SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LMT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 2np5 TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 11 LEU A  61
LEU A 154
MET A 106
LEU A  68
ILE A 130
 None
None
None
None
LMT  A 204 ( 4.8A)
 1.38A 1ee2B-2np5A:
undetectable		 1ee2B-2np5A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		5 / 9 GLY A 359
ALA A 384
THR A 405
THR A 364
SER A 149
 LMT  A1002 ( 3.9A)
None
None
None
None
 1.38A 1gtnR-5i6cA:
undetectable
1gtnS-5i6cA:
undetectable		 1gtnR-5i6cA:
8.03
1gtnS-5i6cA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2np5 TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 12 LEU A 152
LEU A 134
ALA A  88
MET A  89
GLN A 183
 None
LMT  A 204 ( 4.8A)
LMT  A 204 (-3.5A)
None
None
 1.25A 1kt4A-2np5A:
undetectable		 1kt4A-2np5A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		5 / 12 GLY A  13
GLY A  11
ILE A 398
LEU A 407
PRO A 415
 FAD  A 441 (-3.4A)
FAD  A 441 (-3.3A)
None
LMT  A 600 ( 4.9A)
None
 0.99A 1p91B-3hyvA:
3.0		 1p91B-3hyvA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 404
VAL A1005
GLY A 983
ALA A 347
LEU A 376
 None
None
None
None
LMT  A1101 ( 4.4A)
 1.03A 1r9oA-3w9iA:
undetectable		 1r9oA-3w9iA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		4 / 7 PHE B  35
ILE B 129
ILE B 189
THR B 197
 None
None
LMT  B 302 ( 4.6A)
None
 0.94A 1sbrB-4mkiB:
undetectable		 1sbrB-4mkiB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 8 GLU A 240
HIS A 383
ASP A 324
HIS A 378
GLU A 114
 ZN  A 603 (-1.8A)
LMT  A 602 ( 4.7A)
None
None
LMT  A 602 (-2.9A)
 1.46A 1v7zA-5fgnA:
undetectable		 1v7zA-5fgnA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 8 GLU A 240
HIS A 383
ASP A 324
HIS A 378
GLU A 114
 ZN  A 603 (-1.8A)
LMT  A 602 ( 4.7A)
None
None
LMT  A 602 (-2.9A)
 1.45A 1v7zB-5fgnA:
undetectable		 1v7zB-5fgnA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 8 GLU A 240
HIS A 383
ASP A 324
HIS A 378
GLU A 114
 ZN  A 603 (-1.8A)
LMT  A 602 ( 4.7A)
None
None
LMT  A 602 (-2.9A)
 1.46A 1v7zC-5fgnA:
undetectable		 1v7zC-5fgnA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 8 GLU A 240
HIS A 383
ASP A 324
HIS A 378
GLU A 114
 ZN  A 603 (-1.8A)
LMT  A 602 ( 4.7A)
None
None
LMT  A 602 (-2.9A)
 1.45A 1v7zF-5fgnA:
undetectable		 1v7zF-5fgnA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		5 / 12 SER A 297
PHE A 276
GLY A 454
ILE A 272
THR A 457
 LMT  A1003 ( 4.9A)
None
None
None
None
 1.28A 3a25A-5i6cA:
undetectable		 3a25A-5i6cA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 8 GLU A 240
HIS A 383
ASP A 324
HIS A 378
GLU A 114
 ZN  A 603 (-1.8A)
LMT  A 602 ( 4.7A)
None
None
LMT  A 602 (-2.9A)
 1.46A 3a6jA-5fgnA:
undetectable		 3a6jA-5fgnA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 7 GLU A 240
HIS A 383
ASP A 324
HIS A 378
GLU A 114
 ZN  A 603 (-1.8A)
LMT  A 602 ( 4.7A)
None
None
LMT  A 602 (-2.9A)
 1.47A 3a6jB-5fgnA:
undetectable		 3a6jB-5fgnA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 8 GLU A 240
HIS A 383
ASP A 324
HIS A 378
GLU A 114
 ZN  A 603 (-1.8A)
LMT  A 602 ( 4.7A)
None
None
LMT  A 602 (-2.9A)
 1.47A 3a6jF-5fgnA:
undetectable		 3a6jF-5fgnA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 12 LEU A 102
GLY A 304
VAL A 309
ALA A 300
LEU A 263
 LMT  A 802 ( 4.1A)
LMT  A 806 ( 4.5A)
None
None
None
 0.92A 3dh0A-4r0cA:
undetectable		 3dh0A-4r0cA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 12 LEU A 102
GLY A 304
VAL A 309
ALA A 300
LEU A 263
 LMT  A 802 ( 4.1A)
LMT  A 806 ( 4.5A)
None
None
None
 0.94A 3dh0B-4r0cA:
undetectable		 3dh0B-4r0cA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 VAL A 193
LYS A 196
HIS A 302
 ST9  A 403 (-4.8A)
LMT  A 404 (-3.5A)
ZN  A 402 (-3.5A)
 0.86A 3elzA-4zyoA:
undetectable		 3elzA-4zyoA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 376
GLY A 403
ASP A 407
ASP A 408
THR A 379
 LMT  A1101 ( 4.4A)
None
None
None
None
 1.01A 3gguB-3w9iA:
undetectable		 3gguB-3w9iA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 6bms PALMITOYLTRANSFERASE
(Danio
rerio) 		4 / 7 TYR A  59
LEU A 214
PHE A 207
VAL A 203
 None
LMT  A1003 (-4.4A)
PLM  A1006 (-4.1A)
PLM  A1006 (-4.7A)
 1.14A 3jwqC-6bmsA:
undetectable		 3jwqC-6bmsA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		4 / 8 ILE B 186
LEU B 183
LYS B  46
MET B 204
 LMT  B 302 ( 4.5A)
None
SO4  B 301 (-2.7A)
None
 1.05A 3selX-4mkiB:
undetectable		 3selX-4mkiB:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		4 / 8 SER A 325
ASP A 452
GLU A 352
GLU A 389
 LMT  A 602 (-3.3A)
ZN  A 603 (-2.3A)
None
None
 1.06A 3sg9B-5fgnA:
undetectable		 3sg9B-5fgnA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		4 / 8 ASP A 134
MET A 327
VAL A 329
THR A 330
 None
LMT  A 806 ( 4.4A)
None
None
 1.05A 4lnwA-4r0cA:
undetectable		 4lnwA-4r0cA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 376
GLY A 403
ASP A 407
ASP A 408
THR A 379
 LMT  A1101 ( 4.4A)
None
None
None
None
 1.06A 4njtD-3w9iA:
undetectable		 4njtD-3w9iA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 376
PHE A 380
ILE A 402
GLY A 397
VAL A 340
 LMT  A1101 ( 4.4A)
LMT  A1101 ( 4.5A)
None
None
None
 1.07A 4nkvA-3w9iA:
undetectable		 4nkvA-3w9iA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6eu6 AMMONIUM TRANSPORTER
(Candidatus
Kuenenia
stuttgartiensis) 		5 / 12 LEU A 382
ALA A 181
PHE A 379
ILE A 125
GLY A 120
 None
None
None
None
LMT  A 504 (-3.7A)
 1.07A 4nkvA-6eu6A:
undetectable		 4nkvA-6eu6A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 376
PHE A 380
ILE A 402
GLY A 397
VAL A 340
 LMT  A1101 ( 4.4A)
LMT  A1101 ( 4.5A)
None
None
None
 1.04A 4nkvC-3w9iA:
undetectable		 4nkvC-3w9iA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6eu6 AMMONIUM TRANSPORTER
(Candidatus
Kuenenia
stuttgartiensis) 		5 / 12 LEU A 382
ALA A 181
PHE A 379
ILE A 125
GLY A 120
 None
None
None
None
LMT  A 504 (-3.7A)
 1.04A 4nkvC-6eu6A:
undetectable		 4nkvC-6eu6A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 376
PHE A 380
ILE A 402
GLY A 397
VAL A 340
 LMT  A1101 ( 4.4A)
LMT  A1101 ( 4.5A)
None
None
None
 1.05A 4nkvD-3w9iA:
2.3		 4nkvD-3w9iA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6eu6 AMMONIUM TRANSPORTER
(Candidatus
Kuenenia
stuttgartiensis) 		5 / 12 LEU A 382
ALA A 181
PHE A 379
ILE A 125
GLY A 120
 None
None
None
None
LMT  A 504 (-3.7A)
 1.04A 4nkvD-6eu6A:
undetectable		 4nkvD-6eu6A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3cay LPD-12
(-) 		4 / 4 ALA A  10
ALA A  13
ALA A  14
ALA A  17
 None
O12  A  24 ( 3.6A)
LMT  A 512 ( 3.7A)
O12  A  24 ( 3.9A)
 0.12A 4oadA-3cayA:
undetectable		 4oadA-3cayA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3cay LPD-12
(-) 		4 / 4 ALA A  10
ALA A  13
ALA A  14
ALA A  17
 None
O12  A  24 ( 3.6A)
LMT  A 512 ( 3.7A)
O12  A  24 ( 3.9A)
 0.10A 4oaeA-3cayA:
undetectable		 4oaeA-3cayA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 6eu6 AMMONIUM TRANSPORTER
(Candidatus
Kuenenia
stuttgartiensis) 		4 / 6 LEU A 399
VAL A 390
ARG A  46
PHE A 121
 SO4  A 507 ( 3.7A)
LMT  A 504 ( 4.2A)
SO4  A 507 (-3.6A)
SO4  A 507 ( 4.5A)
 1.25A 4uswA-6eu6A:
undetectable		 4uswA-6eu6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 6bms PALMITOYLTRANSFERASE
(Danio
rerio) 		5 / 10 GLY A 151
THR A 228
VAL A 150
HIS A 218
LEU A 221
 None
LMT  A1003 (-4.3A)
None
None
None
 1.25A 4yb6A-6bmsA:
undetectable
4yb6E-6bmsA:
undetectable		 4yb6A-6bmsA:
undetectable
4yb6E-6bmsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 6bms PALMITOYLTRANSFERASE
(Danio
rerio) 		5 / 10 GLY A 151
THR A 228
VAL A 150
HIS A 218
LEU A 221
 None
LMT  A1003 (-4.3A)
None
None
None
 1.26A 4yb6B-6bmsA:
undetectable
4yb6C-6bmsA:
undetectable		 4yb6B-6bmsA:
undetectable
4yb6C-6bmsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 6bms PALMITOYLTRANSFERASE
(Danio
rerio) 		5 / 10 GLY A 151
THR A 228
VAL A 150
HIS A 218
LEU A 221
 None
LMT  A1003 (-4.3A)
None
None
None
 1.25A 4yb6C-6bmsA:
undetectable
4yb6F-6bmsA:
undetectable		 4yb6C-6bmsA:
undetectable
4yb6F-6bmsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 6bms PALMITOYLTRANSFERASE
(Danio
rerio) 		5 / 10 GLY A 151
VAL A 150
THR A 228
HIS A 218
LEU A 221
 None
None
LMT  A1003 (-4.3A)
None
None
 1.36A 4yb6C-6bmsA:
undetectable
4yb6F-6bmsA:
undetectable		 4yb6C-6bmsA:
undetectable
4yb6F-6bmsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 6bms PALMITOYLTRANSFERASE
(Danio
rerio) 		5 / 10 HIS A 218
LEU A 221
GLY A 151
THR A 228
VAL A 150
 None
None
None
LMT  A1003 (-4.3A)
None
 1.26A 4yb6A-6bmsA:
undetectable
4yb6D-6bmsA:
undetectable		 4yb6A-6bmsA:
undetectable
4yb6D-6bmsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 6bms PALMITOYLTRANSFERASE
(Danio
rerio) 		5 / 10 HIS A 218
LEU A 221
GLY A 151
VAL A 150
THR A 228
 None
None
None
None
LMT  A1003 (-4.3A)
 1.34A 4yb6A-6bmsA:
undetectable
4yb6D-6bmsA:
undetectable		 4yb6A-6bmsA:
undetectable
4yb6D-6bmsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 6bms PALMITOYLTRANSFERASE
(Danio
rerio) 		5 / 10 HIS A 218
LEU A 221
GLY A 151
THR A 228
VAL A 150
 None
None
None
LMT  A1003 (-4.3A)
None
 1.26A 4yb6D-6bmsA:
undetectable
4yb6E-6bmsA:
undetectable		 4yb6D-6bmsA:
undetectable
4yb6E-6bmsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 6bms PALMITOYLTRANSFERASE
(Danio
rerio) 		5 / 10 HIS A 218
LEU A 221
GLY A 151
THR A 228
VAL A 150
 None
None
None
LMT  A1003 (-4.3A)
None
 1.26A 4yb6B-6bmsA:
undetectable
4yb6F-6bmsA:
undetectable		 4yb6B-6bmsA:
undetectable
4yb6F-6bmsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		5 / 12 SER A 325
SER A 102
GLU A 298
GLU A 322
GLY A 329
 LMT  A 602 (-3.3A)
None
None
None
None
 1.46A 4zjlA-5fgnA:
undetectable		 4zjlA-5fgnA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5kn7 LIPID A BIOSYNTHESIS
LAUROYL
ACYLTRANSFERASE
(Acinetobacter
baumannii) 		4 / 8 PRO B 121
PHE B 123
TRP B 126
TYR B  79
 None
None
GOL  B 409 (-4.6A)
LMT  B 415 (-3.8A)
 1.32A 5amkA-5kn7B:
undetectable		 5amkA-5kn7B:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4r0c ABGT PUTATIVE
TRANSPORTER FAMILY
(Alcanivorax
borkumensis) 		5 / 12 GLY A 307
GLY A  94
GLY A 304
THR A 330
GLU A  97
 None
None
LMT  A 806 ( 4.5A)
None
None
 1.01A 5eiwA-4r0cA:
undetectable		 5eiwA-4r0cA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5yua ION TRANSPORT
PROTEIN
(Arcobacter
butzleri) 		4 / 6 PHE A1201
PRO A1200
THR A1206
ILE A1202
 None
None
LMT  A1302 (-4.2A)
None
 1.29A 5ih0A-5yuaA:
undetectable		 5ih0A-5yuaA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 5 ILE A  27
ILE A 337
HIS A 338
VAL A 341
 LMT  A1101 (-4.0A)
None
None
LMT  A1101 (-4.9A)
 0.83A 5jmnA-3w9iA:
54.6		 5jmnA-3w9iA:
69.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5v6n PROTON-GATED ION
CHANNEL
(Gloeobacter
violaceus) 		5 / 10 ILE C 236
ILE C 240
GLU C 243
ILE C 259
TYR C 263
 LMT  C 401 ( 4.5A)
LMT  C 401 (-3.9A)
None
None
None
 0.43A 5mvmD-5v6nC:
36.2
5mvmE-5v6nC:
36.2		 5mvmD-5v6nC:
97.26
5mvmE-5v6nC:
97.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A
(Neisseria
meningitidis) 		4 / 8 ILE A  84
GLN A  91
TYR A 123
VAL A 107
 LMT  A 602 (-3.9A)
LMT  A 602 (-2.8A)
None
LMT  A 602 ( 4.8A)
 1.08A 5vlmF-5fgnA:
undetectable		 5vlmF-5fgnA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		5 / 12 LEU B 243
GLN B  90
ILE B 182
LEU B 183
ILE B 207
 None
None
LMT  B 302 ( 4.0A)
None
None
 1.19A 5y2tB-4mkiB:
undetectable		 5y2tB-4mkiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 5v8k P800 REACTION CENTER
CORE PROTEIN
(Heliobacterium
modesticaldum) 		5 / 6 GLY A  77
ASP A  79
GLY A 150
PRO A 151
GLY A 153
 None
LMT  A1034 (-2.7A)
None
None
None
 1.49A 6ag0C-5v8kA:
undetectable		 6ag0C-5v8kA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 3t2y SULFIDE-QUINONE
REDUCTASE, PUTATIVE
(Acidithiobacillu
s
ferrooxidans) 		4 / 4 MET A 360
GLY A 361
HIS A 388
GLY A 364
 LMT  A 501 ( 3.7A)
None
None
None
 0.96A 6fgdA-3t2yA:
4.8		 6fgdA-3t2yA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 5yua ION TRANSPORT
PROTEIN
(Arcobacter
butzleri) 		4 / 6 MET A1174
THR A1175
LEU A1176
MET A1209
 LMT  A1302 (-3.1A)
LMT  A1302 (-4.9A)
LMT  A1302 (-4.4A)
LMT  A1302 (-4.3A)
 0.41A 6mvxA-5yuaA:
21.9
6mvxB-5yuaA:
19.6
6mvxC-5yuaA:
18.2		 6mvxA-5yuaA:
undetectable
6mvxB-5yuaA:
undetectable
6mvxC-5yuaA:
undetectable