SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LFR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 7 LEU A 140
THR A 107
TYR A 138
TRP A 260
 None
None
None
LFR  A1481 (-4.1A)
 1.19A 1v55C-2cgjA:
undetectable
1v55N-2cgjA:
undetectable
1v55P-2cgjA:
undetectable		 1v55C-2cgjA:
19.22
1v55N-2cgjA:
22.18
1v55P-2cgjA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 SER A 256
GLU A 427
ASP A 237
 None
None
LFR  A1481 (-3.0A)
 0.83A 2zthA-2cgjA:
undetectable		 2zthA-2cgjA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 8 LEU A 140
THR A 107
TYR A 138
TRP A 260
 None
None
None
LFR  A1481 (-4.1A)
 1.20A 3asoC-2cgjA:
undetectable
3asoN-2cgjA:
undetectable
3asoP-2cgjA:
undetectable		 3asoC-2cgjA:
19.22
3asoN-2cgjA:
22.18
3asoP-2cgjA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 SER A 256
GLU A 427
ASP A 237
 None
None
LFR  A1481 (-3.0A)
 0.72A 3bwmA-2cgjA:
undetectable		 3bwmA-2cgjA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 SER A 256
GLU A 427
ASP A 237
 None
None
LFR  A1481 (-3.0A)
 0.75A 3bwyA-2cgjA:
undetectable		 3bwyA-2cgjA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 8 HIS A 236
SER A 240
ILE A 243
ARG A 292
 LFR  A1481 (-3.9A)
None
None
None
 1.10A 3sfeB-2cgjA:
undetectable
3sfeC-2cgjA:
undetectable		 3sfeB-2cgjA:
19.31
3sfeC-2cgjA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.45A 4qvmV-2cgjA:
undetectable
4qvmb-2cgjA:
undetectable		 4qvmV-2cgjA:
17.68
4qvmb-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.46A 4qvmH-2cgjA:
undetectable
4qvmN-2cgjA:
undetectable		 4qvmH-2cgjA:
17.68
4qvmN-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.45A 4qw0V-2cgjA:
undetectable
4qw0b-2cgjA:
undetectable		 4qw0V-2cgjA:
17.68
4qw0b-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.46A 4qw0H-2cgjA:
undetectable
4qw0N-2cgjA:
undetectable		 4qw0H-2cgjA:
17.68
4qw0N-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.45A 4qw1V-2cgjA:
undetectable
4qw1b-2cgjA:
undetectable		 4qw1V-2cgjA:
17.68
4qw1b-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.45A 4qw1H-2cgjA:
undetectable
4qw1N-2cgjA:
undetectable		 4qw1H-2cgjA:
17.68
4qw1N-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.47A 4qw3V-2cgjA:
undetectable
4qw3b-2cgjA:
undetectable		 4qw3V-2cgjA:
17.68
4qw3b-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.47A 4qw3H-2cgjA:
undetectable
4qw3N-2cgjA:
undetectable		 4qw3H-2cgjA:
17.68
4qw3N-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 SER A 256
GLU A 427
ASP A 237
 None
None
LFR  A1481 (-3.0A)
 0.70A 4xudA-2cgjA:
undetectable		 4xudA-2cgjA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 8 THR A 107
TYR A 138
TRP A 260
LEU A 140
 None
None
LFR  A1481 (-4.1A)
None
 1.10A 5b1bA-2cgjA:
undetectable
5b1bC-2cgjA:
undetectable
5b1bP-2cgjA:
undetectable		 5b1bA-2cgjA:
22.18
5b1bC-2cgjA:
19.22
5b1bP-2cgjA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.50A 5bxnV-2cgjA:
undetectable
5bxnb-2cgjA:
undetectable		 5bxnV-2cgjA:
17.68
5bxnb-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.49A 5bxnH-2cgjA:
undetectable
5bxnN-2cgjA:
undetectable		 5bxnH-2cgjA:
17.68
5bxnN-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.45A 5d0xV-2cgjA:
undetectable
5d0xb-2cgjA:
undetectable		 5d0xV-2cgjA:
17.68
5d0xb-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.46A 5d0xH-2cgjA:
undetectable
5d0xN-2cgjA:
undetectable		 5d0xH-2cgjA:
17.68
5d0xN-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 7 LEU A 140
THR A 107
TYR A 138
TRP A 260
 None
None
None
LFR  A1481 (-4.1A)
 1.23A 5z84C-2cgjA:
undetectable
5z84N-2cgjA:
undetectable
5z84P-2cgjA:
undetectable		 5z84C-2cgjA:
19.22
5z84N-2cgjA:
22.18
5z84P-2cgjA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 7 THR A 107
TYR A 138
TRP A 260
LEU A 140
 None
None
LFR  A1481 (-4.1A)
None
 1.18A 6nmfA-2cgjA:
undetectable
6nmfC-2cgjA:
undetectable
6nmfP-2cgjA:
undetectable		 6nmfA-2cgjA:
22.18
6nmfC-2cgjA:
19.22
6nmfP-2cgjA:
19.22