SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LI0'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2o2f APOPTOSIS REGULATOR
BCL-2
(Homo
sapiens) 		4 / 8 TYR A 199
LEU A  94
GLU A 197
TRP A 192
 LI0  A1000 (-3.4A)
None
None
None
 1.02A 1i7zA-2o2fA:
undetectable		 1i7zA-2o2fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 2o2f APOPTOSIS REGULATOR
BCL-2
(Homo
sapiens) 		5 / 12 LEU A 116
LEU A  21
PHE A 150
ILE A 170
ALA A 171
 None
None
LI0  A1000 ( 4.4A)
None
None
 1.43A 6qyaB-2o2fA:
undetectable		 6qyaB-2o2fA:
20.07