA-4at3A:
14.24
4rjdB-4at3A:
14.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 560
VAL A 568
ALA A 586
MET A 636
GLY A 639
ASN A 697
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
None
 0.70A 4twpA-4at3A:
32.2		 4twpA-4at3A:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 560
VAL A 568
ALA A 586
LYS A 588
GLY A 639
ASN A 697
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
None
 0.87A 4twpB-4at3A:
32.0		 4twpB-4at3A:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 560
VAL A 568
ALA A 586
MET A 636
GLY A 639
ASN A 697
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
None
 0.66A 4twpB-4at3A:
32.0		 4twpB-4at3A:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A 560
VAL A 568
ILE A 616
ILE A 708
 LTI  A1839 ( 4.2A)
None
None
None
 0.65A 4tyjA-4at3A:
30.8		 4tyjA-4at3A:
38.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A 560
VAL A 568
LYS A 588
ILE A 616
 LTI  A1839 ( 4.2A)
None
None
None
 0.61A 4tyjA-4at3A:
30.8		 4tyjA-4at3A:
38.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 10 LEU A 560
VAL A 568
ILE A 616
VAL A 617
TYR A 635
ARG A 691
ILE A 708
 LTI  A1839 ( 4.2A)
None
None
None
LTI  A1839 (-4.7A)
None
None
 1.18A 4u0iA-4at3A:
32.6		 4u0iA-4at3A:
33.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 10 LEU A 560
VAL A 568
LEU A 611
ILE A 616
VAL A 617
TYR A 635
ILE A 708
 LTI  A1839 ( 4.2A)
None
None
None
None
LTI  A1839 (-4.7A)
None
 0.88A 4u0iA-4at3A:
32.6		 4u0iA-4at3A:
33.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		9 / 11 LEU A 560
VAL A 568
ALA A 586
TYR A 635
MET A 636
GLY A 639
ASN A 697
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-4.7A)
None
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
None
 0.60A 4u5jA-4at3A:
30.2		 4u5jA-4at3A:
33.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 9 LEU A 560
VAL A 568
ALA A 586
TYR A 635
MET A 636
GLY A 639
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-4.7A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
None
 0.61A 4u5jB-4at3A:
30.0		 4u5jB-4at3A:
33.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 9 LEU A 560
VAL A 568
LYS A 588
TYR A 635
ARG A 691
LEU A 699
ILE A 708
 LTI  A1839 ( 4.2A)
None
None
LTI  A1839 (-4.7A)
None
LTI  A1839 (-4.2A)
None
 0.71A 4v01A-4at3A:
31.0		 4v01A-4at3A:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 560
VAL A 568
TYR A 635
ARG A 691
LEU A 699
ILE A 708
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-4.7A)
None
LTI  A1839 (-4.2A)
None
 0.91A 4v01B-4at3A:
30.7		 4v01B-4at3A:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 11 LEU A 560
ALA A 586
MET A 636
GLY A 639
ASN A 697
LEU A 699
 LTI  A1839 ( 4.2A)
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
 0.64A 4wa9A-4at3A:
29.2		 4wa9A-4at3A:
36.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		5 / 6 ARG A 558
LEU A 560
ALA A 586
MET A 636
LEU A 699
 None
LTI  A1839 ( 4.2A)
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.2A)
 0.77A 4wboC-4at3A:
20.6		 4wboC-4at3A:
21.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 560
ALA A 586
LYS A 588
VAL A 617
MET A 636
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
LTI  A1839 (-3.3A)
None
None
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.66A 4xliA-4at3A:
31.0		 4xliA-4at3A:
36.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 560
ALA A 586
VAL A 617
TYR A 635
MET A 636
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.62A 4xliA-4at3A:
31.0		 4xliA-4at3A:
36.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 586
LEU A 608
GLY A 709
ASP A 710
PHE A 711
 LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
None
None
 0.84A 4xv2B-4at3A:
27.9		 4xv2B-4at3A:
29.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 9 LEU A 560
VAL A 568
ALA A 586
MET A 636
GLY A 639
LEU A 699
GLY A 709
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
LTI  A1839 (-3.4A)
None
 0.67A 5aaaA-4at3A:
31.2		 5aaaA-4at3A:
38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 10 LEU A 560
VAL A 568
ALA A 586
LYS A 588
LEU A 699
GLY A 709
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.2A)
LTI  A1839 (-3.4A)
None
 0.83A 5aabA-4at3A:
31.2		 5aabA-4at3A:
38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 10 LEU A 560
VAL A 568
ALA A 586
MET A 636
GLY A 639
LEU A 699
GLY A 709
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
LTI  A1839 (-3.4A)
None
 0.69A 5aabA-4at3A:
31.2		 5aabA-4at3A:
38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		8 / 10 LEU A 560
VAL A 568
ALA A 586
MET A 636
GLY A 639
LEU A 699
GLY A 709
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
LTI  A1839 (-3.4A)
None
 0.65A 5aacA-4at3A:
31.1		 5aacA-4at3A:
38.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 560
GLY A 561
ALA A 586
GLY A 639
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
LTI  A1839 ( 4.3A)
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
None
 0.81A 5ajqA-4at3A:
25.1		 5ajqA-4at3A:
26.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 560
VAL A 568
ALA A 586
GLY A 639
LEU A 699
GLY A 709
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
LTI  A1839 (-3.4A)
 0.67A 5h2uA-4at3A:
30.5		 5h2uA-4at3A:
36.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 560
VAL A 568
ALA A 586
GLY A 639
LEU A 699
GLY A 709
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
LTI  A1839 (-3.4A)
 0.66A 5h2uB-4at3A:
30.8		 5h2uB-4at3A:
36.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 ARG A 558
LEU A 560
ALA A 586
GLY A 639
LEU A 699
GLY A 709
 None
LTI  A1839 ( 4.2A)
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
LTI  A1839 (-3.4A)
 0.68A 5h2uC-4at3A:
30.7		 5h2uC-4at3A:
36.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 560
VAL A 568
ALA A 586
GLY A 639
LEU A 699
GLY A 709
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
LTI  A1839 (-3.4A)
 0.59A 5h2uD-4at3A:
30.7		 5h2uD-4at3A:
36.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 12 GLY A 561
VAL A 568
ALA A 586
VAL A 617
PHE A 633
ASP A 640
LEU A 699
 LTI  A1839 ( 4.3A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.5A)
None
LTI  A1839 (-4.2A)
 1.20A 5l2iA-4at3A:
6.7		 5l2iA-4at3A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 568
ALA A 586
VAL A 617
PHE A 633
ASP A 640
LEU A 699
 None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.5A)
None
LTI  A1839 (-4.2A)
 0.86A 5l2tA-4at3A:
6.8		 5l2tA-4at3A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		5 / 10 LEU A 560
VAL A 568
LYS A 588
MET A 636
GLY A 639
 LTI  A1839 ( 4.2A)
None
None
None
LTI  A1839 (-3.4A)
 0.52A 5mo4A-4at3A:
26.6		 5mo4A-4at3A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 10 LEU A 560
VAL A 568
ALA A 586
VAL A 617
TYR A 635
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
LTI  A1839 (-4.2A)
 0.75A 5n3hA-4at3A:
21.6		 5n3hA-4at3A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 560
ALA A 586
LYS A 588
VAL A 617
GLY A 639
GLY A 709
 LTI  A1839 ( 4.2A)
LTI  A1839 (-3.3A)
None
None
LTI  A1839 (-3.4A)
LTI  A1839 (-3.4A)
 1.18A 5vcvA-4at3A:
22.0		 5vcvA-4at3A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 560
GLY A 561
PHE A 565
VAL A 568
ALA A 586
GLY A 639
 LTI  A1839 ( 4.2A)
LTI  A1839 ( 4.3A)
LTI  A1839 (-3.5A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
 0.60A 5zv2A-4at3A:
32.0		 5zv2A-4at3A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 560
GLY A 561
VAL A 568
ALA A 586
TYR A 635
GLY A 639
 LTI  A1839 ( 4.2A)
LTI  A1839 ( 4.3A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
 0.60A 5zv2A-4at3A:
32.0		 5zv2A-4at3A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		3 / 3 LYS A 588
LEU A 699
ASP A 710
 None
LTI  A1839 (-4.2A)
None
 0.85A 5zv2A-4at3A:
32.0		 5zv2A-4at3A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 560
GLY A 561
PHE A 565
VAL A 568
ALA A 586
LYS A 588
GLY A 639
 LTI  A1839 ( 4.2A)
LTI  A1839 ( 4.3A)
LTI  A1839 (-3.5A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
 0.69A 5zv2B-4at3A:
32.1		 5zv2B-4at3A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 568
ALA A 586
LYS A 588
TYR A 635
MET A 636
GLY A 639
LEU A 699
 None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.62A 6bsdA-4at3A:
31.7		 6bsdA-4at3A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 560
VAL A 568
ALA A 586
LYS A 588
VAL A 617
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
None
LTI  A1839 (-4.2A)
None
 0.75A 6hd6B-4at3A:
32.4		 6hd6B-4at3A:
14.19