SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LFA'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)
4hyj RHODOPSIN
(Exiguobacterium
sibiricum)
5 / 8 LEU A 160
ALA A 118
LEU A 115
LEU A  49
LEU A  92
None
LFA  A 306 ( 4.2A)
None
None
None
1.41A 1dvtA-4hyjA:
undetectable
1dvtB-4hyjA:
undetectable
1dvtA-4hyjA:
21.03
1dvtB-4hyjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli)
5 / 11 PHE M 274
ILE M 189
GLY M 226
PHE M 227
ALA M 180
None
None
LFA  N 486 ( 4.1A)
None
None
1.39A 1ju6A-3rkoM:
undetectable
1ju6A-3rkoM:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
4xtl SODIUM PUMPING
RHODOPSIN

(Dokdonia
eikasta)
4 / 4 THR A 216
LEU A 217
VAL A 246
LEU A 245
LFA  A 330 (-3.6A)
LFA  A 330 ( 4.8A)
None
None
0.90A 1mz9D-4xtlA:
undetectable
1mz9D-4xtlA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)
5o0t PUTATIVE FERRIC
REDUCTASE

(Cylindrospermum
stagnale)
4 / 5 LEU A 264
TRP A 378
MET A 306
LEU A 309
None
HEM  A 504 ( 3.3A)
HEM  A 504 ( 4.6A)
LFA  A 507 ( 4.8A)
1.49A 1p93D-5o0tA:
undetectable
1p93D-5o0tA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli)
5 / 12 LEU N  79
LEU N  82
LEU N  85
ALA N  86
ILE N 248
LFA  N 488 ( 4.8A)
None
None
None
None
0.99A 1s9pC-3rkoN:
undetectable
1s9pC-3rkoN:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)
5o0t PUTATIVE FERRIC
REDUCTASE

(Cylindrospermum
stagnale)
4 / 5 VAL A 302
GLY A 303
VAL A 305
TRP A 352
None
HEM  A 504 (-3.6A)
LFA  A 507 ( 4.5A)
None
1.30A 1tkqB-5o0tA:
undetectable
1tkqB-5o0tA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)
4hyj RHODOPSIN
(Exiguobacterium
sibiricum)
4 / 5 TYR A  83
ILE A 123
ARG A 213
GLY A 197
None
None
None
LFA  A 308 ( 4.0A)
1.38A 2du8G-4hyjA:
undetectable
2du8G-4hyjA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)
4hyj RHODOPSIN
(Exiguobacterium
sibiricum)
4 / 7 ALA A 118
ASP A 119
GLY A 150
ILE A 149
LFA  A 306 ( 4.2A)
None
RET  A 301 (-3.7A)
LFA  A 311 ( 4.3A)
0.83A 2fxdB-4hyjA:
undetectable
2fxdB-4hyjA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli)
4 / 5 PHE L 549
TYR L 545
LEU L 235
VAL L 176
LFA  L 614 ( 4.2A)
LFA  L 614 ( 4.4A)
None
None
1.22A 2m56A-3rkoL:
undetectable
2m56A-3rkoL:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_2
(MINERALOCORTICOID
RECEPTOR)
5jsi BACTERIORHODOPSIN
(Candidatus
Actinomarina
minuta)
4 / 4 LEU A  79
TRP A 169
LEU A 203
MET A  16
LFA  A 306 ( 4.9A)
LYR  A 200 ( 3.6A)
None
LYR  A 200 ( 4.0A)
0.99A 2oaxE-5jsiA:
1.0
2oaxE-5jsiA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli)
5 / 12 ALA L 385
GLY L 395
LEU L 389
PHE L 340
SER L 464
None
None
None
LFA  L 616 (-4.4A)
None
1.33A 3bxoB-3rkoL:
undetectable
3bxoB-3rkoL:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)
4hyj RHODOPSIN
(Exiguobacterium
sibiricum)
4 / 8 ALA A 118
ASP A 119
GLY A 150
ILE A 149
LFA  A 306 ( 4.2A)
None
RET  A 301 (-3.7A)
LFA  A 311 ( 4.3A)
0.83A 3el9A-4hyjA:
undetectable
3el9A-4hyjA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli)
5 / 10 PHE L 340
GLY L  96
GLY L  94
THR L  93
ILE L 124
LFA  L 616 (-4.4A)
None
LFA  L 616 ( 4.1A)
None
None
1.30A 3fw1A-3rkoL:
undetectable
3fw1A-3rkoL:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli)
5 / 12 ALA L 385
GLY L 395
LEU L 389
PHE L 340
SER L 464
None
None
None
LFA  L 616 (-4.4A)
None
1.34A 3pfgA-3rkoL:
undetectable
3pfgA-3rkoL:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli)
4 / 5 LEU N  79
LEU N  82
LEU N 338
SER N 336
LFA  N 488 ( 4.8A)
None
None
None
1.03A 3vhuA-3rkoN:
1.4
3vhuA-3rkoN:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli)
5 / 12 LEU N  79
LEU N  82
LEU N  85
ALA N  86
LEU N 463
LFA  N 488 ( 4.8A)
None
None
None
None
0.64A 4ltwA-3rkoN:
undetectable
4ltwA-3rkoN:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
6eyu BACTERIORHODOPSIN
(Candidatus
Nanosalina
sp.
J07AB43)
5 / 9 ALA A   8
THR A   7
ALA A   5
GLY A  12
ASP A 197
None
None
None
LFA  A 302 (-4.6A)
None
1.14A 4qwuK-6eyuA:
undetectable
4qwuL-6eyuA:
undetectable
4qwuK-6eyuA:
17.48
4qwuL-6eyuA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
6eyu BACTERIORHODOPSIN
(Candidatus
Nanosalina
sp.
J07AB43)
5 / 9 ALA A   8
THR A   7
ALA A   5
GLY A  12
ASP A 197
None
None
None
LFA  A 302 (-4.6A)
None
1.14A 4qwuY-6eyuA:
undetectable
4qwuZ-6eyuA:
undetectable
4qwuY-6eyuA:
17.48
4qwuZ-6eyuA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli)
5 / 12 GLY N 412
ALA N 413
ALA N 274
VAL N 271
TRP N 409
LFA  N 489 ( 3.7A)
None
None
None
None
1.40A 4ryaA-3rkoN:
undetectable
4ryaA-3rkoN:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli)
3 / 3 ASN N 101
PHE N 105
TYR N  92
None
None
LFA  N 487 (-4.6A)
0.89A 4u15A-3rkoN:
2.9
4u15A-3rkoN:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli)
5 / 12 GLY N  78
SER N  84
LEU N  85
ALA N  48
LEU N  52
LFA  N 488 ( 3.8A)
None
None
None
None
0.89A 5kpcA-3rkoN:
undetectable
5kpcA-3rkoN:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)
4hyj RHODOPSIN
(Exiguobacterium
sibiricum)
4 / 5 HIS A  57
ILE A  81
PHE A  15
ALA A  64
None
LFA  A 305 ( 4.5A)
None
None
1.26A 5msdA-4hyjA:
undetectable
5msdA-4hyjA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)
1q90 APOCYTOCHROME F
CYTOCHROME B6

(Chlamydomonas
reinhardtii)
5 / 12 PHE A 259
ILE B  82
PHE B  78
ILE A 252
GLY A 254
None
None
LFA  B 960 ( 4.8A)
None
LFA  B 960 ( 4.0A)
1.07A 5veuB-1q90A:
undetectable
5veuB-1q90A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli;
Escherichia
coli)
5 / 12 VAL L 172
ARG L 175
GLU M 407
HIS M 322
THR M 401
LFA  L 614 ( 4.8A)
None
None
None
None
1.36A 5xiqB-3rkoL:
undetectable
5xiqB-3rkoL:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)
4xtl SODIUM PUMPING
RHODOPSIN

(Dokdonia
eikasta)
5 / 10 ILE A 181
PHE A 211
PHE A 122
LEU A  63
LEU A 262
None
None
LFA  A 319 ( 4.5A)
None
None
1.25A 5y7pB-4xtlA:
undetectable
5y7pB-4xtlA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)
4mnd CTP
L-MYO-INOSITOL-1-PHO
SPHATE
CYTIDYLYLTRANSFERASE
/CDP-L-MYO-INOSITOL
MYO-INOSITOLPHOSPHOT
RANSFERASE

(Archaeoglobus
fulgidus)
4 / 7 LEU A 469
ALA A 472
ALA A 473
THR A 477
None
LFA  A 602 ( 4.6A)
None
LFA  A 602 (-3.8A)
0.57A 6a7jA-4mndA:
undetectable
6a7jA-4mndA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)
5o0t PUTATIVE FERRIC
REDUCTASE

(Cylindrospermum
stagnale)
5 / 12 LEU A 250
ILE A 254
LEU A 262
GLY A 315
ALA A 308
None
GOL  A 511 ( 4.4A)
HEM  A 505 ( 4.0A)
GOL  A 511 (-3.3A)
LFA  A 507 (-3.6A)
1.28A 6qxsD-5o0tA:
undetectable
6qxsD-5o0tA:
21.45