SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LBT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		4 / 8 TYR A  84
LEU A 331
ASP A 153
LEU A 152
 LBT  A 401 ( 3.7A)
None
LBT  A 401 (-3.0A)
None
 1.05A 1e7cA-4rkrA:
undetectable		 1e7cA-4rkrA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE
(Photobacterium
sp.
JT-ISH-224) 		4 / 7 ASP A 232
LEU A 171
SER A 205
ASN A 208
 LBT  A2000 ( 2.9A)
None
None
None
 1.21A 1ig3A-2z4tA:
3.9
1ig3B-2z4tA:
3.9		 1ig3A-2z4tA:
17.33
1ig3B-2z4tA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		6 / 10 LEU A 331
ALA A 307
ILE A 150
LEU A 311
ASP A 153
LEU A 152
 None
None
None
None
LBT  A 401 (-3.0A)
None
 1.15A 1yi4A-4rkrA:
undetectable		 1yi4A-4rkrA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE
(Photobacterium
sp.
JT-ISH-224) 		4 / 8 HIS A 123
ASP A 122
SER A 430
ASP A 232
 LBT  A2000 ( 4.0A)
MG  A5001 (-4.4A)
C5P  A1427 (-2.7A)
LBT  A2000 ( 2.9A)
 0.73A 2p02A-2z4tA:
undetectable		 2p02A-2z4tA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 1w8o BACTERIAL SIALIDASE
(Micromonospora
viridifaciens) 		3 / 3 TYR A 550
ASP A 515
HIS A 539
 None
None
LBT  A1648 (-3.9A)
 0.87A 3e23A-1w8oA:
undetectable		 3e23A-1w8oA:
16.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 3i8t GALECTIN-4
(Mus
musculus) 		6 / 6 HIS A  75
ASN A  77
ARG A  79
ASN A  89
TRP A  96
GLU A  99
 LBT  A 165 (-4.0A)
GOL  A 167 ( 3.2A)
LBT  A 165 (-2.6A)
LBT  A 165 (-3.8A)
LBT  A 165 ( 3.6A)
LBT  A 165 (-3.0A)
 0.25A 3galA-3i8tA:
24.2		 3galA-3i8tA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 5nlh GALECTIN
(Gallus
gallus) 		6 / 6 HIS A  48
ASN A  50
ARG A  52
ASN A  61
TRP A  68
GLU A  71
 LBT  A 201 (-3.5A)
LBT  A 201 (-3.7A)
LBT  A 201 (-2.6A)
LBT  A 201 (-3.9A)
LBT  A 201 (-3.0A)
LBT  A 201 (-2.1A)
 0.20A 3galA-5nlhA:
22.3		 3galA-5nlhA:
33.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 3i8t GALECTIN-4
(Mus
musculus) 		6 / 6 HIS A  75
ASN A  77
ARG A  79
ASN A  89
TRP A  96
GLU A  99
 LBT  A 165 (-4.0A)
GOL  A 167 ( 3.2A)
LBT  A 165 (-2.6A)
LBT  A 165 (-3.8A)
LBT  A 165 ( 3.6A)
LBT  A 165 (-3.0A)
 0.35A 3galB-3i8tA:
24.2		 3galB-3i8tA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 5nlh GALECTIN
(Gallus
gallus) 		6 / 6 HIS A  48
ASN A  50
ARG A  52
ASN A  61
TRP A  68
GLU A  71
 LBT  A 201 (-3.5A)
LBT  A 201 (-3.7A)
LBT  A 201 (-2.6A)
LBT  A 201 (-3.9A)
LBT  A 201 (-3.0A)
LBT  A 201 (-2.1A)
 0.26A 3galB-5nlhA:
22.1		 3galB-5nlhA:
33.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		5 / 12 TYR A  84
GLY A 131
GLY A 115
ALA A 308
PHE A  85
 LBT  A 401 ( 3.7A)
None
None
None
None
 1.00A 3vywC-4rkrA:
3.6		 3vywC-4rkrA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		4 / 7 HIS A 333
TYR A 167
ASN A  82
ARG A 206
 None
None
LBT  A 401 (-3.3A)
LBT  A 401 (-2.8A)
 1.00A 4o7gA-4rkrA:
undetectable
4o7gB-4rkrA:
undetectable		 4o7gA-4rkrA:
22.90
4o7gB-4rkrA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE
(Photobacterium
sp.
JT-ISH-224) 		4 / 8 HIS A 123
ASP A 122
SER A 430
ASP A 232
 LBT  A2000 ( 4.0A)
MG  A5001 (-4.4A)
C5P  A1427 (-2.7A)
LBT  A2000 ( 2.9A)
 0.71A 5a1iA-2z4tA:
undetectable		 5a1iA-2z4tA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE
(Photobacterium
sp.
JT-ISH-224) 		4 / 7 HIS A 123
ASP A 122
SER A 430
ASP A 232
 LBT  A2000 ( 4.0A)
MG  A5001 (-4.4A)
C5P  A1427 (-2.7A)
LBT  A2000 ( 2.9A)
 0.71A 5a1iA-2z4tA:
undetectable		 5a1iA-2z4tA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		4 / 6 TYR A  84
GLY A 305
SER A  91
LEU A 301
 LBT  A 401 ( 3.7A)
None
None
None
 1.24A 5bphA-4rkrA:
6.7		 5bphA-4rkrA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		4 / 4 TYR A  84
GLY A 305
SER A  91
LEU A 301
 LBT  A 401 ( 3.7A)
None
None
None
 1.21A 5bphC-4rkrA:
4.7		 5bphC-4rkrA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		4 / 6 TYR A  84
GLY A 305
SER A  91
LEU A 301
 LBT  A 401 ( 3.7A)
None
None
None
 1.22A 5bphD-4rkrA:
4.6		 5bphD-4rkrA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3i8t GALECTIN-4
(Mus
musculus) 		4 / 8 HIS A  75
ASN A  77
HIS A  59
GLY A 152
 LBT  A 165 (-4.0A)
GOL  A 167 ( 3.2A)
GOL  A 167 (-3.8A)
GOL  A 167 ( 3.7A)
 0.87A 5m8rC-3i8tA:
undetectable		 5m8rC-3i8tA:
16.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 3i8t GALECTIN-4
(Mus
musculus) 		6 / 7 HIS A  75
ASN A  77
ARG A  79
ASN A  89
TRP A  96
GLU A  99
 LBT  A 165 (-4.0A)
GOL  A 167 ( 3.2A)
LBT  A 165 (-2.6A)
LBT  A 165 (-3.8A)
LBT  A 165 ( 3.6A)
LBT  A 165 (-3.0A)
 0.20A 6b8kA-3i8tA:
24.4		 6b8kA-3i8tA:
34.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 5nlh GALECTIN
(Gallus
gallus) 		6 / 7 HIS A  48
ASN A  50
ARG A  52
ASN A  61
TRP A  68
GLU A  71
 LBT  A 201 (-3.5A)
LBT  A 201 (-3.7A)
LBT  A 201 (-2.6A)
LBT  A 201 (-3.9A)
LBT  A 201 (-3.0A)
LBT  A 201 (-2.1A)
 0.17A 6b8kA-5nlhA:
22.3		 6b8kA-5nlhA:
37.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 3i8t GALECTIN-4
(Mus
musculus) 		6 / 8 HIS A  75
ASN A  77
ARG A  79
ASN A  89
TRP A  96
GLU A  99
 LBT  A 165 (-4.0A)
GOL  A 167 ( 3.2A)
LBT  A 165 (-2.6A)
LBT  A 165 (-3.8A)
LBT  A 165 ( 3.6A)
LBT  A 165 (-3.0A)
 0.39A 6b94A-3i8tA:
19.4		 6b94A-3i8tA:
24.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 5nlh GALECTIN
(Gallus
gallus) 		6 / 8 HIS A  48
ASN A  50
ARG A  52
ASN A  61
TRP A  68
GLU A  71
 LBT  A 201 (-3.5A)
LBT  A 201 (-3.7A)
LBT  A 201 (-2.6A)
LBT  A 201 (-3.9A)
LBT  A 201 (-3.0A)
LBT  A 201 (-2.1A)
 0.31A 6b94A-5nlhA:
19.3		 6b94A-5nlhA:
32.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 3i8t GALECTIN-4
(Mus
musculus) 		6 / 10 HIS A  75
ASN A  77
ARG A  79
ASN A  89
TRP A  96
GLU A  99
 LBT  A 165 (-4.0A)
GOL  A 167 ( 3.2A)
LBT  A 165 (-2.6A)
LBT  A 165 (-3.8A)
LBT  A 165 ( 3.6A)
LBT  A 165 (-3.0A)
 0.37A 6b94A-3i8tA:
19.4
6b94B-3i8tA:
19.0		 6b94A-3i8tA:
24.49
6b94B-3i8tA:
24.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_B_W9TB201_0
(GALECTIN-1)		 5nlh GALECTIN
(Gallus
gallus) 		6 / 10 HIS A  48
ASN A  50
ARG A  52
ASN A  61
TRP A  68
GLU A  71
 LBT  A 201 (-3.5A)
LBT  A 201 (-3.7A)
LBT  A 201 (-2.6A)
LBT  A 201 (-3.9A)
LBT  A 201 (-3.0A)
LBT  A 201 (-2.1A)
 0.32A 6b94A-5nlhA:
19.3
6b94B-5nlhA:
18.6		 6b94A-5nlhA:
32.93
6b94B-5nlhA:
32.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE
(Photobacterium
sp.
JT-ISH-224) 		4 / 8 HIS A 123
ASP A 122
SER A 430
ASP A 232
 LBT  A2000 ( 4.0A)
MG  A5001 (-4.4A)
C5P  A1427 (-2.7A)
LBT  A2000 ( 2.9A)
 0.72A 6fboA-2z4tA:
undetectable		 6fboA-2z4tA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE
(Photobacterium
sp.
JT-ISH-224) 		4 / 8 HIS A 123
ASP A 122
SER A 430
ASP A 232
 LBT  A2000 ( 4.0A)
MG  A5001 (-4.4A)
C5P  A1427 (-2.7A)
LBT  A2000 ( 2.9A)
 0.80A 6fcbA-2z4tA:
undetectable		 6fcbA-2z4tA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE
(Photobacterium
sp.
JT-ISH-224) 		4 / 8 HIS A 123
ASP A 122
SER A 430
ASP A 232
 LBT  A2000 ( 4.0A)
MG  A5001 (-4.4A)
C5P  A1427 (-2.7A)
LBT  A2000 ( 2.9A)
 0.71A 6fcdA-2z4tA:
undetectable		 6fcdA-2z4tA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE
(Photobacterium
sp.
JT-ISH-224) 		4 / 7 HIS A 123
ASP A 122
SER A 430
ASP A 232
 LBT  A2000 ( 4.0A)
MG  A5001 (-4.4A)
C5P  A1427 (-2.7A)
LBT  A2000 ( 2.9A)
 0.72A 6g6rA-2z4tA:
undetectable		 6g6rA-2z4tA:
20.42