SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LLN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 12 TYR A 668
HIS A 669
VAL A 841
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.46A 1udtA-5h2rA:
37.8		 1udtA-5h2rA:
32.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 11 TYR A 668
VAL A 841
PHE A 845
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
LLN  A1003 (-4.6A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.70A 1uduA-5h2rA:
36.7		 1uduA-5h2rA:
32.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 12 TYR A 668
VAL A 841
PHE A 845
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
LLN  A1003 (-4.6A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.68A 1uduB-5h2rA:
36.7		 1uduB-5h2rA:
32.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 10 TYR A 668
HIS A 669
PHE A 845
GLN A 875
GLY A 877
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
None
LLN  A1003 (-3.8A)
 0.60A 1uhoA-5h2rA:
37.6		 1uhoA-5h2rA:
32.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		7 / 12 TYR A 668
HIS A 669
HIS A 713
MET A 785
ASN A 826
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
None
LLN  A1003 (-4.0A)
LLN  A1003 (-4.4A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.43A 1xlxA-5h2rA:
39.6		 1xlxA-5h2rA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 12 TYR A 668
HIS A 669
HIS A 713
MET A 785
THR A 842
 LLN  A1003 ( 4.8A)
None
None
LLN  A1003 (-4.0A)
LLN  A1003 (-3.6A)
 1.42A 1xlxA-5h2rA:
39.6		 1xlxA-5h2rA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		7 / 12 TYR A 668
HIS A 669
HIS A 713
MET A 785
PHE A 845
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
None
LLN  A1003 (-4.0A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.40A 1xlxB-5h2rA:
39.5		 1xlxB-5h2rA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		7 / 12 TYR A 668
HIS A 669
MET A 785
PHE A 845
MET A 862
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.5A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.73A 1xlxB-5h2rA:
39.5		 1xlxB-5h2rA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
ASP A 823
TRP A 837
PHE A 845
PHE A 878
 LLN  A1003 ( 4.8A)
None
ZN  A1001 (-2.6A)
None
LLN  A1003 (-4.6A)
LLN  A1003 (-3.8A)
 0.28A 1xmuA-5h2rA:
39.6		 1xmuA-5h2rA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 823
TRP A 837
PHE A 845
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
ZN  A1001 (-2.6A)
None
LLN  A1003 (-4.6A)
 0.40A 1xmuB-5h2rA:
39.6		 1xmuB-5h2rA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		8 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 823
PHE A 845
MET A 862
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
ZN  A1001 (-2.6A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.5A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.76A 1xomA-5h2rA:
39.3		 1xomA-5h2rA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		7 / 12 TYR A 668
HIS A 669
MET A 785
PHE A 845
MET A 862
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.5A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.78A 1xomB-5h2rA:
39.2		 1xomB-5h2rA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 823
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
ZN  A1001 (-2.6A)
LLN  A1003 (-3.8A)
 0.35A 1xoqA-5h2rA:
39.3		 1xoqA-5h2rA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		3 / 3 ASN A 826
TRP A 837
GLN A 875
 LLN  A1003 (-4.4A)
None
LLN  A1003 (-3.0A)
 0.31A 1xoqA-5h2rA:
39.3		 1xoqA-5h2rA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 12 TYR A 668
HIS A 669
ASP A 823
TRP A 837
PHE A 878
 LLN  A1003 ( 4.8A)
None
ZN  A1001 (-2.6A)
None
LLN  A1003 (-3.8A)
 0.33A 1xoqB-5h2rA:
39.2		 1xoqB-5h2rA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		3 / 3 MET A 785
ASN A 826
GLN A 875
 LLN  A1003 (-4.0A)
LLN  A1003 (-4.4A)
LLN  A1003 (-3.0A)
 0.40A 1xoqB-5h2rA:
39.2		 1xoqB-5h2rA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		8 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 823
PHE A 845
MET A 862
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
ZN  A1001 (-2.6A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.5A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.72A 1xosA-5h2rA:
39.6		 1xosA-5h2rA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 12 TYR A 668
HIS A 669
MET A 785
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.38A 1xotA-5h2rA:
39.4		 1xotA-5h2rA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 12 TYR A 668
MET A 785
MET A 862
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
LLN  A1003 (-4.0A)
LLN  A1003 (-3.5A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.80A 1xotA-5h2rA:
39.4		 1xotA-5h2rA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		7 / 12 TYR A 668
HIS A 669
MET A 785
ASN A 826
MET A 862
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
LLN  A1003 (-4.4A)
LLN  A1003 (-3.5A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.66A 1xotB-5h2rA:
39.6		 1xotB-5h2rA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 12 TYR A 668
VAL A 841
PHE A 845
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
LLN  A1003 (-4.6A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.67A 1xozA-5h2rA:
40.5		 1xozA-5h2rA:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 11 TYR A 668
HIS A 669
VAL A 841
PHE A 845
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.6A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.61A 2h42A-5h2rA:
37.9		 2h42A-5h2rA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 12 TYR A 668
HIS A 669
VAL A 841
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.55A 2h42B-5h2rA:
37.6		 2h42B-5h2rA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 12 TYR A 668
VAL A 841
PHE A 845
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
LLN  A1003 (-4.6A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.62A 2h42C-5h2rA:
37.5		 2h42C-5h2rA:
32.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
GLU A 844
PHE A 845
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
None
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.74A 2weyA-5h2rA:
38.7		 2weyA-5h2rA:
29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		7 / 12 TYR A 668
HIS A 669
VAL A 827
GLU A 844
PHE A 845
MET A 862
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
None
LLN  A1003 (-4.6A)
LLN  A1003 (-3.5A)
LLN  A1003 (-3.8A)
 0.71A 2weyA-5h2rA:
38.7		 2weyA-5h2rA:
29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		3 / 3 MET A 862
GLU A 844
ASP A 710
 LLN  A1003 (-3.5A)
None
MG  A1002 ( 2.6A)
 1.03A 3a25A-5h2rA:
undetectable		 3a25A-5h2rA:
22.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
VAL A 841
PHE A 845
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.6A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.54A 3b2rA-5h2rA:
33.2		 3b2rA-5h2rA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 11 TYR A 668
HIS A 669
VAL A 841
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.43A 3b2rB-5h2rA:
33.1		 3b2rB-5h2rA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 9 GLY A 822
VAL A 677
HIS A 673
ASP A 823
VAL A 827
 None
None
ZN  A1001 (-3.4A)
ZN  A1001 (-2.6A)
LLN  A1003 (-4.0A)
 1.37A 3fi0A-5h2rA:
undetectable		 3fi0A-5h2rA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 9 GLY A 822
VAL A 677
HIS A 673
ASP A 823
VAL A 827
 None
None
ZN  A1001 (-3.4A)
ZN  A1001 (-2.6A)
LLN  A1003 (-4.0A)
 1.38A 3fi0C-5h2rA:
undetectable		 3fi0C-5h2rA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 9 GLY A 822
VAL A 677
HIS A 673
ASP A 823
VAL A 827
 None
None
ZN  A1001 (-3.4A)
ZN  A1001 (-2.6A)
LLN  A1003 (-4.0A)
 1.36A 3fi0D-5h2rA:
undetectable		 3fi0D-5h2rA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 9 GLY A 822
VAL A 677
HIS A 673
ASP A 823
VAL A 827
 None
None
ZN  A1001 (-3.4A)
ZN  A1001 (-2.6A)
LLN  A1003 (-4.0A)
 1.36A 3fi0F-5h2rA:
undetectable		 3fi0F-5h2rA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 9 GLY A 822
VAL A 677
HIS A 673
ASP A 823
VAL A 827
 None
None
ZN  A1001 (-3.4A)
ZN  A1001 (-2.6A)
LLN  A1003 (-4.0A)
 1.36A 3fi0K-5h2rA:
undetectable		 3fi0K-5h2rA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 9 GLY A 822
VAL A 677
HIS A 673
ASP A 823
VAL A 827
 None
None
ZN  A1001 (-3.4A)
ZN  A1001 (-2.6A)
LLN  A1003 (-4.0A)
 1.36A 3fi0M-5h2rA:
undetectable		 3fi0M-5h2rA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 9 GLY A 822
VAL A 677
HIS A 673
ASP A 823
VAL A 827
 None
None
ZN  A1001 (-3.4A)
ZN  A1001 (-2.6A)
LLN  A1003 (-4.0A)
 1.33A 3fi0N-5h2rA:
undetectable		 3fi0N-5h2rA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 9 GLY A 822
VAL A 677
HIS A 673
ASP A 823
VAL A 827
 None
None
ZN  A1001 (-3.4A)
ZN  A1001 (-2.6A)
LLN  A1003 (-4.0A)
 1.35A 3fi0O-5h2rA:
undetectable		 3fi0O-5h2rA:
21.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 12 MET A 785
ASN A 826
TRP A 837
MET A 862
PHE A 878
 LLN  A1003 (-4.0A)
LLN  A1003 (-4.4A)
None
LLN  A1003 (-3.5A)
LLN  A1003 (-3.8A)
 0.98A 3g4lA-5h2rA:
38.8		 3g4lA-5h2rA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
MET A 785
ASN A 826
TRP A 837
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
LLN  A1003 (-4.4A)
None
LLN  A1003 (-3.8A)
 0.34A 3g4lA-5h2rA:
38.8		 3g4lA-5h2rA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 823
TRP A 837
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
ZN  A1001 (-2.6A)
None
LLN  A1003 (-3.8A)
 0.43A 3g4lB-5h2rA:
38.9		 3g4lB-5h2rA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 823
ASN A 826
TRP A 837
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
ZN  A1001 (-2.6A)
LLN  A1003 (-4.4A)
None
 0.40A 3g4lC-5h2rA:
38.9		 3g4lC-5h2rA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 823
THR A 842
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
ZN  A1001 (-2.6A)
LLN  A1003 (-3.6A)
 1.33A 3g4lC-5h2rA:
38.9		 3g4lC-5h2rA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 12 TYR A 668
HIS A 669
MET A 785
ASP A 823
TRP A 837
GLN A 875
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
ZN  A1001 (-2.6A)
None
LLN  A1003 (-3.0A)
 0.45A 3g4lD-5h2rA:
39.2		 3g4lD-5h2rA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 9 TYR A 668
MET A 785
ASN A 826
PHE A 845
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
LLN  A1003 (-4.0A)
LLN  A1003 (-4.4A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.63A 3iakA-5h2rA:
38.8		 3iakA-5h2rA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 9 TYR A 668
MET A 785
ASN A 826
PHE A 845
MET A 862
PHE A 878
 LLN  A1003 ( 4.8A)
LLN  A1003 (-4.0A)
LLN  A1003 (-4.4A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.5A)
LLN  A1003 (-3.8A)
 0.82A 3iakA-5h2rA:
38.8		 3iakA-5h2rA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		7 / 9 TYR A 668
HIS A 669
VAL A 841
LEU A 871
GLN A 875
PHE A 878
VAL A 882
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.6A)
LLN  A1003 (-4.9A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
None
 0.59A 3jwqA-5h2rA:
40.4		 3jwqA-5h2rA:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 9 TYR A 668
HIS A 669
VAL A 841
MET A 862
PHE A 878
VAL A 882
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.6A)
LLN  A1003 (-3.5A)
LLN  A1003 (-3.8A)
None
 0.52A 3jwqA-5h2rA:
40.4		 3jwqA-5h2rA:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 11 HIS A 669
ASN A 717
VAL A 841
MET A 862
GLN A 875
PHE A 878
 None
None
LLN  A1003 (-4.6A)
LLN  A1003 (-3.5A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.81A 3jwqB-5h2rA:
40.5
3jwqC-5h2rA:
40.3		 3jwqB-5h2rA:
34.86
3jwqC-5h2rA:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 11 TYR A 668
HIS A 669
VAL A 841
LEU A 871
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.6A)
LLN  A1003 (-4.9A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.69A 3jwqB-5h2rA:
40.5
3jwqC-5h2rA:
40.3		 3jwqB-5h2rA:
34.86
3jwqC-5h2rA:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 11 TYR A 668
HIS A 669
VAL A 841
MET A 862
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.6A)
LLN  A1003 (-3.5A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.62A 3jwqB-5h2rA:
40.5
3jwqC-5h2rA:
40.3		 3jwqB-5h2rA:
34.86
3jwqC-5h2rA:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 7 TYR A 668
HIS A 669
LEU A 871
GLN A 875
PHE A 878
VAL A 882
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.9A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
None
 0.52A 3jwqC-5h2rA:
40.3		 3jwqC-5h2rA:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 7 TYR A 668
HIS A 669
MET A 862
GLN A 875
PHE A 878
VAL A 882
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-3.5A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
None
 0.66A 3jwqC-5h2rA:
40.3		 3jwqC-5h2rA:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 11 TYR A 668
HIS A 669
LEU A 871
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.9A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 1.08A 3jwqA-5h2rA:
40.4
3jwqD-5h2rA:
39.9		 3jwqA-5h2rA:
34.86
3jwqD-5h2rA:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 11 TYR A 668
HIS A 669
PHE A 845
MET A 862
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.6A)
LLN  A1003 (-3.5A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.71A 3jwqA-5h2rA:
40.4
3jwqD-5h2rA:
39.9		 3jwqA-5h2rA:
34.86
3jwqD-5h2rA:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		6 / 7 TYR A 668
ASN A 826
PHE A 845
MET A 862
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
LLN  A1003 (-4.4A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.5A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.67A 3tvxB-5h2rA:
39.5		 3tvxB-5h2rA:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5h2r PHOSPHODIESTERASE
(Trypanosoma
brucei) 		5 / 12 PHE A 887
THR A 680
PHE A 684
VAL A 882
PHE A 878
 None
None
None
None
LLN  A1003 (-3.8A)
 1.44A 3u9fJ-5h2rA:
undetectable
3u9fL-5h2rA:
undetectable		 3u9fJ-5h2rA:
20.65
3u9fL-5h2rA:
20.65