SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LBV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 11 TYR D 255
ASP D 199
ARG D 467
VAL D 261
ILE D 278
 LBV  D 601 (-4.2A)
LBV  D 601 (-4.3A)
None
None
None
 1.38A 1fkjA-5llyD:
undetectable		 1fkjA-5llyD:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 11 TYR D 255
ASP D 199
ARG D 467
VAL D 261
ILE D 278
 LBV  D 601 (-4.2A)
LBV  D 601 (-4.3A)
None
None
None
 1.36A 2fkeA-5llyD:
undetectable		 2fkeA-5llyD:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 2ool SENSOR PROTEIN
(Rhodopseudomonas
palustris) 		4 / 8 ASP A 216
TYR A 185
GLY A 193
PRO A 213
 LBV  A 400 (-4.0A)
LBV  A 400 ( 4.6A)
None
None
 1.00A 2ys6A-2oolA:
undetectable		 2ys6A-2oolA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		4 / 8 ASP A 203
TYR A 172
GLY A 180
PRO A 200
 LBV  A 400 (-3.8A)
LBV  A 400 (-4.4A)
None
None
 0.90A 2ys6A-4e04A:
undetectable		 2ys6A-4e04A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4o01 BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		4 / 8 ASP A 207
TYR A 176
GLY A 184
PRO A 204
 LBV  A 600 (-3.4A)
None
None
None
 0.83A 2ys6A-4o01A:
undetectable		 2ys6A-4o01A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		4 / 8 ASP A 207
TYR A 176
GLY A 184
PRO A 204
 LBV  A 401 (-3.9A)
LBV  A 401 (-4.4A)
None
None
 0.91A 2ys6A-4y5fA:
undetectable		 2ys6A-4y5fA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		4 / 8 ASP D 199
TYR D 168
GLY D 176
PRO D 196
 LBV  D 601 (-4.3A)
LBV  D 601 (-3.9A)
None
None
 0.96A 2ys6A-5llyD:
undetectable		 2ys6A-5llyD:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 6fht BACTERIOPHYTOCHROME,
ADENYLATE CYCLASE
(Synechocystis
sp.
PCC
6803;
Deinococcus
radiodurans) 		4 / 8 ASP A 207
TYR A 176
GLY A 184
PRO A 204
 LBV  A 801 (-3.9A)
LBV  A 801 (-4.5A)
None
None
 0.97A 2ys6A-6fhtA:
undetectable		 2ys6A-6fhtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		5 / 12 PHE A 198
VAL A 159
GLN A 162
ALA A 288
LEU A 308
 LBV  A 401 ( 3.9A)
None
None
LBV  A 401 ( 4.2A)
None
 1.13A 3dh0B-4y5fA:
undetectable		 3dh0B-4y5fA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2ool SENSOR PROTEIN
(Rhodopseudomonas
palustris) 		5 / 12 MET A 273
ILE A 296
VAL A 184
VAL A 173
ARG A 231
 LBV  A 400 ( 4.6A)
None
None
None
None
 1.23A 3fpjB-2oolA:
undetectable		 3fpjB-2oolA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 10 TYR D 255
ASP D 199
ARG D 467
VAL D 261
ILE D 278
 LBV  D 601 (-4.2A)
LBV  D 601 (-4.3A)
None
None
None
 1.35A 3ihzA-5llyD:
undetectable		 3ihzA-5llyD:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 12 CYH A 285
THR A 268
HIS A 256
ILE A 220
VAL A 297
 None
LBV  A 400 (-3.4A)
LBV  A 400 (-3.5A)
None
None
 1.30A 3sp9A-4e04A:
undetectable		 3sp9A-4e04A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 12 THR A 268
HIS A 256
ILE A 220
VAL A 297
ILE A 271
 LBV  A 400 (-3.4A)
LBV  A 400 (-3.5A)
None
None
None
 1.18A 3sp9A-4e04A:
undetectable		 3sp9A-4e04A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		4 / 7 ASP D 199
PHE D 195
GLY D 449
PHE D 259
 LBV  D 601 (-4.3A)
LBV  D 601 (-3.6A)
None
None
 1.09A 3vnsA-5llyD:
undetectable		 3vnsA-5llyD:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4y5f BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		5 / 12 LEU A 220
TYR A 216
GLY A 285
GLY A 184
GLY A 281
 None
LBV  A 401 (-4.8A)
None
None
None
 1.16A 4blvA-4y5fA:
undetectable		 4blvA-4y5fA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 6fht BACTERIOPHYTOCHROME,
ADENYLATE CYCLASE
(Synechocystis
sp.
PCC
6803;
Deinococcus
radiodurans) 		5 / 12 LEU A 220
TYR A 216
GLY A 285
GLY A 184
GLY A 281
 None
LBV  A 801 (-4.5A)
None
None
None
 1.13A 4blvA-6fhtA:
undetectable		 4blvA-6fhtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		4 / 8 HIS A 193
GLU A 181
MET A 166
ILE A 179
 LBV  A 701 (-3.8A)
None
None
None
 1.35A 4cx7A-6et7A:
undetectable
4cx7B-6et7A:
undetectable		 4cx7A-6et7A:
12.57
4cx7B-6et7A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 4o01 BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		3 / 3 ASP A 207
LEU A 463
GLY A 464
 LBV  A 600 (-3.4A)
None
None
 0.55A 4xmfA-4o01A:
undetectable		 4xmfA-4o01A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 211
ALA A 208
ILE A 283
ALA A 305
PHE A 174
 None
LBV  A 400 ( 3.7A)
None
None
None
 1.13A 5n5dB-4e04A:
undetectable		 5n5dB-4e04A:
22.45