SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LPA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		5 / 10 GLY A 107
HIS A 111
THR A 104
HIS A 176
ILE A  76
 LPA  A 401 (-4.2A)
LPA  A 401 (-4.3A)
None
LPA  A 401 (-3.6A)
LPA  A 401 ( 4.2A)
 1.26A 2y7wB-5t8uA:
undetectable		 2y7wB-5t8uA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 7 LEU A  15
GLY A  71
ALA A 136
PHE A 288
 None
None
LPA  A 401 ( 3.8A)
None
 0.99A 3tehB-5ij6A:
undetectable		 3tehB-5ij6A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		5 / 12 ILE A  76
ILE A  75
ALA A 108
LEU A 183
ILE A 212
 LPA  A 401 ( 4.2A)
None
None
None
None
 0.95A 3uvvA-5t8uA:
undetectable		 3uvvA-5t8uA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		4 / 8 GLN A 295
GLY A 107
ASN A 152
GLU A  86
 None
LPA  A 401 (-4.2A)
LPA  A 401 (-4.6A)
None
 0.92A 4fgjA-5t8uA:
undetectable
4fgjB-5t8uA:
undetectable		 4fgjA-5t8uA:
20.38
4fgjB-5t8uA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 ALA A 136
GLY A  44
GLY A  73
ASN A  46
ILE A 247
 LPA  A 401 ( 3.8A)
None
LPA  A 401 (-3.7A)
None
None
 1.04A 4n48B-5ij6A:
undetectable		 4n48B-5ij6A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		3 / 3 GLU A  52
LEU A  43
ARG A  68
 None
None
LPA  A 401 (-3.5A)
 0.68A 6d8fA-5ij6A:
undetectable		 6d8fA-5ij6A:
18.75