SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LGC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_A_FCNA1199_1
(EPOXIDASE)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		5 / 9 ARG A 501
TYR A  53
ASN A 503
HIS A 505
ALA A  96
 LGC  A 602 ( 2.8A)
LGC  A 602 ( 4.5A)
LGC  A 602 (-3.4A)
LGC  A 602 (-3.7A)
FAD  A 601 (-4.6A)
 0.99A 2bnnA-4ynuA:
undetectable
2bnnB-4ynuA:
undetectable		 2bnnA-4ynuA:
19.13
2bnnB-4ynuA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 8 TYR A  53
ASN A 503
HIS A 505
ALA A  96
 LGC  A 602 ( 4.5A)
LGC  A 602 (-3.4A)
LGC  A 602 (-3.7A)
FAD  A 601 (-4.6A)
 0.72A 2bnnA-4ynuA:
undetectable
2bnnB-4ynuA:
undetectable		 2bnnA-4ynuA:
19.13
2bnnB-4ynuA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		3 / 3 TYR A  53
GLU A 413
ASN A 319
 LGC  A 602 ( 4.5A)
LGC  A 602 (-2.9A)
None
 0.96A 2y7hC-4ynuA:
undetectable		 2y7hC-4ynuA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE
(Saccharophagus
degradans) 		3 / 3 ARG A 349
ASP A 345
ASN A 350
 LGC  A 804 (-4.0A)
GOL  A 802 (-3.0A)
LGC  A 804 (-3.0A)
 0.76A 2zzmA-4zlgA:
undetectable		 2zzmA-4zlgA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE
(Saccharophagus
degradans) 		4 / 6 GLU A 619
ASP A 472
ASP A 469
ARG A 349
 LGC  A 804 ( 3.7A)
LGC  A 804 ( 4.0A)
None
LGC  A 804 (-4.0A)
 1.36A 4kcnA-4zlgA:
undetectable		 4kcnA-4zlgA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB304_1
(CHITOSANASE)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 5 TYR A 125
THR A 552
HIS A 505
TYR A 337
 None
None
LGC  A 602 (-3.7A)
None
 1.43A 4oltB-4ynuA:
undetectable		 4oltB-4ynuA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 7 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.44A 4v2yA-4ynuA:
undetectable		 4v2yA-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 7 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.34A 4v2yB-4ynuA:
undetectable		 4v2yB-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 7 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.42A 4v2zA-4ynuA:
undetectable		 4v2zA-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 8 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.33A 4v2zB-4ynuA:
undetectable		 4v2zB-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_A_LVYA151_1
(CEREBLON ISOFORM 4)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 7 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.43A 4v30A-4ynuA:
undetectable		 4v30A-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 8 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.38A 4v30B-4ynuA:
undetectable		 4v30B-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 7 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.43A 5amiA-4ynuA:
undetectable		 5amiA-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 8 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.32A 5amiB-4ynuA:
undetectable		 5amiB-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 7 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.46A 5amjA-4ynuA:
undetectable		 5amjA-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 7 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.36A 5amjB-4ynuA:
undetectable		 5amjB-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 8 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.26A 5amkA-4ynuA:
undetectable		 5amkA-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 7 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.44A 5amkB-4ynuA:
undetectable		 5amkB-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE
(Saccharophagus
degradans) 		4 / 5 TYR A 624
ARG A 341
ASN A 350
GLY A 695
 SO4  A 805 ( 4.7A)
SO4  A 805 (-3.0A)
LGC  A 804 (-3.0A)
SO4  A 805 (-3.8A)
 1.33A 5bphB-4zlgA:
0.0		 5bphB-4zlgA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_A_EF2A202_0
(CEREBLON ISOFORM 4)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 7 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.41A 5oh1A-4ynuA:
undetectable		 5oh1A-4ynuA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 7 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.34A 5oh1B-4ynuA:
undetectable		 5oh1B-4ynuA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_A_9V2A202_0
(CEREBLON ISOFORM 4)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 7 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.47A 5oh3A-4ynuA:
undetectable		 5oh3A-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_B_9V2B202_0
(CEREBLON ISOFORM 4)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 7 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.39A 5oh3B-4ynuA:
undetectable		 5oh3B-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		3 / 3 ARG A 501
LYS A 477
ARG A  81
 LGC  A 602 ( 2.8A)
LGC  A 603 ( 4.9A)
None
 1.30A 6az3C-4ynuA:
undetectable
6az3L-4ynuA:
undetectable
6az3M-4ynuA:
undetectable		 6az3C-4ynuA:
10.04
6az3L-4ynuA:
8.17
6az3M-4ynuA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 4 HIS A 505
LEU A 401
TYR A 199
GLY A  94
 LGC  A 602 (-3.7A)
None
None
FAD  A 601 (-3.0A)
 1.11A 6n91A-4ynuA:
undetectable		 6n91A-4ynuA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		 4ynu GLUCOSE OXIDASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 4 HIS A 505
LEU A 401
TYR A 199
GLY A  94
 LGC  A 602 (-3.7A)
None
None
FAD  A 601 (-3.0A)
 1.15A 6n91B-4ynuA:
undetectable		 6n91B-4ynuA:
9.11