SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LPA'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2Y7W_B_SALB1300_1 (LYSR-TYPE REGULATORYPROTEIN) |
5t8u | LIPOATE-PROTEINLIGASE 1 (Plasmodiumfalciparum) | 5 / 10 | GLY A 107HIS A 111THR A 104HIS A 176ILE A 76 | LPA A 401 (-4.2A)LPA A 401 (-4.3A)NoneLPA A 401 (-3.6A)LPA A 401 ( 4.2A) | 1.26A | 2y7wB-5t8uA:undetectable | 2y7wB-5t8uA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3TEH_B_DAHB786_1 (PHENYLALANYL-TRNASYNTHETASE BETACHAIN) |
5ij6 | LIPOATE--PROTEINLIGASE (Enterococcusfaecalis) | 4 / 7 | LEU A 15GLY A 71ALA A 136PHE A 288 | NoneNoneLPA A 401 ( 3.8A)None | 0.99A | 3tehB-5ij6A:undetectable | 3tehB-5ij6A:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UVV_A_T3A501_1 (THYROID HORMONERECEPTOR ALPHA) |
5t8u | LIPOATE-PROTEINLIGASE 1 (Plasmodiumfalciparum) | 5 / 12 | ILE A 76ILE A 75ALA A 108LEU A 183ILE A 212 | LPA A 401 ( 4.2A)NoneNoneNoneNone | 0.95A | 3uvvA-5t8uA:undetectable | 3uvvA-5t8uA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4FGJ_A_1PQA304_0 (RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE[QUINONE]) |
5t8u | LIPOATE-PROTEINLIGASE 1 (Plasmodiumfalciparum) | 4 / 8 | GLN A 295GLY A 107ASN A 152GLU A 86 | NoneLPA A 401 (-4.2A)LPA A 401 (-4.6A)None | 0.92A | 4fgjA-5t8uA:undetectable4fgjB-5t8uA:undetectable | 4fgjA-5t8uA:20.384fgjB-5t8uA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4N48_B_SAMB601_0 (CAP-SPECIFIC MRNA(NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1) |
5ij6 | LIPOATE--PROTEINLIGASE (Enterococcusfaecalis) | 5 / 12 | ALA A 136GLY A 44GLY A 73ASN A 46ILE A 247 | LPA A 401 ( 3.8A)NoneLPA A 401 (-3.7A)NoneNone | 1.04A | 4n48B-5ij6A:undetectable | 4n48B-5ij6A:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6D8F_A_ACTA803_0 (UNCHARACTERIZEDPROTEIN) |
5ij6 | LIPOATE--PROTEINLIGASE (Enterococcusfaecalis) | 3 / 3 | GLU A 52LEU A 43ARG A 68 | NoneNoneLPA A 401 (-3.5A) | 0.68A | 6d8fA-5ij6A:undetectable | 6d8fA-5ij6A:18.75 |