SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LAQ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 4 HIS A 147
ALA A 146
PHE A  86
GLY A 148
 LAQ  A 401 (-3.7A)
None
None
LAQ  A 401 ( 3.8A)
 1.23A 1mj2B-5iclA:
undetectable		 1mj2B-5iclA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 4 HIS A 147
ALA A 146
PHE A  86
GLY A 148
 LAQ  A 401 (-3.7A)
None
None
LAQ  A 401 ( 3.8A)
 1.26A 1mj2D-5iclA:
undetectable		 1mj2D-5iclA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 4 HIS A 147
ALA A 146
PHE A  86
GLY A 148
 LAQ  A 401 (-3.7A)
None
None
LAQ  A 401 ( 3.8A)
 1.23A 1mjoB-5iclA:
undetectable		 1mjoB-5iclA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 4 HIS A 147
ALA A 146
PHE A  86
GLY A 148
 LAQ  A 401 (-3.7A)
None
None
LAQ  A 401 ( 3.8A)
 1.24A 1mjoA-5iclA:
undetectable		 1mjoA-5iclA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 4 HIS A 147
ALA A 146
PHE A  86
GLY A 148
 LAQ  A 401 (-3.7A)
None
None
LAQ  A 401 ( 3.8A)
 1.25A 1mjoD-5iclA:
undetectable		 1mjoD-5iclA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 SER A  85
ILE A  87
VAL A   4
TYR A  35
LEU A  15
 None
None
None
LAQ  A 401 (-4.9A)
None
 1.19A 2japA-5iclA:
undetectable		 2japA-5iclA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 SER A  85
ILE A  87
VAL A   4
TYR A  35
LEU A  15
 None
None
None
LAQ  A 401 (-4.9A)
None
 1.18A 2japC-5iclA:
undetectable		 2japC-5iclA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 PHE A 145
HIS A  77
LEU A  82
LEU A  32
LEU A  15
 None
LAQ  A 401 (-4.5A)
None
None
None
 1.16A 3adsA-5iclA:
undetectable		 3adsA-5iclA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		4 / 8 GLY A  78
THR A  79
GLN A  52
GLU A  57
 LAQ  A2001 ( 3.2A)
None
None
None
 0.93A 3rglA-2e5aA:
5.9		 3rglA-2e5aA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 7 LEU A  15
GLY A  71
ALA A 136
PHE A 286
 None
None
LAQ  A 401 ( 4.3A)
None
 0.81A 3tehB-5iclA:
undetectable		 3tehB-5iclA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 LEU A  82
ILE A 105
GLU A  18
GLY A 148
GLY A 134
 None
None
None
LAQ  A 401 ( 3.8A)
LAQ  A 401 (-3.2A)
 1.15A 4hfpB-5iclA:
undetectable		 4hfpB-5iclA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		4 / 6 GLY A 138
ASP A 127
GLY A  78
ARG A 100
 LAQ  A2001 ( 3.4A)
MG  A3001 ( 3.3A)
LAQ  A2001 ( 3.2A)
ACY  A5001 ( 4.2A)
 1.01A 4z53A-2e5aA:
3.2
4z53B-2e5aA:
2.6		 4z53A-2e5aA:
18.63
4z53B-2e5aA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 8 GLY A 283
ILE A  42
GLY A  71
PHE A 285
 None
LAQ  A 401 ( 4.1A)
None
None
 0.67A 5alcL-5iclA:
undetectable		 5alcL-5iclA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 6 ASN A  81
THR A 149
ASN A  83
ILE A  42
 LAQ  A 401 (-3.8A)
LAQ  A 401 (-3.1A)
LAQ  A 401 ( 4.2A)
LAQ  A 401 ( 4.1A)
 0.96A 5uigA-5iclA:
undetectable		 5uigA-5iclA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 12 VAL A  80
VAL A  47
HIS A 150
ILE A  87
ASN A  88
 LAQ  A2001 ( 3.6A)
LAQ  A2001 ( 4.8A)
None
None
LAQ  A2001 ( 4.4A)
 1.38A 6mxtA-2e5aA:
undetectable		 6mxtA-2e5aA:
21.69