SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LEA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 GLY A  52
GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.24A 1dx6A-5aocA:
18.2		 1dx6A-5aocA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 GLY A  52
GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.24A 1qtiA-5aocA:
17.9		 1qtiA-5aocA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 GLY A  52
GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.26A 1w6rA-5aocA:
18.3		 1w6rA-5aocA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 9 GLY A  52
GLY A  53
SER A 126
ALA A 127
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-2.3A)
LEA  A1283 (-3.6A)
LEA  A1283 (-4.0A)
 0.91A 2aceA-5aocA:
18.4		 2aceA-5aocA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 9 GLY A  53
GLY A  54
SER A 126
ALA A 127
HIS A 248
 LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-3.6A)
LEA  A1283 (-4.0A)
 0.39A 2aceA-5aocA:
18.4		 2aceA-5aocA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 8 GLY A  53
GLY A  54
ALA A 127
HIS A 248
 LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-3.6A)
LEA  A1283 (-4.0A)
 0.19A 2ha4A-5aocA:
5.0		 2ha4A-5aocA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 7 GLY A  53
GLY A  54
ALA A 127
HIS A 248
 LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-3.6A)
LEA  A1283 (-4.0A)
 0.18A 2ha4B-5aocA:
18.5		 2ha4B-5aocA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 7 GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.39A 3o9mA-5aocA:
18.1		 3o9mA-5aocA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 6 GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.50A 3o9mB-5aocA:
4.8		 3o9mB-5aocA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 3i3f HYPOTHETICAL PROTEIN
(Giardia
intestinalis) 		3 / 3 ARG A 118
ARG A 115
ILE A  87
 LEA  A 142 (-3.8A)
None
None
 0.94A 4b7qA-3i3fA:
undetectable		 4b7qA-3i3fA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 3i3f HYPOTHETICAL PROTEIN
(Giardia
intestinalis) 		3 / 3 ARG A 118
ARG A 115
ILE A  87
 LEA  A 142 (-3.8A)
None
None
 0.74A 4b7qC-3i3fA:
undetectable		 4b7qC-3i3fA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		6 / 12 GLY A  52
GLY A  53
GLY A  54
SER A  57
SER A 126
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
None
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.37A 4ey6A-5aocA:
18.5		 4ey6A-5aocA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 GLY A  52
GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.25A 4ey6B-5aocA:
18.1		 4ey6B-5aocA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 LEU A 240
SER A 126
PHE A 251
HIS A 248
THR A 223
 None
LEA  A1283 (-2.3A)
None
LEA  A1283 (-4.0A)
EDO  A1286 ( 4.9A)
 1.29A 6djzB-5aocA:
undetectable		 6djzB-5aocA:
21.59