SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LSN'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
6 / 9 PHE A 114
GLY A 296
ALA A 297
THR A 301
LEU A 362
LEU A 366
LSN  A 503 (-3.8A)
LSN  A 501 (-3.5A)
LSN  A 501 ( 3.3A)
HEM  A 504 (-4.0A)
LSN  A 503 ( 3.7A)
HEM  A 504 ( 4.4A)
0.76A 1nr6A-5xxiA:
55.4
1nr6A-5xxiA:
76.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
7 / 12 ARG A  97
LEU A 208
ASN A 218
LEU A 366
PRO A 367
LEU A 388
PHE A 476
HEM  A 504 (-2.5A)
LSN  A 501 (-3.9A)
LSN  A 503 (-3.1A)
HEM  A 504 ( 4.4A)
LSN  A 503 (-4.1A)
LSN  A 503 (-4.6A)
LSN  A 503 (-3.8A)
0.86A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
7 / 12 ARG A  97
LEU A 208
THR A 364
LEU A 366
PRO A 367
LEU A 388
PHE A 476
HEM  A 504 (-2.5A)
LSN  A 501 (-3.9A)
LSN  A 503 (-3.2A)
HEM  A 504 ( 4.4A)
LSN  A 503 (-4.1A)
LSN  A 503 (-4.6A)
LSN  A 503 (-3.8A)
0.73A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
6 / 12 ARG A  97
PHE A 100
ALA A 103
ASN A 218
LEU A 366
PRO A 367
HEM  A 504 (-2.5A)
LSN  A 503 (-4.1A)
LSN  A 503 ( 4.0A)
LSN  A 503 (-3.1A)
HEM  A 504 ( 4.4A)
LSN  A 503 (-4.1A)
0.71A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
7 / 12 ARG A  97
PHE A 100
LEU A 208
ASN A 218
LEU A 366
PRO A 367
LEU A 388
HEM  A 504 (-2.5A)
LSN  A 503 (-4.1A)
LSN  A 501 (-3.9A)
LSN  A 503 (-3.1A)
HEM  A 504 ( 4.4A)
LSN  A 503 (-4.1A)
LSN  A 503 (-4.6A)
0.81A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
7 / 12 ARG A  97
PHE A 100
LEU A 208
THR A 364
LEU A 366
PRO A 367
LEU A 388
HEM  A 504 (-2.5A)
LSN  A 503 (-4.1A)
LSN  A 501 (-3.9A)
LSN  A 503 (-3.2A)
HEM  A 504 ( 4.4A)
LSN  A 503 (-4.1A)
LSN  A 503 (-4.6A)
0.84A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
5 / 12 LEU A 102
LEU A 208
ASN A 218
LEU A 388
PHE A 476
LSN  A 503 (-3.5A)
LSN  A 501 (-3.9A)
LSN  A 503 (-3.1A)
LSN  A 503 (-4.6A)
LSN  A 503 (-3.8A)
1.09A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
5 / 12 LEU A 102
LEU A 208
THR A 364
LEU A 388
PHE A 476
LSN  A 503 (-3.5A)
LSN  A 501 (-3.9A)
LSN  A 503 (-3.2A)
LSN  A 503 (-4.6A)
LSN  A 503 (-3.8A)
0.94A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
5 / 12 PHE A 100
LEU A 102
LEU A 208
ASN A 218
LEU A 388
LSN  A 503 (-4.1A)
LSN  A 503 (-3.5A)
LSN  A 501 (-3.9A)
LSN  A 503 (-3.1A)
LSN  A 503 (-4.6A)
1.16A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
5 / 12 PHE A 100
LEU A 102
LEU A 208
THR A 364
LEU A 388
LSN  A 503 (-4.1A)
LSN  A 503 (-3.5A)
LSN  A 501 (-3.9A)
LSN  A 503 (-3.2A)
LSN  A 503 (-4.6A)
1.08A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
7 / 12 ARG A  97
ASN A 218
THR A 364
LEU A 366
PRO A 367
LEU A 388
PHE A 476
HEM  A 504 (-2.5A)
LSN  A 503 (-3.1A)
LSN  A 503 (-3.2A)
HEM  A 504 ( 4.4A)
LSN  A 503 (-4.1A)
LSN  A 503 (-4.6A)
LSN  A 503 (-3.8A)
0.81A 1og5B-5xxiA:
58.9
1og5B-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
7 / 12 ARG A  97
ILE A  99
PHE A 100
ALA A 103
ASN A 218
LEU A 366
PRO A 367
HEM  A 504 (-2.5A)
None
LSN  A 503 (-4.1A)
LSN  A 503 ( 4.0A)
LSN  A 503 (-3.1A)
HEM  A 504 ( 4.4A)
LSN  A 503 (-4.1A)
0.84A 1og5B-5xxiA:
58.9
1og5B-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
8 / 12 ARG A  97
ILE A  99
PHE A 100
ASN A 218
THR A 364
LEU A 366
PRO A 367
LEU A 388
HEM  A 504 (-2.5A)
None
LSN  A 503 (-4.1A)
LSN  A 503 (-3.1A)
LSN  A 503 (-3.2A)
HEM  A 504 ( 4.4A)
LSN  A 503 (-4.1A)
LSN  A 503 (-4.6A)
0.91A 1og5B-5xxiA:
58.9
1og5B-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
5 / 12 ILE A  99
PHE A 100
LEU A 102
ALA A 103
ASN A 218
None
LSN  A 503 (-4.1A)
LSN  A 503 (-3.5A)
LSN  A 503 ( 4.0A)
LSN  A 503 (-3.1A)
1.03A 1og5B-5xxiA:
58.9
1og5B-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
6 / 12 ILE A  99
PHE A 100
LEU A 102
ASN A 218
THR A 364
LEU A 388
None
LSN  A 503 (-4.1A)
LSN  A 503 (-3.5A)
LSN  A 503 (-3.1A)
LSN  A 503 (-3.2A)
LSN  A 503 (-4.6A)
1.12A 1og5B-5xxiA:
58.9
1og5B-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
5 / 12 LEU A 102
ASN A 218
THR A 364
LEU A 388
PHE A 476
LSN  A 503 (-3.5A)
LSN  A 503 (-3.1A)
LSN  A 503 (-3.2A)
LSN  A 503 (-4.6A)
LSN  A 503 (-3.8A)
0.94A 1og5B-5xxiA:
58.9
1og5B-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
10 / 12 VAL A 113
ASN A 204
ILE A 205
LEU A 208
VAL A 237
ASP A 293
GLY A 296
ALA A 297
THR A 301
LEU A 366
HEM  A 504 ( 3.7A)
LSN  A 501 (-3.7A)
None
LSN  A 501 (-3.9A)
LSN  A 501 (-4.5A)
LSN  A 501 (-3.9A)
LSN  A 501 (-3.5A)
LSN  A 501 ( 3.3A)
HEM  A 504 (-4.0A)
HEM  A 504 ( 4.4A)
0.59A 1r9oA-5xxiA:
54.8
1r9oA-5xxiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
10 / 12 VAL A 113
ILE A 205
LEU A 208
VAL A 237
MET A 240
ASP A 293
GLY A 296
ALA A 297
THR A 301
LEU A 366
HEM  A 504 ( 3.7A)
None
LSN  A 501 (-3.9A)
LSN  A 501 (-4.5A)
LSN  A 501 (-3.3A)
LSN  A 501 (-3.9A)
LSN  A 501 (-3.5A)
LSN  A 501 ( 3.3A)
HEM  A 504 (-4.0A)
HEM  A 504 ( 4.4A)
0.75A 1r9oA-5xxiA:
54.8
1r9oA-5xxiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
5 / 12 ASN A 204
LEU A 208
VAL A 237
GLU A 300
THR A 301
LSN  A 501 (-3.7A)
LSN  A 501 (-3.9A)
LSN  A 501 (-4.5A)
None
HEM  A 504 (-4.0A)
1.03A 2vn0A-5xxiA:
51.3
2vn0A-5xxiA:
78.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
3 / 3 ALA A 297
THR A 301
CYH A 435
LSN  A 501 ( 3.3A)
HEM  A 504 (-4.0A)
HEM  A 504 (-2.4A)
0.75A 3e4eA-5xxiA:
50.5
3e4eA-5xxiA:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
3 / 3 ALA A 297
THR A 301
CYH A 435
LSN  A 501 ( 3.3A)
HEM  A 504 (-4.0A)
HEM  A 504 (-2.4A)
0.69A 3e4eB-5xxiA:
44.3
3e4eB-5xxiA:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
5 / 9 GLY A 296
VAL A 177
GLY A 437
VAL A 436
ILE A 178
LSN  A 501 (-3.5A)
None
HEM  A 504 (-3.5A)
HEM  A 504 (-4.1A)
None
0.79A 3oxvC-5xxiA:
undetectable
3oxvC-5xxiA:
14.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
4 / 6 LEU A 208
ALA A 297
THR A 301
LEU A 366
LSN  A 501 (-3.9A)
LSN  A 501 ( 3.3A)
HEM  A 504 (-4.0A)
HEM  A 504 ( 4.4A)
0.87A 3t3zA-5xxiA:
50.1
3t3zA-5xxiA:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
4 / 6 LEU A 208
ALA A 297
THR A 301
LEU A 366
LSN  A 501 (-3.9A)
LSN  A 501 ( 3.3A)
HEM  A 504 (-4.0A)
HEM  A 504 ( 4.4A)
0.88A 3t3zB-5xxiA:
43.6
3t3zB-5xxiA:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
4 / 6 LEU A 208
ALA A 297
THR A 301
LEU A 366
LSN  A 501 (-3.9A)
LSN  A 501 ( 3.3A)
HEM  A 504 (-4.0A)
HEM  A 504 ( 4.4A)
0.88A 3t3zD-5xxiA:
50.0
3t3zD-5xxiA:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_2
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
4 / 5 PHE A 476
PHE A  69
TRP A 212
GLN A 214
LSN  A 503 (-3.8A)
LSN  A 503 ( 4.8A)
None
LSN  A 503 ( 3.0A)
1.15A 4b9zA-5xxiA:
0.0
4b9zA-5xxiA:
20.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
4 / 8 PHE A 114
ALA A 297
LEU A 362
LEU A 366
LSN  A 503 (-3.8A)
LSN  A 501 ( 3.3A)
LSN  A 503 ( 3.7A)
HEM  A 504 ( 4.4A)
0.88A 4ejgB-5xxiA:
49.2
4ejgB-5xxiA:
50.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
4 / 7 PHE A 114
ALA A 297
LEU A 362
LEU A 366
LSN  A 503 (-3.8A)
LSN  A 501 ( 3.3A)
LSN  A 503 ( 3.7A)
HEM  A 504 ( 4.4A)
0.81A 4ejgC-5xxiA:
49.5
4ejgC-5xxiA:
50.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
4 / 7 ASP A 293
ASN A 107
GLU A 104
GLU A 285
LSN  A 501 (-3.9A)
None
None
None
0.89A 4fexB-5xxiA:
undetectable
4fexB-5xxiA:
20.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
12 / 12 ALA A 106
ARG A 108
VAL A 113
PHE A 114
ASN A 204
LEU A 208
VAL A 237
MET A 240
GLY A 296
ALA A 297
LEU A 362
LEU A 366
LSN  A 501 ( 3.9A)
LSN  A 501 (-3.2A)
HEM  A 504 ( 3.7A)
LSN  A 503 (-3.8A)
LSN  A 501 (-3.7A)
LSN  A 501 (-3.9A)
LSN  A 501 (-4.5A)
LSN  A 501 (-3.3A)
LSN  A 501 (-3.5A)
LSN  A 501 ( 3.3A)
LSN  A 503 ( 3.7A)
HEM  A 504 ( 4.4A)
0.20A 5x23A-5xxiA:
63.7
5x23A-5xxiA:
99.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
5 / 5 PRO A 227
GLY A 228
THR A 229
ASN A 231
LYS A 232
LSN  A 502 (-3.7A)
LSN  A 502 (-3.4A)
LSN  A 502 (-3.9A)
LSN  A 502 (-4.3A)
LSN  A 502 (-2.9A)
0.44A 5x23A-5xxiA:
63.7
5x23A-5xxiA:
99.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
8 / 8 PHE A  69
ILE A  74
PHE A 100
ASN A 218
PRO A 363
THR A 364
PRO A 367
PHE A 476
LSN  A 503 ( 4.8A)
LSN  A 503 (-4.7A)
LSN  A 503 (-4.1A)
LSN  A 503 (-3.1A)
LSN  A 503 (-3.6A)
LSN  A 503 (-3.2A)
LSN  A 503 (-4.1A)
LSN  A 503 (-3.8A)
0.36A 5x23A-5xxiA:
63.7
5x23A-5xxiA:
99.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
12 / 12 ALA A 106
ARG A 108
PHE A 114
ASN A 204
LEU A 233
VAL A 237
MET A 240
VAL A 292
ASP A 293
GLY A 296
THR A 301
LEU A 366
LSN  A 501 ( 3.9A)
LSN  A 501 (-3.2A)
LSN  A 503 (-3.8A)
LSN  A 501 (-3.7A)
LSN  A 501 ( 4.0A)
LSN  A 501 (-4.5A)
LSN  A 501 (-3.3A)
LSN  A 501 (-4.9A)
LSN  A 501 (-3.9A)
LSN  A 501 (-3.5A)
HEM  A 504 (-4.0A)
HEM  A 504 ( 4.4A)
0.30A 5x24A-5xxiA:
62.5
5x24A-5xxiA:
99.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
6 / 6 PHE A 226
PRO A 227
GLY A 228
THR A 229
ASN A 231
LYS A 232
LSN  A 502 (-4.7A)
LSN  A 502 (-3.7A)
LSN  A 502 (-3.4A)
LSN  A 502 (-3.9A)
LSN  A 502 (-4.3A)
LSN  A 502 (-2.9A)
0.39A 5x24A-5xxiA:
62.5
5x24A-5xxiA:
99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)
5xxi CYTOCHROME P450 2C9
(Homo
sapiens)
5 / 10 LEU A 234
LEU A 201
GLY A 109
GLY A 296
VAL A 292
None
LSN  A 501 (-4.1A)
None
LSN  A 501 (-3.5A)
LSN  A 501 (-4.9A)
0.97A 6eu9B-5xxiA:
1.9
6eu9B-5xxiA:
10.00