SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LAE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1l3l TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Agrobacterium
tumefaciens) 		4 / 5 THR A  51
THR A 167
THR A  60
HIS A  54
 LAE  A1003 ( 4.2A)
None
None
None
 1.44A 1d4fB-1l3lA:
undetectable		 1d4fB-1l3lA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Sinorhizobium
fredii) 		4 / 5 LEU A  75
ASP A  72
GLY A 115
ALA A  78
 None
LAE  A1001 (-3.0A)
None
None
 0.70A 2aohA-2q0oA:
undetectable		 2aohA-2q0oA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Sinorhizobium
fredii) 		4 / 5 LEU A  75
ASP A  72
GLY A 115
ALA A  78
 None
LAE  A1001 (-3.0A)
None
None
 0.66A 2aohB-2q0oA:
undetectable		 2aohB-2q0oA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1l3l TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Agrobacterium
tumefaciens) 		4 / 8 PHE A 101
ALA A 105
THR A  51
LEU A  40
 LAE  A1003 (-4.2A)
LAE  A1003 (-3.2A)
LAE  A1003 ( 4.2A)
LAE  A1003 (-4.0A)
 0.95A 3l4dA-1l3lA:
undetectable		 3l4dA-1l3lA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 1l3l TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Agrobacterium
tumefaciens) 		4 / 7 THR A 129
GLY A  36
ALA A 131
ILE A 110
 LAE  A1003 (-3.8A)
None
None
LAE  A1003 ( 4.3A)
 0.82A 4txnA-1l3lA:
undetectable		 4txnA-1l3lA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 1l3l TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Agrobacterium
tumefaciens) 		4 / 7 THR A 129
GLY A  36
ALA A 131
ILE A 110
 LAE  A1003 (-3.8A)
None
None
LAE  A1003 ( 4.3A)
 0.86A 4txnB-1l3lA:
undetectable		 4txnB-1l3lA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 1l3l TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Agrobacterium
tumefaciens) 		4 / 7 THR A 129
GLY A  36
ALA A 131
ILE A 110
 LAE  A1003 (-3.8A)
None
None
LAE  A1003 ( 4.3A)
 0.88A 4txnC-1l3lA:
undetectable		 4txnC-1l3lA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 1l3l TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Agrobacterium
tumefaciens) 		4 / 7 THR A 129
GLY A  36
ALA A 131
ILE A 110
 LAE  A1003 (-3.8A)
None
None
LAE  A1003 ( 4.3A)
 0.86A 4txnD-1l3lA:
undetectable		 4txnD-1l3lA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Sinorhizobium
fredii) 		4 / 8 SER A 109
ARG A  38
PRO A 135
ILE A 112
 None
None
None
LAE  A1001 (-4.2A)
 0.93A 5jhdE-2q0oA:
undetectable
5jhdG-2q0oA:
undetectable		 5jhdE-2q0oA:
23.70
5jhdG-2q0oA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
(Sinorhizobium
fredii) 		5 / 12 ALA A  40
LEU A 154
VAL A  74
ASP A  83
PHE A  85
 LAE  A1001 ( 3.9A)
None
LAE  A1001 ( 4.6A)
None
None
 1.42A 5vlmD-2q0oA:
undetectable		 5vlmD-2q0oA:
22.46