SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LDN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
ILE A 245
THR A 277
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 ( 3.8A)
None
 0.98A 1iepB-3my0A:
24.9		 1iepB-3my0A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 ALA A 229
LYS A 231
GLU A 244
LEU A 277
THR A 279
GLY A 285
LEU A 339
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.66A 1m17A-3mdyA:
26.6		 1m17A-3mdyA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 ALA A 227
LYS A 229
GLU A 242
LEU A 275
THR A 277
GLY A 283
LEU A 337
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
None
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.81A 1m17A-3my0A:
26.4		 1m17A-3my0A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 9 GLY A 211
VAL A 218
ALA A 229
LEU A 259
TYR A 281
LEU A 339
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
 0.85A 1muoA-3mdyA:
7.8		 1muoA-3mdyA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 9 GLY A 209
VAL A 216
ALA A 227
LEU A 257
TYR A 279
LEU A 337
 None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.7A)
LDN  A 600 (-4.6A)
 0.97A 1muoA-3my0A:
16.3		 1muoA-3my0A:
28.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
GLY A 285
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.58A 1t46A-3mdyA:
25.5		 1t46A-3mdyA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 ALA A 229
GLU A 244
LEU A 259
THR A 279
LEU A 315
HIS A 330
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
None
None
 0.59A 1uwhA-3mdyA:
24.9		 1uwhA-3mdyA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		5 / 12 ALA A 227
LEU A 257
THR A 277
LEU A 313
HIS A 328
 LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
None
None
 0.50A 1uwhA-3my0A:
24.9		 1uwhA-3my0A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 ALA A 229
LYS A 231
GLU A 244
LEU A 259
THR A 279
LEU A 315
HIS A 330
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 (-3.8A)
None
None
 0.63A 1uwhB-3mdyA:
24.7		 1uwhB-3mdyA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 ALA A 227
LYS A 229
LEU A 257
THR A 277
LEU A 313
HIS A 328
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
None
None
 0.63A 1uwhB-3my0A:
24.9		 1uwhB-3my0A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 VAL A 218
ALA A 229
GLU A 244
LEU A 259
THR A 279
LEU A 315
HIS A 330
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
None
None
 0.71A 1uwjA-3mdyA:
6.6		 1uwjA-3mdyA:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
LEU A 257
THR A 277
LEU A 313
HIS A 328
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
None
None
 0.53A 1uwjA-3my0A:
9.5		 1uwjA-3my0A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		4 / 7 ILE A 210
LYS A 231
ILE A 258
ILE A 328
 LDN  A   1 (-4.1A)
None
None
None
 0.83A 1uwjA-3mdyA:
6.6		 1uwjA-3mdyA:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 ILE A 210
VAL A 218
ALA A 229
GLU A 244
LEU A 259
THR A 279
LEU A 315
HIS A 330
 LDN  A   1 (-4.1A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
None
None
 0.85A 1uwjB-3mdyA:
6.7		 1uwjB-3mdyA:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
LEU A 257
THR A 277
LEU A 313
HIS A 328
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
None
None
 0.53A 1uwjB-3my0A:
9.6		 1uwjB-3my0A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 ILE A 210
VAL A 218
LYS A 231
ASN A 337
LEU A 339
ALA A 349
ASP A 350
 LDN  A   1 (-4.1A)
LDN  A   1 ( 4.8A)
None
LDN  A   1 (-4.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
LDN  A   1 (-3.9A)
 0.84A 2eufB-3mdyA:
26.7		 2eufB-3mdyA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 11 GLY A 211
GLY A 213
VAL A 218
ALA A 229
TYR A 281
SER A 286
LEU A 339
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.4A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 ( 4.8A)
None
LDN  A   1 (-4.5A)
 0.79A 2evaA-3mdyA:
27.3		 2evaA-3mdyA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 11 VAL A 208
GLY A 209
VAL A 216
ALA A 227
TYR A 279
SER A 284
LEU A 337
 LDN  A 600 ( 4.4A)
None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.7A)
None
LDN  A 600 (-4.6A)
 0.81A 2evaA-3my0A:
26.1		 2evaA-3my0A:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 ALA A 229
LYS A 231
GLU A 244
THR A 279
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.63A 2gqgA-3mdyA:
27.5		 2gqgA-3mdyA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 ALA A 227
LYS A 229
GLU A 242
THR A 277
GLY A 283
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.66A 2gqgA-3my0A:
27.1		 2gqgA-3my0A:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.54A 2gqgB-3mdyA:
27.5		 2gqgB-3mdyA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
GLU A 244
THR A 279
GLY A 285
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.78A 2hyyA-3mdyA:
25.0		 2hyyA-3mdyA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
THR A 279
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.82A 2hyyA-3mdyA:
25.0		 2hyyA-3mdyA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 ALA A 227
THR A 277
GLY A 283
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.74A 2hyyA-3my0A:
25.0		 2hyyA-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
THR A 277
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.71A 2hyyA-3my0A:
25.0		 2hyyA-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
GLU A 244
THR A 279
GLY A 285
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.73A 2hyyB-3mdyA:
25.2		 2hyyB-3mdyA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
THR A 279
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.75A 2hyyB-3mdyA:
25.2		 2hyyB-3mdyA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 ALA A 227
THR A 277
GLY A 283
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.74A 2hyyB-3my0A:
25.2		 2hyyB-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
THR A 277
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.78A 2hyyB-3my0A:
25.2		 2hyyB-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
ILE A 245
THR A 277
GLY A 283
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 ( 3.8A)
None
 1.37A 2hyyC-3my0A:
25.2		 2hyyC-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
THR A 277
GLY A 283
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.85A 2hyyC-3my0A:
25.2		 2hyyC-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
GLU A 244
THR A 279
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.83A 2hyyD-3mdyA:
25.0		 2hyyD-3mdyA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
ILE A 245
THR A 277
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 ( 3.8A)
None
 0.94A 2hyyD-3my0A:
24.9		 2hyyD-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
THR A 277
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.76A 2hyyD-3my0A:
24.9		 2hyyD-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		8 / 12 VAL A 216
ALA A 227
LYS A 229
GLU A 242
THR A 277
GLY A 283
ASP A 287
LEU A 337
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-3.8A)
LDN  A 600 (-4.6A)
 1.05A 2itzA-3my0A:
26.1		 2itzA-3my0A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 ALA A 229
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.61A 2oiqA-3mdyA:
24.3		 2oiqA-3mdyA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.62A 2oiqA-3mdyA:
24.3		 2oiqA-3mdyA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 ALA A 227
THR A 277
TYR A 279
GLY A 283
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.72A 2oiqA-3my0A:
24.8		 2oiqA-3my0A:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.84A 2pl0A-3mdyA:
24.4		 2pl0A-3mdyA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 GLY A 211
ALA A 229
LEU A 259
TYR A 281
GLY A 285
ALA A 349
ASP A 350
 LDN  A   1 ( 4.7A)
LDN  A   1 (-3.6A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 ( 3.8A)
LDN  A   1 (-3.9A)
 0.87A 2wgjA-3mdyA:
24.5		 2wgjA-3mdyA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 GLY A 211
VAL A 218
ALA A 229
LEU A 259
TYR A 281
GLY A 285
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
 0.71A 2wgjA-3mdyA:
24.5		 2wgjA-3mdyA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 GLY A 209
VAL A 216
ALA A 227
LEU A 257
TYR A 279
GLY A 283
ALA A 347
 None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 ( 3.8A)
 0.78A 2wgjA-3my0A:
24.5		 2wgjA-3my0A:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
LEU A 257
TYR A 279
GLY A 283
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 ( 3.8A)
None
 0.85A 2wgjA-3my0A:
24.5		 2wgjA-3my0A:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		9 / 12 LYS A 208
ILE A 210
ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
 None
LDN  A   1 (-4.1A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.59A 2y6oA-3mdyA:
25.8		 2y6oA-3mdyA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 ALA A 227
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.47A 2y6oA-3my0A:
25.4		 2y6oA-3my0A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 10 ILE A 210
VAL A 218
ALA A 229
GLY A 285
ASP A 289
LEU A 339
 LDN  A   1 (-4.1A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-3.3A)
LDN  A   1 (-3.7A)
LDN  A   1 (-4.5A)
 0.68A 2y7jD-3mdyA:
24.5		 2y7jD-3mdyA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 VAL A 218
ALA A 229
LEU A 277
THR A 279
GLY A 285
LEU A 339
ASP A 350
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.88A 3bbtD-3mdyA:
24.7		 3bbtD-3mdyA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 ALA A 229
THR A 279
GLY A 285
HIS A 330
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
None
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.46A 3cs9A-3mdyA:
25.2		 3cs9A-3mdyA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 ALA A 227
THR A 277
GLY A 283
HIS A 328
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.40A 3cs9A-3my0A:
25.0		 3cs9A-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 ALA A 229
THR A 279
GLY A 285
HIS A 330
ALA A 349
 LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
None
LDN  A   1 ( 3.8A)
 0.41A 3cs9B-3mdyA:
25.5		 3cs9B-3mdyA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		5 / 12 ALA A 227
THR A 277
GLY A 283
HIS A 328
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
None
LDN  A 600 ( 3.8A)
 0.40A 3cs9B-3my0A:
25.0		 3cs9B-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 ALA A 229
ILE A 247
THR A 279
HIS A 330
ALA A 349
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
None
LDN  A   1 ( 3.8A)
 0.88A 3cs9C-3mdyA:
24.7		 3cs9C-3mdyA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 ALA A 227
ILE A 245
THR A 277
HIS A 328
ALA A 347
ASP A 348
 LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
None
LDN  A 600 ( 3.8A)
None
 0.95A 3cs9C-3my0A:
25.0		 3cs9C-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 ALA A 229
THR A 279
GLY A 285
HIS A 330
ALA A 349
 LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
None
LDN  A   1 ( 3.8A)
 0.38A 3cs9D-3mdyA:
24.3		 3cs9D-3mdyA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		5 / 12 ALA A 227
THR A 277
GLY A 283
HIS A 328
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
None
LDN  A 600 ( 3.8A)
 0.35A 3cs9D-3my0A:
23.8		 3cs9D-3my0A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		9 / 12 GLY A 211
GLY A 216
VAL A 218
ALA A 229
LYS A 231
SER A 286
ASN A 337
LEU A 339
ASP A 350
 LDN  A   1 ( 4.7A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-4.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.61A 3eygA-3mdyA:
28.4		 3eygA-3mdyA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 GLY A 211
GLY A 216
VAL A 218
ALA A 229
LYS A 231
TYR A 281
SER A 286
ASP A 350
 LDN  A   1 ( 4.7A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 ( 4.8A)
None
LDN  A   1 (-3.9A)
 0.73A 3fupA-3mdyA:
28.0		 3fupA-3mdyA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 GLY A 211
GLY A 216
VAL A 218
ALA A 229
LYS A 231
TYR A 281
SER A 286
LEU A 339
 LDN  A   1 ( 4.7A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 ( 4.8A)
None
LDN  A   1 (-4.5A)
 0.72A 3fupA-3mdyA:
28.0		 3fupA-3mdyA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 11 VAL A 218
ALA A 229
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.56A 3g0eA-3mdyA:
23.3		 3g0eA-3mdyA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 11 VAL A 218
ALA A 229
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.66A 3g0fA-3mdyA:
23.7		 3g0fA-3mdyA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 10 VAL A 218
ALA A 229
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.53A 3g0fB-3mdyA:
23.9		 3g0fB-3mdyA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 VAL A 218
ALA A 229
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.57A 3g5dA-3mdyA:
26.5		 3g5dA-3mdyA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.60A 3g5dA-3my0A:
26.4		 3g5dA-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
THR A 277
TYR A 279
GLY A 283
LEU A 337
ALA A 347
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.59A 3g5dA-3my0A:
26.4		 3g5dA-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		9 / 12 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.70A 3g5dB-3mdyA:
26.3		 3g5dB-3mdyA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		9 / 12 VAL A 216
ALA A 227
LYS A 229
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
ALA A 347
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.71A 3g5dB-3my0A:
26.5		 3g5dB-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
GLU A 244
THR A 279
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.70A 3gvuA-3mdyA:
25.6		 3gvuA-3mdyA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
ILE A 245
THR A 277
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.95A 3gvuA-3my0A:
25.3		 3gvuA-3my0A:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 208
VAL A 216
ALA A 227
LYS A 229
GLU A 242
THR A 277
 LDN  A 600 ( 4.4A)
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
 0.93A 3hegA-3my0A:
16.1		 3hegA-3my0A:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 ALA A 227
LYS A 229
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.67A 3k54A-3my0A:
25.6		 3k54A-3my0A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 VAL A 218
ALA A 229
GLU A 244
THR A 279
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.79A 3k5vA-3mdyA:
24.5		 3k5vA-3mdyA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 ALA A 227
THR A 277
GLY A 283
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.76A 3k5vA-3my0A:
17.2		 3k5vA-3my0A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
THR A 277
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.77A 3k5vA-3my0A:
17.2		 3k5vA-3my0A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 VAL A 218
ALA A 229
GLU A 244
THR A 279
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.78A 3k5vB-3mdyA:
24.5		 3k5vB-3mdyA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 ALA A 227
THR A 277
GLY A 283
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.75A 3k5vB-3my0A:
24.2		 3k5vB-3my0A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
THR A 277
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.77A 3k5vB-3my0A:
24.2		 3k5vB-3my0A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 GLY A 211
VAL A 218
ALA A 229
LYS A 231
TYR A 281
SER A 286
LEU A 339
ASP A 350
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 ( 4.8A)
None
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.59A 3lxnA-3mdyA:
27.4		 3lxnA-3mdyA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
ILE A 245
THR A 277
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 ( 3.8A)
None
 0.94A 3ms9A-3my0A:
24.8		 3ms9A-3my0A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
THR A 277
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.73A 3ms9A-3my0A:
24.8		 3ms9A-3my0A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 VAL A 218
ALA A 229
GLU A 244
THR A 279
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.80A 3ms9B-3mdyA:
24.8		 3ms9B-3mdyA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
ILE A 245
THR A 277
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 ( 3.8A)
None
 0.97A 3mssA-3my0A:
24.9		 3mssA-3my0A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
THR A 277
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.75A 3mssA-3my0A:
24.9		 3mssA-3my0A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
ILE A 245
THR A 277
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 ( 3.8A)
None
 0.97A 3mssC-3my0A:
25.0		 3mssC-3my0A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
THR A 277
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.77A 3mssC-3my0A:
25.0		 3mssC-3my0A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 ALA A 229
GLU A 244
THR A 279
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.67A 3mssD-3mdyA:
24.8		 3mssD-3mdyA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 ALA A 229
ILE A 247
THR A 279
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 1.11A 3mssD-3mdyA:
24.8		 3mssD-3mdyA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 ALA A 227
THR A 277
GLY A 283
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.72A 3mssD-3my0A:
24.9		 3mssD-3my0A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 VAL A 218
ALA A 229
LYS A 231
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.57A 3octA-3mdyA:
25.7		 3octA-3mdyA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
LYS A 229
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.59A 3octA-3my0A:
25.4		 3octA-3my0A:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 ALA A 229
THR A 279
TYR A 281
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.48A 3oezA-3mdyA:
24.1		 3oezA-3mdyA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 VAL A 218
ALA A 229
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.64A 3oezA-3mdyA:
24.1		 3oezA-3mdyA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 ALA A 227
THR A 277
TYR A 279
GLY A 283
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.39A 3oezA-3my0A:
24.7		 3oezA-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.82A 3oezB-3mdyA:
24.4		 3oezB-3mdyA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
LYS A 229
GLU A 242
THR A 277
TYR A 279
LEU A 337
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-4.6A)
 0.79A 3oezB-3my0A:
24.8		 3oezB-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
LYS A 229
THR A 277
TYR A 279
LEU A 337
ALA A 347
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.64A 3oezB-3my0A:
24.8		 3oezB-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 VAL A 218
ALA A 229
LYS A 231
LEU A 259
THR A 279
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
 0.53A 3og7A-3mdyA:
24.8		 3og7A-3mdyA:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		5 / 12 VAL A 216
ALA A 227
LYS A 229
LEU A 257
THR A 277
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
 0.34A 3og7A-3my0A:
25.0		 3og7A-3my0A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 208
GLY A 209
VAL A 216
ALA A 227
LYS A 229
THR A 277
LEU A 337
 LDN  A 600 ( 4.4A)
None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
 0.88A 3ohtA-3my0A:
15.5		 3ohtA-3my0A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 GLY A 211
VAL A 218
ALA A 229
LYS A 231
THR A 279
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
 0.50A 3ohtB-3mdyA:
15.4		 3ohtB-3mdyA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 GLY A 209
VAL A 216
ALA A 227
LYS A 229
THR A 277
LEU A 337
 None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
 0.88A 3ohtB-3my0A:
4.5		 3ohtB-3my0A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 ALA A 229
GLU A 244
THR A 279
GLY A 285
HIS A 330
ALA A 349
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
None
LDN  A   1 ( 3.8A)
 0.66A 3oxzA-3mdyA:
25.4		 3oxzA-3mdyA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 ALA A 227
THR A 277
GLY A 283
HIS A 328
ALA A 347
ASP A 348
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
None
LDN  A 600 ( 3.8A)
None
 0.74A 3oxzA-3my0A:
24.9		 3oxzA-3my0A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
GLU A 244
THR A 279
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.69A 3pyyB-3mdyA:
25.1		 3pyyB-3mdyA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
THR A 277
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.69A 3pyyB-3my0A:
24.7		 3pyyB-3my0A:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		9 / 12 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.74A 3qlgA-3mdyA:
25.0		 3qlgA-3mdyA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		8 / 12 VAL A 216
ALA A 227
LYS A 229
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.65A 3qlgA-3my0A:
25.6		 3qlgA-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 VAL A 218
ALA A 229
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.68A 3qlgB-3mdyA:
26.1		 3qlgB-3mdyA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		8 / 12 VAL A 216
ALA A 227
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
ALA A 347
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.73A 3qlgB-3my0A:
26.5		 3qlgB-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.31A 3sxrA-3mdyA:
26.1		 3sxrA-3mdyA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.32A 3sxrB-3mdyA:
25.9		 3sxrB-3mdyA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		9 / 12 ALA A 229
LYS A 231
GLU A 244
THR A 279
LEU A 315
HIS A 330
ARG A 331
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
None
None
None
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 1.01A 3zosA-3mdyA:
23.6		 3zosA-3mdyA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		8 / 12 ALA A 227
LYS A 229
THR A 277
LEU A 313
HIS A 328
ARG A 329
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
None
None
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.95A 3zosA-3my0A:
23.7		 3zosA-3my0A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		9 / 12 ALA A 229
LYS A 231
GLU A 244
THR A 279
LEU A 315
HIS A 330
ARG A 331
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
None
None
None
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.99A 3zosB-3mdyA:
24.0		 3zosB-3mdyA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		8 / 12 ALA A 227
LYS A 229
THR A 277
LEU A 313
HIS A 328
ARG A 329
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
None
None
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.98A 3zosB-3my0A:
23.9		 3zosB-3my0A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 ALA A 227
THR A 277
LEU A 313
HIS A 328
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.86A 3zosB-3my0A:
23.9		 3zosB-3my0A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 ALA A 229
GLU A 244
ILE A 247
THR A 279
TYR A 281
LEU A 339
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
 0.77A 4bkjA-3mdyA:
24.0		 4bkjA-3mdyA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 ALA A 229
ILE A 247
THR A 279
TYR A 281
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.77A 4bkjA-3mdyA:
24.0		 4bkjA-3mdyA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
GLU A 244
ILE A 247
THR A 279
TYR A 281
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
 0.52A 4bkjA-3mdyA:
24.0		 4bkjA-3mdyA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 ALA A 227
ILE A 245
THR A 277
TYR A 279
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.85A 4bkjA-3my0A:
23.9		 4bkjA-3my0A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
ILE A 245
THR A 277
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 1.25A 4bkjA-3my0A:
23.9		 4bkjA-3my0A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
GLU A 244
ILE A 247
THR A 279
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-4.5A)
 0.89A 4bkjB-3mdyA:
24.2		 4bkjB-3mdyA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
ILE A 247
THR A 279
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 1.02A 4bkjB-3mdyA:
24.2		 4bkjB-3mdyA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
ILE A 245
THR A 277
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 1.22A 4bkjB-3my0A:
24.1		 4bkjB-3my0A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 ALA A 229
LYS A 231
GLU A 244
LEU A 259
THR A 279
HIS A 330
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 (-3.8A)
None
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.70A 4c8bA-3mdyA:
24.9		 4c8bA-3mdyA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 ALA A 227
LEU A 257
THR A 277
HIS A 328
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.66A 4c8bA-3my0A:
23.9		 4c8bA-3my0A:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 ALA A 227
LYS A 229
LEU A 257
THR A 277
HIS A 328
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.55A 4c8bA-3my0A:
23.9		 4c8bA-3my0A:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		4 / 5 VAL A 218
ILE A 258
TYR A 281
ILE A 348
 LDN  A   1 ( 4.8A)
None
LDN  A   1 ( 4.8A)
None
 0.52A 4c8bA-3mdyA:
24.9		 4c8bA-3mdyA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		4 / 5 VAL A 216
ILE A 256
TYR A 279
ILE A 346
 LDN  A 600 (-4.5A)
None
LDN  A 600 (-4.7A)
None
 0.76A 4c8bA-3my0A:
23.9		 4c8bA-3my0A:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 ALA A 229
LYS A 231
GLU A 244
ILE A 258
LEU A 259
THR A 279
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
None
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.59A 4c8bB-3mdyA:
25.1		 4c8bB-3mdyA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 ALA A 229
LYS A 231
ILE A 258
LEU A 259
THR A 279
HIS A 330
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 (-3.8A)
None
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.54A 4c8bB-3mdyA:
25.1		 4c8bB-3mdyA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		8 / 12 ALA A 227
LYS A 229
ILE A 256
LEU A 257
THR A 277
HIS A 328
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
None
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.73A 4c8bB-3my0A:
24.0		 4c8bB-3my0A:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 ILE A 256
LEU A 257
THR A 277
HIS A 328
LEU A 337
ALA A 347
ASP A 348
 None
None
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.81A 4c8bB-3my0A:
24.0		 4c8bB-3my0A:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 11 GLY A 211
GLY A 213
VAL A 218
ALA A 229
TYR A 281
GLY A 285
SER A 286
LEU A 339
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.4A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
None
LDN  A   1 (-4.5A)
 0.72A 4ckiA-3mdyA:
29.0		 4ckiA-3mdyA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 11 GLY A 209
VAL A 216
ALA A 227
TYR A 279
GLY A 283
SER A 284
LEU A 337
 None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
None
LDN  A 600 (-4.6A)
 0.81A 4ckiA-3my0A:
27.4		 4ckiA-3my0A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 VAL A 218
ALA A 229
GLU A 244
ILE A 247
THR A 279
TYR A 281
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.78A 4csvA-3mdyA:
25.2		 4csvA-3mdyA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		8 / 12 VAL A 216
ALA A 227
GLU A 242
ILE A 245
THR A 277
TYR A 279
LEU A 337
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-4.6A)
None
 1.18A 4csvA-3my0A:
25.9		 4csvA-3my0A:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		8 / 12 VAL A 216
ALA A 227
ILE A 245
THR A 277
TYR A 279
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 1.10A 4csvA-3my0A:
25.9		 4csvA-3my0A:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		9 / 12 GLY A 211
VAL A 218
ALA A 229
LYS A 231
LEU A 277
GLY A 285
ASP A 289
LEU A 339
ASP A 350
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.3A)
LDN  A   1 (-3.7A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 1.01A 4i22A-3mdyA:
24.8		 4i22A-3mdyA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
ASP A 350
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-3.9A)
 0.93A 4mxoA-3mdyA:
26.1		 4mxoA-3mdyA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.70A 4mxoB-3mdyA:
26.1		 4mxoB-3mdyA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		8 / 12 VAL A 216
ALA A 227
LYS A 229
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.76A 4mxoB-3my0A:
26.5		 4mxoB-3my0A:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.67A 4mxxA-3mdyA:
26.1		 4mxxA-3mdyA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 ALA A 227
LYS A 229
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.57A 4mxxA-3my0A:
26.3		 4mxxA-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
LYS A 229
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.56A 4mxxB-3my0A:
25.0		 4mxxB-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		8 / 12 VAL A 216
ALA A 227
GLU A 242
TYR A 279
GLY A 283
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.77A 4mxyB-3my0A:
26.8		 4mxyB-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		8 / 12 VAL A 216
ALA A 227
LYS A 229
GLU A 242
TYR A 279
GLY A 283
LEU A 337
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
None
 0.87A 4mxyB-3my0A:
26.8		 4mxyB-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		8 / 12 VAL A 216
ALA A 227
GLU A 242
TYR A 279
GLY A 283
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.77A 4mxzB-3my0A:
26.8		 4mxzB-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		8 / 12 VAL A 216
ALA A 227
LYS A 229
GLU A 242
TYR A 279
GLY A 283
LEU A 337
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
None
 0.87A 4mxzB-3my0A:
26.8		 4mxzB-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 11 GLY A 209
VAL A 216
ALA A 227
LYS A 229
LEU A 257
ASN A 335
LEU A 337
 None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.5A)
LDN  A 600 (-4.6A)
 0.85A 4o0sA-3my0A:
24.1		 4o0sA-3my0A:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		4 / 6 VAL A 218
ALA A 229
LEU A 259
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-4.5A)
 0.51A 4o0uA-3mdyA:
7.8		 4o0uA-3mdyA:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		4 / 6 VAL A 216
ALA A 227
LEU A 257
LEU A 337
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.6A)
 0.49A 4o0uA-3my0A:
8.8		 4o0uA-3my0A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		4 / 6 GLY A 211
VAL A 218
ALA A 229
LEU A 339
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-4.5A)
 0.21A 4o0wA-3mdyA:
23.7		 4o0wA-3mdyA:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 8 GLY A 213
VAL A 218
ALA A 229
ASN A 337
LEU A 339
ASP A 350
 LDN  A   1 ( 4.4A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-4.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.61A 4ogrA-3mdyA:
26.9		 4ogrA-3mdyA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 8 ILE A 210
GLY A 213
VAL A 218
ALA A 229
ASN A 337
LEU A 339
 LDN  A   1 (-4.1A)
LDN  A   1 ( 4.4A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-4.3A)
LDN  A   1 (-4.5A)
 0.59A 4ogrA-3mdyA:
26.9		 4ogrA-3mdyA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 7 GLY A 211
ALA A 229
ASN A 337
LEU A 339
ASP A 350
 LDN  A   1 ( 4.7A)
LDN  A   1 (-3.6A)
LDN  A   1 (-4.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.64A 4ogrE-3mdyA:
25.7		 4ogrE-3mdyA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 9 ILE A 210
GLY A 213
VAL A 218
ALA A 229
ASN A 337
LEU A 339
ASP A 350
 LDN  A   1 (-4.1A)
LDN  A   1 ( 4.4A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-4.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.58A 4ogrI-3mdyA:
27.2		 4ogrI-3mdyA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 VAL A 218
LYS A 231
THR A 279
TYR A 281
GLY A 285
LEU A 339
ALA A 349
ASP A 350
 LDN  A   1 ( 4.8A)
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
LDN  A   1 (-3.9A)
 0.78A 4otwA-3mdyA:
24.7		 4otwA-3mdyA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 LYS A 229
THR A 277
TYR A 279
GLY A 283
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.73A 4otwA-3my0A:
24.6		 4otwA-3my0A:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
LYS A 229
THR A 277
TYR A 279
GLY A 283
LEU A 337
ALA A 347
 LDN  A 600 (-4.5A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.68A 4otwA-3my0A:
24.6		 4otwA-3my0A:
27.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 ILE A 210
ALA A 229
GLU A 244
TYR A 281
LEU A 339
ALA A 349
ASP A 350
 LDN  A   1 (-4.1A)
LDN  A   1 (-3.6A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
LDN  A   1 (-3.9A)
 0.82A 4qmnA-3mdyA:
25.5		 4qmnA-3mdyA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 ILE A 210
ALA A 229
LYS A 231
GLU A 244
TYR A 281
LEU A 339
 LDN  A   1 (-4.1A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
 0.76A 4qmnA-3mdyA:
25.5		 4qmnA-3mdyA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 11 ILE A 210
ALA A 229
LYS A 231
GLU A 244
TYR A 281
LEU A 339
ASP A 350
 LDN  A   1 (-4.1A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.98A 4qmsA-3mdyA:
25.7		 4qmsA-3mdyA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 ILE A 210
GLY A 211
VAL A 218
ALA A 229
TYR A 281
LEU A 339
 LDN  A   1 (-4.1A)
LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
 0.52A 4qmzA-3mdyA:
26.5		 4qmzA-3mdyA:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 ALA A 229
GLU A 244
LEU A 315
ARG A 331
ALA A 349
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 ( 3.8A)
 0.90A 4qrcA-3mdyA:
25.9		 4qrcA-3mdyA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-4.5A)
 0.65A 4r7iA-3mdyA:
24.7		 4r7iA-3mdyA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
LYS A 229
GLU A 242
THR A 277
LEU A 337
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
None
 1.11A 4r7iA-3my0A:
24.9		 4r7iA-3my0A:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 10 ILE A 210
ALA A 229
LYS A 231
THR A 279
LEU A 339
 LDN  A   1 (-4.1A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-4.5A)
 0.68A 4rz7A-3mdyA:
7.9		 4rz7A-3mdyA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 ALA A 229
LYS A 231
LEU A 259
THR A 279
SER A 286
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
None
 0.67A 4rzvA-3mdyA:
7.0		 4rzvA-3mdyA:
29.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		5 / 12 ALA A 227
LYS A 229
LEU A 257
THR A 277
SER A 284
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
None
 0.76A 4rzvA-3my0A:
9.8		 4rzvA-3my0A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
LYS A 231
LEU A 259
THR A 279
SER A 286
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
None
 0.63A 4rzvB-3mdyA:
26.0		 4rzvB-3mdyA:
29.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
LYS A 229
LEU A 257
THR A 277
SER A 284
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
None
 0.74A 4rzvB-3my0A:
25.1		 4rzvB-3my0A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 10 VAL A 218
GLU A 244
ILE A 258
TYR A 281
ARG A 331
ILE A 348
 LDN  A   1 ( 4.8A)
None
None
LDN  A   1 ( 4.8A)
None
None
 0.88A 4u0iA-3mdyA:
25.2		 4u0iA-3mdyA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 ALA A 229
LYS A 231
THR A 279
GLY A 285
HIS A 330
LEU A 339
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
None
LDN  A   1 (-4.5A)
 0.51A 4u0iA-3mdyA:
25.2		 4u0iA-3mdyA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 ALA A 227
LYS A 229
THR A 277
GLY A 283
HIS A 328
LEU A 337
ASP A 348
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
None
LDN  A 600 (-4.6A)
None
 0.85A 4u0iA-3my0A:
24.8		 4u0iA-3my0A:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		8 / 11 VAL A 216
ALA A 227
TYR A 279
GLY A 283
ASN A 335
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.5A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.72A 4u5jA-3my0A:
27.6		 4u5jA-3my0A:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 ALA A 229
LEU A 315
HIS A 330
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.55A 4uxqA-3mdyA:
25.8		 4uxqA-3mdyA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		5 / 12 ALA A 227
LEU A 313
HIS A 328
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
None
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.55A 4uxqA-3my0A:
25.3		 4uxqA-3my0A:
29.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 ALA A 229
GLU A 244
LEU A 315
HIS A 330
ALA A 349
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 ( 3.8A)
 0.83A 4v01A-3mdyA:
24.9		 4v01A-3mdyA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 ALA A 229
GLU A 244
LEU A 315
HIS A 330
ALA A 349
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 ( 3.8A)
 0.74A 4v01B-3mdyA:
25.0		 4v01B-3mdyA:
26.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 9 VAL A 216
LYS A 229
TYR A 279
ARG A 329
LEU A 337
ILE A 346
 LDN  A 600 (-4.5A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
None
LDN  A 600 (-4.6A)
None
 1.04A 4v01B-3my0A:
24.5		 4v01B-3my0A:
30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
GLU A 244
HIS A 330
ALA A 349
GLY A 352
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 ( 3.8A)
None
 1.30A 4v04A-3mdyA:
24.8		 4v04A-3mdyA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
GLU A 244
LEU A 315
HIS A 330
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 ( 3.8A)
 0.90A 4v04A-3mdyA:
24.8		 4v04A-3mdyA:
26.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
HIS A 328
ALA A 347
ASP A 348
GLY A 350
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 ( 3.8A)
None
None
 0.93A 4v04A-3my0A:
24.1		 4v04A-3my0A:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
LEU A 313
HIS A 328
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
None
LDN  A 600 ( 3.8A)
None
 1.12A 4v04A-3my0A:
24.1		 4v04A-3my0A:
30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 ALA A 229
GLU A 244
LEU A 315
HIS A 330
ALA A 349
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 ( 3.8A)
 0.78A 4v04B-3mdyA:
24.8		 4v04B-3mdyA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 11 ALA A 229
THR A 279
GLY A 285
ASN A 337
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.54A 4wa9A-3mdyA:
23.8		 4wa9A-3mdyA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 11 ALA A 227
THR A 277
GLY A 283
ASN A 335
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.5A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.48A 4wa9A-3my0A:
24.1		 4wa9A-3my0A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 VAL A 218
ALA A 229
LYS A 231
THR A 279
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.83A 4wa9B-3mdyA:
26.7		 4wa9B-3mdyA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
THR A 277
GLY A 283
ASN A 335
LEU A 337
ALA A 347
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.5A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.80A 4wa9B-3my0A:
25.6		 4wa9B-3my0A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
LYS A 229
THR A 277
GLY A 283
LEU A 337
ALA A 347
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.63A 4xeyA-3my0A:
26.3		 4xeyA-3my0A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
LYS A 229
THR A 277
GLY A 283
LEU A 337
ALA A 347
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.61A 4xeyB-3my0A:
26.1		 4xeyB-3my0A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.76A 4xliA-3mdyA:
27.2		 4xliA-3mdyA:
28.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 ALA A 227
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.64A 4xliA-3my0A:
27.2		 4xliA-3my0A:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 ALA A 227
LYS A 229
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.63A 4xliA-3my0A:
27.2		 4xliA-3my0A:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.59A 4xliB-3mdyA:
27.6		 4xliB-3mdyA:
28.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 ALA A 227
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.59A 4xliB-3my0A:
27.1		 4xliB-3my0A:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 VAL A 218
ALA A 229
LEU A 259
THR A 279
ASP A 350
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.9A)
 0.48A 4xv2A-3mdyA:
25.3		 4xv2A-3mdyA:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		5 / 12 VAL A 216
ALA A 227
LYS A 229
LEU A 257
THR A 277
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
 0.44A 4xv2A-3my0A:
24.4		 4xv2A-3my0A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 GLY A 209
ALA A 227
GLY A 283
LEU A 337
ALA A 347
ASP A 348
 None
LDN  A 600 (-3.2A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.76A 5ajqA-3my0A:
16.6		 5ajqA-3my0A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		9 / 12 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.67A 5bvwA-3mdyA:
24.1		 5bvwA-3mdyA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		8 / 12 VAL A 216
ALA A 227
LYS A 229
THR A 277
TYR A 279
GLY A 283
LEU A 337
ALA A 347
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.75A 5bvwA-3my0A:
24.3		 5bvwA-3my0A:
26.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 VAL A 218
ALA A 229
LYS A 231
LEU A 259
THR A 279
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
 0.65A 5cswA-3mdyA:
25.3		 5cswA-3mdyA:
30.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		5 / 12 VAL A 216
ALA A 227
LYS A 229
LEU A 257
THR A 277
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
 0.45A 5cswA-3my0A:
24.4		 5cswA-3my0A:
28.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 VAL A 218
ALA A 229
LYS A 231
LEU A 259
THR A 279
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
 0.72A 5cswB-3mdyA:
25.1		 5cswB-3mdyA:
30.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		5 / 12 PHE A 231
VAL A 216
ALA A 227
LEU A 257
THR A 277
 None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
 0.86A 5cswB-3my0A:
24.2		 5cswB-3my0A:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		5 / 12 VAL A 216
ALA A 227
LYS A 229
LEU A 257
THR A 277
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
 0.54A 5cswB-3my0A:
24.2		 5cswB-3my0A:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
LEU A 257
THR A 277
GLY A 283
LEU A 337
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.74A 5h2uA-3my0A:
25.4		 5h2uA-3my0A:
29.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 ALA A 229
LEU A 259
THR A 279
GLY A 285
LEU A 339
ASP A 350
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.66A 5h2uB-3mdyA:
24.8		 5h2uB-3mdyA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
THR A 279
GLY A 285
LEU A 339
ASP A 350
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.77A 5h2uB-3mdyA:
24.8		 5h2uB-3mdyA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 VAL A 216
ALA A 227
LEU A 257
THR A 277
GLY A 283
LEU A 337
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.75A 5h2uB-3my0A:
25.7		 5h2uB-3my0A:
29.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 ALA A 229
LEU A 259
THR A 279
GLY A 285
LEU A 339
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.63A 5h2uC-3mdyA:
24.8		 5h2uC-3mdyA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 ALA A 229
LEU A 259
THR A 279
GLY A 285
LEU A 339
ASP A 350
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.61A 5h2uD-3mdyA:
24.8		 5h2uD-3mdyA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		4 / 6 LYS A 231
PHE A 261
SER A 286
ASP A 350
 None
None
None
LDN  A   1 (-3.9A)
 0.59A 5hesA-3mdyA:
24.6		 5hesA-3mdyA:
29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		5 / 12 VAL A 216
ALA A 227
LYS A 229
THR A 277
TYR A 279
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
 0.36A 5hesB-3my0A:
24.5		 5hesB-3my0A:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 ALA A 229
LYS A 231
GLU A 244
LEU A 259
THR A 279
LEU A 315
HIS A 330
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 (-3.8A)
None
None
 0.70A 5hi2A-3mdyA:
25.3		 5hi2A-3mdyA:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 ALA A 227
LYS A 229
LEU A 257
THR A 277
LEU A 313
HIS A 328
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
None
None
 0.72A 5hi2A-3my0A:
24.9		 5hi2A-3my0A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 GLY A 213
VAL A 218
ALA A 229
LEU A 259
THR A 279
 LDN  A   1 ( 4.4A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
 0.69A 5hieA-3mdyA:
25.7		 5hieA-3mdyA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 VAL A 218
ALA A 229
LYS A 231
LEU A 259
THR A 279
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
 0.62A 5hieA-3mdyA:
25.7		 5hieA-3mdyA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		5 / 12 PHE A 231
VAL A 216
ALA A 227
LEU A 257
THR A 277
 None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
 0.78A 5hieA-3my0A:
24.7		 5hieA-3my0A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		5 / 12 VAL A 216
ALA A 227
LYS A 229
LEU A 257
THR A 277
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
 0.40A 5hieA-3my0A:
24.7		 5hieA-3my0A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 GLY A 213
VAL A 218
ALA A 229
LEU A 259
THR A 279
 LDN  A   1 ( 4.4A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
 0.70A 5hieB-3mdyA:
25.5		 5hieB-3mdyA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 VAL A 218
ALA A 229
LYS A 231
LEU A 259
THR A 279
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
 0.61A 5hieB-3mdyA:
25.5		 5hieB-3mdyA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		5 / 12 PHE A 231
VAL A 216
ALA A 227
LEU A 257
THR A 277
 None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
 0.80A 5hieB-3my0A:
24.5		 5hieB-3my0A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		5 / 12 VAL A 216
ALA A 227
LYS A 229
LEU A 257
THR A 277
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
 0.40A 5hieB-3my0A:
24.5		 5hieB-3my0A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 GLY A 211
GLY A 213
PHE A 233
VAL A 218
ALA A 229
THR A 279
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.4A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
 1.19A 5hieC-3mdyA:
26.2		 5hieC-3mdyA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 GLY A 211
GLY A 213
VAL A 218
ALA A 229
LEU A 259
THR A 279
ASP A 350
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.4A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.9A)
 0.96A 5hieC-3mdyA:
26.2		 5hieC-3mdyA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 GLY A 211
VAL A 218
ALA A 229
LYS A 231
LEU A 259
THR A 279
ASP A 350
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.9A)
 1.01A 5hieC-3mdyA:
26.2		 5hieC-3mdyA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 GLY A 209
GLY A 214
PHE A 231
VAL A 216
ALA A 227
THR A 277
 None
None
None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
 1.42A 5hieC-3my0A:
25.0		 5hieC-3my0A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 GLY A 209
PHE A 231
VAL A 216
ALA A 227
LEU A 257
THR A 277
 None
None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
 0.80A 5hieC-3my0A:
25.0		 5hieC-3my0A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 GLY A 209
VAL A 216
ALA A 227
LYS A 229
LEU A 257
THR A 277
 None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
 0.52A 5hieC-3my0A:
25.0		 5hieC-3my0A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 GLY A 213
VAL A 218
ALA A 229
LEU A 259
THR A 279
 LDN  A   1 ( 4.4A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
 0.71A 5hieD-3mdyA:
25.7		 5hieD-3mdyA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 VAL A 218
ALA A 229
LYS A 231
LEU A 259
THR A 279
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
 0.61A 5hieD-3mdyA:
25.7		 5hieD-3mdyA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		5 / 12 PHE A 231
VAL A 216
ALA A 227
LEU A 257
THR A 277
 None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
 0.79A 5hieD-3my0A:
24.6		 5hieD-3my0A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		5 / 12 VAL A 216
ALA A 227
LYS A 229
LEU A 257
THR A 277
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
 0.38A 5hieD-3my0A:
24.6		 5hieD-3my0A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 ILE A 210
ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 (-4.1A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.70A 5i9xA-3mdyA:
25.5		 5i9xA-3mdyA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		6 / 12 ALA A 227
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.51A 5i9xA-3my0A:
25.5		 5i9xA-3my0A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 ILE A 210
ALA A 229
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 (-4.1A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.56A 5i9yA-3mdyA:
25.4		 5i9yA-3mdyA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 ALA A 227
LYS A 229
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.70A 5i9yA-3my0A:
25.4		 5i9yA-3my0A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		4 / 7 GLY A 209
GLY A 211
GLY A 214
VAL A 216
 None
None
None
LDN  A 600 (-4.5A)
 0.33A 5izjB-3my0A:
21.1		 5izjB-3my0A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		4 / 7 GLY A 209
GLY A 211
VAL A 216
LYS A 229
 None
None
LDN  A 600 (-4.5A)
LDN  A 600 (-4.0A)
 0.35A 5izjA-3my0A:
21.4		 5izjA-3my0A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		4 / 7 GLY A 211
VAL A 218
LYS A 231
ASP A 350
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
None
LDN  A   1 (-3.9A)
 0.41A 5j5xA-3mdyA:
22.8		 5j5xA-3mdyA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		4 / 7 GLY A 209
GLY A 211
VAL A 216
LYS A 229
 None
None
LDN  A 600 (-4.5A)
LDN  A 600 (-4.0A)
 0.25A 5j5xA-3my0A:
22.1		 5j5xA-3my0A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 GLY A 211
VAL A 218
ALA A 229
LEU A 339
ALA A 349
ASP A 350
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
LDN  A   1 (-3.9A)
 0.70A 5l2iA-3mdyA:
6.3		 5l2iA-3mdyA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 ILE A 210
GLY A 211
VAL A 218
ALA A 229
LYS A 231
GLU A 244
TYR A 281
GLY A 285
 LDN  A   1 (-4.1A)
LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
 0.79A 5mafA-3mdyA:
24.0		 5mafA-3mdyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		4 / 8 ALA A 229
GLU A 244
LEU A 339
ASP A 350
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.67A 5owrA-3mdyA:
20.4		 5owrA-3mdyA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 ALA A 229
GLU A 244
TYR A 281
GLY A 285
ASP A 289
ASP A 350
 LDN  A   1 (-3.6A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-3.7A)
LDN  A   1 (-3.9A)
 0.83A 5vc3A-3mdyA:
23.5		 5vc3A-3mdyA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 ILE A 210
GLY A 211
ALA A 229
TYR A 281
GLY A 285
ASP A 289
 LDN  A   1 (-4.1A)
LDN  A   1 ( 4.7A)
LDN  A   1 (-3.6A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-3.7A)
 0.79A 5vc3A-3mdyA:
23.5		 5vc3A-3mdyA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		8 / 12 GLU A 206
GLY A 209
ALA A 227
GLU A 242
TYR A 279
GLY A 283
ASP A 287
ASP A 348
 None
None
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-3.8A)
None
 0.75A 5vc3A-3my0A:
25.1		 5vc3A-3my0A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 ALA A 229
LYS A 231
GLU A 244
LEU A 277
THR A 279
GLY A 285
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
 1.04A 5vcvA-3mdyA:
22.6		 5vcvA-3mdyA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
LYS A 231
GLU A 244
LEU A 277
THR A 279
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 (-3.8A)
 0.57A 5vcyA-3mdyA:
22.7		 5vcyA-3mdyA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 ALA A 229
LYS A 231
GLU A 244
LEU A 277
GLY A 285
LEU A 339
ASP A 350
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.61A 5y7zB-3mdyA:
24.9		 5y7zB-3mdyA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
GLY A 285
LEU A 339
ASP A 350
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.70A 5y80A-3mdyA:
24.0		 5y80A-3mdyA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		6 / 12 VAL A 218
ALA A 229
GLU A 244
TYR A 281
GLY A 285
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 ( 3.8A)
 0.77A 5zv2A-3mdyA:
25.1		 5zv2A-3mdyA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		3 / 3 TYR A 281
LEU A 339
ASP A 350
 LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.77A 5zv2B-3mdyA:
24.8		 5zv2B-3mdyA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		5 / 12 ALA A 349
LYS A 334
SER A 335
ASP A 332
ARG A 214
 LDN  A   1 ( 3.8A)
None
None
None
None
 1.26A 5zvgA-3mdyA:
undetectable		 5zvgA-3mdyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		8 / 12 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.41A 6bsdA-3mdyA:
23.9		 6bsdA-3mdyA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
LYS A 229
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.67A 6bsdA-3my0A:
23.9		 6bsdA-3my0A:
11.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens) 		7 / 12 VAL A 216
ALA A 227
LYS A 229
GLU A 242
THR A 277
GLY A 283
LEU A 337
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.80A 6fnmA-3my0A:
25.7		 6fnmA-3my0A:
30.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.77A 6hd4A-3mdyA:
24.4		 6hd4A-3mdyA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens) 		7 / 12 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.78A 6hd6A-3mdyA:
24.5		 6hd6A-3mdyA:
13.02