SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LOP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 3ayf NITRIC OXIDE
REDUCTASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 626
VAL A 624
TRP A 621
 HEM  A 802 (-3.5A)
LOP  A 810 (-4.9A)
LOP  A 810 (-3.6A)
 0.82A 1av2C-3ayfA:
undetectable
1av2D-3ayfA:
undetectable		 1av2C-3ayfA:
3.17
1av2D-3ayfA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 3ayf NITRIC OXIDE
REDUCTASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 626
VAL A 624
TRP A 621
 HEM  A 802 (-3.5A)
LOP  A 810 (-4.9A)
LOP  A 810 (-3.6A)
 0.81A 1w5uC-3ayfA:
undetectable
1w5uD-3ayfA:
undetectable		 1w5uC-3ayfA:
3.17
1w5uD-3ayfA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A 268
GLU A 239
TYR A 350
LEU A 351
TYR A 317
 LOP  A 402 ( 3.5A)
LOP  A 402 ( 2.6A)
LOP  A 402 (-4.0A)
None
LOP  A 402 ( 3.7A)
 1.08A 2f10A-6bqcA:
undetectable		 2f10A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 TYR A 137
ILE A 174
GLY A 175
GLY A 177
HIS A 240
 LOP  A 402 (-2.8A)
None
None
None
LOP  A 402 (-3.2A)
 0.77A 2fk8A-6bqcA:
32.2		 2fk8A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 3ayf NITRIC OXIDE
REDUCTASE
(Geobacillus
stearothermophil
us) 		3 / 3 TRP A 621
ALA A 626
VAL A 624
 LOP  A 810 (-3.6A)
HEM  A 802 (-3.5A)
LOP  A 810 (-4.9A)
 0.85A 2izqA-3ayfA:
undetectable
2izqB-3ayfA:
undetectable		 2izqA-3ayfA:
3.17
2izqB-3ayfA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 3ayf NITRIC OXIDE
REDUCTASE
(Geobacillus
stearothermophil
us) 		4 / 5 ALA A 654
TRP A 621
LEU A 623
ALA A 655
 None
LOP  A 810 (-3.6A)
None
HEM  A 802 (-3.4A)
 1.31A 2jstA-3ayfA:
4.6
2jstB-3ayfA:
4.6		 2jstA-3ayfA:
5.53
2jstB-3ayfA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PCP_C_1PCC212_1
(IMMUNOGLOBULIN)		 2qjp CYTOCHROME B
(Rhodobacter
sphaeroides) 		5 / 10 TYR A 359
PHE A 363
GLY A 357
TYR A 117
SER A 120
 None
None
None
LOP  A 503 (-3.6A)
HEM  A 501 (-4.4A)
 1.49A 2pcpC-2qjpA:
undetectable
2pcpD-2qjpA:
undetectable		 2pcpC-2qjpA:
17.82
2pcpD-2qjpA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 175
GLY A 177
ASP A 221
VAL A 235
GLY A 236
 None
None
None
None
LOP  A 402 ( 3.4A)
 0.64A 2qe6B-6bqcA:
11.8		 2qe6B-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 11 GLY A 314
TYR A 317
PHE A 358
GLY A 269
HIS A 266
 None
LOP  A 402 ( 3.7A)
LOP  A 402 ( 4.6A)
None
CO3  A 401 (-4.0A)
 1.16A 2y7kA-6bqcA:
undetectable		 2y7kA-6bqcA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 314
TYR A 317
PHE A 358
GLY A 269
HIS A 266
 None
LOP  A 402 ( 3.7A)
LOP  A 402 ( 4.6A)
None
CO3  A 401 (-4.0A)
 1.25A 2y7kC-6bqcA:
undetectable		 2y7kC-6bqcA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 10 PHE A  76
GLY A  57
GLY A  59
TYR A 349
GLU A  53
 LOP  A 402 ( 3.8A)
None
None
None
None
 1.50A 3fw1A-6bqcA:
2.3		 3fw1A-6bqcA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		4 / 8 SER A 128
ASP A 125
ASP A 121
TYR A 350
 GOL  A 409 ( 4.9A)
None
None
LOP  A 402 (-4.0A)
 1.05A 3havA-6bqcA:
undetectable		 3havA-6bqcA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 3ayf NITRIC OXIDE
REDUCTASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 626
VAL A 624
TRP A 621
 HEM  A 802 (-3.5A)
LOP  A 810 (-4.9A)
LOP  A 810 (-3.6A)
 0.81A 3l8lA-3ayfA:
undetectable
3l8lB-3ayfA:
undetectable		 3l8lA-3ayfA:
3.17
3l8lB-3ayfA:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 3ayf NITRIC OXIDE
REDUCTASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 626
VAL A 624
TRP A 621
 HEM  A 802 (-3.5A)
LOP  A 810 (-4.9A)
LOP  A 810 (-3.6A)
 0.84A 3l8lC-3ayfA:
undetectable
3l8lD-3ayfA:
undetectable		 3l8lC-3ayfA:
3.17
3l8lD-3ayfA:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  54
GLY A  57
PRO A 279
LEU A  51
LEU A  96
 LOP  A 402 ( 4.2A)
None
None
None
None
 1.06A 3p2kB-6bqcA:
10.7		 3p2kB-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  54
GLY A  57
PRO A 279
LEU A  51
LEU A  96
 LOP  A 402 ( 4.2A)
None
None
None
None
 1.07A 3p2kD-6bqcA:
10.5		 3p2kD-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  58
PHE A  75
ALA A 357
GLY A  83
LEU A  80
 LOP  A 402 (-4.0A)
None
LOP  A 402 (-3.3A)
None
LOP  A 402 ( 4.4A)
 1.24A 4j7xB-6bqcA:
undetectable		 4j7xB-6bqcA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 175
GLY A 177
ILE A 198
SER A 199
HIS A 240
 None
None
None
None
LOP  A 402 (-3.2A)
 0.79A 4qdjA-6bqcA:
16.6		 4qdjA-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 321
TRP A 324
SER A 138
LEU A 131
PHE A 286
 LOP  A 402 ( 4.3A)
None
CO3  A 401 (-4.5A)
None
LOP  A 402 (-3.0A)
 1.33A 4yvxA-6bqcA:
undetectable		 4yvxA-6bqcA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  54
GLY A  57
PRO A 279
LEU A  51
LEU A  96
 LOP  A 402 ( 4.2A)
None
None
None
None
 0.96A 5bw4A-6bqcA:
11.3		 5bw4A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		7 / 12 SER A 138
GLY A 175
GLY A 177
THR A 197
GLN A 202
VAL A 235
HIS A 240
 CO3  A 401 (-4.5A)
None
None
None
None
None
LOP  A 402 (-3.2A)
 0.75A 5kocB-6bqcA:
28.9		 5kocB-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2qjp CYTOCHROME B
(Rhodobacter
sphaeroides) 		4 / 6 LEU A 370
ILE A 106
TRP A  47
MET A  44
 None
None
None
LOP  A 503 (-4.2A)
 1.28A 5ljeA-2qjpA:
undetectable		 5ljeA-2qjpA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 3ayf NITRIC OXIDE
REDUCTASE
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 460
PHE A 482
ALA A 477
LEU A 449
 None
LOP  A 809 (-4.2A)
None
None
 0.83A 5y7pC-3ayfA:
undetectable		 5y7pC-3ayfA:
18.67