SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LFA'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1DVT_A_FLPA125_1 (TRANSTHYRETIN) |
4hyj | RHODOPSIN (Exiguobacteriumsibiricum) | 5 / 8 | LEU A 160ALA A 118LEU A 115LEU A 49LEU A 92 | NoneLFA A 306 ( 4.2A)NoneNoneNone | 1.41A | 1dvtA-4hyjA:undetectable1dvtB-4hyjA:undetectable | 1dvtA-4hyjA:21.031dvtB-4hyjA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1JU6_A_LYAA317_1 (THYMIDYLATE SYNTHASE) |
3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT M (Escherichiacoli) | 5 / 11 | PHE M 274ILE M 189GLY M 226PHE M 227ALA M 180 | NoneNoneLFA N 486 ( 4.1A)NoneNone | 1.39A | 1ju6A-3rkoM:undetectable | 1ju6A-3rkoM:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MZ9_D_VDYD1001_4 (CARTILAGE OLIGOMERICMATRIX PROTEIN) |
4xtl | SODIUM PUMPINGRHODOPSIN (Dokdoniaeikasta) | 4 / 4 | THR A 216LEU A 217VAL A 246LEU A 245 | LFA A 330 (-3.6A)LFA A 330 ( 4.8A)NoneNone | 0.90A | 1mz9D-4xtlA:undetectable | 1mz9D-4xtlA:10.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1P93_D_DEXD4999_2 (GLUCOCORTICOIDRECEPTOR) |
5o0t | PUTATIVE FERRICREDUCTASE (Cylindrospermumstagnale) | 4 / 5 | LEU A 264TRP A 378MET A 306LEU A 309 | NoneHEM A 504 ( 3.3A)HEM A 504 ( 4.6A)LFA A 507 ( 4.8A) | 1.49A | 1p93D-5o0tA:undetectable | 1p93D-5o0tA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1S9P_C_DESC500_1 (ESTROGEN-RELATEDRECEPTOR GAMMA) |
3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli) | 5 / 12 | LEU N 79LEU N 82LEU N 85ALA N 86ILE N 248 | LFA N 488 ( 4.8A)NoneNoneNoneNone | 0.99A | 1s9pC-3rkoN:undetectable | 1s9pC-3rkoN:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1TKQ_B_DVAB8_0 (GRAMICIDIN A) |
5o0t | PUTATIVE FERRICREDUCTASE (Cylindrospermumstagnale) | 4 / 5 | VAL A 302GLY A 303VAL A 305TRP A 352 | NoneHEM A 504 (-3.6A)LFA A 507 ( 4.5A)None | 1.30A | 1tkqB-5o0tA:undetectable | 1tkqB-5o0tA:14.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2DU8_G_BEZG2352_0 (D-AMINO-ACID OXIDASE) |
4hyj | RHODOPSIN (Exiguobacteriumsibiricum) | 4 / 5 | TYR A 83ILE A 123ARG A 213GLY A 197 | NoneNoneNoneLFA A 308 ( 4.0A) | 1.38A | 2du8G-4hyjA:undetectable | 2du8G-4hyjA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2FXD_A_DR7A102_2 (POL PROTEIN) |
4hyj | RHODOPSIN (Exiguobacteriumsibiricum) | 4 / 7 | ALA A 118ASP A 119GLY A 150ILE A 149 | LFA A 306 ( 4.2A)NoneRET A 301 (-3.7A)LFA A 311 ( 4.3A) | 0.83A | 2fxdB-4hyjA:undetectable | 2fxdB-4hyjA:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2M56_A_CAMA502_0 (CAMPHOR5-MONOOXYGENASE) |
3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT L (Escherichiacoli) | 4 / 5 | PHE L 549TYR L 545LEU L 235VAL L 176 | LFA L 614 ( 4.2A)LFA L 614 ( 4.4A)NoneNone | 1.22A | 2m56A-3rkoL:undetectable | 2m56A-3rkoL:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2OAX_E_SNLE5001_2 (MINERALOCORTICOIDRECEPTOR) |
5jsi | BACTERIORHODOPSIN (CandidatusActinomarinaminuta) | 4 / 4 | LEU A 79TRP A 169LEU A 203MET A 16 | LFA A 306 ( 4.9A)LYR A 200 ( 3.6A)NoneLYR A 200 ( 4.0A) | 0.99A | 2oaxE-5jsiA:1.0 | 2oaxE-5jsiA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3BXO_B_SAMB238_0 (N,N-DIMETHYLTRANSFERASE) |
3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT L (Escherichiacoli) | 5 / 12 | ALA L 385GLY L 395LEU L 389PHE L 340SER L 464 | NoneNoneNoneLFA L 616 (-4.4A)None | 1.33A | 3bxoB-3rkoL:undetectable | 3bxoB-3rkoL:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3EL9_A_DR7A100_1 (PROTEASE) |
4hyj | RHODOPSIN (Exiguobacteriumsibiricum) | 4 / 8 | ALA A 118ASP A 119GLY A 150ILE A 149 | LFA A 306 ( 4.2A)NoneRET A 301 (-3.7A)LFA A 311 ( 4.3A) | 0.83A | 3el9A-4hyjA:undetectable | 3el9A-4hyjA:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3FW1_A_STIA233_1 (RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE[QUINONE]) |
3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT L (Escherichiacoli) | 5 / 10 | PHE L 340GLY L 96GLY L 94THR L 93ILE L 124 | LFA L 616 (-4.4A)NoneLFA L 616 ( 4.1A)NoneNone | 1.30A | 3fw1A-3rkoL:undetectable | 3fw1A-3rkoL:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3PFG_A_SAMA264_0 (N-METHYLTRANSFERASE) |
3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT L (Escherichiacoli) | 5 / 12 | ALA L 385GLY L 395LEU L 389PHE L 340SER L 464 | NoneNoneNoneLFA L 616 (-4.4A)None | 1.34A | 3pfgA-3rkoL:undetectable | 3pfgA-3rkoL:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3VHU_A_SNLA1001_2 (MINERALOCORTICOIDRECEPTOR) |
3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli) | 4 / 5 | LEU N 79LEU N 82LEU N 338SER N 336 | LFA N 488 ( 4.8A)NoneNoneNone | 1.03A | 3vhuA-3rkoN:1.4 | 3vhuA-3rkoN:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4LTW_A_STRA301_1 (ANCESTRAL STEROIDRECEPTOR 2) |
3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli) | 5 / 12 | LEU N 79LEU N 82LEU N 85ALA N 86LEU N 463 | LFA N 488 ( 4.8A)NoneNoneNoneNone | 0.64A | 4ltwA-3rkoN:undetectable | 4ltwA-3rkoN:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QWU_K_BO2K301_1 (PROTEASOME SUBUNITBETA TYPE-5PROTEASOME SUBUNITBETA TYPE-6) |
6eyu | BACTERIORHODOPSIN (CandidatusNanosalinasp.J07AB43) | 5 / 9 | ALA A 8THR A 7ALA A 5GLY A 12ASP A 197 | NoneNoneNoneLFA A 302 (-4.6A)None | 1.14A | 4qwuK-6eyuA:undetectable4qwuL-6eyuA:undetectable | 4qwuK-6eyuA:17.484qwuL-6eyuA:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QWU_Y_BO2Y301_1 (PROTEASOME SUBUNITBETA TYPE-5PROTEASOME SUBUNITBETA TYPE-6) |
6eyu | BACTERIORHODOPSIN (CandidatusNanosalinasp.J07AB43) | 5 / 9 | ALA A 8THR A 7ALA A 5GLY A 12ASP A 197 | NoneNoneNoneLFA A 302 (-4.6A)None | 1.14A | 4qwuY-6eyuA:undetectable4qwuZ-6eyuA:undetectable | 4qwuY-6eyuA:17.484qwuZ-6eyuA:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4RYA_A_MTLA501_0 (ABC TRANSPORTERSUBSTRATE BINDINGPROTEIN (SORBITOL)) |
3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli) | 5 / 12 | GLY N 412ALA N 413ALA N 274VAL N 271TRP N 409 | LFA N 489 ( 3.7A)NoneNoneNoneNone | 1.40A | 4ryaA-3rkoN:undetectable | 4ryaA-3rkoN:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4U15_A_0HKA2001_2 (MUSCARINICACETYLCHOLINERECEPTORM3,LYSOZYME,MUSCARINIC ACETYLCHOLINERECEPTOR M3) |
3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli) | 3 / 3 | ASN N 101PHE N 105TYR N 92 | NoneNoneLFA N 487 (-4.6A) | 0.89A | 4u15A-3rkoN:2.9 | 4u15A-3rkoN:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5KPC_A_SAMA401_0 (PAVINEN-METHYLTRANSFERASE) |
3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli) | 5 / 12 | GLY N 78SER N 84LEU N 85ALA N 48LEU N 52 | LFA N 488 ( 3.8A)NoneNoneNoneNone | 0.89A | 5kpcA-3rkoN:undetectable | 5kpcA-3rkoN:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5MSD_A_BEZA1202_0 (CARBOXYLIC ACIDREDUCTASE) |
4hyj | RHODOPSIN (Exiguobacteriumsibiricum) | 4 / 5 | HIS A 57ILE A 81PHE A 15ALA A 64 | NoneLFA A 305 ( 4.5A)NoneNone | 1.26A | 5msdA-4hyjA:undetectable | 5msdA-4hyjA:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VEU_B_RITB602_1 (CYTOCHROME P450 3A5) |
1q90 | APOCYTOCHROME FCYTOCHROME B6 (Chlamydomonasreinhardtii) | 5 / 12 | PHE A 259ILE B 82PHE B 78ILE A 252GLY A 254 | NoneNoneLFA B 960 ( 4.8A)NoneLFA B 960 ( 4.0A) | 1.07A | 5veuB-1q90A:undetectable | 5veuB-1q90A:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5XIQ_B_HFGB1002_0 (PROLYL-TRNASYNTHETASE (PRORS)) |
3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT LNADH-QUINONEOXIDOREDUCTASESUBUNIT M (Escherichiacoli;Escherichiacoli) | 5 / 12 | VAL L 172ARG L 175GLU M 407HIS M 322THR M 401 | LFA L 614 ( 4.8A)NoneNoneNoneNone | 1.36A | 5xiqB-3rkoL:undetectable | 5xiqB-3rkoL:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Y7P_B_CHDB401_0 (BILE SALT HYDROLASE) |
4xtl | SODIUM PUMPINGRHODOPSIN (Dokdoniaeikasta) | 5 / 10 | ILE A 181PHE A 211PHE A 122LEU A 63LEU A 262 | NoneNoneLFA A 319 ( 4.5A)NoneNone | 1.25A | 5y7pB-4xtlA:undetectable | 5y7pB-4xtlA:24.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6A7J_A_TESA502_0 (CYTOCHROME P450) |
4mnd | CTPL-MYO-INOSITOL-1-PHOSPHATECYTIDYLYLTRANSFERASE/CDP-L-MYO-INOSITOLMYO-INOSITOLPHOSPHOTRANSFERASE (Archaeoglobusfulgidus) | 4 / 7 | LEU A 469ALA A 472ALA A 473THR A 477 | NoneLFA A 602 ( 4.6A)NoneLFA A 602 (-3.8A) | 0.57A | 6a7jA-4mndA:undetectable | 6a7jA-4mndA:13.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6QXS_D_FOZD403_0 (THYMIDYLATE SYNTHASE) |
5o0t | PUTATIVE FERRICREDUCTASE (Cylindrospermumstagnale) | 5 / 12 | LEU A 250ILE A 254LEU A 262GLY A 315ALA A 308 | NoneGOL A 511 ( 4.4A)HEM A 505 ( 4.0A)GOL A 511 (-3.3A)LFA A 507 (-3.6A) | 1.28A | 6qxsD-5o0tA:undetectable | 6qxsD-5o0tA:21.45 |