SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LFC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ochrobactrum
anthropi) 		3 / 3 TYR A 120
ARG A 149
GLN A 176
 None
LFC  A 403 (-2.7A)
LFC  A 403 ( 4.7A)
 1.02A 1tw4A-4ovtA:
undetectable		 1tw4A-4ovtA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		 4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ochrobactrum
anthropi) 		5 / 12 PRO A 171
ILE A  88
TYR A 231
GLU A 208
ASN A 234
 LFC  A 403 (-4.0A)
LFC  A 403 (-3.9A)
None
None
LFC  A 403 ( 4.9A)
 1.47A 2oa1A-4ovtA:
undetectable		 2oa1A-4ovtA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		 4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ochrobactrum
anthropi) 		5 / 12 PRO A 171
LYS A  72
ILE A  88
GLU A 208
ASN A 234
 LFC  A 403 (-4.0A)
LFC  A 403 ( 2.8A)
LFC  A 403 (-3.9A)
None
LFC  A 403 ( 4.9A)
 1.35A 2oa1A-4ovtA:
undetectable		 2oa1A-4ovtA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ochrobactrum
anthropi) 		5 / 12 GLU A 208
ARG A 149
ASN A 209
TYR A 146
TYR A 105
 None
LFC  A 403 (-2.7A)
LFC  A 403 (-2.9A)
LFC  A 403 (-4.2A)
None
 1.39A 3ckzA-4ovtA:
undetectable		 3ckzA-4ovtA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ochrobactrum
anthropi) 		5 / 12 GLU A 208
ARG A 149
ASN A 209
TYR A 146
TYR A 105
 None
LFC  A 403 (-2.7A)
LFC  A 403 (-2.9A)
LFC  A 403 (-4.2A)
None
 1.36A 3sanA-4ovtA:
undetectable		 3sanA-4ovtA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ochrobactrum
anthropi) 		5 / 12 GLU A 208
ARG A 149
ASN A 209
TYR A 146
TYR A 105
 None
LFC  A 403 (-2.7A)
LFC  A 403 (-2.9A)
LFC  A 403 (-4.2A)
None
 1.37A 3sanB-4ovtA:
undetectable		 3sanB-4ovtA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ochrobactrum
anthropi) 		5 / 12 GLU A 208
ARG A 149
ASN A 209
TYR A 146
TYR A 105
 None
LFC  A 403 (-2.7A)
LFC  A 403 (-2.9A)
LFC  A 403 (-4.2A)
None
 1.45A 4wa5A-4ovtA:
undetectable		 4wa5A-4ovtA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Ochrobactrum
anthropi) 		4 / 6 ILE A 152
GLY A 147
ASN A 234
ILE A 211
 None
None
LFC  A 403 ( 4.9A)
None
 0.97A 5j4nB-4ovtA:
undetectable		 5j4nB-4ovtA:
20.91