SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LEV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.71A 1iepA-3wzdA:
31.6		 1iepA-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
 0.75A 1iepB-3wzdA:
31.4		 1iepB-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 7 LYS A 868
VAL A 899
ARG A1027
LEU A1035
 None
None
None
LEV  A1201 (-4.8A)
 1.00A 1iepB-3wzdA:
31.4		 1iepB-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
VAL A 899
PHE A 918
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-4.8A)
 0.62A 1opjA-3wzdA:
30.8		 1opjA-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
ILE A 892
VAL A 899
PHE A 918
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
None
LEV  A1201 (-4.7A)
LEV  A1201 (-4.8A)
 0.64A 1opjA-3wzdA:
30.8		 1opjA-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
GLY A 922
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
 0.79A 1opjB-3wzdA:
30.8		 1opjB-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 899
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
None
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.46A 1t46A-3wzdA:
35.2		 1t46A-3wzdA:
53.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.62A 1t46A-3wzdA:
35.2		 1t46A-3wzdA:
53.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 7 VAL A 914
CYH A 919
ARG A1027
CYH A1045
 None
LEV  A1201 (-4.1A)
None
GOL  A1210 ( 3.3A)
 0.87A 1t46A-3wzdA:
35.2		 1t46A-3wzdA:
53.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 (-4.1A)
None
None
 0.61A 1uwhA-3wzdA:
27.6		 1uwhA-3wzdA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 (-4.1A)
None
None
 0.61A 1uwhB-3wzdA:
27.4		 1uwhB-3wzdA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
LYS A 868
GLU A 885
LEU A 889
CYH A 919
LEU A1019
 LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 (-4.1A)
None
 0.68A 1uwhB-3wzdA:
27.4		 1uwhB-3wzdA:
29.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 848
ALA A 866
GLU A 885
CYH A 919
LEU A1019
HIS A1026
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
None
None
 0.65A 1uwjA-3wzdA:
7.8		 1uwjA-3wzdA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 848
ALA A 866
GLU A 885
CYH A 919
LEU A1019
HIS A1026
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
None
None
 0.66A 1uwjB-3wzdA:
7.8		 1uwjB-3wzdA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 9 LEU A 840
VAL A 848
ALA A 866
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.41A 1xbbA-3wzdA:
31.1		 1xbbA-3wzdA:
35.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
ALA A 866
LYS A 868
GLU A 885
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.79A 2gqgA-3wzdA:
31.7		 2gqgA-3wzdA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 899
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.56A 2gqgB-3wzdA:
31.3		 2gqgB-3wzdA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.76A 2hyyA-3wzdA:
25.6		 2hyyA-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 6 LEU A 840
LYS A 868
VAL A 899
ARG A1027
 LEV  A1201 ( 3.8A)
None
None
None
 0.62A 2hyyA-3wzdA:
25.6		 2hyyA-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.74A 2hyyB-3wzdA:
31.8		 2hyyB-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.64A 2hyyC-3wzdA:
31.9		 2hyyC-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
LEU A1035
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-4.8A)
 0.75A 2hyyD-3wzdA:
25.8		 2hyyD-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
VAL A 848
LYS A 868
GLU A 885
LEU A 889
VAL A 916
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 ( 4.6A)
 0.50A 2ivuA-3wzdA:
26.5		 2ivuA-3wzdA:
44.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLY A 922
LEU A1035
ASP A1046
PHE A1047
LEU A1049
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
LEV  A1201 (-3.3A)
LEV  A1201 ( 4.5A)
 0.80A 3bbtB-3wzdA:
29.5		 3bbtB-3wzdA:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
LEU A 889
GLY A 922
LEU A1035
ASP A1046
LEU A1049
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 ( 4.4A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
LEV  A1201 ( 4.5A)
 1.02A 3bbtB-3wzdA:
29.5		 3bbtB-3wzdA:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLY A 922
LEU A1035
ASP A1046
PHE A1047
LEU A1049
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
LEV  A1201 (-3.3A)
LEV  A1201 ( 4.5A)
 0.85A 3bbtD-3wzdA:
29.5		 3bbtD-3wzdA:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		10 / 12 LEU A 840
GLU A 850
ALA A 866
VAL A 899
VAL A 916
PHE A 918
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 LEV  A1201 ( 3.8A)
None
LEV  A1201 (-3.5A)
None
LEV  A1201 ( 4.6A)
LEV  A1201 (-4.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.47A 3c7qA-3wzdA:
39.0		 3c7qA-3wzdA:
99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		10 / 12 LEU A 840
GLY A 841
GLU A 850
ALA A 866
VAL A 899
VAL A 916
PHE A 918
CYH A 919
LEU A1035
CYH A1045
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.1A)
None
LEV  A1201 (-3.5A)
None
LEV  A1201 ( 4.6A)
LEV  A1201 (-4.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.81A 3c7qA-3wzdA:
39.0		 3c7qA-3wzdA:
99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 10 LEU A 840
VAL A 848
LYS A 868
PHE A 918
VAL A 898
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
LEV  A1201 (-4.7A)
None
 0.83A 3cs9A-3wzdA:
25.8		 3cs9A-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 10 LEU A 840
VAL A 848
LYS A 868
VAL A 899
PHE A 918
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
None
LEV  A1201 (-4.7A)
 0.48A 3cs9A-3wzdA:
25.8		 3cs9A-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
ILE A 892
GLY A 922
HIS A1026
LEU A1035
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-3.6A)
None
LEV  A1201 (-4.8A)
 0.70A 3cs9A-3wzdA:
25.8		 3cs9A-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
GLU A 885
ILE A 892
GLY A 922
HIS A1026
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-3.6A)
None
 0.59A 3cs9B-3wzdA:
32.7		 3cs9B-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 9 LEU A 840
VAL A 848
LYS A 868
VAL A 899
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
None
LEV  A1201 (-4.8A)
 0.42A 3cs9B-3wzdA:
32.7		 3cs9B-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
GLU A 885
ILE A 892
PHE A 918
HIS A1026
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
None
 0.54A 3cs9C-3wzdA:
26.3		 3cs9C-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
HIS A1026
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
None
 0.59A 3cs9D-3wzdA:
30.9		 3cs9D-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 6 LEU A 840
VAL A 848
LYS A 868
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
LEV  A1201 (-4.8A)
 0.53A 3cs9D-3wzdA:
30.9		 3cs9D-3wzdA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 11 LEU A 840
VAL A 848
ALA A 866
VAL A 899
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.61A 3g0eA-3wzdA:
33.2		 3g0eA-3wzdA:
50.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 11 LEU A 840
VAL A 848
ALA A 866
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.71A 3g0fA-3wzdA:
33.6		 3g0fA-3wzdA:
52.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 10 LEU A 840
VAL A 848
ALA A 866
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.66A 3g0fB-3wzdA:
34.2		 3g0fB-3wzdA:
52.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 899
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.85A 3g5dB-3wzdA:
30.8		 3g5dB-3wzdA:
34.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
None
LEV  A1201 (-4.8A)
 0.56A 3gvuA-3wzdA:
31.8		 3gvuA-3wzdA:
38.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.68A 3k5vA-3wzdA:
30.8		 3k5vA-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.68A 3k5vB-3wzdA:
30.6		 3k5vB-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 11 ALA A 866
VAL A 899
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.65A 3miyA-3wzdA:
31.4		 3miyA-3wzdA:
33.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-4.8A)
 0.70A 3ms9A-3wzdA:
31.1		 3ms9A-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.70A 3ms9B-3wzdA:
31.2		 3ms9B-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-4.8A)
 0.70A 3mssA-3wzdA:
31.2		 3mssA-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.70A 3mssB-3wzdA:
31.3		 3mssB-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
ILE A 892
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.72A 3mssB-3wzdA:
31.3		 3mssB-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-4.8A)
 0.71A 3mssC-3wzdA:
31.2		 3mssC-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.77A 3mssD-3wzdA:
31.2		 3mssD-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
ALA A 866
ILE A 888
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.9A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 1.06A 3mssD-3wzdA:
31.2		 3mssD-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
VAL A 899
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
None
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.66A 3octA-3wzdA:
31.0		 3octA-3wzdA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.80A 3pyyA-3wzdA:
25.9		 3pyyA-3wzdA:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
VAL A 899
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.8A)
 0.51A 3pyyB-3wzdA:
31.6		 3pyyB-3wzdA:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 899
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.80A 3qlgA-3wzdA:
25.2		 3qlgA-3wzdA:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
VAL A 899
GLY A 922
LEU A1035
ASP A1046
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.79A 3qlgB-3wzdA:
25.3		 3qlgB-3wzdA:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
VAL A 848
ALA A 866
VAL A 899
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.38A 3sxrA-3wzdA:
29.8		 3sxrA-3wzdA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
VAL A 848
ALA A 866
VAL A 899
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.35A 3sxrB-3wzdA:
29.8		 3sxrB-3wzdA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
ALA A 866
LYS A 868
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
None
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.58A 3ue4A-3wzdA:
31.8		 3ue4A-3wzdA:
37.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.50A 3ue4B-3wzdA:
32.3		 3ue4B-3wzdA:
37.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.64A 3ue4B-3wzdA:
32.3		 3ue4B-3wzdA:
37.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		11 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
ILE A 892
VAL A 916
PHE A 918
GLY A 922
LEU A1019
HIS A1026
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
None
LEV  A1201 ( 4.6A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
None
None
 0.58A 3wzeA-3wzdA:
38.9		 3wzeA-3wzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
VAL A 916
PHE A 918
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 ( 4.6A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
 0.57A 3wzeA-3wzdA:
38.9		 3wzeA-3wzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 8 VAL A 898
VAL A 899
CYH A 919
LEU A1035
ILE A1044
CYH A1045
 None
None
LEV  A1201 (-4.1A)
LEV  A1201 (-4.8A)
None
GOL  A1210 ( 3.3A)
 0.39A 3wzeA-3wzdA:
38.9		 3wzeA-3wzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		10 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
VAL A 899
VAL A 916
PHE A 918
GLY A 922
LEU A1035
CYH A1045
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 ( 4.6A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.47A 4ag8A-3wzdA:
38.5		 4ag8A-3wzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		10 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 916
PHE A 918
GLY A 922
LEU A1035
CYH A1045
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.6A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.61A 4ag8A-3wzdA:
38.5		 4ag8A-3wzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 916
GLY A 922
LEU A1035
CYH A1045
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 ( 4.6A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.46A 4agcA-3wzdA:
38.3		 4agcA-3wzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 11 LEU A 840
ALA A 866
VAL A 899
VAL A 916
PHE A 918
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
None
LEV  A1201 ( 4.6A)
LEV  A1201 (-4.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.33A 4agdA-3wzdA:
37.6		 4agdA-3wzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		10 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 916
PHE A 918
GLY A 922
LEU A1019
HIS A1026
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 ( 4.6A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
None
None
 0.58A 4asdA-3wzdA:
38.3		 4asdA-3wzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
VAL A 916
PHE A 918
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 ( 4.6A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
 0.66A 4asdA-3wzdA:
38.3		 4asdA-3wzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 6 ILE A 892
VAL A 899
CYH A 919
LEU A1035
ILE A1044
CYH A1045
 None
None
LEV  A1201 (-4.1A)
LEV  A1201 (-4.8A)
None
GOL  A1210 ( 3.3A)
 0.39A 4asdA-3wzdA:
38.3		 4asdA-3wzdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 10 ALA A 866
VAL A 899
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.48A 4ks8A-3wzdA:
23.1		 4ks8A-3wzdA:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 899
GLY A 922
ASP A1046
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
LEV  A1201 (-3.6A)
GOL  A1210 ( 3.4A)
 0.86A 4mxoA-3wzdA:
30.3		 4mxoA-3wzdA:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 899
GLY A 922
LEU A1035
ASP A1046
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.82A 4mxoB-3wzdA:
30.4		 4mxoB-3wzdA:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
VAL A 899
GLY A 922
LEU A1035
ASP A1046
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
None
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.75A 4mxyB-3wzdA:
30.4		 4mxyB-3wzdA:
35.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
VAL A 899
GLY A 922
LEU A1035
ASP A1046
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
None
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.75A 4mxzB-3wzdA:
30.4		 4mxzB-3wzdA:
35.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 7 ALA A 866
CYH A 919
ASN A1033
LEU A1035
ASP A1046
 LEV  A1201 (-3.5A)
LEV  A1201 (-4.1A)
GOL  A1210 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.77A 4ogrE-3wzdA:
22.7		 4ogrE-3wzdA:
26.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.6A)
None
DTT  A1202 (-2.0A)
 0.49A 4qrcA-3wzdA:
28.9		 4qrcA-3wzdA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 848
ALA A 866
GLU A 885
CYH A 919
CYH A1024
LEU A1035
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
DTT  A1202 (-2.0A)
LEV  A1201 (-4.8A)
 0.59A 4r7iA-3wzdA:
34.8		 4r7iA-3wzdA:
48.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 5 LEU A 840
VAL A 899
VAL A 914
ARG A1027
 LEV  A1201 ( 3.8A)
None
None
None
 0.51A 4r7iA-3wzdA:
34.8		 4r7iA-3wzdA:
48.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
PHE A 918
GLY A 922
ASN A1033
LEU A1035
ASP A1046
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
GOL  A1210 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.77A 4twpA-3wzdA:
31.8		 4twpA-3wzdA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
PHE A 918
GLY A 922
ASN A1033
LEU A1035
ASP A1046
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
GOL  A1210 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.78A 4twpB-3wzdA:
32.2		 4twpB-3wzdA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 866
GLU A 885
ILE A 892
VAL A 916
CYH A1024
HIS A1026
LEU A1035
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 ( 4.6A)
DTT  A1202 (-2.0A)
None
LEV  A1201 (-4.8A)
 0.59A 4tyjA-3wzdA:
29.7		 4tyjA-3wzdA:
51.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 6 LEU A 840
VAL A 848
LYS A 868
ARG A1027
ILE A1044
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
None
None
 0.84A 4tyjA-3wzdA:
29.7		 4tyjA-3wzdA:
51.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 6 LEU A 840
VAL A 848
LYS A 868
ILE A1044
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
None
 0.65A 4tyjA-3wzdA:
29.7		 4tyjA-3wzdA:
51.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 10 LEU A 840
VAL A 848
GLU A 885
VAL A 899
VAL A 914
ARG A1027
ILE A1044
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.7A)
None
None
None
None
 0.75A 4u0iA-3wzdA:
35.3		 4u0iA-3wzdA:
53.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 ALA A 866
LEU A 889
CYH A 919
GLY A 922
CYH A1024
HIS A1026
LEU A1035
CYH A1045
 LEV  A1201 (-3.5A)
LEV  A1201 ( 4.4A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
DTT  A1202 (-2.0A)
None
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.53A 4u0iA-3wzdA:
35.3		 4u0iA-3wzdA:
53.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 866
LYS A 868
LEU A 889
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 LEV  A1201 (-3.5A)
None
LEV  A1201 ( 4.4A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.66A 4u0iA-3wzdA:
35.3		 4u0iA-3wzdA:
53.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
HIS A1026
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.6A)
None
DTT  A1202 (-2.0A)
None
LEV  A1201 (-4.8A)
 0.49A 4uxqA-3wzdA:
29.3		 4uxqA-3wzdA:
52.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
ILE A 892
VAL A 916
LEU A1019
HIS A1026
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 ( 4.6A)
None
None
 0.44A 4v01A-3wzdA:
26.5		 4v01A-3wzdA:
54.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 9 LEU A 840
VAL A 848
LYS A 868
ARG A1027
LEU A1035
ILE A1044
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
None
LEV  A1201 (-4.8A)
None
 0.93A 4v01A-3wzdA:
26.5		 4v01A-3wzdA:
54.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 9 LEU A 840
VAL A 848
LYS A 868
CYH A1024
ARG A1027
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
DTT  A1202 (-2.0A)
None
LEV  A1201 (-4.8A)
 1.08A 4v01A-3wzdA:
26.5		 4v01A-3wzdA:
54.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
HIS A1026
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.6A)
None
DTT  A1202 (-2.0A)
None
 0.46A 4v01B-3wzdA:
26.6		 4v01B-3wzdA:
54.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 9 LEU A 840
VAL A 848
ILE A 892
ARG A1027
LEU A1035
ILE A1044
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
None
LEV  A1201 (-4.8A)
None
 0.75A 4v01B-3wzdA:
26.6		 4v01B-3wzdA:
54.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
HIS A1026
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.6A)
None
DTT  A1202 (-2.0A)
None
 0.47A 4v04A-3wzdA:
34.6		 4v04A-3wzdA:
54.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 10 LEU A 840
VAL A 848
LYS A 868
ARG A1027
LEU A1035
ILE A1044
LEU A1049
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
None
LEV  A1201 (-4.8A)
None
LEV  A1201 ( 4.5A)
 1.28A 4v04B-3wzdA:
29.4		 4v04B-3wzdA:
54.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
HIS A1026
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.6A)
None
DTT  A1202 (-2.0A)
None
 0.58A 4v04B-3wzdA:
29.4		 4v04B-3wzdA:
54.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
LYS A 868
PHE A 918
GLY A 922
ASN A1033
LEU A1035
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
GOL  A1210 (-3.6A)
LEV  A1201 (-4.8A)
 0.87A 4wa9B-3wzdA:
32.3		 4wa9B-3wzdA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.53A 4xeyA-3wzdA:
27.8		 4xeyA-3wzdA:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.55A 4xeyB-3wzdA:
31.8		 4xeyB-3wzdA:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
ALA A 866
LYS A 868
GLU A 885
VAL A 899
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.61A 4xliA-3wzdA:
31.3		 4xliA-3wzdA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
ALA A 866
LYS A 868
GLU A 885
VAL A 899
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.66A 4xliB-3wzdA:
27.2		 4xliB-3wzdA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 9 LEU A 840
VAL A 848
ALA A 866
GLY A 922
LEU A1035
ASP A1046
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.71A 5aaaA-3wzdA:
31.4		 5aaaA-3wzdA:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 10 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLY A 922
LEU A1035
ASP A1046
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.72A 5aabA-3wzdA:
31.5		 5aabA-3wzdA:
35.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
GLY A 841
ALA A 866
LYS A 868
PHE A 918
CYH A 919
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.1A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.75A 5ajqA-3wzdA:
22.5		 5ajqA-3wzdA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
LYS A 868
PHE A 918
CYH A 919
GLY A 922
LEU A1035
ASP A1046
 LEV  A1201 ( 3.8A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.94A 5ajqA-3wzdA:
22.5		 5ajqA-3wzdA:
27.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
VAL A 848
ALA A 866
GLY A 922
LEU A1035
ASP A1046
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.72A 5h2uB-3wzdA:
29.8		 5h2uB-3wzdA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A 840
ALA A 866
GLY A 922
LEU A1035
ASP A1046
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.55A 5h2uC-3wzdA:
29.6		 5h2uC-3wzdA:
37.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 866
LYS A 868
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 (-4.1A)
None
None
 0.64A 5hi2A-3wzdA:
27.4		 5hi2A-3wzdA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 5 LEU A 889
CYH A 919
LEU A1035
ASP A1046
 LEV  A1201 ( 4.4A)
LEV  A1201 (-4.1A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.43A 5mafA-3wzdA:
23.1		 5mafA-3wzdA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 10 LEU A 840
VAL A 848
LYS A 868
GLU A 885
PHE A 918
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
LEV  A1201 (-3.7A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
 0.63A 5mo4A-3wzdA:
undetectable		 5mo4A-3wzdA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 8 ALA A 866
GLU A 885
CYH A 919
LEU A1035
ASP A1046
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.90A 5owrA-3wzdA:
20.9		 5owrA-3wzdA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.61A 5te0A-3wzdA:
22.5		 5te0A-3wzdA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 5 LEU A 840
VAL A 848
CYH A 919
CYH A1045
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-4.1A)
GOL  A1210 ( 3.3A)
 0.38A 5te0A-3wzdA:
22.5		 5te0A-3wzdA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 4 VAL A 848
LYS A 868
VAL A 899
ASN A1033
 LEV  A1201 ( 4.9A)
None
None
GOL  A1210 (-3.6A)
 0.81A 5vc3A-3wzdA:
22.6		 5vc3A-3wzdA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
ALA A 866
LYS A 868
GLU A 885
VAL A 899
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
LEV  A1201 (-3.6A)
 1.10A 5vcvA-3wzdA:
22.6		 5vcvA-3wzdA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
 1.17A 5vcyA-3wzdA:
22.2		 5vcyA-3wzdA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 9 LEU A 840
ALA A 866
VAL A 899
CYH A 919
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
 0.41A 5w5vA-3wzdA:
5.3		 5w5vA-3wzdA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.76A 5y7zA-3wzdA:
21.9		 5y7zA-3wzdA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.76A 5y7zA-3wzdA:
21.9		 5y7zA-3wzdA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.78A 5y7zB-3wzdA:
21.9		 5y7zB-3wzdA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
LEU A1035
ASP A1046
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.74A 5y80A-3wzdA:
21.3		 5y80A-3wzdA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 848
ALA A 866
GLY A 922
LEU A1035
ASP A1046
LEU A1049
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
LEV  A1201 ( 4.5A)
 0.76A 5yu9D-3wzdA:
28.9		 5yu9D-3wzdA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
GLY A 841
VAL A 848
ALA A 866
GLU A 885
VAL A 916
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.1A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.6A)
LEV  A1201 (-3.6A)
 0.37A 5zv2A-3wzdA:
30.1		 5zv2A-3wzdA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		3 / 3 LYS A 868
LEU A1035
ASP A1046
 None
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.42A 5zv2A-3wzdA:
30.1		 5zv2A-3wzdA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
GLY A 841
VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 916
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.1A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.6A)
LEV  A1201 (-3.6A)
 0.57A 5zv2B-3wzdA:
35.6		 5zv2B-3wzdA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
LYS A 868
GLU A 885
ILE A 892
VAL A 899
LEU A1035
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
None
LEV  A1201 (-4.8A)
 0.61A 6hd4A-3wzdA:
30.7		 6hd4A-3wzdA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
LYS A 868
GLU A 885
ILE A 892
VAL A 899
LEU A1035
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
None
LEV  A1201 (-4.8A)
 0.62A 6hd4B-3wzdA:
30.5		 6hd4B-3wzdA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 899
PHE A 918
LEU A1035
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-4.8A)
 0.59A 6hd6A-3wzdA:
30.6		 6hd6A-3wzdA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
ILE A 892
VAL A 899
PHE A 918
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
None
LEV  A1201 (-4.7A)
LEV  A1201 (-4.8A)
 0.73A 6hd6B-3wzdA:
30.3		 6hd6B-3wzdA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A 901
ILE A 888
ALA A 866
CYH A1024
LEU A1049
 None
LEV  A1201 (-3.9A)
LEV  A1201 (-3.5A)
DTT  A1202 (-2.0A)
LEV  A1201 ( 4.5A)
 1.11A 6ie8A-3wzdA:
undetectable		 6ie8A-3wzdA:
22.15