SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LSN'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1NR6_A_DIFA501_1 (CYTOCHROME P450 2C5) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 6 / 9 | PHE A 114GLY A 296ALA A 297THR A 301LEU A 362LEU A 366 | LSN A 503 (-3.8A)LSN A 501 (-3.5A)LSN A 501 ( 3.3A)HEM A 504 (-4.0A)LSN A 503 ( 3.7A)HEM A 504 ( 4.4A) | 0.76A | 1nr6A-5xxiA:55.4 | 1nr6A-5xxiA:76.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OG5_A_SWFA502_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 7 / 12 | ARG A 97LEU A 208ASN A 218LEU A 366PRO A 367LEU A 388PHE A 476 | HEM A 504 (-2.5A)LSN A 501 (-3.9A)LSN A 503 (-3.1A)HEM A 504 ( 4.4A)LSN A 503 (-4.1A)LSN A 503 (-4.6A)LSN A 503 (-3.8A) | 0.86A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OG5_A_SWFA502_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 7 / 12 | ARG A 97LEU A 208THR A 364LEU A 366PRO A 367LEU A 388PHE A 476 | HEM A 504 (-2.5A)LSN A 501 (-3.9A)LSN A 503 (-3.2A)HEM A 504 ( 4.4A)LSN A 503 (-4.1A)LSN A 503 (-4.6A)LSN A 503 (-3.8A) | 0.73A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OG5_A_SWFA502_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 6 / 12 | ARG A 97PHE A 100ALA A 103ASN A 218LEU A 366PRO A 367 | HEM A 504 (-2.5A)LSN A 503 (-4.1A)LSN A 503 ( 4.0A)LSN A 503 (-3.1A)HEM A 504 ( 4.4A)LSN A 503 (-4.1A) | 0.71A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OG5_A_SWFA502_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 7 / 12 | ARG A 97PHE A 100LEU A 208ASN A 218LEU A 366PRO A 367LEU A 388 | HEM A 504 (-2.5A)LSN A 503 (-4.1A)LSN A 501 (-3.9A)LSN A 503 (-3.1A)HEM A 504 ( 4.4A)LSN A 503 (-4.1A)LSN A 503 (-4.6A) | 0.81A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OG5_A_SWFA502_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 7 / 12 | ARG A 97PHE A 100LEU A 208THR A 364LEU A 366PRO A 367LEU A 388 | HEM A 504 (-2.5A)LSN A 503 (-4.1A)LSN A 501 (-3.9A)LSN A 503 (-3.2A)HEM A 504 ( 4.4A)LSN A 503 (-4.1A)LSN A 503 (-4.6A) | 0.84A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OG5_A_SWFA502_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 5 / 12 | LEU A 102LEU A 208ASN A 218LEU A 388PHE A 476 | LSN A 503 (-3.5A)LSN A 501 (-3.9A)LSN A 503 (-3.1A)LSN A 503 (-4.6A)LSN A 503 (-3.8A) | 1.09A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OG5_A_SWFA502_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 5 / 12 | LEU A 102LEU A 208THR A 364LEU A 388PHE A 476 | LSN A 503 (-3.5A)LSN A 501 (-3.9A)LSN A 503 (-3.2A)LSN A 503 (-4.6A)LSN A 503 (-3.8A) | 0.94A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OG5_A_SWFA502_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 5 / 12 | PHE A 100LEU A 102LEU A 208ASN A 218LEU A 388 | LSN A 503 (-4.1A)LSN A 503 (-3.5A)LSN A 501 (-3.9A)LSN A 503 (-3.1A)LSN A 503 (-4.6A) | 1.16A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OG5_A_SWFA502_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 5 / 12 | PHE A 100LEU A 102LEU A 208THR A 364LEU A 388 | LSN A 503 (-4.1A)LSN A 503 (-3.5A)LSN A 501 (-3.9A)LSN A 503 (-3.2A)LSN A 503 (-4.6A) | 1.08A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OG5_B_SWFB502_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 7 / 12 | ARG A 97ASN A 218THR A 364LEU A 366PRO A 367LEU A 388PHE A 476 | HEM A 504 (-2.5A)LSN A 503 (-3.1A)LSN A 503 (-3.2A)HEM A 504 ( 4.4A)LSN A 503 (-4.1A)LSN A 503 (-4.6A)LSN A 503 (-3.8A) | 0.81A | 1og5B-5xxiA:58.9 | 1og5B-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OG5_B_SWFB502_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 7 / 12 | ARG A 97ILE A 99PHE A 100ALA A 103ASN A 218LEU A 366PRO A 367 | HEM A 504 (-2.5A)NoneLSN A 503 (-4.1A)LSN A 503 ( 4.0A)LSN A 503 (-3.1A)HEM A 504 ( 4.4A)LSN A 503 (-4.1A) | 0.84A | 1og5B-5xxiA:58.9 | 1og5B-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OG5_B_SWFB502_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 8 / 12 | ARG A 97ILE A 99PHE A 100ASN A 218THR A 364LEU A 366PRO A 367LEU A 388 | HEM A 504 (-2.5A)NoneLSN A 503 (-4.1A)LSN A 503 (-3.1A)LSN A 503 (-3.2A)HEM A 504 ( 4.4A)LSN A 503 (-4.1A)LSN A 503 (-4.6A) | 0.91A | 1og5B-5xxiA:58.9 | 1og5B-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OG5_B_SWFB502_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 5 / 12 | ILE A 99PHE A 100LEU A 102ALA A 103ASN A 218 | NoneLSN A 503 (-4.1A)LSN A 503 (-3.5A)LSN A 503 ( 4.0A)LSN A 503 (-3.1A) | 1.03A | 1og5B-5xxiA:58.9 | 1og5B-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OG5_B_SWFB502_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 6 / 12 | ILE A 99PHE A 100LEU A 102ASN A 218THR A 364LEU A 388 | NoneLSN A 503 (-4.1A)LSN A 503 (-3.5A)LSN A 503 (-3.1A)LSN A 503 (-3.2A)LSN A 503 (-4.6A) | 1.12A | 1og5B-5xxiA:58.9 | 1og5B-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OG5_B_SWFB502_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 5 / 12 | LEU A 102ASN A 218THR A 364LEU A 388PHE A 476 | LSN A 503 (-3.5A)LSN A 503 (-3.1A)LSN A 503 (-3.2A)LSN A 503 (-4.6A)LSN A 503 (-3.8A) | 0.94A | 1og5B-5xxiA:58.9 | 1og5B-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1R9O_A_FLPA501_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 10 / 12 | VAL A 113ASN A 204ILE A 205LEU A 208VAL A 237ASP A 293GLY A 296ALA A 297THR A 301LEU A 366 | HEM A 504 ( 3.7A)LSN A 501 (-3.7A)NoneLSN A 501 (-3.9A)LSN A 501 (-4.5A)LSN A 501 (-3.9A)LSN A 501 (-3.5A)LSN A 501 ( 3.3A)HEM A 504 (-4.0A)HEM A 504 ( 4.4A) | 0.59A | 1r9oA-5xxiA:54.8 | 1r9oA-5xxiA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1R9O_A_FLPA501_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 10 / 12 | VAL A 113ILE A 205LEU A 208VAL A 237MET A 240ASP A 293GLY A 296ALA A 297THR A 301LEU A 366 | HEM A 504 ( 3.7A)NoneLSN A 501 (-3.9A)LSN A 501 (-4.5A)LSN A 501 (-3.3A)LSN A 501 (-3.9A)LSN A 501 (-3.5A)LSN A 501 ( 3.3A)HEM A 504 (-4.0A)HEM A 504 ( 4.4A) | 0.75A | 1r9oA-5xxiA:54.8 | 1r9oA-5xxiA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2VN0_A_TDZA501_1 (CYTOCHROME P450 2C8) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 5 / 12 | ASN A 204LEU A 208VAL A 237GLU A 300THR A 301 | LSN A 501 (-3.7A)LSN A 501 (-3.9A)LSN A 501 (-4.5A)NoneHEM A 504 (-4.0A) | 1.03A | 2vn0A-5xxiA:51.3 | 2vn0A-5xxiA:78.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3E4E_A_4PZA501_1 (CYTOCHROME P450 2E1) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 3 / 3 | ALA A 297THR A 301CYH A 435 | LSN A 501 ( 3.3A)HEM A 504 (-4.0A)HEM A 504 (-2.4A) | 0.75A | 3e4eA-5xxiA:50.5 | 3e4eA-5xxiA:58.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3E4E_B_4PZB501_1 (CYTOCHROME P450 2E1) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 3 / 3 | ALA A 297THR A 301CYH A 435 | LSN A 501 ( 3.3A)HEM A 504 (-4.0A)HEM A 504 (-2.4A) | 0.69A | 3e4eB-5xxiA:44.3 | 3e4eB-5xxiA:58.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OXV_C_478C200_1 (HIV-1 PROTEASE) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 5 / 9 | GLY A 296VAL A 177GLY A 437VAL A 436ILE A 178 | LSN A 501 (-3.5A)NoneHEM A 504 (-3.5A)HEM A 504 (-4.1A)None | 0.79A | 3oxvC-5xxiA:undetectable | 3oxvC-5xxiA:14.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3T3Z_A_9PLA501_1 (CYTOCHROME P450 2E1) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 4 / 6 | LEU A 208ALA A 297THR A 301LEU A 366 | LSN A 501 (-3.9A)LSN A 501 ( 3.3A)HEM A 504 (-4.0A)HEM A 504 ( 4.4A) | 0.87A | 3t3zA-5xxiA:50.1 | 3t3zA-5xxiA:58.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3T3Z_B_9PLB501_1 (CYTOCHROME P450 2E1) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 4 / 6 | LEU A 208ALA A 297THR A 301LEU A 366 | LSN A 501 (-3.9A)LSN A 501 ( 3.3A)HEM A 504 (-4.0A)HEM A 504 ( 4.4A) | 0.88A | 3t3zB-5xxiA:43.6 | 3t3zB-5xxiA:58.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3T3Z_D_9PLD501_1 (CYTOCHROME P450 2E1) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 4 / 6 | LEU A 208ALA A 297THR A 301LEU A 366 | LSN A 501 (-3.9A)LSN A 501 ( 3.3A)HEM A 504 (-4.0A)HEM A 504 ( 4.4A) | 0.88A | 3t3zD-5xxiA:50.0 | 3t3zD-5xxiA:58.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4B9Z_A_ACRA1818_2 (ALPHA-GLUCOSIDASE,PUTATIVE, ADG31B) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 4 / 5 | PHE A 476PHE A 69TRP A 212GLN A 214 | LSN A 503 (-3.8A)LSN A 503 ( 4.8A)NoneLSN A 503 ( 3.0A) | 1.15A | 4b9zA-5xxiA:0.0 | 4b9zA-5xxiA:20.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4EJG_B_NCTB501_1 (CYTOCHROME P450 2A13) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 4 / 8 | PHE A 114ALA A 297LEU A 362LEU A 366 | LSN A 503 (-3.8A)LSN A 501 ( 3.3A)LSN A 503 ( 3.7A)HEM A 504 ( 4.4A) | 0.88A | 4ejgB-5xxiA:49.2 | 4ejgB-5xxiA:50.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4EJG_C_NCTC501_1 (CYTOCHROME P450 2A13) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 4 / 7 | PHE A 114ALA A 297LEU A 362LEU A 366 | LSN A 503 (-3.8A)LSN A 501 ( 3.3A)LSN A 503 ( 3.7A)HEM A 504 ( 4.4A) | 0.81A | 4ejgC-5xxiA:49.5 | 4ejgC-5xxiA:50.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4FEX_B_KANB301_1 (AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE APHA1-IAB) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 4 / 7 | ASP A 293ASN A 107GLU A 104GLU A 285 | LSN A 501 (-3.9A)NoneNoneNone | 0.89A | 4fexB-5xxiA:undetectable | 4fexB-5xxiA:20.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5X23_A_LSNA502_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 12 / 12 | ALA A 106ARG A 108VAL A 113PHE A 114ASN A 204LEU A 208VAL A 237MET A 240GLY A 296ALA A 297LEU A 362LEU A 366 | LSN A 501 ( 3.9A)LSN A 501 (-3.2A)HEM A 504 ( 3.7A)LSN A 503 (-3.8A)LSN A 501 (-3.7A)LSN A 501 (-3.9A)LSN A 501 (-4.5A)LSN A 501 (-3.3A)LSN A 501 (-3.5A)LSN A 501 ( 3.3A)LSN A 503 ( 3.7A)HEM A 504 ( 4.4A) | 0.20A | 5x23A-5xxiA:63.7 | 5x23A-5xxiA:99.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5X23_A_LSNA503_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 5 / 5 | PRO A 227GLY A 228THR A 229ASN A 231LYS A 232 | LSN A 502 (-3.7A)LSN A 502 (-3.4A)LSN A 502 (-3.9A)LSN A 502 (-4.3A)LSN A 502 (-2.9A) | 0.44A | 5x23A-5xxiA:63.7 | 5x23A-5xxiA:99.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5X23_A_LSNA504_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 8 / 8 | PHE A 69ILE A 74PHE A 100ASN A 218PRO A 363THR A 364PRO A 367PHE A 476 | LSN A 503 ( 4.8A)LSN A 503 (-4.7A)LSN A 503 (-4.1A)LSN A 503 (-3.1A)LSN A 503 (-3.6A)LSN A 503 (-3.2A)LSN A 503 (-4.1A)LSN A 503 (-3.8A) | 0.36A | 5x23A-5xxiA:63.7 | 5x23A-5xxiA:99.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5X24_A_LSNA502_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 12 / 12 | ALA A 106ARG A 108PHE A 114ASN A 204LEU A 233VAL A 237MET A 240VAL A 292ASP A 293GLY A 296THR A 301LEU A 366 | LSN A 501 ( 3.9A)LSN A 501 (-3.2A)LSN A 503 (-3.8A)LSN A 501 (-3.7A)LSN A 501 ( 4.0A)LSN A 501 (-4.5A)LSN A 501 (-3.3A)LSN A 501 (-4.9A)LSN A 501 (-3.9A)LSN A 501 (-3.5A)HEM A 504 (-4.0A)HEM A 504 ( 4.4A) | 0.30A | 5x24A-5xxiA:62.5 | 5x24A-5xxiA:99.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5X24_A_LSNA503_1 (CYTOCHROME P450 2C9) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 6 / 6 | PHE A 226PRO A 227GLY A 228THR A 229ASN A 231LYS A 232 | LSN A 502 (-4.7A)LSN A 502 (-3.7A)LSN A 502 (-3.4A)LSN A 502 (-3.9A)LSN A 502 (-4.3A)LSN A 502 (-2.9A) | 0.39A | 5x24A-5xxiA:62.5 | 5x24A-5xxiA:99.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6EU9_B_REAB601_1 (RETINOIC ACIDRECEPTOR) |
5xxi | CYTOCHROME P450 2C9 (Homosapiens) | 5 / 10 | LEU A 234LEU A 201GLY A 109GLY A 296VAL A 292 | NoneLSN A 501 (-4.1A)NoneLSN A 501 (-3.5A)LSN A 501 (-4.9A) | 0.97A | 6eu9B-5xxiA:1.9 | 6eu9B-5xxiA:10.00 |