SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LMZ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1c41 LUMAZINE SYNTHASE
(Magnaporthe
grisea) 		8 / 12 TRP A  25
GLY A  58
SER A  59
TRP A  60
GLU A  61
LEU A 120
HIS A 127
ILE A 131
 LMZ  A 201 (-3.5A)
LMZ  A 201 (-2.9A)
LMZ  A 201 (-2.5A)
None
LMZ  A 201 (-2.6A)
LMZ  A 201 (-3.8A)
LMZ  A 201 ( 3.8A)
LMZ  A 201 (-4.3A)
 0.62A 1kyvA-1c41A:
26.7
1kyvE-1c41A:
27.6		 1kyvA-1c41A:
47.50
1kyvE-1c41A:
47.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1c41 LUMAZINE SYNTHASE
(Magnaporthe
grisea) 		7 / 11 TRP A  25
GLY A  58
SER A  59
TRP A  60
GLU A  61
LEU A 120
HIS A 127
 LMZ  A 201 (-3.5A)
LMZ  A 201 (-2.9A)
LMZ  A 201 (-2.5A)
None
LMZ  A 201 (-2.6A)
LMZ  A 201 (-3.8A)
LMZ  A 201 ( 3.8A)
 0.47A 1kyvA-1c41A:
26.7
1kyvB-1c41A:
26.7		 1kyvA-1c41A:
47.50
1kyvB-1c41A:
47.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1c41 LUMAZINE SYNTHASE
(Magnaporthe
grisea) 		8 / 12 TRP A  25
GLY A  58
SER A  59
TRP A  60
GLU A  61
LEU A 120
HIS A 127
ILE A 131
 LMZ  A 201 (-3.5A)
LMZ  A 201 (-2.9A)
LMZ  A 201 (-2.5A)
None
LMZ  A 201 (-2.6A)
LMZ  A 201 (-3.8A)
LMZ  A 201 ( 3.8A)
LMZ  A 201 (-4.3A)
 0.59A 1kyvB-1c41A:
26.7
1kyvC-1c41A:
27.1		 1kyvB-1c41A:
47.50
1kyvC-1c41A:
47.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1c41 LUMAZINE SYNTHASE
(Magnaporthe
grisea) 		8 / 12 TRP A  25
GLY A  58
SER A  59
TRP A  60
GLU A  61
LEU A 120
HIS A 127
ILE A 131
 LMZ  A 201 (-3.5A)
LMZ  A 201 (-2.9A)
LMZ  A 201 (-2.5A)
None
LMZ  A 201 (-2.6A)
LMZ  A 201 (-3.8A)
LMZ  A 201 ( 3.8A)
LMZ  A 201 (-4.3A)
 0.60A 1kyvC-1c41A:
27.1
1kyvD-1c41A:
26.7		 1kyvC-1c41A:
47.50
1kyvD-1c41A:
47.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1c41 LUMAZINE SYNTHASE
(Magnaporthe
grisea) 		8 / 12 TRP A  25
GLY A  58
SER A  59
TRP A  60
GLU A  61
LEU A 120
HIS A 127
ILE A 131
 LMZ  A 201 (-3.5A)
LMZ  A 201 (-2.9A)
LMZ  A 201 (-2.5A)
None
LMZ  A 201 (-2.6A)
LMZ  A 201 (-3.8A)
LMZ  A 201 ( 3.8A)
LMZ  A 201 (-4.3A)
 0.59A 1kyvD-1c41A:
26.7
1kyvE-1c41A:
27.6		 1kyvD-1c41A:
47.50
1kyvE-1c41A:
47.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1c41 LUMAZINE SYNTHASE
(Magnaporthe
grisea) 		6 / 11 GLY A  58
SER A  59
TRP A  60
GLU A  61
LEU A 120
HIS A 127
 LMZ  A 201 (-2.9A)
LMZ  A 201 (-2.5A)
None
LMZ  A 201 (-2.6A)
LMZ  A 201 (-3.8A)
LMZ  A 201 ( 3.8A)
 0.49A 2a58A-1c41A:
26.5
2a58E-1c41A:
26.5		 2a58A-1c41A:
47.00
2a58E-1c41A:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1c41 LUMAZINE SYNTHASE
(Magnaporthe
grisea) 		6 / 12 GLY A  58
SER A  59
TRP A  60
GLU A  61
LEU A 120
HIS A 127
 LMZ  A 201 (-2.9A)
LMZ  A 201 (-2.5A)
None
LMZ  A 201 (-2.6A)
LMZ  A 201 (-3.8A)
LMZ  A 201 ( 3.8A)
 0.48A 2a58A-1c41A:
26.5
2a58B-1c41A:
26.4		 2a58A-1c41A:
47.00
2a58B-1c41A:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1c41 LUMAZINE SYNTHASE
(Magnaporthe
grisea) 		6 / 12 GLY A  58
SER A  59
TRP A  60
GLU A  61
LEU A 120
HIS A 127
 LMZ  A 201 (-2.9A)
LMZ  A 201 (-2.5A)
None
LMZ  A 201 (-2.6A)
LMZ  A 201 (-3.8A)
LMZ  A 201 ( 3.8A)
 0.48A 2a58B-1c41A:
26.4
2a58C-1c41A:
26.5		 2a58B-1c41A:
47.00
2a58C-1c41A:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1c41 LUMAZINE SYNTHASE
(Magnaporthe
grisea) 		6 / 11 GLY A  58
SER A  59
TRP A  60
GLU A  61
LEU A 120
HIS A 127
 LMZ  A 201 (-2.9A)
LMZ  A 201 (-2.5A)
None
LMZ  A 201 (-2.6A)
LMZ  A 201 (-3.8A)
LMZ  A 201 ( 3.8A)
 0.49A 2a58C-1c41A:
26.5
2a58D-1c41A:
26.5		 2a58C-1c41A:
47.00
2a58D-1c41A:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1c41 LUMAZINE SYNTHASE
(Magnaporthe
grisea) 		6 / 12 GLY A  58
SER A  59
TRP A  60
GLU A  61
LEU A 120
HIS A 127
 LMZ  A 201 (-2.9A)
LMZ  A 201 (-2.5A)
None
LMZ  A 201 (-2.6A)
LMZ  A 201 (-3.8A)
LMZ  A 201 ( 3.8A)
 0.49A 2a58D-1c41A:
26.5
2a58E-1c41A:
26.5		 2a58D-1c41A:
47.00
2a58E-1c41A:
47.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 1c2y PROTEIN (LUMAZINE
SYNTHASE)
(Spinacia
oleracea) 		5 / 9 ALA A  56
ALA A  21
LEU A  31
SER A  97
VAL A 100
 LMZ  A 201 (-3.1A)
LMZ  A 201 ( 3.8A)
None
None
None
 1.28A 4or0A-1c2yA:
undetectable		 4or0A-1c2yA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1c2y PROTEIN (LUMAZINE
SYNTHASE)
(Spinacia
oleracea) 		5 / 11 ALA A 137
GLY A  34
GLU A  33
GLY A  79
ASN A 134
 None
None
None
LMZ  A 201 ( 4.9A)
None
 1.17A 5ayfA-1c2yA:
undetectable		 5ayfA-1c2yA:
21.11