SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LOH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN
(Skeletonema
marinoi) 		5 / 12 LEU A 149
PHE A 152
PHE A 112
LEU A 120
LEU A  41
 LOH  A 150 ( 4.3A)
None
None
None
None
 1.30A 3tbgA-6ftlA:
undetectable		 3tbgA-6ftlA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN
(Skeletonema
marinoi) 		5 / 12 LEU A 149
PHE A 152
PHE A 112
LEU A 120
LEU A  41
 LOH  A 150 ( 4.3A)
None
None
None
None
 1.28A 3tbgC-6ftlA:
undetectable		 3tbgC-6ftlA:
13.10