SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LAT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3wg1 GALACTOSIDE-BINDING
LECTIN
(Agrocybe
aegerita) 		5 / 10 THR A  48
PHE A  65
ALA A  64
ASN A  51
VAL A  29
 None
None
LAT  A 201 ( 4.2A)
None
None
 1.33A 1claA-3wg1A:
undetectable		 1claA-3wg1A:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 1z3v CELLULASE
(Phanerochaete
chrysosporium) 		10 / 12 ALA A 140
TYR A 142
ASP A 170
SER A 171
GLN A 172
GLU A 207
ASP A 209
GLU A 212
ARG A 240
ASP A 366
 None
None
None
None
LAT  A 500 (-3.3A)
None
None
LAT  A 500 ( 4.5A)
LAT  A 500 (-3.1A)
None
 0.54A 1dy4A-1z3vA:
62.2		 1dy4A-1z3vA:
55.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 1z3v CELLULASE
(Phanerochaete
chrysosporium) 		10 / 12 ALA A 140
TYR A 142
TYR A 168
ASP A 170
SER A 171
GLN A 172
GLU A 207
ASP A 209
GLU A 212
ASP A 366
 None
None
None
None
None
LAT  A 500 (-3.3A)
None
None
LAT  A 500 ( 4.5A)
None
 0.24A 1dy4A-1z3vA:
62.2		 1dy4A-1z3vA:
55.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_2
(EXOGLUCANASE 1)		 1z3v CELLULASE
(Phanerochaete
chrysosporium) 		4 / 5 HIS A 223
TRP A 364
ALA A 369
TRP A 373
 LAT  A 500 ( 4.9A)
None
LAT  A 500 ( 4.3A)
LAT  A 500 (-3.7A)
 0.29A 1dy4A-1z3vA:
62.2		 1dy4A-1z3vA:
55.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 4izx RICIN B-LIKE LECTIN
(Macrolepiota
procera) 		5 / 11 ILE A  31
ASN A  28
GLY A 119
GLY A  33
ASP A  22
 None
None
None
None
LAT  A 201 (-2.8A)
 1.23A 1ho5A-4izxA:
undetectable		 1ho5A-4izxA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I1E_A_DM2A3001_1
(BOTULINUM NEUROTOXIN
TYPE B)		 1dll TETANUS TOXIN
(Clostridium
tetani) 		5 / 9 GLY A1269
HIS A1271
SER A1287
TRP A1289
TYR A1290
 None
LAT  A2000 ( 4.9A)
GOL  A3000 ( 2.6A)
GOL  A3000 ( 3.3A)
GOL  A3000 ( 4.0A)
 0.44A 1i1eA-1dllA:
0.0		 1i1eA-1dllA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ym3 GALECTIN-4
(Homo
sapiens) 		4 / 8 SER A 220
ASN A 238
GLN A 313
PHE A 221
 None
LAT  A 401 (-4.0A)
None
None
 1.35A 1rs6A-4ym3A:
undetectable		 1rs6A-4ym3A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ym3 GALECTIN-4
(Homo
sapiens) 		4 / 8 SER A 220
ASN A 238
GLN A 313
PHE A 221
 None
LAT  A 401 (-4.0A)
None
None
 1.34A 1rs7B-4ym3A:
undetectable		 1rs7B-4ym3A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4izx RICIN B-LIKE LECTIN
(Macrolepiota
procera) 		4 / 8 SER A  60
SER A  62
SER A  57
GLN A  42
 None
None
None
LAT  A 201 ( 4.4A)
 0.82A 2cmlC-4izxA:
undetectable		 2cmlC-4izxA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3wg1 GALACTOSIDE-BINDING
LECTIN
(Agrocybe
aegerita) 		4 / 8 ILE A 118
PHE A  96
ARG A  66
LEU A  50
 None
None
LAT  A 201 (-3.0A)
None
 0.88A 2eilN-3wg1A:
undetectable
2eilW-3wg1A:
undetectable		 2eilN-3wg1A:
15.15
2eilW-3wg1A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 4i4s BEL BETA-TREFOIL
(Boletus
edulis) 		5 / 10 ILE A  24
LEU A  71
ASN A  93
ASN A  67
ILE A  84
 None
None
LAT  A 201 (-3.1A)
None
LAT  A 201 (-3.9A)
 1.22A 2nnhB-4i4sA:
undetectable		 2nnhB-4i4sA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3wg1 GALACTOSIDE-BINDING
LECTIN
(Agrocybe
aegerita) 		4 / 8 ILE A 118
PHE A  96
ARG A  66
LEU A  50
 None
None
LAT  A 201 (-3.0A)
None
 0.92A 3ablN-3wg1A:
undetectable
3ablW-3wg1A:
undetectable		 3ablN-3wg1A:
15.15
3ablW-3wg1A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3wg1 GALACTOSIDE-BINDING
LECTIN
(Agrocybe
aegerita) 		4 / 8 ILE A 118
PHE A  96
ARG A  66
LEU A  50
 None
None
LAT  A 201 (-3.0A)
None
 0.84A 3ag3N-3wg1A:
undetectable
3ag3W-3wg1A:
undetectable		 3ag3N-3wg1A:
15.15
3ag3W-3wg1A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 6fof GALECTIN-3,GALECTIN-
3
(Homo
sapiens) 		4 / 5 VAL C 172
PHE C 149
ARG C 186
ARG C 169
 None
None
LAT  C 301 (-4.0A)
None
 1.38A 3bjwE-6fofC:
undetectable		 3bjwE-6fofC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1gzc ERYTHRINA
CRISTA-GALLI LECTIN
(Erythrina
crista-galli) 		5 / 12 GLY A  90
ALA A  88
PHE A 131
THR A 130
LEU A 160
 None
LAT  A1559 ( 3.8A)
LAT  A1559 ( 3.7A)
None
None
 0.72A 3dh0A-1gzcA:
undetectable		 3dh0A-1gzcA:
19.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 3m2m GALECTIN-1
(Rattus
norvegicus) 		6 / 6 HIS A  44
ASN A  46
ARG A  48
ASN A  61
TRP A  68
GLU A  71
 LAT  A 999 (-3.7A)
LAT  A 999 (-4.1A)
LAT  A 999 (-3.1A)
LAT  A 999 (-3.7A)
LAT  A 999 (-3.7A)
LAT  A 999 (-3.0A)
 0.32A 3galA-3m2mA:
20.1		 3galA-3m2mA:
30.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 3wg1 GALACTOSIDE-BINDING
LECTIN
(Agrocybe
aegerita) 		5 / 6 HIS A  62
ARG A  66
ASN A  75
TRP A  83
GLU A  86
 LAT  A 201 (-3.9A)
LAT  A 201 (-3.0A)
LAT  A 201 (-4.1A)
LAT  A 201 (-3.8A)
LAT  A 201 (-2.8A)
 0.37A 3galA-3wg1A:
16.1		 3galA-3wg1A:
23.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 4bmb GALECTIN-8
(Homo
sapiens) 		6 / 6 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A1155 (-3.9A)
LAT  A1155 (-3.9A)
LAT  A1155 (-2.7A)
LAT  A1155 (-3.9A)
LAT  A1155 (-3.6A)
LAT  A1155 (-3.0A)
 0.25A 3galA-4bmbA:
23.3		 3galA-4bmbA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 4ym3 GALECTIN-4
(Homo
sapiens) 		6 / 6 HIS A 236
ASN A 238
ARG A 240
ASN A 249
TRP A 256
GLU A 259
 LAT  A 401 (-3.9A)
LAT  A 401 (-4.0A)
LAT  A 401 (-2.6A)
LAT  A 401 (-3.7A)
LAT  A 401 ( 3.8A)
LAT  A 401 (-3.1A)
 0.27A 3galA-4ym3A:
22.8		 3galA-4ym3A:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 5dux GALECTIN-4
(Homo
sapiens) 		6 / 6 HIS B  63
ASN B  65
ARG B  67
ASN B  77
TRP B  84
GLU B  87
 LAT  B 201 (-3.9A)
LAT  B 201 (-3.8A)
LAT  B 201 (-2.6A)
LAT  B 201 (-3.9A)
LAT  B 201 ( 3.8A)
LAT  B 201 (-2.4A)
 0.25A 3galA-5duxB:
24.8		 3galA-5duxB:
36.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 5gzg GALECTIN-8
(Homo
sapiens) 		6 / 6 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A 201 (-3.9A)
LAT  A 201 (-4.2A)
LAT  A 201 (-2.3A)
LAT  A 201 (-3.6A)
LAT  A 201 (-3.7A)
LAT  A 201 (-3.0A)
 0.29A 3galA-5gzgA:
23.2		 3galA-5gzgA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 6fof GALECTIN-3,GALECTIN-
3
(Homo
sapiens) 		6 / 6 HIS C 158
ASN C 160
ARG C 162
ASN C 174
TRP C 181
GLU C 184
 LAT  C 301 (-3.8A)
LAT  C 301 (-4.1A)
LAT  C 301 (-2.7A)
LAT  C 301 (-3.8A)
LAT  C 301 (-3.8A)
LAT  C 301 ( 2.8A)
 0.26A 3galA-6fofC:
22.3		 3galA-6fofC:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 3m2m GALECTIN-1
(Rattus
norvegicus) 		6 / 6 HIS A  44
ASN A  46
ARG A  48
ASN A  61
TRP A  68
GLU A  71
 LAT  A 999 (-3.7A)
LAT  A 999 (-4.1A)
LAT  A 999 (-3.1A)
LAT  A 999 (-3.7A)
LAT  A 999 (-3.7A)
LAT  A 999 (-3.0A)
 0.34A 3galB-3m2mA:
19.6		 3galB-3m2mA:
30.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 3wg1 GALACTOSIDE-BINDING
LECTIN
(Agrocybe
aegerita) 		5 / 6 HIS A  62
ARG A  66
ASN A  75
TRP A  83
GLU A  86
 LAT  A 201 (-3.9A)
LAT  A 201 (-3.0A)
LAT  A 201 (-4.1A)
LAT  A 201 (-3.8A)
LAT  A 201 (-2.8A)
 0.48A 3galB-3wg1A:
15.6		 3galB-3wg1A:
23.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4bmb GALECTIN-8
(Homo
sapiens) 		4 / 6 HIS A  65
ASN A  67
ARG A  45
TRP A  86
 LAT  A1155 (-3.9A)
LAT  A1155 (-3.9A)
LAT  A1155 (-2.9A)
LAT  A1155 (-3.6A)
 1.22A 3galB-4bmbA:
23.0		 3galB-4bmbA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4bmb GALECTIN-8
(Homo
sapiens) 		6 / 6 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A1155 (-3.9A)
LAT  A1155 (-3.9A)
LAT  A1155 (-2.7A)
LAT  A1155 (-3.9A)
LAT  A1155 (-3.6A)
LAT  A1155 (-3.0A)
 0.35A 3galB-4bmbA:
23.0		 3galB-4bmbA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4ym3 GALECTIN-4
(Homo
sapiens) 		6 / 6 HIS A 236
ASN A 238
ARG A 240
ASN A 249
TRP A 256
GLU A 259
 LAT  A 401 (-3.9A)
LAT  A 401 (-4.0A)
LAT  A 401 (-2.6A)
LAT  A 401 (-3.7A)
LAT  A 401 ( 3.8A)
LAT  A 401 (-3.1A)
 0.30A 3galB-4ym3A:
22.6		 3galB-4ym3A:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 5dux GALECTIN-4
(Homo
sapiens) 		6 / 6 HIS B  63
ASN B  65
ARG B  67
ASN B  77
TRP B  84
GLU B  87
 LAT  B 201 (-3.9A)
LAT  B 201 (-3.8A)
LAT  B 201 (-2.6A)
LAT  B 201 (-3.9A)
LAT  B 201 ( 3.8A)
LAT  B 201 (-2.4A)
 0.34A 3galB-5duxB:
24.5		 3galB-5duxB:
36.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 6 HIS A  65
ASN A  67
ARG A  45
ASN A  79
TRP A  86
 LAT  A 201 (-3.9A)
LAT  A 201 (-4.2A)
LAT  A 201 (-2.8A)
LAT  A 201 (-3.6A)
LAT  A 201 (-3.7A)
 1.43A 3galB-5gzgA:
22.9		 3galB-5gzgA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 5gzg GALECTIN-8
(Homo
sapiens) 		6 / 6 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A 201 (-3.9A)
LAT  A 201 (-4.2A)
LAT  A 201 (-2.3A)
LAT  A 201 (-3.6A)
LAT  A 201 (-3.7A)
LAT  A 201 (-3.0A)
 0.37A 3galB-5gzgA:
22.9		 3galB-5gzgA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 6fof GALECTIN-3,GALECTIN-
3
(Homo
sapiens) 		6 / 6 HIS C 158
ASN C 160
ARG C 162
ASN C 174
TRP C 181
GLU C 184
 LAT  C 301 (-3.8A)
LAT  C 301 (-4.1A)
LAT  C 301 (-2.7A)
LAT  C 301 (-3.8A)
LAT  C 301 (-3.8A)
LAT  C 301 ( 2.8A)
 0.42A 3galB-6fofC:
22.3		 3galB-6fofC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5dux GALECTIN-4
(Homo
sapiens) 		3 / 3 ARG B  67
ASP B 141
ASP B  69
 LAT  B 201 (-2.6A)
None
None
 0.73A 3jayA-5duxB:
undetectable		 3jayA-5duxB:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5dux GALECTIN-4
(Homo
sapiens) 		3 / 3 ARG B  67
ASP B 141
ASP B  69
 LAT  B 201 (-2.6A)
None
None
 0.74A 3jb2A-5duxB:
undetectable		 3jb2A-5duxB:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5dux GALECTIN-4
(Homo
sapiens) 		3 / 3 ARG B  67
ASP B 141
ASP B  69
 LAT  B 201 (-2.6A)
None
None
 0.67A 3jb3A-5duxB:
undetectable		 3jb3A-5duxB:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 1gzc ERYTHRINA
CRISTA-GALLI LECTIN
(Erythrina
crista-galli) 		4 / 4 GLY A 105
TYR A 106
GLY A 217
ASP A  46
 None
None
LAT  A1559 (-3.1A)
None
 1.04A 3kl3A-1gzcA:
undetectable		 3kl3A-1gzcA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 12 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A1155 (-3.9A)
NA  A1156 (-3.3A)
None
GOL  A1157 (-3.6A)
 1.48A 3mbhB-4bmbA:
undetectable		 3mbhB-4bmbA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 12 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A 201 (-3.9A)
NA  A 202 (-3.3A)
None
None
 1.47A 3mbhB-5gzgA:
undetectable		 3mbhB-5gzgA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 12 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A1155 (-3.9A)
NA  A1156 (-3.3A)
None
GOL  A1157 (-3.6A)
 1.46A 3mbhC-4bmbA:
undetectable		 3mbhC-4bmbA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 12 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A 201 (-3.9A)
NA  A 202 (-3.3A)
None
None
 1.45A 3mbhC-5gzgA:
undetectable		 3mbhC-5gzgA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 12 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A1155 (-3.9A)
NA  A1156 (-3.3A)
None
GOL  A1157 (-3.6A)
 1.49A 3mbhD-4bmbA:
undetectable		 3mbhD-4bmbA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 12 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A 201 (-3.9A)
NA  A 202 (-3.3A)
None
None
 1.48A 3mbhD-5gzgA:
undetectable		 3mbhD-5gzgA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 12 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A1155 (-3.9A)
NA  A1156 (-3.3A)
None
GOL  A1157 (-3.6A)
 1.49A 3mbhE-4bmbA:
undetectable		 3mbhE-4bmbA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 12 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A 201 (-3.9A)
NA  A 202 (-3.3A)
None
None
 1.47A 3mbhE-5gzgA:
undetectable		 3mbhE-5gzgA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4bmb GALECTIN-8
(Homo
sapiens) 		5 / 11 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A1155 (-3.9A)
NA  A1156 (-3.3A)
None
GOL  A1157 (-3.6A)
 1.48A 3mbhF-4bmbA:
undetectable		 3mbhF-4bmbA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3wg1 GALACTOSIDE-BINDING
LECTIN
(Agrocybe
aegerita) 		5 / 11 ALA A  49
THR A  48
ALA A  64
ALA A  15
GLY A  14
 None
None
LAT  A 201 ( 4.2A)
None
None
 0.86A 3mg0K-3wg1A:
undetectable
3mg0L-3wg1A:
undetectable		 3mg0K-3wg1A:
19.74
3mg0L-3wg1A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3wg1 GALACTOSIDE-BINDING
LECTIN
(Agrocybe
aegerita) 		5 / 12 ALA A  49
THR A  48
ALA A  64
ALA A  15
GLY A  14
 None
None
LAT  A 201 ( 4.2A)
None
None
 0.88A 3mg0Y-3wg1A:
undetectable
3mg0Z-3wg1A:
undetectable		 3mg0Y-3wg1A:
19.74
3mg0Z-3wg1A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 4a3x EPA1P
([Candida]
glabrata) 		4 / 8 ALA A 163
ASP A 165
ILE A 109
VAL A 169
 None
LAT  A1269 ( 2.5A)
None
None
 0.72A 3nu9A-4a3xA:
undetectable		 3nu9A-4a3xA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 4izx RICIN B-LIKE LECTIN
(Macrolepiota
procera) 		3 / 3 ASP A  22
GLY A  25
TYR A  34
 LAT  A 201 (-2.8A)
LAT  A 201 (-3.5A)
LAT  A 201 ( 3.5A)
 0.54A 3w9tC-4izxA:
16.4		 3w9tC-4izxA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 4izx RICIN B-LIKE LECTIN
(Macrolepiota
procera) 		3 / 3 ASP A  22
GLY A  25
TYR A  34
 LAT  A 201 (-2.8A)
LAT  A 201 (-3.5A)
LAT  A 201 ( 3.5A)
 0.53A 3w9tG-4izxA:
16.5		 3w9tG-4izxA:
17.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 1z3v CELLULASE
(Phanerochaete
chrysosporium) 		9 / 9 ASN A 138
ALA A 140
TYR A 142
TYR A 168
ASP A 170
GLU A 207
ASP A 209
GLU A 212
TRP A 364
 None
None
None
None
None
None
None
LAT  A 500 ( 4.5A)
None
 0.47A 4ipmA-1z3vA:
62.5		 4ipmA-1z3vA:
55.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ym3 GALECTIN-4
(Homo
sapiens) 		4 / 7 SER A 220
ASN A 238
GLN A 313
PHE A 221
 None
LAT  A 401 (-4.0A)
None
None
 1.44A 4kcnB-4ym3A:
undetectable		 4kcnB-4ym3A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1z3v CELLULASE
(Phanerochaete
chrysosporium) 		4 / 5 TYR A 168
SER A 362
ASP A 209
ASP A 251
 None
None
None
LAT  A 500 ( 3.8A)
 1.23A 4qtuB-1z3vA:
undetectable		 4qtuB-1z3vA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wg1 GALACTOSIDE-BINDING
LECTIN
(Agrocybe
aegerita) 		4 / 7 ILE A 118
PHE A  96
ARG A  66
LEU A  50
 None
None
LAT  A 201 (-3.0A)
None
 0.92A 5iy5N-3wg1A:
undetectable
5iy5W-3wg1A:
undetectable		 5iy5N-3wg1A:
15.15
5iy5W-3wg1A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3m2m GALECTIN-1
(Rattus
norvegicus) 		4 / 5 HIS A  52
ASP A 125
GLY A 124
ASN A  46
 LAT  A 999 (-3.9A)
None
None
LAT  A 999 (-4.1A)
 1.41A 5x7pB-3m2mA:
undetectable		 5x7pB-3m2mA:
6.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 3m2m GALECTIN-1
(Rattus
norvegicus) 		7 / 7 HIS A  44
ASN A  46
ARG A  48
ASN A  61
TRP A  68
GLU A  71
ARG A  73
 LAT  A 999 (-3.7A)
LAT  A 999 (-4.1A)
LAT  A 999 (-3.1A)
LAT  A 999 (-3.7A)
LAT  A 999 (-3.7A)
LAT  A 999 (-3.0A)
LAT  A 999 ( 4.7A)
 0.47A 6b8kA-3m2mA:
19.9		 6b8kA-3m2mA:
36.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 3wg1 GALACTOSIDE-BINDING
LECTIN
(Agrocybe
aegerita) 		6 / 7 HIS A  62
ARG A  66
ASN A  75
TRP A  83
GLU A  86
ARG A  88
 LAT  A 201 (-3.9A)
LAT  A 201 (-3.0A)
LAT  A 201 (-4.1A)
LAT  A 201 (-3.8A)
LAT  A 201 (-2.8A)
LAT  A 201 (-4.4A)
 0.47A 6b8kA-3wg1A:
15.8		 6b8kA-3wg1A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4bmb GALECTIN-8
(Homo
sapiens) 		6 / 7 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A1155 (-3.9A)
LAT  A1155 (-3.9A)
LAT  A1155 (-2.7A)
LAT  A1155 (-3.9A)
LAT  A1155 (-3.6A)
LAT  A1155 (-3.0A)
 0.17A 6b8kA-4bmbA:
23.2		 6b8kA-4bmbA:
28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4ym3 GALECTIN-4
(Homo
sapiens) 		6 / 7 HIS A 236
ASN A 238
ARG A 240
ASN A 249
TRP A 256
GLU A 259
 LAT  A 401 (-3.9A)
LAT  A 401 (-4.0A)
LAT  A 401 (-2.6A)
LAT  A 401 (-3.7A)
LAT  A 401 ( 3.8A)
LAT  A 401 (-3.1A)
 0.19A 6b8kA-4ym3A:
22.4		 6b8kA-4ym3A:
24.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 5dux GALECTIN-4
(Homo
sapiens) 		4 / 7 ASN B  77
TRP B  84
GLU B  87
ARG B  89
 LAT  B 201 (-3.9A)
LAT  B 201 ( 3.8A)
LAT  B 201 (-2.4A)
LAT  B 201 ( 3.7A)
 1.10A 6b8kA-5duxB:
24.6		 6b8kA-5duxB:
31.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 5dux GALECTIN-4
(Homo
sapiens) 		6 / 7 HIS B  63
ASN B  65
ARG B  67
ASN B  77
TRP B  84
GLU B  87
 LAT  B 201 (-3.9A)
LAT  B 201 (-3.8A)
LAT  B 201 (-2.6A)
LAT  B 201 (-3.9A)
LAT  B 201 ( 3.8A)
LAT  B 201 (-2.4A)
 0.21A 6b8kA-5duxB:
24.6		 6b8kA-5duxB:
31.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 5gzg GALECTIN-8
(Homo
sapiens) 		6 / 7 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A 201 (-3.9A)
LAT  A 201 (-4.2A)
LAT  A 201 (-2.3A)
LAT  A 201 (-3.6A)
LAT  A 201 (-3.7A)
LAT  A 201 (-3.0A)
 0.17A 6b8kA-5gzgA:
23.1		 6b8kA-5gzgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 6fof GALECTIN-3,GALECTIN-
3
(Homo
sapiens) 		4 / 7 ARG C 186
ASN C 166
GLU C 165
ARG C 162
 LAT  C 301 (-4.0A)
None
LAT  C 301 ( 4.7A)
LAT  C 301 (-2.7A)
 1.16A 6b8kA-6fofC:
27.8		 6b8kA-6fofC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 6fof GALECTIN-3,GALECTIN-
3
(Homo
sapiens) 		7 / 7 HIS C 158
ASN C 160
ARG C 162
ASN C 174
TRP C 181
GLU C 184
ARG C 186
 LAT  C 301 (-3.8A)
LAT  C 301 (-4.1A)
LAT  C 301 (-2.7A)
LAT  C 301 (-3.8A)
LAT  C 301 (-3.8A)
LAT  C 301 ( 2.8A)
LAT  C 301 (-4.0A)
 0.27A 6b8kA-6fofC:
27.8		 6b8kA-6fofC:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 3m2m GALECTIN-1
(Rattus
norvegicus) 		8 / 8 HIS A  44
ASN A  46
ARG A  48
HIS A  52
ASN A  61
TRP A  68
GLU A  71
ARG A  73
 LAT  A 999 (-3.7A)
LAT  A 999 (-4.1A)
LAT  A 999 (-3.1A)
LAT  A 999 (-3.9A)
LAT  A 999 (-3.7A)
LAT  A 999 (-3.7A)
LAT  A 999 (-3.0A)
LAT  A 999 ( 4.7A)
 0.33A 6b94A-3m2mA:
26.7		 6b94A-3m2mA:
92.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 3wg1 GALACTOSIDE-BINDING
LECTIN
(Agrocybe
aegerita) 		6 / 8 HIS A  62
ARG A  66
ASN A  75
TRP A  83
GLU A  86
ARG A  88
 LAT  A 201 (-3.9A)
LAT  A 201 (-3.0A)
LAT  A 201 (-4.1A)
LAT  A 201 (-3.8A)
LAT  A 201 (-2.8A)
LAT  A 201 (-4.4A)
 0.55A 6b94A-3wg1A:
14.7		 6b94A-3wg1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 4bmb GALECTIN-8
(Homo
sapiens) 		6 / 8 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A1155 (-3.9A)
LAT  A1155 (-3.9A)
LAT  A1155 (-2.7A)
LAT  A1155 (-3.9A)
LAT  A1155 (-3.6A)
LAT  A1155 (-3.0A)
 0.42A 6b94A-4bmbA:
18.9		 6b94A-4bmbA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 4ym3 GALECTIN-4
(Homo
sapiens) 		6 / 8 HIS A 236
ASN A 238
ARG A 240
ASN A 249
TRP A 256
GLU A 259
 LAT  A 401 (-3.9A)
LAT  A 401 (-4.0A)
LAT  A 401 (-2.6A)
LAT  A 401 (-3.7A)
LAT  A 401 ( 3.8A)
LAT  A 401 (-3.1A)
 0.33A 6b94A-4ym3A:
18.7		 6b94A-4ym3A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 5dux GALECTIN-4
(Homo
sapiens) 		6 / 8 HIS B  63
ASN B  65
ARG B  67
ASN B  77
TRP B  84
GLU B  87
 LAT  B 201 (-3.9A)
LAT  B 201 (-3.8A)
LAT  B 201 (-2.6A)
LAT  B 201 (-3.9A)
LAT  B 201 ( 3.8A)
LAT  B 201 (-2.4A)
 0.31A 6b94A-5duxB:
19.5		 6b94A-5duxB:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 5dux GALECTIN-4
(Homo
sapiens) 		5 / 8 HIS B  63
ASN B  77
TRP B  84
GLU B  87
ARG B  89
 LAT  B 201 (-3.9A)
LAT  B 201 (-3.9A)
LAT  B 201 ( 3.8A)
LAT  B 201 (-2.4A)
LAT  B 201 ( 3.7A)
 1.11A 6b94A-5duxB:
19.5		 6b94A-5duxB:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 5gzg GALECTIN-8
(Homo
sapiens) 		6 / 8 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A 201 (-3.9A)
LAT  A 201 (-4.2A)
LAT  A 201 (-2.3A)
LAT  A 201 (-3.6A)
LAT  A 201 (-3.7A)
LAT  A 201 (-3.0A)
 0.41A 6b94A-5gzgA:
18.7		 6b94A-5gzgA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 6fof GALECTIN-3,GALECTIN-
3
(Homo
sapiens) 		4 / 8 ARG C 186
ASN C 166
GLU C 165
ARG C 162
 LAT  C 301 (-4.0A)
None
LAT  C 301 ( 4.7A)
LAT  C 301 (-2.7A)
 1.16A 6b94A-6fofC:
19.2		 6b94A-6fofC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 6fof GALECTIN-3,GALECTIN-
3
(Homo
sapiens) 		7 / 8 HIS C 158
ASN C 160
ARG C 162
ASN C 174
TRP C 181
GLU C 184
ARG C 186
 LAT  C 301 (-3.8A)
LAT  C 301 (-4.1A)
LAT  C 301 (-2.7A)
LAT  C 301 (-3.8A)
LAT  C 301 (-3.8A)
LAT  C 301 ( 2.8A)
LAT  C 301 (-4.0A)
 0.59A 6b94A-6fofC:
19.2		 6b94A-6fofC:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_B_W9TB201_0
(GALECTIN-1)		 3m2m GALECTIN-1
(Rattus
norvegicus) 		9 / 10 HIS A  44
ASN A  46
ARG A  48
HIS A  52
ASP A  54
ASN A  61
TRP A  68
GLU A  71
ARG A  73
 LAT  A 999 (-3.7A)
LAT  A 999 (-4.1A)
LAT  A 999 (-3.1A)
LAT  A 999 (-3.9A)
None
LAT  A 999 (-3.7A)
LAT  A 999 (-3.7A)
LAT  A 999 (-3.0A)
LAT  A 999 ( 4.7A)
 0.38A 6b94A-3m2mA:
26.7
6b94B-3m2mA:
25.9		 6b94A-3m2mA:
92.50
6b94B-3m2mA:
92.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 3wg1 GALACTOSIDE-BINDING
LECTIN
(Agrocybe
aegerita) 		6 / 10 HIS A  62
ARG A  66
ASN A  75
TRP A  83
GLU A  86
ARG A  88
 LAT  A 201 (-3.9A)
LAT  A 201 (-3.0A)
LAT  A 201 (-4.1A)
LAT  A 201 (-3.8A)
LAT  A 201 (-2.8A)
LAT  A 201 (-4.4A)
 0.62A 6b94A-3wg1A:
14.8
6b94B-3wg1A:
14.2		 6b94A-3wg1A:
20.12
6b94B-3wg1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 4bmb GALECTIN-8
(Homo
sapiens) 		6 / 10 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A1155 (-3.9A)
LAT  A1155 (-3.9A)
LAT  A1155 (-2.7A)
LAT  A1155 (-3.9A)
LAT  A1155 (-3.6A)
LAT  A1155 (-3.0A)
 0.41A 6b94A-4bmbA:
18.9
6b94B-4bmbA:
18.6		 6b94A-4bmbA:
29.57
6b94B-4bmbA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 4ym3 GALECTIN-4
(Homo
sapiens) 		6 / 10 HIS A 236
ASN A 238
ARG A 240
ASN A 249
TRP A 256
GLU A 259
 LAT  A 401 (-3.9A)
LAT  A 401 (-4.0A)
LAT  A 401 (-2.6A)
LAT  A 401 (-3.7A)
LAT  A 401 ( 3.8A)
LAT  A 401 (-3.1A)
 0.35A 6b94A-4ym3A:
18.7
6b94B-4ym3A:
18.2		 6b94A-4ym3A:
24.46
6b94B-4ym3A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 5dux GALECTIN-4
(Homo
sapiens) 		6 / 10 HIS B  63
ASN B  65
ARG B  67
ASN B  77
TRP B  84
GLU B  87
 LAT  B 201 (-3.9A)
LAT  B 201 (-3.8A)
LAT  B 201 (-2.6A)
LAT  B 201 (-3.9A)
LAT  B 201 ( 3.8A)
LAT  B 201 (-2.4A)
 0.33A 6b94A-5duxB:
19.4
6b94B-5duxB:
19.1		 6b94A-5duxB:
27.69
6b94B-5duxB:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 5gzg GALECTIN-8
(Homo
sapiens) 		6 / 10 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A 201 (-3.9A)
LAT  A 201 (-4.2A)
LAT  A 201 (-2.3A)
LAT  A 201 (-3.6A)
LAT  A 201 (-3.7A)
LAT  A 201 (-3.0A)
 0.40A 6b94A-5gzgA:
18.7
6b94B-5gzgA:
18.4		 6b94A-5gzgA:
23.17
6b94B-5gzgA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 6fof GALECTIN-3,GALECTIN-
3
(Homo
sapiens) 		7 / 10 HIS C 158
ASN C 160
ARG C 162
ASN C 174
TRP C 181
GLU C 184
ARG C 186
 LAT  C 301 (-3.8A)
LAT  C 301 (-4.1A)
LAT  C 301 (-2.7A)
LAT  C 301 (-3.8A)
LAT  C 301 (-3.8A)
LAT  C 301 ( 2.8A)
LAT  C 301 (-4.0A)
 0.45A 6b94A-6fofC:
19.2
6b94B-6fofC:
18.5		 6b94A-6fofC:
undetectable
6b94B-6fofC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 3wg1 GALACTOSIDE-BINDING
LECTIN
(Agrocybe
aegerita) 		4 / 4 ARG A  66
GLU A  69
GLU A  86
ARG A  88
 LAT  A 201 (-3.0A)
None
LAT  A 201 (-2.8A)
LAT  A 201 (-4.4A)
 0.85A 6fk2A-3wg1A:
15.8		 6fk2A-3wg1A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 3wg1 GALACTOSIDE-BINDING
LECTIN
(Agrocybe
aegerita) 		4 / 4 ARG A  88
GLU A  86
GLU A  69
ARG A  66
 LAT  A 201 (-4.4A)
LAT  A 201 (-2.8A)
None
LAT  A 201 (-3.0A)
 0.97A 6fk2A-3wg1A:
15.8		 6fk2A-3wg1A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 6fof GALECTIN-3,GALECTIN-
3
(Homo
sapiens) 		4 / 4 ARG C 162
GLU C 165
GLU C 184
ARG C 186
 LAT  C 301 (-2.7A)
LAT  C 301 ( 4.7A)
LAT  C 301 ( 2.8A)
LAT  C 301 (-4.0A)
 0.22A 6fk2A-6fofC:
27.9		 6fk2A-6fofC:
undetectable