SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LEO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 2a2g PROTEIN
(ALPHA-2U-GLOBULIN)
(Rattus
norvegicus) 		4 / 6 VAL A  40
MET A  42
VAL A  82
ASN A  88
 LEO  A 201 ( 4.8A)
None
None
None
 0.55A 1e06A-2a2gA:
22.9		 1e06A-2a2gA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 2a2g PROTEIN
(ALPHA-2U-GLOBULIN)
(Rattus
norvegicus) 		4 / 8 TYR A  80
PHE A  90
THR A  95
LEU A  15
 None
LEO  A 201 ( 4.2A)
None
None
 1.09A 1ea1A-2a2gA:
undetectable		 1ea1A-2a2gA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 2a2g PROTEIN
(ALPHA-2U-GLOBULIN)
(Rattus
norvegicus) 		4 / 8 PHE A  90
PHE A  54
VAL A 101
TYR A 120
 LEO  A 201 ( 4.2A)
LEO  A 201 (-4.0A)
None
LEO  A 201 (-4.6A)
 0.90A 6huoC-2a2gA:
undetectable
6huoD-2a2gA:
undetectable		 6huoC-2a2gA:
20.93
6huoD-2a2gA:
19.44