SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LSS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		3 / 3 TRP A  77
HIS A  50
MET A 106
 None
LSS  A1818 (-4.0A)
None
 1.22A 1l5qB-5ah5A:
undetectable		 1l5qB-5ah5A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 7 TYR A 117
ASN A  53
HIS A 533
GLY A 526
 None
LSS  A1818 (-3.4A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.5A)
 1.38A 1mxgA-5ah5A:
undetectable		 1mxgA-5ah5A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 12 GLY A  49
HIS A  50
ASN A  53
SER A 493
VAL A 565
 LSS  A1818 (-3.3A)
LSS  A1818 (-4.0A)
LSS  A1818 (-3.4A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 0.67A 1qu3A-5ah5A:
29.7		 1qu3A-5ah5A:
25.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		8 / 8 MET A  43
TYR A  46
ASP A  84
SER A 324
TYR A 327
TYR A 361
HIS A 367
HIS A 371
 LSS  A1638 (-3.9A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 ( 3.9A)
LSS  A1638 (-4.8A)
None
LSS  A1638 (-3.8A)
LSS  A1638 (-3.7A)
 0.41A 2bteA-3ziuA:
44.0		 2bteA-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		4 / 8 TYR A 327
TYR A  46
HIS A 371
HIS A 367
 LSS  A1638 (-4.8A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 0.89A 2bteA-3ziuA:
44.0		 2bteA-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		4 / 8 TYR A 361
TYR A  46
HIS A 371
HIS A 367
 None
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 1.21A 2bteA-3ziuA:
44.0		 2bteA-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		8 / 8 MET A  38
TYR A  41
ASP A  78
SER A 493
TYR A 496
TYR A 523
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.34A 2bteA-5ah5A:
46.5		 2bteA-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 8 TYR A 496
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 0.83A 2bteA-5ah5A:
46.5		 2bteA-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		8 / 8 MET A  43
TYR A  46
ASP A  84
SER A 324
TYR A 327
TYR A 361
HIS A 367
HIS A 371
 LSS  A1638 (-3.9A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 ( 3.9A)
LSS  A1638 (-4.8A)
None
LSS  A1638 (-3.8A)
LSS  A1638 (-3.7A)
 0.46A 2bteD-3ziuA:
37.4		 2bteD-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		4 / 8 TYR A 327
TYR A  46
HIS A 371
HIS A 367
 LSS  A1638 (-4.8A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 0.92A 2bteD-3ziuA:
37.4		 2bteD-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		4 / 8 TYR A 361
TYR A  46
HIS A 371
HIS A 367
 None
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 1.33A 2bteD-3ziuA:
37.4		 2bteD-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		8 / 8 MET A  38
TYR A  41
ASP A  78
SER A 493
TYR A 496
TYR A 523
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.33A 2bteD-5ah5A:
39.7		 2bteD-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 8 TYR A 496
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 0.87A 2bteD-5ah5A:
39.7		 2bteD-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		7 / 7 MET A  43
TYR A  46
ASP A  84
TYR A 327
TYR A 361
HIS A 367
HIS A 371
 LSS  A1638 (-3.9A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-4.8A)
None
LSS  A1638 (-3.8A)
LSS  A1638 (-3.7A)
 0.46A 2bytA-3ziuA:
43.7		 2bytA-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		4 / 7 TYR A 327
TYR A  46
HIS A 371
HIS A 367
 LSS  A1638 (-4.8A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 0.87A 2bytA-3ziuA:
43.7		 2bytA-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		4 / 7 TYR A 361
TYR A  46
HIS A 371
HIS A 367
 None
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 1.30A 2bytA-3ziuA:
43.7		 2bytA-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		7 / 7 MET A  38
TYR A  41
ASP A  78
TYR A 496
TYR A 523
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.31A 2bytA-5ah5A:
46.2		 2bytA-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 7 TYR A 496
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 0.81A 2bytA-5ah5A:
46.2		 2bytA-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 7 TYR A 523
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 1.47A 2bytA-5ah5A:
46.2		 2bytA-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		7 / 7 MET A  43
TYR A  46
ASP A  84
TYR A 327
TYR A 361
HIS A 367
HIS A 371
 LSS  A1638 (-3.9A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-4.8A)
None
LSS  A1638 (-3.8A)
LSS  A1638 (-3.7A)
 0.46A 2bytD-3ziuA:
44.4		 2bytD-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		4 / 7 TYR A 327
TYR A  46
HIS A 371
HIS A 367
 LSS  A1638 (-4.8A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 0.87A 2bytD-3ziuA:
44.4		 2bytD-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		4 / 7 TYR A 361
TYR A  46
HIS A 371
HIS A 367
 None
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 1.30A 2bytD-3ziuA:
44.4		 2bytD-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		7 / 7 MET A  38
TYR A  41
ASP A  78
TYR A 496
TYR A 523
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.30A 2bytD-5ah5A:
47.1		 2bytD-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 7 TYR A 496
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 0.82A 2bytD-5ah5A:
47.1		 2bytD-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 7 TYR A 523
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 1.47A 2bytD-5ah5A:
47.1		 2bytD-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		8 / 8 MET A  43
TYR A  46
ASP A  84
SER A 324
TYR A 327
TYR A 361
HIS A 367
HIS A 371
 LSS  A1638 (-3.9A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 ( 3.9A)
LSS  A1638 (-4.8A)
None
LSS  A1638 (-3.8A)
LSS  A1638 (-3.7A)
 0.63A 2v0gA-3ziuA:
44.1		 2v0gA-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		4 / 8 TYR A 327
TYR A  46
HIS A 371
HIS A 367
 LSS  A1638 (-4.8A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 0.90A 2v0gA-3ziuA:
44.1		 2v0gA-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		4 / 8 TYR A 361
TYR A  46
HIS A 371
HIS A 367
 None
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 1.34A 2v0gA-3ziuA:
44.1		 2v0gA-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		8 / 8 MET A  38
TYR A  41
ASP A  78
SER A 493
TYR A 496
TYR A 523
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.53A 2v0gA-5ah5A:
47.1		 2v0gA-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 8 TYR A 496
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 0.86A 2v0gA-5ah5A:
47.1		 2v0gA-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0G_D_LEUD1883_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		5 / 5 TYR A  46
ASP A  84
TYR A 327
TYR A 361
HIS A 367
 LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-4.8A)
None
LSS  A1638 (-3.8A)
 0.40A 2v0gD-3ziuA:
43.7		 2v0gD-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0G_D_LEUD1883_0
(AMINOACYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 5 TYR A  41
ASP A  78
TYR A 496
TYR A 523
HIS A 529
 LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-4.0A)
 0.36A 2v0gD-5ah5A:
46.1		 2v0gD-5ah5A:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		5 / 12 ILE A  81
GLU A 366
ILE A 403
GLU A  58
HIS A 367
 None
LSS  A1638 (-3.0A)
LSS  A1638 (-4.2A)
LSS  A1638 (-4.4A)
LSS  A1638 (-3.8A)
 1.19A 4a97B-3ziuA:
2.8
4a97C-3ziuA:
2.9		 4a97B-3ziuA:
18.65
4a97C-3ziuA:
18.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		6 / 7 MET A  43
ASP A  84
SER A 324
GLU A 366
HIS A 367
HIS A 371
 LSS  A1638 (-3.9A)
LSS  A1638 (-3.7A)
LSS  A1638 ( 3.9A)
LSS  A1638 (-3.0A)
LSS  A1638 (-3.8A)
LSS  A1638 (-3.7A)
 0.78A 4aq7A-3ziuA:
29.5		 4aq7A-3ziuA:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		6 / 7 MET A  38
ASP A  78
SER A 493
GLU A 528
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.6A)
LSS  A1818 (-2.9A)
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.90A 4aq7A-5ah5A:
32.4		 4aq7A-5ah5A:
38.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQ7_D_LEUD902_0
(LEUCINE--TRNA LIGASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		8 / 9 MET A  43
ASP A  84
SER A 324
TYR A 327
TYR A 361
GLU A 366
HIS A 367
HIS A 371
 LSS  A1638 (-3.9A)
LSS  A1638 (-3.7A)
LSS  A1638 ( 3.9A)
LSS  A1638 (-4.8A)
None
LSS  A1638 (-3.0A)
LSS  A1638 (-3.8A)
LSS  A1638 (-3.7A)
 0.72A 4aq7D-3ziuA:
40.3		 4aq7D-3ziuA:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQ7_D_LEUD902_0
(LEUCINE--TRNA LIGASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		8 / 9 MET A  38
ASP A  78
SER A 493
TYR A 496
TYR A 523
GLU A 528
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-2.9A)
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.85A 4aq7D-5ah5A:
42.5		 4aq7D-5ah5A:
38.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		5 / 7 ASP A  84
SER A 324
TYR A 361
HIS A 367
HIS A 371
 LSS  A1638 (-3.7A)
LSS  A1638 ( 3.9A)
None
LSS  A1638 (-3.8A)
LSS  A1638 (-3.7A)
 0.66A 4arcA-3ziuA:
40.5		 4arcA-3ziuA:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 3ziu LEUCYL-TRNA
SYNTHETASE
(Mycoplasma
mobile) 		5 / 7 TYR A  46
ASP A  84
SER A 324
TYR A 361
HIS A 371
 LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 ( 3.9A)
None
LSS  A1638 (-3.7A)
 0.29A 4arcA-3ziuA:
40.5		 4arcA-3ziuA:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		6 / 7 TYR A  41
ASP A  78
SER A 493
TYR A 523
HIS A 529
HIS A 533
 LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.6A)
None
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.75A 4arcA-5ah5A:
43.2		 4arcA-5ah5A:
38.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 8 TRP A 175
GLU A 528
HIS A 533
THR A  99
 None
LSS  A1818 (-2.9A)
LSS  A1818 (-3.6A)
None
 1.47A 5hqaA-5ah5A:
undetectable		 5hqaA-5ah5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 6 PRO A  40
ILE A 103
GLY A  76
GLU A 122
 LSS  A1818 (-4.3A)
None
None
None
 1.01A 6gqiA-5ah5A:
undetectable		 6gqiA-5ah5A:
21.91