SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LP6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IBG_H_OBNH1_1 (IGG2B-KAPPA 40-50 FAB (HEAVY CHAIN))	2w7z	PENTAPEPTIDE REPEAT FAMILY PROTEIN (Enterococcus faecalis)	4 / 6	LEU A 182 TRP A 164 PHE A 174 VAL A 194	None None None LP6 A 193 ( 2.7A)	1.30A	1ibgH-2w7zA: undetectable	1ibgH-2w7zA: 21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LK0_D_Z80D92_1 (PROTEIN S100-B)	2w7z	PENTAPEPTIDE REPEAT FAMILY PROTEIN (Enterococcus faecalis)	3 / 3	HIS A 90 PHE A 74 PHE A 94	LP6 A 110 ( 4.1A) None None	0.78A	3lk0D-2w7zA: undetectable	3lk0D-2w7zA: 18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LA0_A_198A601_1 (SERUM ALBUMIN)	2w7z	PENTAPEPTIDE REPEAT FAMILY PROTEIN (Enterococcus faecalis)	5 / 10	LEU A 113 ALA A 122 PHE A 124 PHE A 144 LEU A 154	LP6 A 2 ( 4.7A) None None None CL A1213 (-4.9A)	1.46A	4la0A-2w7zA: undetectable	4la0A-2w7zA: 16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDQ_P_CHDP306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2w7z	PENTAPEPTIDE REPEAT FAMILY PROTEIN (Enterococcus faecalis)	4 / 5	PHE A 144 PHE A 129 LEU A 109 PHE A 89	None None LP6 A 110 ( 4.5A) None	1.31A	5xdqP-2w7zA: undetectable 5xdqW-2w7zA: undetectable	5xdqP-2w7zA: 23.33 5xdqW-2w7zA: 19.48

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1IBG_H_OBNH1_1","IGG2B-KAPPA 40-50 FAB (HEAVY CHAIN)","2w7z","PENTAPEPTIDE REPEAT FAMILY PROTEIN","Enterococcus faecalis",4,"LEU A 182;TRP A 164;PHE A 174;VAL A 194","None;None;None;LP6 A 193 ( 2.7A)","1.30A","1ibgH-2w7zA:undetectable",null],["3LK0_D_Z80D92_1","PROTEIN S100-B","2w7z","PENTAPEPTIDE REPEAT FAMILY PROTEIN","Enterococcus faecalis",3,"HIS A  90;PHE A  74;PHE A  94","LP6 A 110 ( 4.1A);None;None","0.78A","3lk0D-2w7zA:undetectable","1ibgH-2w7zA:21.69"],["4LA0_A_198A601_1","SERUM ALBUMIN","2w7z","PENTAPEPTIDE REPEAT FAMILY PROTEIN","Enterococcus faecalis",5,"LEU A 113;ALA A 122;PHE A 124;PHE A 144;LEU A 154","LP6 A   2 ( 4.7A);None;None;None; CL A1213 (-4.9A)","1.46A","4la0A-2w7zA:undetectable","3lk0D-2w7zA:18.40"],["5XDQ_P_CHDP306_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2w7z","PENTAPEPTIDE REPEAT FAMILY PROTEIN","Enterococcus faecalis",4,"PHE A 144;PHE A 129;LEU A 109;PHE A  89","None;None;LP6 A 110 ( 4.5A);None","1.31A","5xdqP-2w7zA:undetectable;5xdqW-2w7zA:undetectable","4la0A-2w7zA:16.92"]]