SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LB2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		5 / 12 ALA A 311
LEU A 175
PRO A 174
THR A 294
ILE A 308
 None
None
None
LB2  A 501 ( 4.6A)
None
 1.31A 1mx8A-4r2fA:
undetectable		 1mx8A-4r2fA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		4 / 6 PHE A 124
GLY A 117
GLY A 118
ASN A 329
 None
LB2  A 501 (-3.1A)
LB2  A 501 (-3.3A)
None
 0.97A 2qr2A-4r2fA:
undetectable
2qr2B-4r2fA:
undetectable		 2qr2A-4r2fA:
20.79
2qr2B-4r2fA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		5 / 9 PHE A 326
GLY A 118
PRO A 327
GLY A 413
ILE A 227
 LB2  A 501 (-4.0A)
LB2  A 501 (-3.3A)
None
None
None
 1.48A 3ko0H-4r2fA:
undetectable
3ko0I-4r2fA:
0.0		 3ko0H-4r2fA:
12.27
3ko0I-4r2fA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 12 ALA A  73
GLY A  69
PHE A  70
THR A  41
LEU A 114
 None
None
LB2  A 502 (-3.7A)
None
None
 0.98A 4n48B-5u6sA:
2.9		 4n48B-5u6sA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 12 ALA A  73
GLY A  69
PHE A  70
THR A  41
LEU A 114
 None
None
LB2  A 502 (-3.7A)
None
None
 1.01A 4n49A-5u6sA:
3.1		 4n49A-5u6sA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudarthrobacte
r
chlorophenolicus) 		3 / 3 GLY A 117
THR A 115
ASN A 328
 LB2  A 501 (-3.1A)
None
LB2  A 501 (-3.0A)
 0.71A 5odiG-4r2fA:
undetectable		 5odiG-4r2fA:
20.96