SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LOG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 225
SER A 437
ASN A 356
THR A 291
 LOG  A1614 ( 4.2A)
None
None
None
 1.24A 1h7xA-4az7A:
5.1		 1h7xA-4az7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 225
SER A 437
ASN A 356
THR A 291
 LOG  A1614 ( 4.2A)
None
None
None
 1.23A 1h7xB-4az7A:
10.5		 1h7xB-4az7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 225
SER A 437
ASN A 356
THR A 291
 LOG  A1614 ( 4.2A)
None
None
None
 1.23A 1h7xC-4az7A:
6.5		 1h7xC-4az7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 225
SER A 437
ASN A 356
THR A 291
 LOG  A1614 ( 4.2A)
None
None
None
 1.23A 1h7xD-4az7A:
2.0		 1h7xD-4az7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 SER A 421
PRO A 466
SER A 468
ALA A 424
 LOG  A 702 ( 4.5A)
GAL  A 701 (-3.7A)
None
SO4  A 705 (-3.5A)
 0.99A 1k5qA-5bxpA:
undetectable
1k5qB-5bxpA:
undetectable		 1k5qA-5bxpA:
14.93
1k5qB-5bxpA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 GLU A 257
GLU A 216
TRP A 373
TRP A 465
 None
GAL  A 701 (-2.8A)
LOG  A 702 ( 3.9A)
LOG  A 702 (-3.8A)
 1.35A 1q0yH-5bxpA:
undetectable
1q0yL-5bxpA:
undetectable		 1q0yH-5bxpA:
15.99
1q0yL-5bxpA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 8 SER A 191
ILE A 192
ASP A 193
ARG A 196
 None
None
None
LOG  A1614 (-2.8A)
 1.11A 2v57A-4az7A:
undetectable		 2v57A-4az7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 8 SER A 191
ILE A 192
ASP A 193
ARG A 196
 None
None
None
LOG  A1614 (-2.8A)
 1.11A 2v57C-4az7A:
undetectable		 2v57C-4az7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YK1_H_NCTH300_1
(FAB FRAGMENT, HEAVY
CHAIN
FAB FRAGMENT, LIGHT
CHAIN)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		5 / 10 ILE A 372
VAL A 390
TRP A 373
GLU A 392
TYR A 212
 None
None
LOG  A 702 ( 3.9A)
None
None
 1.39A 2yk1H-5bxpA:
undetectable
2yk1L-5bxpA:
undetectable		 2yk1H-5bxpA:
14.31
2yk1L-5bxpA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 8 HIS A 316
GLY A 318
ASN A 259
TRP A 465
 None
None
GAL  A 701 (-4.0A)
LOG  A 702 (-3.8A)
 1.23A 3ccfA-5bxpA:
undetectable		 3ccfA-5bxpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		6 / 12 ARG A 196
ASP A 226
HIS A 297
ASP A 360
TRP A 439
TYR A 469
 LOG  A1614 (-2.8A)
None
LOG  A1614 (-4.1A)
LOG  A1614 (-3.9A)
LOG  A1614 (-3.4A)
LOG  A1614 (-4.3A)
 0.81A 3lmyA-4az7A:
27.2		 3lmyA-4az7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		6 / 12 ARG A 196
HIS A 297
ASP A 360
TRP A 439
TYR A 469
TRP A 517
 LOG  A1614 (-2.8A)
LOG  A1614 (-4.1A)
LOG  A1614 (-3.9A)
LOG  A1614 (-3.4A)
LOG  A1614 (-4.3A)
LOG  A1614 (-3.8A)
 0.50A 3lmyA-4az7A:
27.2		 3lmyA-4az7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 HIS A 263
ASP A 320
TRP A 394
TYR A 419
TRP A 465
 GAL  A 701 (-3.5A)
GAL  A 701 (-3.0A)
LOG  A 702 (-3.5A)
LOG  A 702 (-4.4A)
LOG  A 702 (-3.8A)
 0.49A 3lmyA-5bxpA:
31.4		 3lmyA-5bxpA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		7 / 12 ARG A 196
ASP A 226
HIS A 297
ASP A 360
GLU A 361
TRP A 439
TYR A 469
 LOG  A1614 (-2.8A)
None
LOG  A1614 (-4.1A)
LOG  A1614 (-3.9A)
LOG  A1614 (-3.0A)
LOG  A1614 (-3.4A)
LOG  A1614 (-4.3A)
 0.83A 3lmyB-4az7A:
27.3		 3lmyB-4az7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 196
ASP A 226
HIS A 297
GLU A 361
TYR A 482
 LOG  A1614 (-2.8A)
None
LOG  A1614 (-4.1A)
LOG  A1614 (-3.0A)
LOG  A1614 (-4.4A)
 1.44A 3lmyB-4az7A:
27.3		 3lmyB-4az7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		7 / 12 ARG A 196
HIS A 297
ASP A 360
GLU A 361
TRP A 439
TYR A 469
TRP A 517
 LOG  A1614 (-2.8A)
LOG  A1614 (-4.1A)
LOG  A1614 (-3.9A)
LOG  A1614 (-3.0A)
LOG  A1614 (-3.4A)
LOG  A1614 (-4.3A)
LOG  A1614 (-3.8A)
 0.57A 3lmyB-4az7A:
27.3		 3lmyB-4az7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		7 / 12 HIS A 263
ASP A 320
GLU A 321
TRP A 373
TRP A 394
TYR A 419
TRP A 465
 GAL  A 701 (-3.5A)
GAL  A 701 (-3.0A)
LOG  A 702 (-3.1A)
LOG  A 702 ( 3.9A)
LOG  A 702 (-3.5A)
LOG  A 702 (-4.4A)
LOG  A 702 (-3.8A)
 0.57A 3lmyB-5bxpA:
31.3		 3lmyB-5bxpA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 7 ASP A 519
ASP A 193
ASP A 299
ASN A 225
 LOG  A1614 (-2.8A)
None
None
LOG  A1614 ( 4.2A)
 1.09A 4feuB-4az7A:
undetectable		 4feuB-4az7A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		3 / 3 ASN A 364
ASP A 360
ASP A 193
 None
LOG  A1614 (-3.9A)
None
 0.66A 4obwD-4az7A:
undetectable		 4obwD-4az7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 GLY A 318
TRP A 465
GLN A 416
TYR A 427
 None
LOG  A 702 (-3.8A)
None
LOG  A 702 (-4.5A)
 1.21A 5vlmG-5bxpA:
undetectable		 5vlmG-5bxpA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 GLU A 216
TRP A 465
HIS A 316
 GAL  A 701 (-2.8A)
LOG  A 702 (-3.8A)
None
 0.58A 5xipA-5bxpA:
3.0		 5xipA-5bxpA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 5 ASN A 364
GLY A 195
HIS A 297
ASP A 360
 None
None
LOG  A1614 (-4.1A)
LOG  A1614 (-3.9A)
 0.91A 6gh9A-4az7A:
undetectable		 6gh9A-4az7A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 5 ASN A 364
GLY A 227
HIS A 297
ASP A 360
 None
None
LOG  A1614 (-4.1A)
LOG  A1614 (-3.9A)
 0.89A 6gh9A-4az7A:
undetectable		 6gh9A-4az7A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 ASP A 467
GLU A 321
ASP A 320
GLU A 257
 LOG  A 702 (-2.9A)
LOG  A 702 (-3.1A)
GAL  A 701 (-3.0A)
None
 1.23A 6mn5A-5bxpA:
undetectable		 6mn5A-5bxpA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 ASP A 467
GLU A 321
ASP A 320
GLU A 257
 LOG  A 702 (-2.9A)
LOG  A 702 (-3.1A)
GAL  A 701 (-3.0A)
None
 1.32A 6mn5C-5bxpA:
undetectable		 6mn5C-5bxpA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5bxp LACTO-N-BIOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 ASP A 467
GLU A 321
ASP A 320
GLU A 257
 LOG  A 702 (-2.9A)
LOG  A 702 (-3.1A)
GAL  A 701 (-3.0A)
None
 1.36A 6mn5D-5bxpA:
undetectable		 6mn5D-5bxpA:
7.63