SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LGU'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 7 TYR A 555
GLU A 254
PHE A 462
TRP A 467
 MAW  A1003 (-4.9A)
LGU  A1002 (-4.5A)
MAW  A1003 (-4.4A)
MAW  A1003 (-3.8A)
 1.10A 1b2iA-3aflA:
undetectable		 1b2iA-3aflA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 ARG A 314
ALA A 318
GLU A 254
VAL A 293
 LGU  A1002 (-4.3A)
None
LGU  A1002 (-4.5A)
None
 0.83A 2bxgA-3aflA:
2.3		 2bxgA-3aflA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2zab ALGINATE LYASE
(Sphingomonas
sp.
A1) 		4 / 7 SER A 143
PHE A 284
ARG A 146
GLN A 286
 None
LGU  A 403 ( 3.8A)
LGU  A 403 (-3.1A)
None
 1.30A 2c8aA-2zabA:
undetectable		 2c8aA-2zabA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 6 SER A 350
TYR A 365
SER A 524
GLN A 536
 None
LGU  A1002 (-3.5A)
None
None
 1.18A 2cl5B-3aflA:
undetectable		 2cl5B-3aflA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 10 LEU A 148
ALA A 151
GLU A 150
LEU A 188
HIS A 200
 MAV  A 803 ( 4.8A)
None
None
None
LGU  A 802 ( 4.2A)
 1.41A 2ocfA-4ojzA:
undetectable		 2ocfA-4ojzA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 8 ALA A 360
SER A 310
SER A 532
ALA A 531
 None
LGU  A1002 ( 2.8A)
None
None
 0.82A 2vh3B-3aflA:
undetectable		 2vh3B-3aflA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 6 SER A 350
TYR A 365
SER A 524
GLN A 536
 None
LGU  A1002 (-3.5A)
None
None
 1.15A 2zvjA-3aflA:
undetectable		 2zvjA-3aflA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 6 PHE A 266
TYR A 252
HIS A 200
THR A 204
 None
None
LGU  A 802 ( 4.2A)
None
 1.19A 3lb3B-4ojzA:
undetectable		 3lb3B-4ojzA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 5 TYR A 349
SER A 310
ASP A 356
ILE A 501
 None
LGU  A1002 ( 2.8A)
None
None
 1.38A 3uj7B-3aflA:
undetectable		 3uj7B-3aflA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		4 / 7 TYR A 555
ASP A 416
HIS A 311
HIS A 563
 MAW  A1003 (-4.9A)
None
LGU  A1002 ( 3.9A)
None
 1.27A 3zodA-3aflA:
undetectable		 3zodA-3aflA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 7 TRP A 145
HIS A  86
ASN A 441
TYR A 450
 None
None
BEM  A 804 ( 4.7A)
LGU  A 802 (-4.4A)
 1.35A 4a3uA-4ojzA:
undetectable		 4a3uA-4ojzA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 7 TRP A 145
HIS A  86
ASN A 441
TYR A 450
 None
None
BEM  A 804 ( 4.7A)
LGU  A 802 (-4.4A)
 1.40A 4a3uB-4ojzA:
undetectable		 4a3uB-4ojzA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 SER A 530
LEU A 529
TYR A 365
ASP A 500
GLY A 502
 LGU  A1001 (-3.3A)
None
LGU  A1002 (-3.5A)
None
None
 1.35A 4j7xA-3aflA:
undetectable		 4j7xA-3aflA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 3afl OLIGO ALGINATE LYASE
(Agrobacterium
fabrum) 		5 / 12 SER A 530
LEU A 529
TYR A 365
ASP A 500
GLY A 502
 LGU  A1001 (-3.3A)
None
LGU  A1002 (-3.5A)
None
None
 1.32A 4j7xF-3aflA:
undetectable		 4j7xF-3aflA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 8 ASN A 201
ALA A 258
HIS A 202
HIS A 200
 MAV  A 803 ( 4.1A)
None
MAV  A 803 (-3.8A)
LGU  A 802 ( 4.2A)
 1.08A 5km8A-4ojzA:
undetectable
5km8B-4ojzA:
undetectable		 5km8A-4ojzA:
13.07
5km8B-4ojzA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2zab ALGINATE LYASE
(Sphingomonas
sp.
A1) 		4 / 7 HIS A 306
ARG A 150
HIS A 191
GLU A 151
 None
LGU  A 401 (-3.8A)
LGU  A 403 (-3.7A)
None
 1.31A 6mn4F-2zabA:
undetectable		 6mn4F-2zabA:
22.76