SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LLL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		3 / 3 ARG A  50
GLU A  56
ASP A 192
 None
None
LLL  A 500 (-2.8A)
 0.81A 3g2oA-3hamA:
undetectable		 3g2oA-3hamA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 8 ASP A 192
ASP A 213
CYH A 225
TRP A 265
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.5A)
GOL  A 301 (-3.4A)
LLL  A 500 (-3.8A)
 0.99A 3havA-3hamA:
39.0		 3havA-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 8 ASP A 192
SER A 194
ASP A 213
CYH A 225
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
GOL  A 301 (-3.4A)
 0.86A 3havA-3hamA:
39.0		 3havA-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 8 ASP A 192
SER A 194
CYH A 225
ASP A 232
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
GOL  A 301 (-3.4A)
LLL  A 500 (-3.3A)
 0.91A 3havA-3hamA:
39.0		 3havA-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 8 ASP A 213
CYH A 225
TRP A 265
TYR A 272
 LLL  A 500 (-3.5A)
GOL  A 301 (-3.4A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.21A 3havA-3hamA:
39.0		 3havA-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 8 SER A 194
ASP A 213
CYH A 225
TYR A 272
 LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
GOL  A 301 (-3.4A)
LLL  A 500 ( 4.7A)
 1.13A 3havA-3hamA:
39.0		 3havA-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_B_SRYB403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		6 / 9 ASP A 192
SER A 194
ASN A 261
ASP A 262
TRP A 265
ASP A 268
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
GOL  A 301 (-3.3A)
LLL  A 500 (-3.7A)
LLL  A 500 (-3.8A)
None
 0.95A 3havB-3hamA:
37.9		 3havB-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_B_SRYB403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		7 / 9 ASP A 192
SER A 194
ASP A 213
CYH A 225
ASN A 261
TRP A 265
ASP A 268
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
GOL  A 301 (-3.4A)
GOL  A 301 (-3.3A)
LLL  A 500 (-3.8A)
None
 0.82A 3havB-3hamA:
37.9		 3havB-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_B_SRYB403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 9 ASP A 213
ASN A 261
ASP A 262
TRP A 265
ASP A 268
 LLL  A 500 (-3.5A)
GOL  A 301 (-3.3A)
LLL  A 500 (-3.7A)
LLL  A 500 (-3.8A)
None
 1.37A 3havB-3hamA:
37.9		 3havB-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		10 / 12 ASN A 191
ASP A 192
SER A 194
ASN A 196
CYH A 225
SER A 230
ASP A 232
ASN A 261
ASP A 262
TRP A 265
 GOL  A 301 (-4.9A)
LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.3A)
GOL  A 301 (-3.4A)
LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
GOL  A 301 (-3.3A)
LLL  A 500 (-3.7A)
LLL  A 500 (-3.8A)
 0.70A 3havC-3hamA:
37.4		 3havC-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		6 / 12 ASN A 197
CYH A 225
ASN A 261
ASP A 262
TRP A 265
TYR A 272
 None
GOL  A 301 (-3.4A)
GOL  A 301 (-3.3A)
LLL  A 500 (-3.7A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.14A 3havC-3hamA:
37.4		 3havC-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 12 ASN A 221
ASN A 197
CYH A 225
TRP A 265
TYR A 272
 None
None
GOL  A 301 (-3.4A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.33A 3havC-3hamA:
37.4		 3havC-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		7 / 12 ASN A 221
SER A 194
CYH A 225
SER A 230
ASP A 232
TRP A 265
TYR A 272
 None
LLL  A 500 (-3.3A)
GOL  A 301 (-3.4A)
LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.37A 3havC-3hamA:
37.4		 3havC-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		10 / 12 ASP A 192
SER A 194
ASN A 196
CYH A 225
SER A 230
ASP A 232
ASN A 261
ASP A 262
TRP A 265
TYR A 272
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.3A)
GOL  A 301 (-3.4A)
LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
GOL  A 301 (-3.3A)
LLL  A 500 (-3.7A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 0.79A 3havC-3hamA:
37.4		 3havC-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		7 / 12 ASP A 213
CYH A 225
SER A 230
ASN A 261
ASP A 262
TRP A 265
TYR A 272
 LLL  A 500 (-3.5A)
GOL  A 301 (-3.4A)
LLL  A 500 (-2.8A)
GOL  A 301 (-3.3A)
LLL  A 500 (-3.7A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.06A 3havC-3hamA:
37.4		 3havC-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SG8_A_TOYA305_1
(APH(2'')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 12 ASP A 192
SER A 194
ASP A 213
TRP A 265
TYR A 272
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.49A 3sg8A-3hamA:
32.7		 3sg8A-3hamA:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SG8_B_TOYB305_1
(APH(2'')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 12 ASP A 192
SER A 194
ASP A 213
TRP A 265
TYR A 272
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.49A 3sg8B-3hamA:
32.4		 3sg8B-3hamA:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SG9_A_KANA304_1
(APH(2'')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 10 ASP A 192
SER A 194
ASP A 213
TRP A 265
TYR A 272
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.32A 3sg9A-3hamA:
32.7		 3sg9A-3hamA:
34.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 8 ASP A 192
SER A 194
ASP A 213
TRP A 265
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
LLL  A 500 (-3.8A)
 0.88A 3sg9B-3hamA:
20.9		 3sg9B-3hamA:
34.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFB_A_KANA401_1
(APH(2')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 9 ASP A 192
SER A 194
ASP A 213
TRP A 265
TYR A 272
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 0.98A 4dfbA-3hamA:
21.0		 4dfbA-3hamA:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFU_A_KANA401_1
(APH(2')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 12 ASP A 192
SER A 194
ASP A 213
TRP A 265
TYR A 272
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.37A 4dfuA-3hamA:
32.8		 4dfuA-3hamA:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFU_B_KANB402_1
(APH(2')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 12 ASP A 192
SER A 194
ASP A 213
TRP A 265
TYR A 272
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.44A 4dfuB-3hamA:
32.9		 4dfuB-3hamA:
33.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		3 / 3 ASN A 196
ASP A 233
ASP A 222
 LLL  A 500 (-3.3A)
None
None
 0.88A 4obwD-3hamA:
undetectable		 4obwD-3hamA:
23.17