SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LCK'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LIN_A_TFPA155_1 (CALMODULIN)	3c8w	ACETOACETATE DECARBOXYLASE ADC (Legionella pneumophila)	4 / 7	GLU A 98 MET A 61 PHE A 123 ALA A 250	None None LCK A 125 ( 4.1A) None	1.02A	1linA-3c8wA: undetectable	1linA-3c8wA: 15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B9L_A_AZZA1010_1 (SERUM ALBUMIN)	3c8w	ACETOACETATE DECARBOXYLASE ADC (Legionella pneumophila)	4 / 8	LEU A 127 PHE A 81 ARG A 118 GLY A 116	None LCK A 125 ( 4.4A) LCK A 125 (-3.9A) None	0.89A	3b9lA-3c8wA: undetectable	3b9lA-3c8wA: 17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JQ7_B_DX2B271_1 (PTERIDINE REDUCTASE 1)	3c8w	ACETOACETATE DECARBOXYLASE ADC (Legionella pneumophila)	4 / 8	ARG A 118 PHE A 107 TYR A 145 PRO A 124	LCK A 125 (-3.9A) None None LCK A 125 ( 3.2A)	1.26A	3jq7B-3c8wA: undetectable	3jq7B-3c8wA: 22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NXU_B_RITB600_2 (CYTOCHROME P450 3A4)	3c8w	ACETOACETATE DECARBOXYLASE ADC (Legionella pneumophila)	5 / 9	ILE A 73 LEU A 243 ARG A 118 LEU A 127 GLY A 116	None None LCK A 125 (-3.9A) None None	1.32A	3nxuB-3c8wA: undetectable	3nxuB-3c8wA: 19.92

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1LIN_A_TFPA155_1","CALMODULIN","3c8w","ACETOACETATE DECARBOXYLASE ADC","Legionella pneumophila",4,"GLU A  98;MET A  61;PHE A 123;ALA A 250","None;None;LCK A 125 ( 4.1A);None","1.02A","1linA-3c8wA:undetectable",null],["3B9L_A_AZZA1010_1","SERUM ALBUMIN","3c8w","ACETOACETATE DECARBOXYLASE ADC","Legionella pneumophila",4,"LEU A 127;PHE A  81;ARG A 118;GLY A 116","None;LCK A 125 ( 4.4A);LCK A 125 (-3.9A);None","0.89A","3b9lA-3c8wA:undetectable","1linA-3c8wA:15.99"],["3JQ7_B_DX2B271_1","PTERIDINE REDUCTASE 1","3c8w","ACETOACETATE DECARBOXYLASE ADC","Legionella pneumophila",4,"ARG A 118;PHE A 107;TYR A 145;PRO A 124","LCK A 125 (-3.9A);None;None;LCK A 125 ( 3.2A)","1.26A","3jq7B-3c8wA:undetectable","3b9lA-3c8wA:17.47"],["3NXU_B_RITB600_2","CYTOCHROME P450 3A4","3c8w","ACETOACETATE DECARBOXYLASE ADC","Legionella pneumophila",5,"ILE A  73;LEU A 243;ARG A 118;LEU A 127;GLY A 116","None;None;LCK A 125 (-3.9A);None;None","1.32A","3nxuB-3c8wA:undetectable","3jq7B-3c8wA:22.58"]]