SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LAF'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		4 / 8 TYR A 289
TYR A 324
VAL A 218
ILE A  54
 None
LAF  A1337 (-4.6A)
None
None
 1.10A 4aftD-1gzgA:
0.0
4aftE-1gzgA:
0.0		 4aftD-1gzgA:
21.52
4aftE-1gzgA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 181
ASP A 176
TYR A 202
 MG  A1338 (-4.7A)
None
LAF  A1337 ( 4.6A)
 0.87A 4yo9B-1gzgA:
0.0		 4yo9B-1gzgA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		4 / 6 TYR A 211
TYR A 324
GLY A 262
ASP A 267
 LAF  A1336 ( 3.9A)
LAF  A1337 (-4.6A)
None
None
 1.34A 5emlA-1gzgA:
6.0		 5emlA-1gzgA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 317
LEU A 322
PHE A  86
TYR A 324
THR A 280
MET A 258
 None
None
LAF  A1337 (-4.4A)
LAF  A1337 (-4.6A)
None
None
 1.48A 5eskA-1gzgA:
0.0		 5eskA-1gzgA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  80
PRO A  81
ALA A 312
GLY A 262
TYR A 283
 None
None
None
None
LAF  A1337 (-3.5A)
 1.04A 5igtA-1gzgA:
0.0		 5igtA-1gzgA:
24.29