SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LLX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 11 HIS A 146
HIS A 183
ASP A 269
LEU A 276
TYR A 308
 LLX  A 400 (-3.8A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.3A)
LLX  A 400 (-4.4A)
 0.98A 1c3sA-3maxA:
48.5		 1c3sA-3maxA:
34.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		10 / 11 PRO A  34
HIS A 145
HIS A 146
PHE A 155
ASP A 181
HIS A 183
PHE A 210
ASP A 269
LEU A 276
TYR A 308
 None
LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.3A)
LLX  A 400 (-4.4A)
 0.50A 1c3sA-3maxA:
48.5		 1c3sA-3maxA:
34.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		4 / 6 GLN A 265
TYR A 177
ASP A 181
GLY A 185
 LLX  A 400 ( 4.8A)
None
ZN  A 379 (-2.3A)
None
 1.22A 1ekjC-3maxA:
undetectable
1ekjD-3maxA:
undetectable		 1ekjC-3maxA:
21.45
1ekjD-3maxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		4 / 6 ASP A 181
GLY A 185
GLN A 265
TYR A 177
 ZN  A 379 (-2.3A)
None
LLX  A 400 ( 4.8A)
None
 1.19A 1ekjC-3maxA:
undetectable
1ekjD-3maxA:
undetectable		 1ekjC-3maxA:
21.45
1ekjD-3maxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 ILE A 310
ASP A 274
ALA A 287
GLY A 306
LEU A 264
 None
None
None
LLX  A 400 (-3.7A)
None
 1.09A 1kiaC-3maxA:
3.1		 1kiaC-3maxA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 9 GLY A 154
PRO A  34
GLY A 306
GLY A 307
ASP A 269
 LLX  A 400 (-3.6A)
None
LLX  A 400 (-3.7A)
None
ZN  A 379 ( 2.5A)
 1.07A 1mxdA-3maxA:
undetectable		 1mxdA-3maxA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 11 GLY A 154
PRO A  34
GLY A 306
GLY A 307
ASP A 269
 LLX  A 400 (-3.6A)
None
LLX  A 400 (-3.7A)
None
ZN  A 379 ( 2.5A)
 1.06A 1mxgA-3maxA:
undetectable		 1mxgA-3maxA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		4 / 7 TYR A  18
TRP A 140
HIS A 286
GLY A 306
 None
None
None
LLX  A 400 (-3.7A)
 1.04A 1mxgA-3maxA:
undetectable		 1mxgA-3maxA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 ASP A 274
LEU A 276
HIS A  38
 None
LLX  A 400 (-4.3A)
None
 0.78A 1qknA-3maxA:
undetectable		 1qknA-3maxA:
20.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		10 / 12 ASP A 104
HIS A 145
HIS A 146
GLY A 154
PHE A 155
ASP A 181
HIS A 183
PHE A 210
ASP A 269
TYR A 308
 None
LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-3.6A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.4A)
 0.35A 1t69A-3maxA:
55.9		 1t69A-3maxA:
41.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 TYR A 157
HIS A 145
HIS A 183
ASP A 269
TYR A 308
 None
LLX  A 400 (-4.0A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.4A)
 1.48A 1t69A-3maxA:
55.9		 1t69A-3maxA:
41.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.73A 1v54A-3maxA:
undetectable		 1v54A-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.75A 1v54N-3maxA:
undetectable		 1v54N-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.74A 1v55N-3maxA:
undetectable		 1v55N-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 11 HIS A 145
HIS A 146
ASP A 181
ASP A 269
GLY A 267
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
ZN  A 379 (-2.3A)
ZN  A 379 ( 2.5A)
None
 1.16A 1zz1A-3maxA:
44.5		 1zz1A-3maxA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 11 HIS A 145
HIS A 146
ASP A 181
PHE A 210
GLY A 305
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
ZN  A 379 (-2.3A)
LLX  A 400 (-3.6A)
LLX  A 400 (-3.5A)
 0.92A 1zz1A-3maxA:
44.5		 1zz1A-3maxA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		9 / 11 HIS A 145
HIS A 146
PHE A 155
ASP A 181
HIS A 183
PHE A 210
ASP A 269
GLY A 306
TYR A 308
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 0.57A 1zz1A-3maxA:
44.5		 1zz1A-3maxA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 HIS A 145
HIS A 146
ASP A 181
ASP A 269
GLY A 267
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
ZN  A 379 (-2.3A)
ZN  A 379 ( 2.5A)
None
 1.19A 1zz1B-3maxA:
44.8
1zz1C-3maxA:
44.6		 1zz1B-3maxA:
25.25
1zz1C-3maxA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		9 / 12 HIS A 145
HIS A 146
PHE A 155
ASP A 181
HIS A 183
PHE A 210
ASP A 269
GLY A 306
TYR A 308
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 0.49A 1zz1B-3maxA:
44.8
1zz1C-3maxA:
44.6		 1zz1B-3maxA:
25.25
1zz1C-3maxA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		9 / 12 HIS A 145
HIS A 146
GLY A 154
ASP A 181
HIS A 183
PHE A 210
ASP A 269
GLY A 306
TYR A 308
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-3.6A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 0.57A 1zz1C-3maxA:
44.6		 1zz1C-3maxA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_D_SHHD2752_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		8 / 9 HIS A 145
HIS A 146
PHE A 155
ASP A 181
HIS A 183
PHE A 210
ASP A 269
TYR A 308
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.4A)
 0.56A 1zz1D-3maxA:
44.6		 1zz1D-3maxA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.73A 2dyrA-3maxA:
undetectable		 2dyrA-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.75A 2dyrN-3maxA:
undetectable		 2dyrN-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.75A 2dysN-3maxA:
undetectable		 2dysN-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.73A 2eijN-3maxA:
undetectable		 2eijN-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.74A 2eikN-3maxA:
undetectable		 2eikN-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.75A 2eilA-3maxA:
undetectable		 2eilA-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.74A 2eilN-3maxA:
undetectable		 2eilN-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.72A 2eimA-3maxA:
undetectable		 2eimA-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.73A 2y69A-3maxA:
undetectable		 2y69A-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.68A 2y69N-3maxA:
undetectable		 2y69N-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.75A 2zxwA-3maxA:
undetectable		 2zxwA-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.70A 2zxwN-3maxA:
undetectable		 2zxwN-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.75A 3ablA-3maxA:
undetectable		 3ablA-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.76A 3ablN-3maxA:
undetectable		 3ablN-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.76A 3abmA-3maxA:
undetectable		 3abmA-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.68A 3abmN-3maxA:
undetectable		 3abmN-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.71A 3ag1N-3maxA:
undetectable		 3ag1N-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.75A 3ag4N-3maxA:
undetectable		 3ag4N-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.72A 3asnA-3maxA:
undetectable		 3asnA-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.73A 3asnN-3maxA:
undetectable		 3asnN-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.72A 3asoA-3maxA:
undetectable		 3asoA-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.74A 3asoN-3maxA:
undetectable		 3asoN-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 5 HIS A 145
HIS A 146
ASP A 181
HIS A 183
ASP A 269
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
 0.21A 3c0zA-3maxA:
42.2		 3c0zA-3maxA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		4 / 8 HIS A 145
ASP A 181
ASP A 269
GLY A 267
 LLX  A 400 (-4.0A)
ZN  A 379 (-2.3A)
ZN  A 379 ( 2.5A)
None
 0.87A 3c0zB-3maxA:
42.1		 3c0zB-3maxA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 8 HIS A 145
HIS A 146
ASP A 181
PHE A 210
GLY A 305
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
ZN  A 379 (-2.3A)
LLX  A 400 (-3.6A)
LLX  A 400 (-3.5A)
 0.94A 3c0zB-3maxA:
42.1		 3c0zB-3maxA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		8 / 8 HIS A 145
HIS A 146
PHE A 155
ASP A 181
HIS A 183
PHE A 210
ASP A 269
GLY A 306
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
 0.37A 3c0zB-3maxA:
42.1		 3c0zB-3maxA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		4 / 8 PHE A 210
ASP A 269
PHE A 155
ASP A 181
 LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
 0.90A 3c0zB-3maxA:
42.1		 3c0zB-3maxA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		6 / 6 ASP A 104
HIS A 145
HIS A 146
ASP A 181
HIS A 183
ASP A 269
 None
LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
 0.40A 3c0zC-3maxA:
42.3		 3c0zC-3maxA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 8 GLY A 306
GLY A 305
GLY A 143
HIS A 145
ILE A 161
 LLX  A 400 (-3.7A)
LLX  A 400 (-3.5A)
None
LLX  A 400 (-4.0A)
None
 1.27A 3d41A-3maxA:
undetectable		 3d41A-3maxA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.72A 3dtuA-3maxA:
undetectable		 3dtuA-3maxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.73A 3dtuC-3maxA:
undetectable		 3dtuC-3maxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 TYR A 177
ASP A 160
HIS A 146
 None
None
LLX  A 400 (-3.8A)
 0.85A 3e23A-3maxA:
3.4		 3e23A-3maxA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.71A 3wg7A-3maxA:
undetectable		 3wg7A-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.73A 3wg7N-3maxA:
undetectable		 3wg7N-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.68A 3x2qN-3maxA:
undetectable		 3x2qN-3maxA:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 10 HIS A 145
HIS A 146
ASP A 181
ASP A 269
GLY A 267
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
ZN  A 379 (-2.3A)
ZN  A 379 ( 2.5A)
None
 1.33A 4bz6A-3maxA:
52.3		 4bz6A-3maxA:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		7 / 10 HIS A 145
HIS A 146
ASP A 181
HIS A 183
ASP A 269
GLY A 306
TYR A 308
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 0.24A 4bz6A-3maxA:
52.3		 4bz6A-3maxA:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 HIS A 145
HIS A 146
ASP A 181
ASP A 269
GLY A 267
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
ZN  A 379 (-2.3A)
ZN  A 379 ( 2.5A)
None
 1.33A 4bz6A-3maxA:
52.3
4bz6B-3maxA:
52.3		 4bz6A-3maxA:
33.85
4bz6B-3maxA:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		8 / 12 HIS A 145
HIS A 146
ASP A 181
HIS A 183
PHE A 210
ASP A 269
GLY A 306
TYR A 308
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 0.28A 4bz6A-3maxA:
52.3
4bz6B-3maxA:
52.3		 4bz6A-3maxA:
33.85
4bz6B-3maxA:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 HIS A 145
HIS A 146
GLY A 154
ASP A 181
GLY A 305
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-3.6A)
ZN  A 379 (-2.3A)
LLX  A 400 (-3.5A)
 0.82A 4bz6C-3maxA:
52.3		 4bz6C-3maxA:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		9 / 12 HIS A 145
HIS A 146
GLY A 154
ASP A 181
HIS A 183
PHE A 210
ASP A 269
GLY A 306
TYR A 308
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-3.6A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 0.27A 4bz6C-3maxA:
52.3		 4bz6C-3maxA:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 10 HIS A 145
HIS A 146
ASP A 181
ASP A 269
GLY A 267
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
ZN  A 379 (-2.3A)
ZN  A 379 ( 2.5A)
None
 1.32A 4bz6D-3maxA:
52.5		 4bz6D-3maxA:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		7 / 10 HIS A 145
HIS A 146
ASP A 181
HIS A 183
ASP A 269
GLY A 306
TYR A 308
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 0.23A 4bz6D-3maxA:
52.5		 4bz6D-3maxA:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		12 / 12 HIS A  33
PRO A  34
ASP A 104
HIS A 145
HIS A 146
GLY A 154
PHE A 155
ASP A 181
HIS A 183
ASP A 269
GLY A 306
TYR A 308
 None
None
None
LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-3.6A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 0.20A 4lxzA-3maxA:
69.3		 4lxzA-3maxA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 HIS A  33
PRO A  34
ASP A 269
GLY A 307
TYR A 308
 None
None
ZN  A 379 ( 2.5A)
None
LLX  A 400 (-4.4A)
 1.16A 4lxzA-3maxA:
69.3		 4lxzA-3maxA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 HIS A 145
HIS A 146
GLY A 154
ASP A 181
GLY A 305
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-3.6A)
ZN  A 379 (-2.3A)
LLX  A 400 (-3.5A)
 0.81A 4lxzA-3maxA:
69.3		 4lxzA-3maxA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 11 ASP A 104
PHE A 155
HIS A 146
ASP A 181
GLY A 306
 None
LLX  A 400 (-4.1A)
LLX  A 400 (-3.8A)
ZN  A 379 (-2.3A)
LLX  A 400 (-3.7A)
 1.35A 4lxzB-3maxA:
68.2		 4lxzB-3maxA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		11 / 11 HIS A  33
PRO A  34
ASP A 104
HIS A 145
HIS A 146
PHE A 155
ASP A 181
HIS A 183
ASP A 269
GLY A 306
TYR A 308
 None
None
None
LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 0.21A 4lxzB-3maxA:
68.2		 4lxzB-3maxA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 11 HIS A  33
PRO A  34
ASP A 269
GLY A 307
TYR A 308
 None
None
ZN  A 379 ( 2.5A)
None
LLX  A 400 (-4.4A)
 1.15A 4lxzB-3maxA:
68.2		 4lxzB-3maxA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 11 HIS A 145
HIS A 146
ASP A 181
ASP A 269
GLY A 267
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
ZN  A 379 (-2.3A)
ZN  A 379 ( 2.5A)
None
 1.38A 4lxzB-3maxA:
68.2		 4lxzB-3maxA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 HIS A 145
HIS A 146
GLY A 154
ASP A 181
GLY A 305
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-3.6A)
ZN  A 379 (-2.3A)
LLX  A 400 (-3.5A)
 0.82A 4lxzC-3maxA:
67.5		 4lxzC-3maxA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		12 / 12 PRO A  34
ASP A 104
HIS A 145
HIS A 146
GLY A 154
PHE A 155
ASP A 181
HIS A 183
PHE A 210
ASP A 269
GLY A 306
TYR A 308
 None
None
LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-3.6A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 0.24A 4lxzC-3maxA:
67.5		 4lxzC-3maxA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		6 / 12 HIS A 145
HIS A 146
GLY A 154
ASP A 181
PHE A 210
GLY A 305
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-3.6A)
ZN  A 379 (-2.3A)
LLX  A 400 (-3.6A)
LLX  A 400 (-3.5A)
 1.05A 4qa0A-3maxA:
56.6		 4qa0A-3maxA:
40.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		10 / 12 HIS A 145
HIS A 146
GLY A 154
PHE A 155
ASP A 181
HIS A 183
PHE A 210
ASP A 269
GLY A 306
TYR A 308
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-3.6A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 0.34A 4qa0A-3maxA:
56.6		 4qa0A-3maxA:
40.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 11 HIS A 145
HIS A 146
ASP A 181
ASP A 269
GLY A 267
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
ZN  A 379 (-2.3A)
ZN  A 379 ( 2.5A)
None
 1.32A 4qa0B-3maxA:
56.5		 4qa0B-3maxA:
40.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		9 / 11 HIS A 145
HIS A 146
PHE A 155
ASP A 181
HIS A 183
PHE A 210
ASP A 269
GLY A 306
TYR A 308
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 0.28A 4qa0B-3maxA:
56.5		 4qa0B-3maxA:
40.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		6 / 11 HIS A 145
HIS A 146
PHE A 155
ASP A 181
PHE A 210
GLY A 305
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
LLX  A 400 (-3.6A)
LLX  A 400 (-3.5A)
 1.07A 4qa0B-3maxA:
56.5		 4qa0B-3maxA:
40.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 11 HIS A 146
HIS A 183
ASP A 269
GLY A 306
TYR A 308
 LLX  A 400 (-3.8A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 1.02A 4qa0B-3maxA:
56.5		 4qa0B-3maxA:
40.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 11 TYR A 157
HIS A 145
HIS A 183
ASP A 269
TYR A 308
 None
LLX  A 400 (-4.0A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.4A)
 1.45A 4qa0B-3maxA:
56.5		 4qa0B-3maxA:
40.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 GLY A 154
PHE A 155
PHE A 210
ASP A 181
GLY A 305
 LLX  A 400 (-3.6A)
LLX  A 400 (-4.1A)
LLX  A 400 (-3.6A)
ZN  A 379 (-2.3A)
LLX  A 400 (-3.5A)
 1.30A 4qa2A-3maxA:
55.6		 4qa2A-3maxA:
40.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		10 / 12 HIS A 145
HIS A 146
GLY A 154
PHE A 155
ASP A 181
HIS A 183
PHE A 210
ASP A 269
GLY A 306
TYR A 308
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-3.6A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 0.32A 4qa2A-3maxA:
55.6		 4qa2A-3maxA:
40.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		7 / 12 HIS A 145
HIS A 146
GLY A 154
PHE A 155
ASP A 181
PHE A 210
GLY A 305
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-3.6A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
LLX  A 400 (-3.6A)
LLX  A 400 (-3.5A)
 1.05A 4qa2A-3maxA:
55.6		 4qa2A-3maxA:
40.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 HIS A 146
HIS A 183
ASP A 269
GLY A 306
TYR A 308
 LLX  A 400 (-3.8A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 1.02A 4qa2A-3maxA:
55.6		 4qa2A-3maxA:
40.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 PHE A 155
PHE A 210
ASP A 269
GLY A 307
TYR A 308
 LLX  A 400 (-4.1A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
None
LLX  A 400 (-4.4A)
 1.29A 4qa2A-3maxA:
55.6		 4qa2A-3maxA:
40.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 GLY A 154
PHE A 155
PHE A 210
ASP A 181
GLY A 305
 LLX  A 400 (-3.6A)
LLX  A 400 (-4.1A)
LLX  A 400 (-3.6A)
ZN  A 379 (-2.3A)
LLX  A 400 (-3.5A)
 1.27A 4qa2B-3maxA:
56.9		 4qa2B-3maxA:
40.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		10 / 12 HIS A 145
HIS A 146
GLY A 154
PHE A 155
ASP A 181
HIS A 183
PHE A 210
ASP A 269
GLY A 306
TYR A 308
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-3.6A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 0.29A 4qa2B-3maxA:
56.9		 4qa2B-3maxA:
40.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		7 / 12 HIS A 145
HIS A 146
GLY A 154
PHE A 155
ASP A 181
PHE A 210
GLY A 305
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-3.6A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
LLX  A 400 (-3.6A)
LLX  A 400 (-3.5A)
 1.05A 4qa2B-3maxA:
56.9		 4qa2B-3maxA:
40.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 HIS A 146
HIS A 183
ASP A 269
GLY A 306
TYR A 308
 LLX  A 400 (-3.8A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 1.01A 4qa2B-3maxA:
56.9		 4qa2B-3maxA:
40.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.74A 5b1aA-3maxA:
undetectable		 5b1aA-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.76A 5b1aN-3maxA:
undetectable		 5b1aN-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 HIS A 146
HIS A 183
ASP A 269
LEU A 276
TYR A 308
 LLX  A 400 (-3.8A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.3A)
LLX  A 400 (-4.4A)
 1.05A 5eeiA-3maxA:
43.4		 5eeiA-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		11 / 12 PRO A  34
HIS A 145
HIS A 146
GLY A 154
PHE A 155
ASP A 181
HIS A 183
PHE A 210
ASP A 269
LEU A 276
TYR A 308
 None
LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-3.6A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.3A)
LLX  A 400 (-4.4A)
 0.50A 5eeiA-3maxA:
43.4		 5eeiA-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 SER A 153
HIS A 145
HIS A 183
ASP A 269
TYR A 308
 None
LLX  A 400 (-4.0A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.4A)
 1.08A 5eeiA-3maxA:
43.4		 5eeiA-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 HIS A 146
HIS A 183
ASP A 269
LEU A 276
TYR A 308
 LLX  A 400 (-3.8A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.3A)
LLX  A 400 (-4.4A)
 1.04A 5eeiB-3maxA:
43.5		 5eeiB-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		11 / 12 PRO A  34
HIS A 145
HIS A 146
GLY A 154
PHE A 155
ASP A 181
HIS A 183
PHE A 210
ASP A 269
LEU A 276
TYR A 308
 None
LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-3.6A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.3A)
LLX  A 400 (-4.4A)
 0.48A 5eeiB-3maxA:
43.5		 5eeiB-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 SER A 153
HIS A 145
HIS A 183
ASP A 269
TYR A 308
 None
LLX  A 400 (-4.0A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.4A)
 1.06A 5eeiB-3maxA:
43.5		 5eeiB-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 HIS A  33
HIS A 183
ASP A 269
GLY A 307
TYR A 308
 None
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
None
LLX  A 400 (-4.4A)
 1.24A 5eenA-3maxA:
43.7		 5eenA-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		11 / 12 HIS A  33
PRO A  34
HIS A 145
HIS A 146
PHE A 155
ASP A 181
HIS A 183
PHE A 210
ASP A 269
GLY A 306
TYR A 308
 None
None
LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 0.47A 5eenA-3maxA:
43.7		 5eenA-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		6 / 12 HIS A 145
HIS A 146
ASP A 181
HIS A 183
ASP A 269
GLY A 267
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
None
 1.26A 5eenA-3maxA:
43.7		 5eenA-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 HIS A 145
HIS A 146
ASP A 181
PHE A 210
GLY A 305
 LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
ZN  A 379 (-2.3A)
LLX  A 400 (-3.6A)
LLX  A 400 (-3.5A)
 0.91A 5eenA-3maxA:
43.7		 5eenA-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		6 / 12 SER A 153
HIS A 145
HIS A 183
ASP A 269
GLY A 306
TYR A 308
 None
LLX  A 400 (-4.0A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 1.06A 5eenA-3maxA:
43.7		 5eenA-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		6 / 12 SER A 153
HIS A 183
PHE A 210
ASP A 269
GLY A 306
TYR A 308
 None
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-3.7A)
LLX  A 400 (-4.4A)
 1.42A 5eenA-3maxA:
43.7		 5eenA-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 HIS A  33
PRO A  34
ASP A 274
LEU A 276
TYR A 308
 None
None
None
LLX  A 400 (-4.3A)
LLX  A 400 (-4.4A)
 1.40A 5eenB-3maxA:
43.8		 5eenB-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		11 / 12 HIS A  33
PRO A  34
HIS A 145
HIS A 146
PHE A 155
ASP A 181
HIS A 183
PHE A 210
ASP A 269
LEU A 276
TYR A 308
 None
None
LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.3A)
LLX  A 400 (-4.4A)
 0.48A 5eenB-3maxA:
43.8		 5eenB-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 SER A 153
HIS A 145
HIS A 183
ASP A 269
TYR A 308
 None
LLX  A 400 (-4.0A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.4A)
 1.04A 5eenB-3maxA:
43.8		 5eenB-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 SER A 153
HIS A 183
PHE A 210
ASP A 269
TYR A 308
 None
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.4A)
 1.47A 5eenB-3maxA:
43.8		 5eenB-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		10 / 12 HIS A  33
PRO A  34
HIS A 145
HIS A 146
PHE A 155
ASP A 181
HIS A 183
PHE A 210
ASP A 269
TYR A 308
 None
None
LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.4A)
 0.50A 5ef8A-3maxA:
43.6		 5ef8A-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 SER A 153
HIS A 145
HIS A 183
ASP A 269
TYR A 308
 None
LLX  A 400 (-4.0A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.4A)
 1.07A 5ef8A-3maxA:
43.6		 5ef8A-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 SER A 153
HIS A 183
PHE A 210
ASP A 269
TYR A 308
 None
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.4A)
 1.39A 5ef8A-3maxA:
43.6		 5ef8A-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		10 / 12 PRO A  34
HIS A 145
HIS A 146
PHE A 155
ASP A 181
HIS A 183
PHE A 210
ASP A 269
LEU A 276
TYR A 308
 None
LLX  A 400 (-4.0A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.1A)
ZN  A 379 (-2.3A)
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.3A)
LLX  A 400 (-4.4A)
 0.47A 5ef8B-3maxA:
43.9		 5ef8B-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 SER A 153
HIS A 145
HIS A 183
ASP A 269
TYR A 308
 None
LLX  A 400 (-4.0A)
ZN  A 379 (-3.2A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.4A)
 1.05A 5ef8B-3maxA:
43.9		 5ef8B-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		5 / 12 SER A 153
HIS A 183
PHE A 210
ASP A 269
TYR A 308
 None
ZN  A 379 (-3.2A)
LLX  A 400 (-3.6A)
ZN  A 379 ( 2.5A)
LLX  A 400 (-4.4A)
 1.46A 5ef8B-3maxA:
43.9		 5ef8B-3maxA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.75A 5iy5N-3maxA:
undetectable		 5iy5N-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.73A 5w97a-3maxA:
undetectable		 5w97a-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.72A 5xdqA-3maxA:
undetectable		 5xdqA-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.73A 5xdqN-3maxA:
undetectable		 5xdqN-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.73A 5xdxA-3maxA:
undetectable		 5xdxA-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.71A 5xdxN-3maxA:
undetectable		 5xdxN-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.75A 5z84A-3maxA:
undetectable		 5z84A-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.73A 5z84N-3maxA:
undetectable		 5z84N-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.74A 5z85A-3maxA:
undetectable		 5z85A-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.73A 5z85N-3maxA:
undetectable		 5z85N-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.68A 5z86A-3maxA:
undetectable		 5z86A-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.71A 5z86N-3maxA:
undetectable		 5z86N-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.74A 5zcoA-3maxA:
undetectable		 5zcoA-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.72A 5zcoN-3maxA:
undetectable		 5zcoN-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.74A 5zcpA-3maxA:
undetectable		 5zcpA-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.74A 5zcpN-3maxA:
undetectable		 5zcpN-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.73A 5zcqA-3maxA:
undetectable		 5zcqA-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.73A 5zcqN-3maxA:
undetectable		 5zcqN-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.68A 6hu9a-3maxA:
undetectable		 6hu9a-3maxA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.74A 6hu9m-3maxA:
undetectable		 6hu9m-3maxA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.75A 6nknA-3maxA:
undetectable		 6nknA-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.75A 6nknN-3maxA:
undetectable		 6nknN-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.74A 6nmpA-3maxA:
undetectable		 6nmpA-3maxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3max HISTONE DEACETYLASE
2
(Homo
sapiens) 		3 / 3 HIS A 183
HIS A 146
HIS A 145
 ZN  A 379 (-3.2A)
LLX  A 400 (-3.8A)
LLX  A 400 (-4.0A)
 0.75A 6nmpN-3maxA:
undetectable		 6nmpN-3maxA:
19.96