SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LOC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 5nkn NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 10 PHE A 134
THR A 136
LEU A  94
THR A  54
VAL A  33
 LOC  A 201 (-3.8A)
LOC  A 201 (-3.5A)
None
LOC  A 201 ( 4.6A)
None
 1.38A 1o76A-5nknA:
undetectable		 1o76A-5nknA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5nkn NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		4 / 8 LEU A 144
THR A 136
LEU A 148
VAL A 121
 None
LOC  A 201 (-3.5A)
None
None
 0.93A 1sn5C-5nknA:
undetectable		 1sn5C-5nknA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 5nkn NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		4 / 7 LEU A 144
THR A 136
LEU A 148
VAL A 121
 None
LOC  A 201 (-3.5A)
None
None
 0.93A 1tyrB-5nknA:
undetectable		 1tyrB-5nknA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 5nkn NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		4 / 6 VAL A 167
PHE A 134
ARG A  43
ARG A 154
 None
LOC  A 201 (-3.8A)
None
None
 1.08A 3bjwF-5nknA:
undetectable		 3bjwF-5nknA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 5nkn NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		4 / 8 LEU A 144
THR A 136
LEU A 148
VAL A 121
 None
LOC  A 201 (-3.5A)
None
None
 0.96A 4ik6B-5nknA:
undetectable		 4ik6B-5nknA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5nkn NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 9 PHE A 134
THR A 136
LEU A  94
THR A  54
VAL A  33
 LOC  A 201 (-3.8A)
LOC  A 201 (-3.5A)
None
LOC  A 201 ( 4.6A)
None
 1.35A 5cp4A-5nknA:
undetectable		 5cp4A-5nknA:
undetectable